何玉梅教授

【 发布日期: 11-14 】 【 浏览次数: 】 【 作者: 】


 

 

一、基本信息

姓名:何玉梅                              

职称:教授

联系邮箱:hym0909@smu.edu.cn

 

二、拟招收博士后开展的研究方向

1、髓系抑制性细胞(MDSC)对妊娠并发症的调控机制研究;

2MDSC对炎症性疾病的调控机制研究;

32型固有淋巴样细胞(ILC2)的分化发育及调控机制研究

 

三、主持科研项目

1、南方医科大学高层次人才启动项目:

MDSC对炎症性疾病的调控机制及病理意义;

2、国家自然科学基金面上项目:

OLFM4通过上调S100A9诱导新生儿PMN-MDSCNEC的抑制作用及分子机制;

3、广州市科技计划项目一般项目专题:

氨基酰化酶1介导PMN-MDSCNEC的预防作用及其分子机制;

4、广东省自然科学基金-面上项目:

KIF4调控PMN-MDSC的分子机制及在坏死性小肠炎中的病理意义研究;

5、国家自然科学基金青年科学基金项目:

Sty1-Oxs1信号途径调控氧化应激的机制研究;

6、中国博士后基金:

重金属与氧化胁迫耐受基因Oxs1在裂殖酵母中的功能分析。

 

四、代表性论文

1He YM#, Li X#, Perego M#, Nefedova Y, Kossenkov AV, Jensen EA, Kagan V, Liu YF, Fu SY, Ye QJ, Zhou YH, Wei L, Gabrilovich DI*, Zhou J*. Transitory presence of myeloid-derived suppressor cells in neonates is critical for control of inflammation. Nature Medicine 2018,24 :224-231. (IF=32.6)

2Yumei He; Yan Chen; Wen Song; Lei Zhu; Zhicheng Dong; David W. Ow*. A Pap1-Oxs1 signaling pathway for disulfide stress in Schizosaccharomyces pombe. Nucleic Acids Research 2017 Jan 9; 45(1):106-114. (IF=11.2)

3Cao, Yingjiao# ; He, Yumei# ; Wang, Xiangyang; Liu, Yongdong; Shi, Kun; Zheng; Su, Xue; Lei, Aihua; He, Juan; Zhou, Jie*. Polymorphonuclear myeloid-derived suppressor cells attenuate allergic airway inflammation by negatively regulating group 2 innate lymphoid cells. Immunology, 2019 Apr;156(4):402-412. (IF=4.2)

4Liu Y, Perego M, Xiao Q, He Y, Fu S, He J, Liu W, Li X, Tang Y, Li X, Yuan W, Zhou W, Wu F, Jia C, Cui Q, Worthen GS, Jensen EA, Gabrilovich DI* Zhou J* Lactoferrin-induced myeloid-derived suppressor cell therapy attenuates pathologic inflammatory conditions in newborn mice. J Clin Invest. 2019 Oct 1;129(10):4261-4275. (IF=12.3)

5Quan Yang, Xing Li, Haiwen Chen, Yingjiao Cao, Yumei He, Jianyang Wei, Zhou, Jie*. IRF7 regulates the development of granulocytic myeloid-derived suppressor cells through S100A9 transrepression in cancer. Oncogene 2017 May 25; 36 (21):2969-2980. (IF=7.5)

6Nan J, Xing YF, Hu B, Tang JX, Dong HM, He YM, Ruan DY, Ye QJ, Cai JR, Ma XK, Chen J, Cai XR, Lin ZX, Wu XY, Li X. Endoplasmic reticulum stress induced LOX-1+CD15+ polymorphonuclear myeloid-derived suppressor cells in hepatocellular carcinoma. Immunology 2017 May;154(1):144-155. (IF=4.2)

7Lei, Aihua#; Yang, Qiong#; Li, Xing; Chen, Haiwen; Shi, Maohua; He, Yumei; Zhou, Jie*. Atorvastatin promotes the expansion of myeloid-derived suppressor cells and attenuates murine colitis. Immunology 2016 Dec; 149(4):432-446. (IF=4.2)