一、基本信息

姓名：范建兵                                

职称：教授

联系邮箱：jianbing_fan@anchordx.com 

二、学习经历

1978.9-1982.1   复旦大学          生物化学专业    本科

1982.1-1985.3  中科院细胞所      细胞生物学专业  硕士

1986-1992    美国哥伦比亚大学  遗传学专业      博士

1992-1996        美国斯坦福大学      遗传与发育专业  博后

 

三、拟招收博士后开展的研究方向

1. 生物化学与分子生物学；

2. 生物信息分析。

 

四、主要学术任职

        1. 总编： Editor-in-Chief of Genomics Data

        2. 执行主编： Executive Editor of Genomics

        3. 编辑委员会成员：Genome Research, Translational Cancer Research

        4. 北京基因研究所（BGI）和国家基因组南方研究中心（上海）客座教授和高级顾问

        5. 医学遗传学国家重点实验室（湘雅医学院）学术委员会委员

        6. 加拿大基因组学组织的研究评审委员

 

五、主要获奖情况

        1. 美国遗传学会旅行奖（Genetic Society of America Travel Award），美国遗传学会，1986

        2. 美国宜曼达公司科技创新奖（Illumina Innovation Award），Illumina 公司，2002；  

        3. 广州市创新领军人才，广州市，2016；

        4. 广州开发区创新领军人才，广州开发区，2016；

        5. 全国基因检测行业年度十大风云人物，2017

        6. 2018年广州市产业聚集领军人才工程创新领军团队带头人，广州市，2018

 

六、代表性论文

1. G.D. Schuler, M.S. Boguski, et al, J.-B. Fan, et al, E.S. Lander and T.J. Hudson. A gene map of the human genome. Science 274:540-546. 1996. (IF 37.205)

 

2. D.G. Wang, J.-B. Fan, C.-J. Siao, A. Berno, P. Young, R. Sapolsky, …., T.J. Hudson, R. lipshutz, M. Chee and E.S. Lander. Large-scale identification, mapping, and genotyping of single-nucleotide polymorphisms in the human genome. Science 280:1077-1082. 1998. (IF 37.205)

 

3. J.G. Hacia, J.-B. Fan, O. Ryder, L. Jin, K. Edgemon, G. Ghandour, R.A. Mayer, B. Sun, L. Hsie, C.M. Robbins, L.C. Brody, D. Wang, E.S. Lander, R. Lipshutz, S.P.A. Fodor and F.S. Collins. Determination of ancestral alleles for human single nucleotide polymorphisms using high density oligonucleotide arrays. Nature Genetics 22:164-167. 1999. (IF 27.958)

 

4. M.K. Halushka, J.-B. Fan, K. Bentley, L. Hsie, N. Shen, A. Weder, R. Cooper, R. Lipshutz and A. Chakravarti. Patterns of single nucleotide polymorphisms in candidate genes for blood-pressure homeostasis. Nature Genetics 22:239-247. 1999. (IF 27.958)

 

5. J.-B. Fan, X. Chen, M.K. Halushka, A. Berno, X.-H. Huang, T. Ryder, R. Lipshutz, D. Lockhart and A. Chakravarti. Parallel genotyping of human SNPs using generic high-density oligonucleotide tag arrays. Genome Research 10:853-860. 2000. (IF 11.351)

 

6. J.M. Yeakley, J.-B. Fan*, D. Doucet, L. Luo, E. Wickham, Z. Ye, M.S. Chee and X.-D. Fu*. Profiling alternative splicing on fiber-optic arrays. Nature Biotechnology 20:353-358. 2002. (*co-corresponding author) (IF 41.666)

 

7. J.-B. Fan, A. Oliphant, R. Shen, B. Kermani, F. Garcia, K.L. Gunderson, M. Hansen, F. Steemers, B.L. Butler, P. Deloukas, et al. and M.S. Chee. Highly parallel SNP genotyping. Cold Spring Harbor Symposium Biology 68:69-78. 2003.

 

8. J.-B. Fan*, J.M. Yeakley, …, A. Oliphant, D.L. Barker and M.S. Chee. A versatile assay for high-throughput gene expression profiling on universal array matrices. Genome Research 14:878-885. 2004. (IF 11.351)

 

9. M. Bibikova, D. Talantov, E. Chudin, J.M. Yeakley, J. Chen, D. Doucet, E. Wickham, D. Atkins, D. Barker, M. Chee, Y. Wang and J.-B. Fan*. Quantitative gene expression profiling in formalin-fixed, paraffin-embedded tissues using universal bead arrays. American Journal of Pathology 165 (5):1790-1807. 2004. (IF 4.0570)

 

10. M. Bibikova, Z. Lin,  L. Zhou, E. Chudin, E. Wickham Garcia, B. Wu, D. Doucet, N.J. Thomas, Y. Wang, E. Vollmer, T. Goldmann, C. Seifart, W. Jiang, D.L. Barker, M.S. Chee, J. Floros and J.-B. Fan*. High-throughput DNA methylation profiling using universal bead arrays. Genome Research 16:383-393. 2006. (IF 11.351)

 

11. H.-R. Li, J. Wang-Rodriguez, T.M. Nair, J.M. Yeakley, Y.-S. Kwon, M. Bibikova, C. Zheng, L. Zhou, K. Zhang, T. Downs, X.-D. Fu* and J.-B. Fan*. Two-dimensional transcriptome profiling: Identification of messenger RNA isoform signatures in prostate cancer from archived paraffin-embedded cancer specimens. Cancer Research 66(8):4079-4088. 2006. (IF 9.122)

 

12. J.-B. Fan, M.S. Chee and K.L. Gunderson. Highly-parallel genomic assays. Nature Reviews Genetics 7:632-644. 2006. (IF 40.282)

 

13. M. Bibikova, E. Chudin, ..., M. Rao, D.L. Barker, J.F. Loring and J.-B. Fan*. Human embryonic stem cells have a unique epigenetic signature. Genome Research 16(9):1075-1083. 2006. (IF 11.351)

 

 

14. The International HapMap Consortium (Illumina team: L.M. Galver, J.-B. Fan, K. Gunderson, S.S. Murray, A.R. Oliphant, M.S. Chee). A second generation human haplotype map of over 3.1 million SNPs. Nature 449(7164):851-861. 2007. (IF40.137)

 

15. M. Bibikova, L.C. Laurent, B. Ren, J.F. Loring and J.-B. Fan*. Unraveling epigenetic regulation in embryonic stem cells. Cell Stem Cell 2(2):123-134. 2008. (IF 23.393)

 

16. J. Chen, J. Lozach, E. Wickham Garcia, B. Barnes, S. Luo, I. Mikoulitch, L. Zhou, G. Schroth and J.-B. Fan*. Highly sensitive and specific microRNA expression profiling using BeadArray technology. Nucleic Acids Research. doi: 10.1093/nar/gkn387. 2008. (IF 10.161)

 

17. C. April, B. Klotzle, T. Royce, E. Wickham-Garcia, T. Boyaniwsky, J. Izzo, D. Cox, W. Jones, R. Rubio, K. Holton, U. Matulonis, J. Quackenbush and J.-B. Fan*. Whole-genome gene expression profiling of formalin-fixed, paraffin-embedded tissue samples. PLoS-ONE 4(12): e8162. doi:10.1371/journal.pone.0008162. 2009. (IF 2.806)

 

18. M. Bibikova, B. Barnes, C. Tsan, V. Ho, B. Klotzle, J.M. Le, D. Delano, L. Zhang, G.P. Schroth, K.L. Gunderson, J.-B. Fan and R. Shen. High density DNA methylation array with single CpG site resolution. Genomics 98(4):288-295. 2011. (IF 2.801)

 

19. F. Kaper, S. Swamy, B. Klotzle, S. Munchel, J. Cottrell, M. Bibikova, H.-Y. Chuang, S. Kruglyak, M. Ronaghi, M.A. Eberle and J.-B. Fan*. Whole-genome haplotyping by dilution, amplification and sequencing. Proc Natl Acad Sci USA. 110(14):5552-5557. 2013. (IF 9.661)

 

20. E. Laurenti, S. Doulatov, S. Zandi, I. Plumb, J. Chen, C. April, J.-B. Fan and J.E. Dick. The transcriptional architecture of early human hematopoiesis identifies multilevel control of lymphoid commitment. Nature Immunology 14(7):756-763. 2013. (IF 21.506)

 

21. P. van Galen, A. Kreso, E. Wienholds, E. Laurenti, K. Eppert, E.R. Lechman, N. Mbong, K. Hermans, S. Dobson, C. April, J.-B. Fan and J.E. Dick. Reduced lymphoid lineage priming promotes human hematopoietic stem cell expansion, Cell Stem Cell 14(1):94-106. 2014. (IF 23.393)

 

22. C. Wang, M. Cicek,… B.J. Winterhoff, J.-B. Fan, M. Bibikova, ….K.L. Knutson, B.L. Fridley and E.L. Goode. Tumor hypomethylation at 6p21.3 associates with longer time to recurrence of high-grade serous epithelial ovarian cancer. Cancer Research 74(11):3084-3091. 2014. (IF 9.122)

 

23. E.A. Perez, E.A. Thompson,… J.-B. Fan, .. J.R. Gralow and M.M. Reinholz. Genomic analysis reveals that immune function genes are strongly linked to clinical outcome in the NCCTG (Alliance) N9831 adjuvant trastuzumab trial. Journal of Clinical Oncology, 33(7):701-708. 2015. (IF 24.007)

 

24. E. Laurenti, C. Frelin, ……, J.-B. Fan, N. Iscove and J.E. Dick. CDK6 levels regulate quiescence exit in human hematopoietic stem cells. Cell Stem Cell, 16(3):302-313. 2015. (IF 23.393)

 

25. J. Chien, H. Sicotte, J.-B. Fan, S. Humphray,…..S.H. Kaufmann, L. Hartmann, V. Shridhar and E. Goode. TP53 mutations, tetraploidy and homologous recombination repair defects in early stage high-grade serous ovarian cancer. Nucleic Acids Research, 43(14):6945-6958. doi: 10.1093/nar/gkv111. 2015. (IF 10.161)

 

26. X. Cai, F. Janku, Q. Zhan and J.-B. Fan. Accessing genetic information with liquid biopsies. Trends in Genetics, 31(10):564-575. 2015. (IF 10.843)

 

27. J. Fan, N. Salathia, R. Liu, …, J.-B. Fan, K. Zhang, J. Chun and P.V. Kharchenko. Characterizing transcriptional heterogeneity through pathway and gene set overdispersion analysis. Nat Methods 13(3):241-244. doi: 10.1038/nmeth.3734. 2016. (IF 25.062)

 

28. S. Nair, X. Zhang…, J.-B. Fan, … Y. Hu and R. Li. Genetic suppression reveals DNA repair-independent antagonism between BRCA1 and COBRA1 in mammary gland development. Nat Commun. 7:10913. doi: 10.1038/ncomms10913. 2016. (IF 12.123)

 

29. B.B. Lake, R. Ai, G.E. Kaeser, N. Salathia, …., J.-B. Fan*, W. Wang*, J. Chun* and K. Zhang*. Neuronal subtypes and diversity revealed by single-nucleus RNA sequencing of the human brain. Science 352(6293):1586-1590. 2016. (*Co-senior Authors). (IF 37.205)

 

30. Y. Ito, D. Ofengeim, ….., J.-B. Fan, … J. Ravits and J.Y. Yuan. RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS. Science 353(6299):603-608. 2016. (IF 37.205)

 

31. S. Zhao, M.S. Geybels, A. Leonardson, …., E.A. Ostrander, J.-B. Fan*, Z. Feng* and J.L. Stanford*. Epigenome-wide tumor DNA methylation profiling identifies novel prognostic biomarkers of metastatic-lethal progression in men with clinically localized prostate cancer. Clin Cancer Res. 23(1):311-319. 2017. (*Co-senior Authors). (IF 9.619)

 

32. S. Kommoss, B. Winterhoff, A.L. Oberg, G.E. Konecny, C. Wang, S.M. Riska, J.-B. Fan, …, L.C. Hartmann, E.L. Goode, S.C. Dowdy and J. Pfisterer. Bevacizumab may differentially improve ovarian cancer outcome in patients with proliferative and mesenchymal molecular subtypes. Clin Cancer Res. 23(14):3794-3801. 2017. (IF 9.619)

 

33. F. Janku, S. Zhang, …, G. Mills, J.-B. Fan and N. Salathia. Development and validation of an ultra-deep next-generation sequencing assay for testing of plasma cell-free DNA from patients with advanced cancer. Clin Cancer Res. 2017 May 23. pii: clincanres.0291.2016. doi: 10.1158/1078-0432.CCR-17-0291. 2017. (IF 9.619)

34. Wenhua Liang, Yue Zhao, Weizhe Huang, Yangbin Gao, Weihong Xu, Jinsheng Tao, Meng Yang, Lequn Li, Wei Ping, Hui Shen, Xiangning Fu, Zhiwei Chen, Peter W. Laird, Xuyu Cai*, Jian-Bing Fan*，Jianxing He*. Non-invasive diagnosis of early-stage lung cancer using high-throughput targeted DNA methylation sequencing of circulating tumor DNA (ctDNA).[J]. Theranostics,2019,9(7).(IF = 8.5)