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范建兵 教授

发布时间:2017-08-21

基本信息

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教师姓名: 范建兵

技术职称: 教授

联系方式: 020-34438809/jianbing_fan@anchordx.com

学术任职:曾任北京基因研究所(BGI)和国家基因组南方研究中心(上海)的客座教授和高级顾问2009-2014年,任医学遗传学国家重点实验室学术委员会委员;2013-至今,任加拿大基因组学组织的研究评审委员(Research Oversight Committee (ROC), Genome Canada)。

研究方向:基因检测技术、肿瘤基因组研究及精准医疗

个人简介

范博士曾任Illumina公司资深技术总监,拥有30余年从事人类基因组学、基因芯片(Microarrays)及高通量测序技术开发的经验。作为Illumina公司初期基因芯片技术(BeadArray technology)的核心研发人员及公司第23号员工,见证和参与了Illumina公司17年来的辉煌成长。范博士带领团队成功研发的一系列产品广泛用于基因组学基因分型(SNP genotyping),基因表达(gene expression)和核酸甲基化(DNA methylation)等领域,为人类基因组学的迅猛发展做出了卓越贡献。近年来,范博士致力于开发高通量测序技术的临床应用,挑战高难度医学样本,如肿瘤石蜡切片、血液、唾液、循环肿瘤细胞(CTCs)以及血浆游离DNAcfDNA)等,带领开发的一系列技术被运用到了多种临床产品中,包括无创产前筛查(NIPT),胚胎植入前遗传筛查和诊断(PGS/PGD),癌症基因检测以及早期筛查等。此外,范博士带领团队完成了世界首个高通量测序平台(Illumina MiSeqDx)的美国 FDA认证,成为高通量测序技术临床应用的一重大里程碑。加入Illumina之前,范博士任职于基因芯片行业巨头Affymetrix,带领团队开发用于大规模基因组基因分型(SNP genotyping)的科研产品。加入Affymetrix前,范博士任职于UCSF/Stanford Human Genome Center,参与了包括人类基因组计划(Human Genome Project)在内的众多人类基因组遗传学研究课题。

范博士毕业于美国哥伦比亚大学人类遗传学系,曾与许多国际顶级科研/研发机构成功进行学术和商业合作,包括 HarvardMITJohns HopkinsUCSDNIHMayo ClinicJohnson & Johnson(强生药业),Pfizer(辉瑞药业)等,并共同发表学术论文170余篇(第一作者21篇;通讯作者45篇;近五年(2010-201583篇,他引总数超过一万次),出版专著一部;拥有授权专利26项,其中国际专利23项。研发出新产品10 项、新工艺20 项、新技术20 项,其中10 项已成功产业化,累计销售额超过7 亿美元。

同时作为多部国际学术期刊的编辑委员会成员(Editorial board of Genomic Research, Translational Cancer Research),执行编辑(Executive Editor of Genomics)和总编(Editor-in-Chief of Genomics Data),在基因组学领域拥有广泛的国际影响力。因此,经常获邀担任中国国家科委、中国顶级大学和企业以及“千人计划”的特邀评审,在国内外具有强大的行业影响力和广泛的学术联系。早在1997年,范建兵博士和程京博士、王国玮博士就被中国驻美使馆和国家外国专家局特地邀请回国,作为由强伯勤院士主持的中国“生物芯片暨基因组学发展战略”高级研讨会(北京香山会议)的主讲专家。这次会议对生物芯片及其他新兴基因组学技术和产业在中国的快速建立和发展起到了十分积极的促进作用,也为二代测序技术和产业在中国的发展奠定了基础。范博士还是BGI和国家基因组南方研究中心(上海)的兼职教授;2009-2014年,范博士担任医学遗传学国家重点实验室(长沙)学术委员会委员。

范博士2016年入选国家“千人计划”特聘教授。

获得奖励

1.  1986年  美国遗传学会旅行奖(Genetic Society of America Travel Award

2.  2002年  美国宜曼达公司科技创新奖(Illumina Innovation Award

3.  2015年  百华协会会员(BayHelix member

4.  2016年  国家“千人计划”特聘教授(National 1000-TalentDistinguished Expert

代表性著作/论文

1. G.D. Schuler, M.S. Boguski, et al, J.-B. Fan, et al, E.S. Lander and T.J. Hudson. A gene map of the human genome. Science 274:540-546. 1996.

2. D.G. Wang, J.-B. Fan, C.-J. Siao, A. Berno, P. Young, R. Sapolsky, …., T.J. Hudson, R. lipshutz, M. Chee and E.S. Lander. Large-scale identification, mapping, and genotyping of single-nucleotide polymorphisms in the human genome. Science 280:1077-1082. 1998.

3. J.G. Hacia, J.-B. Fan, O. Ryder, L. Jin, K. Edgemon, G. Ghandour, R.A. Mayer, B. Sun, L. Hsie, C.M. Robbins, L.C. Brody, D. Wang, E.S. Lander, R. Lipshutz, S.P.A. Fodor and F.S. Collins. Determination of ancestral alleles for human single nucleotide polymorphisms using high density oligonucleotide arrays. Nature Genetics 22:164-167. 1999.

4. M.K. Halushka, J.-B. Fan, K. Bentley, L. Hsie, N. Shen, A. Weder, R. Cooper, R. Lipshutz and A. Chakravarti. Patterns of single nucleotide polymorphisms in candidate genes for blood-pressure homeostasis. Nature Genetics 22:239-247. 1999.

5. J.-B. Fan, X. Chen, M.K. Halushka, A. Berno, X.-H. Huang, T. Ryder, R. Lipshutz, D. Lockhart and A. Chakravarti. Parallel genotyping of human SNPs using generic high-density oligonucleotide tag arrays. Genome Research 10:853-860. 2000.

6. J.M. Yeakley, J.-B. Fan*, D. Doucet, L. Luo, E. Wickham, Z. Ye, M.S. Chee and X.-D. Fu*. Profiling alternative splicing on fiber-optic arrays. Nature Biotechnology 20:353-358. 2002. (*co-corresponding author)

7. J.-B. Fan, A. Oliphant, R. Shen, B. Kermani, F. Garcia, K.L. Gunderson, M. Hansen, F. Steemers, B.L. Butler, P. Deloukas, et al. and M.S. Chee. Highly parallel SNP genotyping. Cold Spring Harbor Symposium Biology 68:69-78. 2003.

8. J.-B. Fan*, J.M. Yeakley, …, A. Oliphant, D.L. Barker and M.S. Chee. A versatile assay for high-throughput gene expression profiling on universal array matrices. Genome Research 14:878-885. 2004.

9. M. Bibikova, D. Talantov, E. Chudin, J.M. Yeakley, J. Chen, D. Doucet, E. Wickham, D. Atkins, D. Barker, M. Chee, Y. Wang and J.-B. Fan*. Quantitative gene expression profiling in formalin-fixed, paraffin-embedded tissues using universal bead arrays. American Journal of Pathology 165 (5):1790-1807. 2004.

10. M. Bibikova, Z. Lin,  L. Zhou, E. Chudin, E. Wickham Garcia, B. Wu, D. Doucet, N.J. Thomas, Y. Wang, E. Vollmer, T. Goldmann, C. Seifart, W. Jiang, D.L. Barker, M.S. Chee, J. Floros and J.-B. Fan*. High-throughput DNA methylation profiling using universal bead arrays. Genome Research 16:383-393. 2006.

11. H.-R. Li, J. Wang-Rodriguez, T.M. Nair, J.M. Yeakley, Y.-S. Kwon, M. Bibikova, C. Zheng, L. Zhou, K. Zhang, T. Downs, X.-D. Fu* and J.-B. Fan*. Two-dimensional transcriptome profiling: Identification of messenger RNA isoform signatures in prostate cancer from archived paraffin-embedded cancer specimens. Cancer Research 66(8):4079-4088. 2006.

12. J.-B. Fan, M.S. Chee and K.L. Gunderson. Highly-parallel genomic assays. Nature Reviews Genetics 7:632-644. 2006.

13. M. Bibikova, E. Chudin, ..., M. Rao, D.L. Barker, J.F. Loring and J.-B. Fan*. Human embryonic stem cells have a unique epigenetic signature. Genome Research 16(9):1075-1083. 2006.

14. The International HapMap Consortium (Illumina team: L.M. Galver, J.-B. Fan, K. Gunderson, S.S. Murray, A.R. Oliphant, M.S. Chee). A second generation human haplotype map of over 3.1 million SNPs. Nature 449(7164):851-861. 2007.

15. M. Bibikova, L.C. Laurent, B. Ren, J.F. Loring and J.-B. Fan*. Unraveling epigenetic regulation in embryonic stem cells. Cell Stem Cell 2(2):123-134. 2008.

16. J. Chen, J. Lozach, E. Wickham Garcia, B. Barnes, S. Luo, I. Mikoulitch, L. Zhou, G. Schroth and J.-B. Fan*. Highly sensitive and specific microRNA expression profiling using BeadArray technology. Nucleic Acids Research. doi: 10.1093/nar/gkn387. 2008.

17. C. April, B. Klotzle, T. Royce, E. Wickham-Garcia, T. Boyaniwsky, J. Izzo, D. Cox, W. Jones, R. Rubio, K. Holton, U. Matulonis, J. Quackenbush and J.-B. Fan*. Whole-genome gene expression profiling of formalin-fixed, paraffin-embedded tissue samples. PLoS-ONE 4(12): e8162. doi:10.1371/journal.pone.0008162. 2009.

18. M. Bibikova, B. Barnes, C. Tsan, V. Ho, B. Klotzle, J.M. Le, D. Delano, L. Zhang, G.P. Schroth, K.L. Gunderson, J.-B. Fan and R. Shen. High density DNA methylation array with single CpG site resolution. Genomics 98(4):288-295. 2011.

19. F. Kaper, S. Swamy, B. Klotzle, S. Munchel, J. Cottrell, M. Bibikova, H.-Y. Chuang, S. Kruglyak, M. Ronaghi, M.A. Eberle and J.-B. Fan*. Whole-genome haplotyping by dilution, amplification and sequencing. Proc Natl Acad Sci USA. 110(14):5552-5557. 2013.

20. E. Laurenti, S. Doulatov, S. Zandi, I. Plumb, J. Chen, C. April, J.-B. Fan and J.E. Dick. The transcriptional architecture of early human hematopoiesis identifies multilevel control of lymphoid commitment. Nature Immunology 14(7):756-763. 2013.

21. P. van Galen, A. Kreso, E. Wienholds, E. Laurenti, K. Eppert, E.R. Lechman, N. Mbong, K. Hermans, S. Dobson, C. April, J.-B. Fan and J.E. Dick. Reduced lymphoid lineage priming promotes human hematopoietic stem cell expansion, Cell Stem Cell 14(1):94-106. 2014

22. C. Wang, M. Cicek,… B.J. Winterhoff, J.-B. Fan, M. Bibikova, ….K.L. Knutson, B.L. Fridley and E.L. Goode. Tumor hypomethylation at 6p21.3 associates with longer time to recurrence of high-grade serous epithelial ovarian cancer. Cancer Research 74(11):3084-3091. 2014.

23. E.A. Perez, E.A. Thompson,… J.-B. Fan, .. J.R. Gralow and M.M. Reinholz. Genomic analysis reveals that immune function genes are strongly linked to clinical outcome in the NCCTG (Alliance) N9831 adjuvant trastuzumab trial. Journal of Clinical Oncology, 33(7):701-708. 2015.

24. E. Laurenti, C. Frelin, ……, J.-B. Fan, N. Iscove and J.E. Dick. CDK6 levels regulate quiescence exit in human hematopoietic stem cells. Cell Stem Cell, 16(3):302-313. 2015.

25. J. Chien, H. Sicotte, J.-B. Fan, S. Humphray,…..S.H. Kaufmann, L. Hartmann, V. Shridhar and E. Goode. TP53 mutations, tetraploidy and homologous recombination repair defects in early stage high-grade serous ovarian cancer. Nucleic Acids Research, 43(14):6945-6958. doi: 10.1093/nar/gkv111. 2015.

26. X. Cai, F. Janku, Q. Zhan and J.-B. Fan*. Accessing genetic information with liquid biopsies. Trends in Genetics, 31(10):564-575. 2015.

27. J. Fan, N. Salathia, R. Liu, …, J.-B. Fan, K. Zhang, J. Chun and P.V. Kharchenko. Characterizing transcriptional heterogeneity through pathway and gene set overdispersion analysis. Nat Methods 13(3):241-244. doi: 10.1038/nmeth.3734. 2016.

28. S. Nair, X. Zhang…, J.-B. Fan, … Y. Hu and R. Li. Genetic suppression reveals DNA repair-independent antagonism between BRCA1 and COBRA1 in mammary gland development. Nat Commun. 7:10913. doi: 10.1038/ncomms10913. 2016.

29. B.B. Lake, R. Ai, G.E. Kaeser, N. Salathia, …., J.-B. Fan*, W. Wang*, J. Chun* and K. Zhang*. Neuronal subtypes and diversity revealed by single-nucleus RNA sequencing of the human brain. Science 352(6293):1586-1590. 2016. (*Co-senior Authors).

30. Y. Ito, D. Ofengeim, ….., J.-B. Fan, … J. Ravits and J.Y. Yuan. RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS. Science 353(6299):603-608. 2016.

31. S. Zhao, M.S. Geybels, A. Leonardson, …., E.A. Ostrander, J.-B. Fan*, Z. Feng* and J.L. Stanford*. Epigenome-wide tumor DNA methylation profiling identifies novel prognostic biomarkers of metastatic-lethal progression in men with clinically localized prostate cancer. Clin Cancer Res. 23(1):311-319. 2017. (*Co-senior Authors).

32. S. Kommoss, B. Winterhoff, A.L. Oberg, G.E. Konecny, C. Wang, S.M. Riska, J.-B. Fan, …, L.C. Hartmann, E.L. Goode, S.C. Dowdy and J. Pfisterer. Bevacizumab may differentially improve ovarian cancer outcome in patients with proliferative and mesenchymal molecular subtypes. Clin Cancer Res. 23(14):3794-3801. 2017.

33. F. Janku, S. Zhang, …, G. Mills, J.-B. Fan and N. Salathia. Development and validation of an ultra-deep next-generation sequencing assay for testing of plasma cell-free DNA from patients with advanced cancer. Clin Cancer Res. 2017 May 23. pii: clincanres.0291.2016. doi: 10.1158/1078-0432.CCR-17-0291. 2017.


主持课题

序号

课题名称

项目来源

资助金额

起止年份

1

常见恶性肿瘤分子病理和分子细胞学技术研发

科技部重大专项2017YFC1309000

100万

2017-2020

2

基于ctDNA甲基化检测技术的消化道肿瘤研究及无创早期筛查

广东省科技计划重大专项

156002

300万

2017-2020

3


NIH/MH, U01 MH098977

$9.3 M ($2.3 M)

2012 –2017

4


NIH/NCI, 5 R44 CA097851-03

$488,204

2005-2006

5


NIH/NCI, 2 R44 CA097851-02

$506,021

2004-2005

6


NIH/NCI, 1 R44 CA097851-01

$99,579

2002-2002

7


NIH/NHGRI, 5 R44 HG02003-03

$248,825

2001-2002

8


NIH/NCI, R33 CA88351

$2,035,223

2001-2004