窗体顶端
一、基本信息
姓名：徐伟
职称：教授
联系邮箱：xuwei3322@smu.edu.cn
二、学习经历
1996.9-2000.6 湖北农学院，农学，本科
2000.9-2003.6 华南农业大学，生物化学与分子生物学，硕士
2006.9-2009.6 中国科学院研究生院，生物技术与医药，博士
三、拟招收博士后开展的研究方向
1. 药理学，结构药理学方向；
2. 药学，药物设计方向；
3. 结构生物学，药物靶标结构解析方向
四、主要获奖情况
广东省杰出青年医学人才，广东省卫生健康委员会，2018
五、代表性论文
1. Yupeng Feng, Chufang Li, Peiyu Hu, Qian Wang, Xuehua Zheng, Yongkun Zhao, Yi Shi, Songtao Yang, Changhua Yi, Ying Feng, Chunxiu Wu, Linbing Qu, Wei Xu, Yao Li, Caijun Sun, Fu George Gao, Xianzhu Xia, Liqiang Feng, Ling Chen. An adenovirus serotype 2-vectored ebolavirus vaccine generates robust antibody and cell-mediated immune responses in mice and rhesus macaques. Emerging Microbes & Infections. 2018,7:101 ；
2. Ying Feng, Xihui Sun, Xianmiao Ye, Yupeng Feng, Jinlin Wang, Xuehua Zheng, Xinglong Liu, Changhua Yi, Mingli Hao, Qian Wang, Feng Li, Wei Xu, Liang Li, Chufang Li, Rong Zhou, Ling Chen, Liqiang Feng. Hexon and fiber of adenovirus type 14 and 55 are major targets of neutralizing antibody but only fiber-specific antibody contributes to cross-neutralizing activity. Virology. 2018,518,272-283 ；
3. Britney Johnson#, Laura A. VanBlargan#, Wei Xu#, James P. White, Chao Shan, Pei-Yong Shi, Rong Zhang, Jagat Adhikari, Michael L.Gross, Daisy W. Leung, Michael S. Diamond, Gaya K. Amarasinghe. Human IFIT3 modulates IFIT1 RNA binding specificity and protein stability. Immunity. 2018,48:1-13 ；
4. Wei Xu, Priya Luthra, Chao Wu, Jyoti Batra, Daisy W. Leung. Christopher F. Basler, Gaya K. Amarasinghe. Ebola virus VP30 and nucleoprotein interactions modulate viral RNA synthesis. Nature Communications. 2017,8:15576.；
5. Wei Xu, Megan R. Edwards, Dominika M. Borek, Alicia R. Feagins, Anuradha Mittal, Joshua B. Alinger, Kayla N. Berry, Benjamin Yen, Jennifer Hamilton, Rohit V.Pappu, Tom J. Brett, Daisy W. Leung, Christopher F. Basler, Gaya K. Amarasinghe. Ebola virus VP24 targets a unique NLS-binding site on karyopherin alpha5 to selectively compete with nuclear import of phosphorylated STAT1. Cell Host & Microbe.2014, 16(2):187-200；
6. Megan R. Edwards, Britney Johnson, Chad E. Mire, Wei Xu, Reed S. Shabman, Lauren N. Speller, Daisy W. Leung, Thomas W. Geisbert, Gaya K. Amarasinghe, Christopher F. Basler. The Marburg Virus VP24 Protein Interacts with Keap1 to Activate the Cytoprotective Antioxidant Response Pathway. Cell Reports.2014, 27;6(6):1017-25；
7. Craig S Brown, Michael S Lee, Daisy W Leung, Tianjiao Wang, Wei Xu, Priya Luthra, Manu Anantpadma, Reed S Shabman, Lisa M Melito, Karen S Macmillan, Dominika M Borek, Zbyszek Otwinowski, Parameshwaran Ramanan, Alisha J Stubbs, Dayna S Peterson, Jennifer M Binning, Marco Tonelli, Mark A Olson, Rob Davey, Joseph M Ready, Christopher F Basler, Gaya K Amarasinghe. In silico derived small molecules bind the filovirus VP35 protein and inhibit its polymerase co-factor activity. J Mol Biol. 2014 15;426(10):2045-58；
8. Jennifer M Binning, Tianjiao Wang, Priya Luthra, Reed S Shabman, Dominika M Borek, Gai Liu, Wei Xu, Daisy W Leung, Christopher F Basler, Gaya K Amarasinghe. Development of RNA aptamers targeting Ebola virus VP35. Biochemistry. 2013,26;52(47): 8406-19.；
9. Wei Xu, Jingping Lu, Qi-zhuang Ye. Structural analysis of bengamide derivatives as inhibitors of methionine aminopeptidases. J. Med. Chem., 2012, 55 (18), 8021–8027. ；
10. Sanling Liu, Jianmei Dong, Guoqiang Mei, Guiyun Liu, Wei Xu, Zhong Su, Jinsong Liu. Crystallization and preliminary crystallographic studies of a cysteine protease inhibitor from the human nematode parasite Ascaris lumbricoides. Acta Cryst. F. 2011. 67, 228–230；
11. Wei Xu#, Lina Yi#, Yumei Feng, Ling Chen, Jinsong Liu. Structural Insight into the Activation Mechanism of Human Pancreatic Prophospholipase A2. J Biol Chem. 2009,284,16659-16666.
