一、基本信息
姓名：官道刚
职称：教授
联系邮箱：guandg0929@hotmail.com
二、学习经历
2005.9‐2011.7，中山大学，生物化学与分子生物学（生物信息学方向），博士（直博）
2011.7-2012.8，中山大学，生物化学与分子生物学（生物信息学方向），
研究助理
2012.8-2014.8，香港浸会大学，理学院生物系，高级研究助理
2014.9-2016.8，香港浸会大学，理学院生物系，助理教授（研究）
2016.9-2019.8，香港浸会大学，整合生物信息医学与转化科学研究所，助理教授（研究）
三、拟招收博士后开展的研究方向
1.单细胞数据解析疾病发生、细胞命运决定、胚胎发育过程中复杂基因调控网络；
2.多维度数据联合建模解析复杂疾病的分子机理确定疾病相关的分子靶点或靶点网络；
3. 针对疾病相关的分子靶点或靶点网络筛选药物或药物组合。
四、代表性论文
1) Guan D, Yan B, Thieme C, Hua J, Zhu H, Boheler KR, Zhao Z, Kragler F, Xia Y, Zhang S. PlaMoM: a comprehensive database compiles plant mobile macromolecule. Nucleic Acids Res. 2017 Jan 4;45(D1): D1021-D1028.
2) Guan D, Xia Y, Zhang S. Analyzing and Predicting Phloem Mobility of Macromolecules with an Online Database; Methods Mol Biol. 2019; 2014:433-438;
3) Guan D, Shao J, Zhao Z, Wang P, Qin J, Deng Y, Boheler KR, Wang J, Yan B: PTHGRN: unraveling post-translational hierarchical gene regulatory networks using PPI, ChIP-seq and gene expression data. Nucleic Acids Res 2014, 42:W130-136. (cover story)
4) Guan D, Shao J, Deng Y, Wang P, Zhao Z, Liang Y,Wang J, Yan B: CMGRN: a web server for constructing multilevel gene regulatory networks using ChIP-seq and gene expression data. Bioinformatics, 2014, 30(8): 1190-1192.
5) Guan DG, Liao JY, Qu ZH, Zhang Y, Qu mirExplorer: detecting microRNAs from genome and next generation sequencing data using the AdaBoost method with transition probability matrix and combined features. RNA Biol 2011, 8(5):922-934.
6) Yan B#, Guan D# (Co-first author),Wang C, Wang J, He B, Qin J, KR Boheler, Lu A, Zhang G, Zhu H. An integrative method to decode regulatory logics in gene transcription. Nature Communications, 2017, 8(1): 1044-1044.
7) Zhang Z#, Li J#, Guan D# (Co-first author), Liang C#, Zhuo Z, Liu J, Lu A, Zhang G, Zhang B. A newly identified lncRNA MAR1 acts as a miR-487b sponge to promote skeletal muscle differentiation and regeneration. Journal of Cachexia, Sarcopenia and Muscle, 2018, 9(3): 613-626.
8) Zhang Z#, Li J#, Guan D# (Co-first author), Liang C#, Zhuo Z, Liu J, Lu A, Zhang G, Zhang B. Long Noncoding RNA lncMUMA Reverses Established Skeletal Muscle Atrophy Following Mechanical Unloading, Molecular Therapy , 2018, 26(11): 2669-2680.
9) Liang C#, Peng S#, Li J#, Lu J#, Guan D# (Co-first author), Jiang F#, Lu Cheng, Li F, He X, Zhu H, Au D, Yang D, Zhang B, Lu A, Zhang G. Inhibition of osteoblastic Smurf1 promotes bone formation in mouse models of distinctive age2 related osteoporosis. Nature Communications, 2018, 9(1): 3428.
10) Ho VW#, Wong MK#, An X#, Guan D# (Co-first author), Shao J, Ng HC, Ren X, He K, Liao J, Ang Y, Chen L, Huang X, Yan B, Xia Y, Chan LL, Chow KL, Yan H, Zhao Z: Systems- level quantification of division timing reveals a common genetic architecture controlling asynchrony and fate asymmetry. Mol Syst Biol 2015, 11(6):814.
11) Wang C, Ren Q, Chen X, Song Z, Ning Z, Gan J, Ma X, Liang D, Guan D*(Co- corresponding author), Liu Z*, Lu A*. System Pharmacology-Based Strategy to Decode the Synergistic Mechanism of Zhi-zhu Wan for Functional Dyspepsia. Front Pharmacol. 2018, 9, 841.
12) Chen X, Zheng C, Wang C, Guo Z, Gao S, Ning Z, Huang C, Lu C, Fu Y, Guan D*(Co- corresponding author), Lu A*, Wang Y*. Systems-Mapping of Herbal Effects on Complex Diseases Using the Network-Perturbation Signatures. Front Pharmacol. 2018 Oct. 9, 1174.
13) He K#, Li WX#, Guan D# (Co-first author), Gong M, Ye S, Fang Z, Huang JF, Lu A. Regulatory network reconstruction of five essential microRNAs for survival analysis in breast cancer by integrating miRNA and mRNA expression datasets. Funct Integr Genomics. 2019 Mar 12.
14) Kan He, Guoying Wu, Wen-Xing Li, Daogang Guan(Co-first author), Wenwen Lv, Mengting Gong, Shoudong Ye, Aiping Lu,A transcriptomic study of myogenic differentiation under the overexpression of PPARγ by RNA-Seq. Scientific reports, 2017.
15) Zhang C, Guan D(Co-first author), Jiang M, Liang C, Li L, Zhao N, Zha Q, Zhang W, Lu C, Zhang G, Liu J, Lu A. Efficacy of leflunomide combined with ligustrazine in the treatment of rheumatoid arthritis: prediction with network pharmacology and validation in a clinical trial; Chin Med. 2019 Aug 2;14:26.
16) Liang C, Li J, Lu C, Xie D, Liu J, Zhong C, Wu X, Dai R, Zhang H, Guan D, Guo B, He B, Li F, He X, Zhang W, Zhang BT, Zhang G, Lu A. HIF1伪 inhibition facilitates Leflunomide-AHR-CRP signaling to attenuate bone erosion in CRP-aberrant rheumatoid arthritis. Nature communications, 2019 Oct 8; 10(1):4579.
17) Zheng Y, Wang X, Zhang Z, Guo B, Dang L, He B, Zhang C, Zhou J, Shi W, Zhao Y, Zhan H, Xu Y, Liang C, Liu J, Guan D, Wang L, Wu X, Li J, Zhuo Z, Lin Z, Qiu H, Zhong L, Bian Z, Shi Y, Zhang B, Zhang G, Lu A. Bushen yijing fang reduces fall risk in late postmenopausal women with osteopenia: a randomized double-blind and placebo-controlled trial. Scientific reports, 2019, 9(1): 2089.
18) Zhang C, Guan D, Jiang M, Liang C, Li L, Zhao N, Zha Q, Zhang W, Lu C, Zhang G, Liu J, Lu A. Efficacy of leflunomide combined with ligustrazine in the treatment of rheumatoid arthritis: prediction with network pharmacology and validation in a clinical trial; Chin Med. 2019 Aug 2;14:26.
19) Zhang Y, Guan DG, Yang JH, Shao P, Zhou H, Qu LH: ncRNAimprint: a comprehensive database of mammalian imprinted noncoding RNAs. RNA 2010, 16(10):1889-1901.
20) Zhang C, Zhou W, Guan DG, Wang YH, Lu AP. Network Intervention, a Method to Address Complex Therapeutic Strategies. Front Pharmacol. 2018 Jul 12;9:754.
21) ENY Poon*, B Hao, D Guan, MJ Li, J Lu, Y Yang, B Wu, SE Webb, SCM Wu, ALMiller, Y Liang, X Yao, J Wang, B Yan*, KR Boheler. Integrated transcriptomics and regulatory network analyses identify microRNA-200c as a novel repressor of differentiation and maturation of human pluripotent stem cell-derived cardiomyocytes. Cardiovascular Research 2018.
22) Shao P, Liao JY, Guan DG, Yang JH, Zheng LL, Jing Q, Zhou H, Qu LH: Drastic expression change of transposon-derived piRNA-like RNAs and microRNAs in early stages of chicken embryos implies a role in gastrulation. RNA Biol 2012, 9(2):212-227. (cover story)
23) Li F, Lu J, Liu J, Liang C, Wang M, Wang L, Li D, Yao H, Zhang Q, Wen J, Zhang Z, Li J, Lu Q, He X, Guo B, Guan D, Yu Y, Dang L, Wu X, Li Y, Chen G, Jiang F, Sun S, Zhang B, Lu A, Zhang G. A water-soluble nucleolin aptamer-paclitaxel conjugate fortumor-specific targeting in 1 ovarian cancer. Nature Communications 2017.
24) Wang L, Liang C, Li F, Guan D, Wu X, Fu X, Lu A, Zhang G. PARP1 in carcinomas and PARP1 inhibitors as antineoplastic drugs. Int J Mol Sci. 2017. 18 (10), 2111
25) Lv Q, Meng Z, Yu Y, Jiang F, Guan D, Liang C, Zhou J, Lu A, Zhang G. Molecular Mechanisms and Translational Therapies for Human Epidermal Receptor 2 Positive Breast Cancer. Int J Mol Sci. 2016 Dec 14;17(12).
26) Lv H, Jiang F, Guan D, Lu C, Guo B, Chan C, Peng S, Liu B, Guo W, Zhu H, Xu X, Lu A,Zhang G. Metabolomics and Its Application in the Development of Discovering Biomarkers for Osteoporosis Research. Int J Mol Sci. 2016 Dec 2;17(12).
27) Wong MK, Guan D, Ng HC, Ho VW, An X, Li R, Ren X, Zhao Z: Timing of Tissue-specific Cell Division Requires a Differential Onset of Zygotic Transcription during Metazoan Embryogenesis. Journal of Biological Chemistry,2016
28) Zhang J, Yan B, Spath SS, Qun H, Cornelius S, Guan D, Shao J, Hagiwara K, Van WaesC, Chen Z, Su X, Bi Y: Integrated transcriptional profiling and genomic analyses reveal RPN2 and HMGB1 as promising biomarkers in colorectal cancer. Cell Biosci 2015, 5:53.
29) Wang J, Yan B, Liu SM, Sun H, Pan Y, Guan D, Zhang X, Xu J, Ma H: Transcriptomic and Functional Pathway Analysis of Human Cervical Carcinoma Cancer Cells Response to Microtubule Inhibitor. J Cancer 2015, 6(10):930-937.
30) Wen JZ, Liao JY, Zheng LL, Xu H, Yang JH, Guan DG, Zhang SM, Zhou H, Qu LH: A contig-based strategy for the genome-wide discovery of microRNAs without complete genome resources. PLoS One 2014, 9(2):e88179.
31) Yan B, Li H, Yang X, Shao J, Jang M, Guan D, Zou S, Van Waes C, Chen Z, Zhan M: Unraveling regulatory programs for NF-kappaB, p53 and microRNAs in head and neck squamous cell carcinoma. PLoS One 2013, 8(9):e73656.
32) Shao P, Yang JH, Zhou H, Guan DG, Qu LH: Genome-wide analysis of chicken snoRNAs provides unique implications for the evolution of vertebrate snoRNAs. BMC Genomics 2009, 10:86.
33) Liu N, Xiao ZD, Yu CH, Shao P, Liang YT, Guan DG, Yang JH, Chen CL, Qu LH, Zhou H: SnoRNAs from the filamentous fungus Neurospora crassa: structural, functional and evolutionary insights. BMC Genomics 2009, 10:515.
