欢迎访问南方医科大学基础医学院  |  南医首页

黄巧冰 教授

发布时间:2017-08-21

基本信息

undefined

 

导师姓名:黄巧冰

技术职称:教授

联系方式:020-61648465bing@smu.edu.cn

学术任职:中国微循环学会第四届常务理事、中国病理生理学会休克专业委员会副主任委员、中国病理生理学会微循环专业委员会副主任委员、中国微循环学会糖尿病专业委员会副主任委员、中国微循环学会痰瘀专业委员会副主任委员、中西医结合学会微循环专业委员会常委、广东省病理生理学会常务理事兼监事长。

研究方向:内皮细胞功能变化机制在疾病发生中的作用

个人简介

黄巧冰,南方医科大学基础医学院病理生理教研室教授,博士生导师。主要从事基础医学相关的研究和教学工作,是学校南方医科大学教学指导委员会主任委员,广东省教学名师。研究上主要关注慢性疾病如糖尿病和急性疾病如烧伤性休克等疾病发生过程中内皮细胞功能变化的作用和机制。先后承担了6项国家自然科学基金的研究任务,发表论文100余篇,其中第一和通讯作者发表SCI收录论文30余篇。现任中国微循环学会第四届常务理事,担任中国病理生理学会微循环专业委员会副主任委员等职务。是美国微循环学会和美国生理学会的正式会员,中国病理生理杂志常务编委,微循环学杂志副主编,任多家国内中英文杂志的编委,同时是AJP Heart CircBurnShockMicrocirculation等近20份国际杂志的审稿人。

获得奖励

1. 2010年广东省科技进步一等奖 重症休克的发生机理 排名第四(赵克森,刘杰,黄绪亮,黄巧冰,姜勇,金春华,阚文宏,赵桂玲,潘秉兴)

2. 2009年广东省教学成果奖二等奖,2008年南方医科大学教学成果一等奖 “坚持五个开放,提高课程教学质量的研究和实践” 赵克森,姜勇,黄巧冰,李本富,龚小卫

3. 个人奖励:

2010.09 南医优秀教师。

2014.12首届南方医科大学优秀本科教师

2014.12 “责任南医”先进典型。

2015.07广东省师德先进个人

2015.09广东省南粤优秀教师

2017.06广东省高等学校教学名师奖(本科类)


代表性著作/论文

1. Huang Q, Yuan Y. Interaction of PKC and NOS in signal transduction of microvascular hyperpermeability. Am J Physiol, 1997; 273(5 Pt 2):H2442-51(IF4.281)

2. Huang Q, Wu M, Meininger C, Kelly K, Yuan Y. Neutrophil-dependent augmentation of PAF-induced vasoconstriction and albumin flux in coronary arterioles. Am J Physiol, 1998; 275(4 Pt 2):H1138-47 (IF4.281)

3. Huang Q, Xu W, Ustinova E, Wu M, Childs E, Hunter F, Yuan S. Myosin Light Chain Kinase-dependent Microvascular Hyperpermeability in Thermal Injury.  Shock, 2003 20(4): 363-368 (IF3.113)

4. Liu X, Wu W, Li Q, Huang X, Chen B, Du J, Zhao K, Huang Q*. Effect of sphingosine 1-phosphate on morphological and functional responses in endothelia and venules after scalding injury. Burns, 2009;35(8):1171-9. (IF 2.056)

5. Guo X, Wang L, Chen B, Li Q, Wang J, Zhao M, Wu W, Zhu P, Huang X, Huang Q*. ERM protein moesin is phosphorylated by advanced glycation end products and modulates endothelial permeability. Am J Physiol Heart Circ Physiol, 2009; 297(1):H238-46 (IF3.973)

6. Wang S, Huang Q, Guo X, Brunk UT, Han J, Zhao K, Zhao M. The p38 alpha and p38 delta MAP kinases may be gene therapy targets in the future treatment of severe burns. Shock, 2010;34(2):176-182 (并列第一作者) (IF 3.113)

7. Wu W, Huang Q, He F, Xiao M, Pang S, Guo X, Brunk UT, Zhao K, Zhao M. Roles of mitogen-activated protein kinases in the modulation of endothelial cell function following thermal injury. Shock, 2011;35(6):618-25 (共同第一作者) (IF 3.113)  

8. Wang L, Li Q, Du J, Chen B, Li Q, Huang X, Guo X, Huang Q*. Advanced glycation end products induce moesin phosphorylation in murine retinal endothelium. Acta Diabetol, 2012; 49:47-55. (IF: 3.175)

9. Li QQ, Liu H, Du J, Chen B, Li Q, Guo X, Huang X, Huang Q*. Advanced glycation end products induce moesin phosphorylation in murine brain endothelium. Brain Res, 2011; 1373: 1-10 (IF 2.746)

10. Du J, Zeng C, Li Q, Chen B, Liu H, Huang X, Huang Q*. LPS and TNF-α induce expression of sphingosine-1-phosphate receptor-2 in human microvascular endothelial cells. Pathol Res Pract, 2012;208(2):82-8(IF1.543)

11. Wang J, Liu H, Chen B, Li Q, Huang X, Wang L, Guo X, Huang Q*. RhoA/ROCK-Dependent Moesin Phosphorylation Regulates AGE-induced Endothelial Cellular Response. Cardiovasc Diabetol; 2012; 17(11):7. (IF 3.346)

12. Wu W, Huang Q, Miao J, Xiao M, Liu H, Zhao K, Zhao M. MK2 plays an important role for the increased vascular permeability that follows thermal injury. Burns, 2013; 39(5):923-934. (IF2.056)  

13. Chen B, Mutschler M, Yuan Y, Neugebauer E, Huang Q*, Maegele M*. Superimposed traumatic brain injury modulates vasomotor responses in third-order vessels after hemorrhagic shock. Scand J Trauma Resusc Emerg Med, 2013;21(1):77. doi: 10.1186/1757-7241-21-77  (共同通讯作者) (IF 2.036 )  

14. Wang L, Luo H, Chen X, Jiang Y*, Huang Q*. Functional Characterization of S100A8 and S100A9 in Altering Monolayer Permeability of Human Umbilical Endothelial Cells. PLoS One, 2014 3;9(3):e90472. ( IF 3.534)

15. Wu L, Wang D, Xiao Y, Zhou X, Wang L, Chen B, Li Q, Guo X, Huang Q*. Endoplasmic reticulum stress plays a role in the advanced glycation end product-induced inflammatory response in endothelial cells. Life Sci, 2014;110(1):44-51. (IF2.936)  

16. Wang S, Huang Q, Guo J, Guo X, Sun Q, Brunk UT, Han D, Zhao K, Zhao M. Local thermal injury induces general endothelial cell contraction through p38 MAP kinase activation. APMIS, 2014;122(9):832-41. 并列第一作者(IF1.922)

17. Xia JL, Wang LQ, Wu LL, Huang QB. Doxycycline Hyclate Protects Lipopolysaccharide-Induced Endothelial Barrier Dysfunction by Inhibiting the Activation of p38 Mitogen-Activated Protein Kinase. Biol Pharm Bull, 2014;37(12):1882-90. (IF 1.778 )

18. Li Q, Chen B, Zeng C, Fan A, Yuan Y, Guo X, Huang X, Huang Q. Differential activation of receptors and signal pathways upon stimulation by different doses of sphingosine-1-phosphate in endothelial cells. Exp Physiol, 2015; 100 (1): 95- 107. (IF2.912)

19. Xu Q, Liu J, Wang Z, Guo X, Zhou G, Liu Y, Huang Q*, Su L*. Heat stress-induced disruption of endothelial barrier function is via PAR1 signaling and suppressed by xuebijing injection. PLoS One. 2015;10(2):e0118057. (*共同通讯作者) (IF3.534)

20. Zhang W, Xu Q, Wu J, Zhou X, Weng J, Xu J, Wang W, Huang Q*, Guo X*. Role of Src in Vascular Hyperpermeability Induced by Advanced Glycation End Products. Sci Rep. 2015;5:14090. 共同通讯作者 (IF 5.578)

21. Liu Y, Zhou G, Wang Z, Guo X, Xu Q, Huang Q*, Su L*. NF-κB signaling is essential for resistance to heat stress-induced early stage apoptosis in human umbilical vein endothelial cells. Sci Rep, 2015 Sep 4;5:13547. doi: 10. 1038 / srep13547. (IF 5.578)

22. Fan A, Wang Q, Yuan Y, Cheng J, Chen L, Guo X, Li Q, Chen B, Huang X, Huang Q*. Liver X receptor-α and miR-130a-3p regulate expression of sphingosine 1-phosphate receptor 2 in human umbilical vein endothelial cells. Am J Physiol Cell Physiol, 2016;310(3):C216-26. (IF 3.602 )

23. Wang Q, Fan A, Yuan Y, Chen L, Guo X, Huang X, Huang Q*. Role of Moesin in Advanced Glycation End Products-Induced Angiogenesis of Human Umbilical Vein Endothelial Cells. Sci Rep. 2016 Mar 9; 6:22749. (IF5.597)

24. Jin H, Li Z, Guo X, Tong H, Liu Z, Chen Y, Su L, Huang Q*. Microcirculatory Disorders and Protective Role of Anti-oxidant in Severe Heat Stroke: A Rat Study. Shock, 2016;46(6):688-695 (IF 3.113)

25. Du W, Su J, Ye D, Wang Y, Huang Q*, Gong X*. Pinellia ternata Attenuates Mucus Secretion and Airway Inflammation after Inhaled Corticosteroid Withdrawal in COPD Rats. Am J Chin Med, 2016;44(5):1027-41. (IF 3.222 )

26. Zhang SS, Wu Z, Zhang Z, Xiong ZY, Chen H, Huang QB. Glucagon-like peptide-1 inhibits the receptor for advanced glycation endproducts to prevent podocyte apoptosis induced by advanced oxidative protein products. Biochem Biophys Res Commun, 2017, Jan 12,482:1413-1419. (IF 2.466)

27. Wang L, Wu J, Guo X, Huang X, Huang Q*. RAGE Plays a Role in LPS-Induced NF-κB Activation and Endothelial Hyperpermeability. Sensors (Basel) (IEEE sensors journal), 2017; 7(4):  pii: E722. doi: 10.3390/s17040722.  (IF 2.677)

28. Wan Y, Meng F, Wu N, Zhou T, Venter J, Francis H, Kennedy L, Glaser T, Bernuzzi F, Invernizzi P, Glaser S, Huang Q, Alpinin G. Substance P increases liver fibrosis by differential changes in senescence of cholangiocytes and hepatic stellate cells. Hepatology, 2017 Mar 3. doi: 10.1002/hep.29138. [Epub ahead of print] (IF:13.246)

29. Wu J, He GT, Zhang WJ, Xu J, Huang QB*. IRE1α Signaling Pathways Involved in Mammalian Cell Fate Determination (review). Cell Physiol Biochem, 2016;38(3):847-858. (IF 5.104)

30. Zhang WJ, Li PX, Guo XH, Huang QB*. Role of moesin, Src and ROS in Advanced Glycation End Product-induced Vascular Endothelial Dysfunction. Microcirculation, 2017; 24(3) doi: 10.1111/micc.12358 (IF:2.532)


主持课题

序号

课题名称

项目来源

资助金额

(万元)

起止年份

1

烧伤休克微血管通透性变化的细胞内信号传导机制(39870808)

国家自然科学基金

14

1999.01-2001.12

2

ERM蛋白在晚期糖基化终产物致内皮细胞损伤中的作用(30771028)

国家自然科学基金

30

2008.01-

2010.12

3

细胞内的钙信号时空动力学在1-磷酸鞘胺醇介导的内皮细胞屏障功能调节中的作用(30971201)

国家自然科学基金

30

2010.01-

2012.12

4

miRNA参与炎性介质介导的内皮细胞1-磷酸鞘氨醇受体表达的调节(81170297)

国家自然科学基金

14

2012.01-

2012.12

5

ERM蛋白在血管新生和糖尿病微血管病中的作用(81370226)

国家自然科学基金

70

2014.01-

2017.12


中性粒细胞介导的微血管通透性变化的细胞信号机制 (30028008)

国家自然科学基金海外青年学者合作研究

40

2001-2003

6

衰老肺肺泡—毛细血管膜屏障功能障碍的机制研究(G2000057004)  

国家重点基础研究规划项目(973分题子课题)

25

2000-2005

7

蛋白质异常修饰在心、脑血管病发生中的作用及机制 (10717)

广东省自然科学基金研究团队项目

10

2001-2005

8

烧伤休克微血管通透性变化的细胞内信号传导机制(980220)

广东省

自然科学基金

5

1999-2001

9

内源性保护机制对严重创伤血管反应性和通透性的调控作用(2005CB522601)

国家重点基础研究规划项目(973分题子课题)

10

2005.10-2010.10

10

炎症相关疾病的细胞信号机制研究及其新药筛选(IRT0730)

教育部"长江学者和创新团队发展计划"创新团队

10

2007

11

血管内皮损伤在重症中暑重要脏器损害的机制研究(S2013030013217)

广东省自然科学基金团队项目

20

2014.01-

2017.12

12

病理生理学

国家双语教学示范课程

20

2008.12

-2013.12

13

基础医学整合课程改革

2014年度广东省高等教育教学改革项目(本科类)(综合类)

6

2014.01-2016.02

14

基础医学整合课程教学团队

省质量工程项目

5

2014.01-2016.02