一、基本信息

姓名：郭家松

职称：教授

联系邮箱：jiasongguo@aliyun.com

 

二、学习经历

1988.9-1992.7    江西大学，生物学专业，学士

1992.9-1995.5    南昌大学，组织解剖学专业，硕士

2000.9-2003.7    中山大学，组织胚胎学专业，博士

2005.2-2006.8    香港大学，访问学者

2007.8-2007.12    香港大学，访问学者

2010.4-2012.3     美国范德堡大学，博士后

 

三、拟招收博士后开展的研究方向

1. 神经损伤与修复；

2. 干细胞与组织工程在神经修复中的应用。

 

四、主要学术任职

1. 中国解剖学会再生医学分会副主委

2. 中国研究型医院学会神经再生与修复专业委员会常委

          3.  中国研究型医院学会神经再生与修复专业委员会基础学组副组长

          4. 广东省解剖学会常务理事

          5.  广东省脑发育与脑病防治学会干细胞分会副主委

          6. 《Neural Regeneration Research》(IF=2.472)编委

          7. 《中国临床解剖学杂志》编委

 

五、主要获奖情况

1. 解放军总后优秀教师，原解放军总后勤部，2004；

2. 广东省高校千百十人才计划省级培养对象，广东省教育厅，2010。

 

六、代表性论文

1. Li L, Li Y，Fan Z，Wang X, Li Z, Wen J, Deng J, Tan D, Pan M, Hu X, Zhang H, Lai M, Guo J(郭家松)*.Ascorbic acid facilitates neural regeneration after sciatic nerve crush injury. Front Cell Neurosci. 2019 Mar 21;13:108. doi: 10.3389

2. Liu H, Yang M, Wu G, Yang L, Cao Y, Liu C, Tan Z, Jin Y, Guo J(郭家松)*, Zhu L*. Effects of different oxygen concentrations on the proliferation, survival, migration, and osteogenic differentiation of MC3T3-E1 cells. Connect Tissue Res. 2019 May;60(3):240-253. doi: 10.1080/03008207  

3. Yang M, Liu H, Wang Y, Wu G, Qiu S, Liu C, Tan Z, Guo J(郭家松)*, Zhu L*. Hypoxia reduces the osteogenic differentiation of peripheral blood mesenchymal stem cells by upregulating Notch-1 expression, Connect Tissue Res. 2019 DOI: 10.1080/03008207.2019.1611792

4. Tan D, Wen J, Li L, Wang X, Qian C, Pan M, Lai M, Deng J, Hu X, Zhang H, Guo J(郭家松)*.   Inhibition of RhoA-Subfamily GTPases Suppresses Schwann Cell Proliferation Through Regulating AKT Pathway Rather Than ROCK Pathway. Front Cell Neurosci. 2018 Nov 20;12:437. doi: 10.3389/fncel.2018.00437. 

5. Wen J, Tan D, Li L, Wang X, Pan M, Guo J(郭家松)*.RhoA regulates Schwann cell differentiation through JNK pathway. Exp Neurol, 2018 Oct;308:26-34. 

6. Zhang Z, Wu G, Yang L, Cao Y, Liu C, Jin Y, Wang Y, Yang L, Guo J(郭家松)*, Zhu L*. Self-assembling peptide and nHA/CTS composite scaffolds increase seed cell adhesion and promote femoral condylar bone regeneration. Materials Science & Engineering C, 2018, 93：445-454 （IF= 5.08）

7. Qian C, Tan D, Wang X, Li L, Wen J, Pan M, Li Y, Wu W, Guo J(郭家松)*. Peripheral nerve injury induced astrocyte activation in spinal ventral horn contributes to nerve regeneration, Neural Plast. 2018 ; doi: 10.1155/2018/8561704.  

8. Wen J, Qian C, Pan M, Wang X, Li Y, Lu Y, Zhou Z, Yan Q, Li L, Liu Z, Wu W, Guo J(郭家松)*. Lentivirus-Mediated RNA Interference Targeting RhoA Slacks the Migration, Proliferation, and Myelin Formation of Schwann Cells. Mol Neurobiol, 2017; 54(2):1229-1239.  

9. Pan M, Wang X, Chen Y, Cao S, Wen J, Wu G, Li Y, Li L, Qian C, Qin Z, Li Z, Tan D, Fan Z, Wu W, Guo J(郭家松)*. Tissue engineering with peripheral blood-derived mesenchymal stem cells promotes the regeneration of injured peripheral nerves. Exp Neurol, 2017; 292:92-101.  

10. Wen J, Li L, Tan D, Guo J(郭家松)*. Preparation of Teased Nerve Fibers from Rat Sciatic Nerve. Bio-protocols，2017; 7(19) DOI:10.21769/BioProtoc.2572.  

11. Wen J, Tan D, Li L, Guo J(郭家松)*. Isolation and Purification of Schwann Cells from Spinal Nerves of Neonatal Rat. Bio-protocols，2017; 7(20) DOI:10.21769/BioProtoc.2588.  

12. Qin ZQ, Zheng H, Zhou L, Ou YH, Huang B, Yan B, Qin ZS, Yang CL, Su YC, Bai XC*, Guo J(郭家松)*, Lin J*. Tsc1 deficiency impairs mammary development in mice by suppression of AKT, nuclear ERα, and cell-cycle-driving proteins. Sci Rep, 2016; 6:19587. doi: 10.1038/srep19587 

13. Qian CH, Wen JK, Guo J(郭家松)*. Inhibiting the RhoA signaling pathway promotes regeneration of axons and myelin sheath.  Neural Regen Res. 2015; 10(12):1957. 

14. Wang XH, Guo J(郭家松)*. Significance and strategy of promoting seed cell survival in tissue-engineered artificial nerve construction. Neural Regen Res. 2015; 10(11):1795.  

15. Wu G, Pan M, Wang X, Wen J, Cao S, Li Z, Li Y, Qian C, Liu Z, Wu W, Zhu L*, Guo J(郭家松)*. Osteogenesis of peripheral blood mesenchymal stem cells in self assembling peptide nanofiber for healing critical size calvarial bony defect，Sci Rep, 2015; 5:16681. doi: 10.1038/srep16681.  

16. Guo J(郭家松)*, Qian CH, Ling EA, Zeng YS*. Nanofiber scaffolds for treatment of spinal cord injury. Cur Med Chem. 2014; 21:4282-4289.  

17. Wang XH, Pan MJ, Wen JK, Tang YJ, Hamilton AD, Li YY, Qian CH, Liu ZY, Wu WT, Guo J(郭家松)*. A novel artificial nerve graft for repairing long-distance sciatic nerve defects: a self-assembling peptide nanofiber scaffold-containing poly(lactic-co-glycolic acid) conduit. Neural Regen Res. 2014; 9(24):2132-2141.  

18. Zhan XD, Gao MY, Jiang YW,  Zhang WW, Wong WM, Yuan Q, Su H,  Kang X,  Dai X,  Zhang W, Guo J(郭家松)*, Wu W*. Nanofiber nerve scaffolds facilitate functional regeneration of peripheral nerve injury, Nanomedicine, 2013;9(3):305-315.  

19. Zhang WW, Zhan XD, Gao MY, Hamilton AD, Liu ZY, Jiang Y, Su H, Dai X, He B, Kang XN, Zeng YS, Wu W*, Guo J(郭家松)*. Self assembling peptide nanofiber scaffold enhanced with RhoA inhibitor CT04 improves axonal regeneration in the transected spinal cord，J Nanomaterials, 2012; doi:10.1155/2012/724857. 

20. Guo J(郭家松), Wang L, Zhang Y, Wu J, Arpag S, Hu B, Imhof BA, Tian X, Carter BD, Suter U, Li J*. Abnormal junctions and permeability of myelin in PMP22-deficient nerves. Ann Neurol. 2014; 75(2):255-265.

21. Guo J(郭家松), Ma YH, Yan Q, Wang L, Zeng YS, Wu JL, Li J*. Fig4 Expression in the Nervous System and Its Protection against Abnormal Lysosomal Accumulation. J Neuropathol Exp Neurol, 2012;71(1),28-39. 

22. Guo J(郭家松), Leung KKG, Su H, Yuan QJ, Wang L, Chu TH, Zhang W, Pu JKS, Ng GKP, Wong WM, Dai X, Wu WT*. Self assembling peptide nanofiber scaffold promotes the reconstruction of acutely injured brain. Nanomedicine, 2009; 5(3):345-351. 

23. Guo J(郭家松), Su H, Zeng Y, Liang YX, Ellis-Behnke RG, So KF, Wu W*. Reknitting the injured spinal cord by self-assembling peptide nanofiber scaffold. Nanomedicine, 2007; 3(4):311-321.

24. Guo J(郭家松), Zeng YS*, Li HB, Huang WL, Liu RY, Li XB, Ding Y, Wu LZ, Cai DZ. Cotransplant of neural stem cells and NT-3 genetically modified Schwann cells promote the recovery transected spinal cord injury. Spinal Cord, 2007; 45(1): 15-24.

25. Guo J(郭家松), Zeng Y, Liang YX, Wang L, Su H, Wu W*. Cyclosporine affects the proliferation and differentiation of neural stem cells in culture. Neuroreport, 2007;18(9):863-868. Cover story

26. Guo J(郭家松), So KF, Wu W. Self assembling peptides mediate neural regeneration. In So KF, Xu XM. Edited《Neural Regeneration》 Elsevier, 2015

27. Guo J(郭家松), Leung KKG, Wu W. Bridging the Gap for Regeneration after CNS Injury by Nanofiber Scaffolds: use of SAPNS for Traumatic Brain and Spinal Cord Injury. In Martin CR, Preedy VR, Hunter RJ, edited 《Nanomedicine and the Nervous System》. Science Publishers, New York, 2012:330-346