一、基本信息

姓名：刘靖华                                

职称：教授

联系邮箱：liujhua@smu.edu.cn

 

二、拟招收博士后开展的研究方向

1. 脓毒性休克的发生机制与防治措施；

2. 细菌脂蛋白（BLP）耐受的分子机制；

3. 感染免疫。

 

三、主要学术任职

1. 广东省病理生理学会，理事；

2. 广东省病理生理学会危重病医学专业委员会，副主任委员；

3. 中国研究型医院休克与脓毒症专业委员会，常务委员；

4. 中国病理生理学会休克专业委员会，委员；

5. 中国病理生理学受体与细胞信号转导专业委员会，委员。

 

四、代表性论文(第一作者或者通讯作者)

1. Yuyun Zhong, Ping Ye, Zhuzhong Mei, Sui Huang, Mengyi Huang, Li Yue, Shixian Niu, Shuqi Zhao, Junwei Cai, Juan Wang, Yong Jiang, Jinghua Liu. The novel methyltransferase SETD4 regulates TLR agonist-induced expression of cytokines through methylation of lysine 4 at histone 3 in macrophages. Molecular Immunology. 2019; 114:179-188

2. Shuqi Zhao, Dalin Xi, Junwei Cai, Wenting Chen, Jing Xiang, Na Peng, Juan Wang, Yong Jiang, Zhuzhong Mei, Jinghua Liu. Rab20 is critical for bacterial lipoprotein tolerization-enhanced bactericidal activity in macrophages during bacterial infection. Sci China Life Sci. 2019; 31. doi: 10.1007/s11427-019-9527-3.

3. Yue Li, Shixian Niu, Dalin Xi, Shuqi Zhao, Jiang Sun, Yong Jiang, Jinghua Liu. Differences in LPS-induced inflammatory response between MEFs and BMDMs. J Interferon Cytokine Res. 2019; 39:375-382.

4. Mei ZZ, Sun H, Ou X, Li L, Cai J, Hu S, Wang J, Luo H, Liu J, Jiang Y. The natural antisense transcript NATTD regulates the transcription of decapping scavenger (DcpS) enzyme. Int J Biochem Cell Biol. 2019; 110:103-110.

5. Shuqi Zhao, Yuyun Zhong, Xiaoxia Fu, Yiqian Wang, Ping Ye, Junwei Cai, Yun Liu, Jiang Sun, Zhuzhong Mei, Yong Jiang, and Jinghua Liu  H3K4 methylation regulates LPS-induced proinflammatory cytokine expression and release in macrophages. Shock. 2019; 51:401-406.

6. Wenting Chen, Hanhui Zhong, Xiaofei Wang, Qiongni Pang, Jinlin Zhuang, Jian Hu, Yeming Chen, Jijie Hu, Jinghua Liu, Jing Tang. Mig6 reduces inflammatory mediators production by regulating the activation of EGFR in LPS-induced endotoxemia. J Cell Physiol. 2018; 233:6975-6983

7. Jinghua Liu, Juan Wang, Haihua Luo, Zhijie Li, Tianyu Zhong, Jing, Yong Jiang. Screening cytokine/chemokine profiles in serum and organs from an endotoxic shock mouse model by LiquiChip. SCIENCE CHINA Life Sciences. 2017; 60:1242-1250

8. Jinghua Liu, Jing Xiang, Xue Li, Siobhan Blankson, Shuqi Zhao, Junwei Cai, Yong Jiang, H. Paul Redmond, and Jiang Huai Wang. NF-kB activation is critical for bacterial lipoprotein tolerance-enhanced bactericidal activity in macrophages during microbial infection. Sci. Rep. 2017; 1, 7:40418 | DOI: 10.1038/srep40418

9. Zhuzhong Mei, Xinyu Chen, Shuiwang Hu, Ni Wang, Xiao-Li Ou, Jing Wang, Hai-Hua Luo, Jinghua Liu, Yong Jiang. Kelch-like Protein 21 (KLHL21) Targets IκB Kinase-β to Regulate Nuclear Factor κ-Light Chain Enhancer of Activated B Cells (NF-κB) Signaling Negatively. J Bio Chem. 2016; 291:18176-897.

10. Zhifeng Liu, Jinghua Liu, Yawei Liu, Youqing Tang, Fansu Meng, Xuegang Sun, Jing Tang, Jiang Huai Wang, and Lei Su. Proteomic analysis and identification of intestinal FBP as a predictor of gut dysfunction during heat stroke in mice. Journal of Surgical Research. 2012; 173:332-340

11. Julliette M. Buckley, JingHua Liu, Chong Hui Li, SiobhanBlankson, Qiong Di Wu, Yong Jiang, H.Paul Redmond, and Jiang Huai Wang. Increased susceptibility of ST2-deficient mice to polymicrobial sepsis is associated with an impaired bactericidal function. J Immunol. 2011; 187:4293-9

12. Jinghua Liu, Julliette M. Buckley, H. Paul Redmond, and Jiang Huai Wang. ST2 negatively regulates TLR2 signaling, but is not required for bacterial lipoprotein-induced tolerance. J Immunol. 2010; 15;184(10):5802-8

13. Jinghua Liu, Shanchao Zhao, Jing Tang, Zhijie Li, Tianyu Zhong, Yawei Liu, Dengyu Chen, Mingzhe Zhao, Yusheng Li, Xiaowei Gong, Peng Deng, Jiang Huai Wang, Yong Jiang. Advanced glycation end products and lipopolysaccharide synergistically stimulate proinflammatory cytokine chemokine production in endothelial cells via activation of both mitogen-activated protein kinases and nuclear factor-kB. FEBS Journal, 2009,276(8) 4598-4606