一、基本信息
姓名：肖东
职称：研究员
联系邮箱：Xiao_d@hotmail.com；xiaodong@smu.edu.cn
二、拟招收博士后开展的研究方向
1. 肿瘤发病机制及肿瘤热疗、诱导分化治疗及免疫治疗等；
2. RNA甲基化修饰(m6A)与自噬和肿瘤；
3. 干细胞、衰老和再生；
4. 肝脏人源化动物模型研发与应用。
三、主要学术任职
1. 中国整形美容协会干细胞研究与应用分会，常务理事；
2. 中国实验小型猪专业委员会，委员；
3. 广东省精准医学应用学会疾病模型分会，委员。
四、代表性论文
1. Chen BZ, Gu P, Jia JS, Liu W, Liu YM, Liu W, Xu T, Lin XL, Lin TY, Liu Y, Chen HW, Xu MC, Yuan J, Zhang JN, Zhang LH#, Xiao D(肖东)#, Gu WW#. Optimization strategy for generating gene-edited Tibet Minipigs by synchronized oestrus and cytoplasmic microinjection. International Journal of Biological Sciences, 2019, in press.
2. Chen Y, Deng X, Chen W, Shi P, Lian M, Wang H, Wang K, Qian D,Xiao D(肖东)#, Long H#. Silencing of microRNA-708 promotes cell growth and epithelial-to-mesenchymal transition by activating the SPHK2/AKT/β-catenin pathway in glioma.Cell Death Dis, 2019, 10(6):448.
3. Zhao WT, Lin XL, Liu Y, Han LX, Li J, Lin TY, Shi JW, Wang SC, Lian M, Chen HW, Sun Y, Xu K, Jia JS#, Luo RC#,Xiao D(肖东)#. miR-26a promotes hepatocellular carcinoma invasion and metastasis by inhibiting PTEN and inhibits cell growth by repressing EZH2. Lab Invest, 2019, 99(10):1484-1500.
4. Shi JW, Zhang TT, Liu W, Yang J, Lin XL, Jia JS, Shen HF, Wang SC, Li J, Zhao WT, Gu WW#, Sun Y#, Xiao D(肖东)#. Direct conversion of pig fibroblasts to chondrocyte-like cells by c-Myc.Cell Death Discov, 2019, 5:55.
5. Bie YN, Gu P, Chen YT, Zhou XX, Tian YG, Yang Q, Li HY, Lin X, Guan YH, Lin TY, Lu X, Shen HF, Fang TX, Liu YM, Xiao D(肖东)#, Gu WW#. TZAP plays an inhibitory role in the self-renewal of porcine mesenchymal stromal cells and is implicated the regulation of premature senescence via the p53 pathway.J Transl Med, 2019,17(1):72.
6. Lin X, Chen L, Li H, Liu Y, Guan Y, Li X, Jia Z, Lin X, Jia J, Sun Y,Xiao D(肖东)#. miR-155 accelerates proliferation of mouse hepatocytes during liver regeneration by directly targeting SOCS1.Am J Physiol Gastrointest Liver Physiol, 2018,315(4): G443-G453.
7. Liu YM, Liu W, Jia JS, Chen BZ, Chen HW, Liu Y, Bie YN, Gu P, Sun Y#., Xiao D(肖东)#, Gu WW#. Abnormalities of hair structure and skin histology derived from CRISPR/Cas9-based knockout of phospholipase C-delta 1 in mice.J Transl Med, 2018,16(1):141.
8. Liu W, Wu LH, Yue M, Na-Shun BY, Shi JW, Tang H, Chen Y, Chen BZ, Yuan J#, Xiao D(肖东)#, Gu WW#. Generation of DKK1 transgenic Tibet minipigs by somatic cell nuclear transfer (SCNT).Oncotarget, 2017,8(43):74331-74339.
9. Lin XL, Qin YJ, Jia JS, Lin TY, Lin X, Chen L, Zeng H, Han YJ, Wu LH, Huang S, Wang M, Huang SH, Xie RY, Liang LQ, Liu Y, Liu RY, Zhang TT, Li J, Wang SC, Sun PH, Huang WH, Yao KT#, Xu K#, Du T#, Xiao D(肖东)#. miR-155 enhances insulin sensitivity by coordinated regulation of multiple genes in mice.PLoS Genetics，2016, 12(10):e1006308.
10. Lin XL, Zhao WT, Jia JS, Lin TY, Xiao GF, Wang SC, Lin X, Liu Y, Chen L, Qin YJ, Li J, Zhang TT, Hao WC, Chen BZ, Xie RY, Cheng YS, Xu K, Yao KT, Huang WH#, Xiao D(肖东)#, Sun Y#. Ectopic expression of Cripto-1 in transgenic mouse embryos causes hemorrhages, fatal cardiac defects and embryonic lethality.Scientific Reports (Sci Rep), 2016, 6:34501.
11. Rong XX, Wei F, Lin XL, Qin YJ, Chen L, Wang HY, Shen HF, Jia LT, Xie RY, Lin TY, Hao WC, Yang J, Yang S, Chen YS, Huang WH, Li AM, Sun Y#, Luo RC#, Xiao D(肖东)#. Recognition and killing of cancer stem-like cell population in hepatocellular carcinoma cells by cytokine-induced killer cells via NKG2d-ligands recognition. Oncoimmunology, 2016, 5(3):e1086060.
12. Lin XL, Jia JJ, Qin YJ, Lin X, Xiao GF, Li YQ, Xie RY, Li W, Huang HL, Zhong L, Wu QH, Wang WS, Huang WH, Yao KT#, Xiao D(肖东)#, Sun Y#. Simple and rapid determination of homozygous transgenic mice via in vivo fluorescence imaging. Oncotarget, 2015, 6(36):39073-39087.
13. Li J, Yang S, Yan W, Yang J, Qin YJ, Lin XL, Xie RY, Wang SC, Jin W, Gao F, Shi JW, Zhao WT, Jia JS, Shen HF, Ke JR, Liu B, Zhao YQ, Huang WH, Yao KT#, Li DJ#, Xiao D(肖东)#. MicroRNA-19 triggers epithelial-mesenchymal transition of lung cancer cells accompanied by growth inhibition.Lab Invest, 2015, 95(9):1056-1070.
14. Lin X, Jia J, Du T, Li W, Wang X, Wei J, Lin X, Zeng H, Yao L, Chen X, Zhuang J, Weng J, Liu Y, Lin J, Wu Q, Wang W, Yao K#, Xu K#, Xiao D(肖东)#. Overexpression of miR-155 in the liver of transgenic mice alters the expression profiling of hepatic genes associated with lipid metabolism. PLoS One, 2015, 10(3): e0118417.
15. Gao F#, Zhang Y, Wang S, Liu Y, Zheng L, Yang J, Huang W, Ye Y, Luo W#, Xiao D(肖东)#. Hes1 is involved in the self-renewal and tumourigenicity of stem-like cancer cells in colon cancer. Scientific Reports (Sci Rep), 2014, 4:3963.
16. Wang SC, Lin XL, Li J, Zhang TT, Wang HY, Shi JW, Yang S, Zhao WT, Xie RY, Wei F, Qin YJ, Chen L, Yang J, Yao KT#, Xiao D(肖东)#. MicroRNA-122 Triggers Mesenchymal-Epithelial Transition and Suppresses Hepatocellular Carcinoma Cell Motility and Invasion by Targeting RhoA. PLoS One, 2014,9(7):e101330.
17. Shi JW, Liu W, Zhang TT, Wang SC, Lin XL, Li J, Jia JS, Sheng HF, Yao ZF, Zhao WT, Zhao ZL, Xie RY, Yang S, Gao F, Fan QR, Zhang MY, Yue M, Yuan J#, Gu WW#, Yao KT#, Xiao D(肖东)#. The enforced expression of c-Myc in pig fibroblasts triggers mesenchymal-epithelial transition (MET) via F-actin reorganization and RhoA/Rock athway inactivation. Cell Cycle, 2013,12(7):1119 -1127.
18. Sun Y*, Xiao D(肖东)*, Li HA, Jiang JF, Li Q, Zhang RS, Chen XG. Phenotypic changes of human cells in human-rat liver during partial hepatectomy-induced regeneration. World J Gastroenterol, 2009, 15(29):3611-3620.
19. Sun Y, Chen XG#, Xiao D(肖东)#. Tetracycline-inducible expression systems: new strategies and practices in the transgenic mouse modeling. Acta Biochim Biophys Sin, 2007, 39(4):235-246.
20. Xiao D(肖东)#, Sun Y, Gu WW, Chen XG#. Tetracycline-controlled transcriptional regulation systems: countermeasures to eliminate basal transgene leak of Tet-based systems. Progress in Natural Science, 2007, 17(1):11-19.
21. Xiao D(肖东), Lin HR. Cysteamine—a somatostatin-inhibiting agent—induced growth hormone secretion and growth acceleration in juvenile grass carp (Ctenopharyngodon idellus). Gen Comp Endocrinol, 2003, 134(3):285-295.
22. Xiao D(肖东), Lin HR. Effects of cysteamine—a somatostatin-inhibiting agent on serum growth hormone (GH) levels and growth in juvenile grass carp (Ctenopharyngodon idellus). Comp Biochem Physiol A, 2003, 134(1):91-97.
23. Xiao D(肖东), Chu MM, Lee EK, Lin HR, Wong AOL. Regulation of growth hormone release in common carp pituitary cells by pituitary adenylate cyclase-activating polypeptide: Signal transduction involves cAMP- and calcium-dependent mechanisms. Neuroendocrinology, 2002, 76(5):325-338.
