生物治疗研究所


 

 

一、基本信息

姓名:李妍                                 

职称:教授,博士生导师, 博士后合作导师

联系邮箱:liyan_nys@hotmail.com

联系电话:020- 62789135

 

二、学习经历

1989.9-1994.7   吉林大学,医药信息学专业,学士

2001.9-2004.7   第一军医大学,免疫学专业,硕士

2004.9-2007.7   南方医科大学,免疫学专业,博士

 

三、承担教学任务

《生物治疗学》、《新概念疫苗》、《生物工程下游技术》

 

四、主要研究方向

1. 感染免疫;

2. Notch信号通路参与抗幽门螺杆菌感染中的作用;

 

五、主要学术任职

1. 中国免疫学会,会员;

 

六、培养学生情况

 培养5名硕士研究生, 其中2名获得国家级研究生奖学金。

 

七、主要获奖情况

1. 加拿大血液中心博士后奖学金,2008

 

八、  代表性论文

1.     Ning Y, Ye J, Wen J, Wu D, Chen Z, Lin Y, Hu B, Luo MLuo JNing L, Li Y*. Identification of two Lpp20 CD4+ T cell epitopes in helicobacter pylori-infected subjects. Front. Microbiol2018, 9884.

2.     Lin Y, Ye J, Luo MHu B, Wu D, Wen J, Chen Z, Yang C, Ning L, Li Y*. Ning Y. Group B Streptococcus DNA copy numbers measured by digital PCR correlates with perinatal outcomes. Anal Chem. 2019, 91(15): 9466-9471.

3.     Ye J, Wen J, Ning Y, Li Y* . High notch expression implies poor survival in pancreatic ductal adenocarcinoma: A systematic review and meta-analysis. Pancreatology, 2018, 188):954-961.

4.     Li Y, Ye J, Chen Z, Wen J, Li F, Su P, Lin Y, Hu B, Wu D, Ning L, Xue Q, Gu H, Ning Y. Annonaceous acetogenins mediated up-regulation of Notch2 exerts growth inhibition in human gastric cancer cells in vitro. Oncotarget, 2017, 8(13):21140-21152

5.     Li Y, Chen Z, Ye J, Ning L, Luo J, Zhang Li, Jiang Y, Xi Y, Ning Y. Antibody production and Th1-biased response induced by an epitope vaccine composed of cholera toxin B unit and Helicobacter pylori Lpp20 epitopes. Helicobacter, 2016, 213):234-48

6.     Li Y, Hao H, Zhou M, Zhou H, Ye J, Ning L, Ning Y. Intron , not intronof human thrombopoietin, improves expression in the milk of transgenic mice regulated by goat beta-casein promoter. Sci Report, 20155:16051

7.     Li Y, Zhou M, Zhou H, Ning Y. The last intron of the human thrombopoietin gene enhances expression in milk of transgenic mice. Funct Integr Genomics. 2014, 14(1):229-36

8.     Li Y, Jiang Y, Xi Y, Zhang L, Luo J, He D, Zeng S,Ning Y.Identification and characterization of H-2d restricted CD4+ T cell epitopes on Lpp20 of Helicobacter pylori. BMC Immunology, 2012, 13(1):68.

9.     Li Y, Ning Y, Wang Y, Peng D, Jiang Y, Zhang L, Long M, Luo J, Li M. Mimotopes selected with a neutralizing antibody against urease B from Helicobacter pylori induce enzyme inhibitory antibodies in mice upon vaccination. BMC Biotechnology, 2010, 10:84.

10.Li Y, Ning YS, Wang YD, Luo J, Wang W, Dong WQ, Li M. Production of mouse monoclonal antibodies against Helicobacter pylori Catalase and mapping the antigenic epitope by phage display library. Vaccine, 2008, 26(9): 1263-1269.

11.Li Y, Ning YS, Wang YD, Hong YH, Luo J, Dong WQ, Li M. Production of Mouse Monoclonal Antibodies against Helicobacter pylori Lpp20 and Mapping the Antigenic Epitope by Phage Display Library. Journal of Immunological Methods2007325 1-2):1-8.

12.Lê KA, Li Y(共同第一), Xu X, Yang W, Liu T, Zhao X, Tang YG, Cai D, Go VL, Pandol S, Hui H.Alterations in Fecal Lactobacillus and Bifidobacterium Species in Type 2 Diabetic Patients in Southern China Population. Front Physiol. 2013;3:496