白晓春教授

【 发布日期： 11-15 】 【 浏览次数： 】 【 作者： 】


 

 

 

一、基本信息

姓名：白晓春                                

职称：教授，现任南方医科大学基础医学院院长、广东省骨与关节退行性疾病重点实验室主任

联系邮箱：baixc15@smu.edu.cn

 

二、个人简介

国家杰出青年基金获得者，“-”科技创新领军人才，入选国家百千万人才工程，主要从事：(1)骨与关节退行病变的机制；(2)骨与软骨组织损伤与修复的研究，任广东省骨与关节退行性疾病重点实验室主任，近5年承担课题12项，其中国家自然科学基金重点类项目4项，获国家科技进步二等奖(参与人)、云南省科技进步一等奖(第二完成人)、广东省科技进步二等奖和广州市科技进步一等奖各1项，以第一或通讯作者在Science、J Cell Biol、PNAS、Nat Commun、Ann Rheum Dis、Blood、Adv Sci、J Bone Miner Res等期刊上发表论文80多篇，论文他引2000多次，并多次被F1000推荐和国家基金委网站报道。

 

三、拟招收博士后开展的研究方向

1. 骨与关节退行性病变的机制；

2. 骨与软骨组织损伤与修复；

3. 细胞信号转导。

 

四、主要学术任职

    1. 广东省骨与关节退行性疾病重点实验室，主任；

    2. 中国细胞生物学会，资深会员；

    3. 美国骨矿研究协会(ASBMR)，会员；

    4. 中华医学会骨科分会基础组，委员；

    5. 中华医学会医学细胞生物学分会，委员；

    6. 中华医学会骨质疏松分会基础与转化医学组，常务委员；

    7. 国际矫形与创伤外科学会(SCIOT)中国部骨科基础学会，常务委员。

 

五、主要获奖情况

    1. 慢性肾病进展的机制和临床防治，国家科技进步二等奖，2016，第十完成人；

    2. 原发性骨质疏松症的信号网络调控机制及其干预策略，云南省科技进步一等奖，2018，第二完成人；

    3. 细胞增殖分化若干关键信号通路调控机制及其意义的研究，广东省科技进步二等奖，2011，第一完成人；

    4. 细胞增殖分化若干关键信号通路调控机制及其意义的研究，广东市科技进步一等奖，2011，第一完成人

 

六、代表性论文

2019

1 .Lin C, Liu L, Zeng C, Cui Z, Chen Y, Lai P, Wang H, Shao Y , Zhang H, Zhang R, Zhao C, Fang H, Cai D*,Bai X*. Activation of mTORC1 in subchondral bone preosteoblasts promotes osteoarthritis by stimulating bone sclerosis and secretion of CXCL12. Bone Res.2019 online.(IF: 12.354) 一区，Nat Rev Rheum评述(highlight)


2018

2. Zhang H, Lin C, Zeng C, Wang Z, Wang H, Lu J, Liu X, Shao Y, Zhao C, Pan J, Xu S, Zhang Y, Xie D, Cai D*, Bai X*. Synovial macrophage M1 polarisation exacerbates experimental osteoarthritis partially through R-spondin-2. Ann Rheum Dis.2018 Oct;77(10):1524-1534 （IF:12.35）一区，基金委网站报道

 

3. Li K, Zhang Y, Zhang Y, Jiang W, Shen J, Xu S, Cai D, Shen J, Huang B, Li M, Song Q, Jiang Y, Liu A, Bai X*. Tyrosine kinase Fyn promotes osteoarthritis by activating the β-catenin pathway. Ann Rheum Dis. 2018 Jun;77(6):935-943. （IF:12.35）一区，基金委网站报道

 

4. Zou W, Lai M, Zhang Y, Zheng, Xing Z, Li T, Zou Z, Song Q,Zhao X, Xia L, Yang J, Liu A,Zhang H, Cui Z*, Jiang Y*, Bai X*. Exosome Release Is Regulated by mTORC1. Adv Sci. 2018 Dec 11;6(3):1801313..(IF: 12.441)


5. Ma C, Tian X, Kim JP, Xie D, Ao X, Shan D, Lin Q, Hudock MR, Bai X*,Yang J*. Citrate-based materials fuel human stem cells by metabonegenic regulation. Proc Natl Acad Sci U S A.2018 Dec 11;115(50):E11741-E11750 (IF: 9.504)


6. Xu S, Zhang Y, Wang J, Li K, Tan K, Liang K, Shen J, Cai D, Jin D, Li M, Xiao G, Xu J, Jiang Y, Bai X*. TSC1 regulates osteoclast podosome organization and bone resorption through mTORC1 and Rac1/Cdc42. Cell Death Differ. 2018 Jan 22. doi: 10.1038/s41418-017-0049-4. [Epub ahead of print] PubMed PMID: 29358671. （IF:8）

 

7. Wang Y, Xiao M, Tao C, Chen J, Wang Z, Yang J, Chen Z, Zou Z, Liu A, Cai D, Jiang Y, Ding C, Li M, Bai X*. Inactivation of mTORC1 Signaling in Osterix-Expressing Cells Impairs B-cell Differentiation. J Bone Miner Res. 2018 Apr;33(4):732-742.（IF: 6.314）

 

8.  Lu J, Zhang H, Cai D, Zeng C, Lai P, Shao Y, Fang H, Li D, Ouyang J, Zhao C, Xie D, Huang B, Yang J, Jiang Y, Bai X*. Positive-Feedback Regulation of Subchondral H-Type Vessel Formation by Chondrocyte Promotes Osteoarthritis Development in Mice. J Bone Miner Res. 2018 May;33(5):909-920.（IF: 6.314）Cover Figure

 

9. Lin X, Sun Q, Zhou L, He M, Dong X, Lai M, Liu M, Su Y, Jia C, Han Z, Liu S, Zheng H, Jiang Y, Ling H, Li M, Chen J, Zou Z*, Bai X*. Colonic epithelial mTORC1 promotes ulcerative colitis through COX-2-mediated Th17 responses. Mucosal Immunol. Nov;11(6):1663-1673（IF: 7.360）

 

2017

 

10. Xiao M, Wang Y, Tao C, Wang Z, Yang J, Chen Z, Zou Z, Li M, Liu A, Jia C, Huang B, Yan B, Lai P, Ding C, Cai D, Xiao G, Jiang Y, Bai X*. Osteoblasts support megakaryopoiesis through production of interleukin-9. Blood. 2017 Jun 15;129(24):3196-3209. （IF: 15.132）一区

 

11. Wang H, Zhang H, Sun Q, Wang Y, Yang J, Yang J, Zhang T, Luo S, Wang L, Jiang Y, Zeng C, Cai D*, Bai X*.Intra-articular Delivery of Antago-miR-483-5p Inhibits Osteoarthritis by Modulating Matrilin 3 and Tissue Inhibitor of Metalloproteinase 2. Mol Ther. 2017 Mar 1;25(3):715-727. （IF: 7.008）一区

 

12. Zhang Y, Xu S, Li K, Tan K, Liang K, Wang J, Shen J, Zou W, Hu L, Cai D, Ding C, Li M, Xiao G, Liu B, Liu A, Bai X*. mTORC1 inhibits NF-κB/NFATc1 signaling and prevents osteoclast precursor differentiation, in vitro and in mice. J Bone Miner Res.2017 Sep;32(9):1829-1840 (IF: 6.314）

 

13. Zhang Y, Xu S, Liang KY, Li K, Zou ZP, Yang CL, Tan K, Cao X, Jiang Y, Gao TM, Bai XC*. Neuronal mTORC1 is required for maintaining the nonreactive state of astrocytes. J Biol Chem. 2017 Jan 6;292(1):100-111（IF: 4.01）

 

14. Zhang H, Wang H, Zeng C, Yan B, Ouyang J, Liu X, Sun Q, Zhao C, Fang H, Pan J, Xie D, Yang J, Zhang T, Bai X*, Cai D*. mTORC1 activation downregulates FGFR3 and PTH/PTHrP receptor in articular chondrocytes to initiate osteoarthritis. Osteoarthritis Cartilage. 2017 Jun;25(6):952-963. （IF: 5.454）一区

 

2016

15. Huang B, Wang W, Li Q, Wang Z , Yan B, Zhang Z, Wang L , Huang M, Jia C, Lu J, Liu S,  Chen H, Li M, Cai D, Jiang Y, Jin D*, Bai X*. Osteoblasts secrete Cxcl9 to regulate angiogenesis in bone, Nat Commun.2016 Dec 14;7:13885. （IF: 12.353）一区, F1000推荐，基金委网站报道

 

16. Yang J, Zhou X, Fan X, Xiao M, Yang D, Liang B, Dai M, Shan L, Lu J, Lin Z, Liu R, Liu J, Wang L, Zhong M, Jiang Y, Bai X*. mTORC1 promotes aging-related venous thrombosis in mice via elevation of platelet volume and activation. Blood.2016 Aug 4;128(5):615-24. （IF: 15.132）一区，with commentary

 

17. Yan B, Zhang Z, Jin D, Cai C, Jia C, Liu W, Wang T, Li S, Zhang H, Huang B, Lai P, Wang H, Liu A, Zeng C, Cai D, Jiang Y, Bai X*.mTORC1 regulates PTHrP to coordinate chondrocyte growth, proliferation and differentiation. Nat Commun. 2016 Apr 4;7:11151. （IF: 12.353）一区,基金委网站报道

 

 

18. Xu S, Zhang Y, Liu B, Li K, Huang B, Yan B, Zhang Z, Liang K, Jia C, Lin J, Zeng C, Cai D, Jin D, Jiang Y, Bai X*. Activation of mTORC1 in B Lymphocytes Promotes Osteoclast Formation via Regulation of β-Catenin and RANKL/OPG. J Bone Miner Res.2016 Jul;31(7):1320-33. （IF: 6.314）

 

2015

19. Zou Z, Chen J, Liu A, Zhou X, Song Q, Jia C, Chen Z, Lin J, Yang C, Li M, Jiang Y, Bai X*. mTORC2 promotes cell survival through c-Myc-dependent up-regulation of E2F1. J Cell Biol. 2015 Oct 12;211(1):105-22. （IF: 8.784）In this issue, with commentary

 

20. Huang B, Wang Y, Wang W, Chen J, Lai P, Liu Z, Yan B, Xu S, Zhang Z, Zeng C, Rong L, Liu B, Cai D, Jin D, Bai X*. mTORC1 Prevents Preosteoblast Differentiation through the Notch Signaling Pathway. PLoS Genet. 2015 Aug 4;11(8):e1005426. （IF: 5.54）

 

21. Dong H, Chen Z, Wang C, Xiong Z, Zhao W, Jia C, Lin J, Lin Y, Yuan W, Zhao AZ*, Bai X*. Rictor Regulates Spermatogenesis by Controlling Sertoli Cell Cytoskeletal Organization and Cell Polarity in the Mouse Testis. Endocrinology.2015 Nov;156(11):4244-56. （IF: 3.961）

 

22. Chen Z, Kang X, Wang L, Dong H, Wang C, Xiong Z, Zhao W, Jia C, Lin J, Zhang W, Yuan W, Zhong M, Du H*, Bai X*. Rictor/mTORC2 pathway in oocytes regulates folliculogenesis, and its inactivation causes premature ovarian failure. J Biol Chem. 2015 Mar 6;290(10):6387-96. （IF: 4.01）

 

2014

23. Huang MJ, Wang L, Jin DD, Zhang ZM, Chen TY, Jia CH, Wang Y, Zhen XC, Huang B, Yan B, Chen YH, Li SF, Yang JC, Dai YF, Bai XC*. Enhancement of the synthesis of n-3 PUFAs in fat-1 transgenic mice inhibits mTORC1 signalling and delays surgically induced osteoarthritis in comparison with wild-type mice. Ann Rheum Dis, 2014, 73(9):1719-27. (IF: 12.35) 一区

 

24. Chen Z, Dong H, Jia C, Song Q, Chen J, Zhang Y, Lai P, Fan X, Zhou X, Liu M, Lin J, Yang C, Li M, Gao T, Bai X*. Activation of mTORC1 in collecting ducts causes hyperkalemia. J Am Soc Nephrol, 2014, 25(3):534-45. (IF: 8.655) 一区

 

25. Song Q, Xu Y, Yang C, Chen Z, Jia C, Chen J, Zhang Y, Lai P, Fan X, Zhou X, Lin J, Li M,  Ma W, Luo S, Bai X*. miR-483-5p promotes invasion and metastasis of lung adenocarcinoma by targeting RhoGDI1 and ALCAM. Cancer Res,2014 ,74(11):3031-42. (IF: 9.13) 一区

 

26. Chen Z, Zhang Y, Jia C, Wang Y, Lai P, Zhou X, Wang Y, Song Q, Lin J, Ren Z, Gao Q, Zhao Z, Zheng H, Wan Z, Gao T, Zhao A, Dai Y*, Bai X*. mTORC1/2 targeted by n-3 polyunsaturated fatty acids in the prevention of mammary tumorigenesis and tumor progression.Oncogene, 2014, 33(37):4548-57. (IF: 6.854)

 

27. Guo J, Xie Z, Tran RT, Xie D, Jin D, Bai X, Yang J*. Click chemistry plays a dual role in  biodegradable polymer design. Adv Mater, 2014, 26(12):1906-11. (IF: 21.95) 一区

 

2013

28. Jia CH, Li M, Liu J, Zhao L, Lin J, Lai PL, Zhou X, Zhang Y, Chen ZG, Li HY, Liu AL, Yang   CL, Gao TM, Jiang Y, Bai XC*. IKK-β mediates hydrogen peroxide induced cell death through p85 S6K1. Cell Death Differ,2013, 20(2):248-58. (IF: 8)

 

29. Wen ZH, Su YC, Lai PL, Zhang Y, Xu YF, Zhao A, Yao GY, Jia CH, Lin J, Xu S, Wang L,  Wang XK, Liu AL, Jiang Y, Dai YF*, Bai XC*. Critical role of arachidonic acid-activated mTOR signaling in breast carcinogenesis and angiogenesis.Oncogene,2013, 32(2):160-70. (IF: 6.854)

 

2010

30. Bai X*, Jiang Y*. Key factors in mTOR regulation. Cell Mol Life Sci, 2010, 67(2):239-53. (IF: 6.721)

 

31. Ma D@, Bai X@, Zou H, Lai Y, Jiang Y. Rheb GTPase controls apoptosis by regulating interaction of FKBP38 with Bcl-2 and Bcl-XL.J Biol Chem. 2010 Mar 19;285(12):8621-7 (IF: 4.01) equal contribution

 

2007

32. Bai XC, Ma DZ, Liu AL, Shen XY, Wang QM, Liu YJ, Jiang Y*. Rheb activates mTOR by antagonizing its endogenous  inhibitor, FKBP38. Science,2007, 318(5852): 977-980. (IF: 41.058) 一区，Highlight，F1000推荐，with commentary，SCI引用252次

 

2005

33. Bai XC*, Lu D, Liu AL, Zhang ZM, Li XM, Zou ZP, Zeng WS, Cheng BL, Luo SQ. Reactive oxygen species stimulates receptor activator of NF-kappaB ligand expression in osteoblast. J Biol Chem. 2005 Apr 29;280(17):17497-506 (IF: 4.01) SCI引用190次

 

2004

34. Bai XC, Lu D, Bai J, Zheng H, Ke ZY, Li XM, Luo SQ*. Oxidative stress  inhibits osteoblastic differentiation of bone cells by ERK and NF-kappaB. Biochem Biophys Res Commun. 2004 Jan 30;314(1):197-207. (IF: 2.559) SCI引用295次