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唐时幸

发布时间:2017-06-20 10:20:22 作者:

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职 称:教授


通信地址:

广州大道北1838号南方医科大学公共卫生学院

Email:tamgshixing@smu.edu.cn


职 务:无

职称级别:


学术任职:中国生物技术协会体外诊断技术分会常委,全国体外诊断产业技术创新战略联盟理事


最高学历:博士


所属科室:流行病学系


研究方向:感染性疾病的分子流行病学研究


科研项目:1. 国家科技重大专项“重大传染病新型诊断     技术与产品研发”;

              2. 广州市健康医疗协同创新重大专项“性传播疾病综合防控技术研究与应用”

成果奖励:

1.        军队科技进步二等奖(1996年), 排名第一。

2.        美国国家健康研究院优秀研究人员奖(2001年)

3.        美国食品与药物管理局科研成就奖(2007)

4.    美国食品与药物管理局杰出评审团队奖(2009年)

5.    美国食品与药物管理局杰出分析科学奖(2011年)

6.        以“传染病检测方法和试剂研究领域国际知名专家“获选广东省创新领军人才(2012年)

专利/Patents:

1.        发明专利“用于高通量抗体快速检测的荧光素酶免疫吸附方法201710297294.2”

2.        “HIV重组融合抗原及其表达基因和制备方法CN102492041B”

3.        “H7亚型禽流感病毒胶体金试纸条CN204731247U”

4.        “样品垫处理液、H7亚型禽流感病毒胶体金试纸条及其制备方法CN104251908A”

5.        “乙肝病毒表面抗原重组嵌合蛋白及其制备方法和应用CN103864903A”

6.        “HCV重组融合抗原及其表达基因和制备方法CN103819565A”

代表论文:

1.      Tang     S, Yu GL, Chen SR. Intrauterine infection with Hepatitis B virus. Lancet     1990; 335:302

2.      Tang     S, Collier AJ, and Elliott RM. Alterations to both the primary and     predicted secondary structure of stem-loop IIIc of the HCV 1b 5’UTR lead to     mutants severely defective in translation which cannot be complemented in     trans by the wild type 5’UTR sequence.  J. Virol. 1999;73:2359-2364.

3.      Tang     S, Murakami T, Agresta BE, Campbell S, Freed EO, Levin JG. Human     immunodeficiency virus type 1 N-terminal capsid mutants that exhibit     aberrant core morphology and are blocked in initiation of reverse     transcription in infected cells. J. Virol. 2001;75:9357-9366.

4.      Tang     S, Murakami T, Cheng N, Steven AC, Freed EO, and Levin JG. Human immunodeficiency     virus type 1 N-terminal capsid mutants containing cores with abnormally     high levels of capsid protein and virtually no reverse transcriptase. J.     Virol. 2003;77:12592-12602

5.      Tang     S, Ablan S, Dueck M, Ayala-López W, Soto B, Caplan M, Nagashima, Hewlett     IK, Freed EO, Levin JG. A Second-Site Suppressor Significantly Improves the     Defective Phenotype Imposed by Mutation of an Aromatic Residue in the     N-terminal Domain of the HIV-1 Capsid Protein. Virology. 2007; 359:105-115

6.      Tang     S, Zhao J, Storhoff J, Norris, P., Little R., Yarchoan R., Stramer S, Patno     T, Domanus M, Dhar D., Mirkin C A, Hewllett I K. Nanoparticle-based     biobarcode amplification assay (BCA) for sensitive detection of human     immunodeficiency virus Type 1 (HIV-1) capsid (p24) antigen. J. AIDS, 2007;     46(2):231-7

7.      Tang     S, Moayeri M, Chen Z, Harma H, Zhao J, Purcell RH, Leppla SH, Hewlett IK.     Detection of anthrax toxin by an ultrasensitive immunoassay using europium     nanoparticles. Clinical and Vaccine Immunology. 2009; 16 (3):408-413

8.      Tang     S, Moayeri M, Chen Z, Harma H, Zhao J, Purcell RH, Leppla SH, Hewlett IK.     Detection of anthrax toxin by an ultrasensitive immunoassay using europium     nanoparticles. Clinical and Vaccine Immunology. 2009; 16 (3):408-413

9.      Tang     S and Hewlett I. Nanoparticle-based Immunoassay for Sensitive and Early     Detection of Human Immunodeficiency Type 1 Capsid (p24) Antigen. J. Infect.     Dis. 2010; 210(s1): S59-S64.

10.  Tang S, Zhao     J, Wang A, Viswanath R, Harma H, Little RF, Yarchoan R, Stramer SL, Lee S,     Wood O, Wong EY, Wang X, Hewlett IK. Characterization of immune responses     to capsid protein (p24) of human immunodeficiency virus type 1:     implications for detection. Clinical Vaccine Immunology, 2010;     17(8):1244-51

11.  Tang S and     Hewlett I. Europium nanoparticle-based immunoassays for sensitive detection     of pathogens. Chemistry Today, 2009; 27(6):50-52

12.  Tang S, Zhao     J, Viswanath R, Nyambi PN, Redd AD, Dastyar A, Spacek LA, Quinn TC, Wang X,     Wood O, Gaddam D and Hewlett IK. Absence of Detectable Xenotropic Murine     Leukemia Virus-related Virus in Plasma or Peripheral Blood Mononuclear     Cells of Human Immunodeficiency Virus Type One Infected Blood donors or     Individuals in Africa. Transfusion 2011; 51(3):463-8

13.  Tang S, Zhao     J, Haleyurgirisetty M, Gaddam D, Viswanath R, Wood O, Devadas K, Zhang P,     Hewlett IK. Absence of Detectable XMRV and other MLV-related Virus in     Healthy Blood donors in the United States. PLoS One 2011; 6(11):e27391

14.  Sastalla I,     Tang S, Crown D, Liu S, Eckhaus M, Hewlett I, Leppla S, and Moayeri M.     Anthrax edema toxin impairs protein clearance in mice. Infection and     Immunity 2012; 80(2):529-38

15.  Zhao J, Tang     S, Ragupathy V, Gaddam D, Wang X, Zhang P, Nyambi PN, Hewlett I. CRF22_01A1     is involved in the emergence of new HIV-1 recombinants in Cameroon. J     Acquir Immune Defic Syndr. 2012 Apr 30. 60(4):344-50

16.  Kang K, Chen     L, Zhao X, Qin C, Zhan Z , Wang J, Li W, Dzakah EE , Huang W, Shu Y, Jiang     T, Cao W, Xie Q, Luo X, Tang S. Developemnt of Rapid Immunochromatographic     Test for Detecting Hemagglutinin Antigen of H7 Subtype in Patients Infected     with Novel Avian Influenza A (H7N9) Virus. PLoS One 2014; 9(3):e92306

17.  Li X, Wu Y,     Ren X, Deng S, Hu G, Yu S, Tang S. Characterization of Humoral Immune     Responses against Capsid Protein p24 and Transmembrane Glycoprotein gp41 of     Human Immunodeficiency Virus Type 1 in China. PLoS One.     2016;11(11):e0165874

18.  Wu Y, Ren X,     Yin D, Wang H, Wan Z, Li X, Hu G, Tang S. Characterization of a novel HIV-1     unique 1 recombinant form between CRF07_BC and CRF55_01B in men who have     sex with men in Guangzhou, China. PLoS One 2017; 12(4): e0175770.

19.  Yue Wu,     Haiying Wang, Xuqi Ren2,3, Zhengwei Wan, Guifang Hu1,     Shixing Tang. HIV-1 CRF07_BC with a Seven Amino Acid Deletion in the gag p6     Region Dominates in HIV-1-Infected Men Who Have Sex with Men in China. AIDS     Res Hum Retroviruses 2017; accepted

20.  Haiying     Wang, Zhengwei Wan, Qiang Sun, Yue Wu, Xiufen Li, Xiaoping An, Shuyun Deng,     Nalin Zhu, Xuqi Ren, Yigang Tong, Shixing Tang. Identification of a Novel hepegivirus HHpgV-1 in China     Associated with Coinfection of HCV and HIV-1. Emerging Infect Dis 2017;     under review

21.  Haiying     Wang, Zhengwei Wan, Ru Xu, Yujuan Guan, Nalin Zhu, Jianping Li, Zhiwei Xie,     Aiqi Lu, Fuchun Zhang, Yongshui Fu, Shixing Tang. A Novel Human Pegivirus HHpgV-1 is Tightly Associated     with HCV and HIV-1 Infection but Does Not Worsen HCV-related Liver     Damage.Clin Infect Dis 2017; under review

                               
                               
   
教育背景

1990/8–1993/7, 北京军事医学科学院流行病学博士

1986/8–1989/7, 广州第一军医大学流行病学硕士

1981/8–1986/7, 广州第一军医大学临床医学学士

工作经历

2014/12-至今,南方医科大学,公共卫生学院,教授

2011/7-2014/9,广州万孚生物技术股份有限公司副总经理首席科学家

2004/3-2011/6,美国食品药物管理局(FDA)生物产品评审中心资深科学家

1997/10-2004/3,美国健康研究院(NIH)资深科学家

1996/10-1997/10,英国格拉斯哥大学(Univ. of Glasgow)病毒学研究所助研

1995/8-1996/10,军事医学科学院微生物流行病研究所,助研

1993/8-1995/7,北京医科大学博士后

研究方向

1.        HIV分子流行病学与复制机制研究

2.        性传播疾病与艾滋病病原体共感染研究

3.        新发传染病研究

4.        传染病新型检测技术与方法研究

RESEARCH INTERESTS

1.      Molecular     epidemiology and virology of HIV infection and replication

2.      Co-infection     and interaction of sexually transmitted diseases and HIV infection

3.      Identification     and characterization of emerging and re-emerging infectious diseases

4.        Development     of novel diagnostic technologies for infectious diseases