一、基本信息
姓名：彭鸿娟
职称：教授
联系邮箱：hongjuan@smu.edu.cn，floriapeng@hotmail.com
二、学习经历
1989.9-1993.7 厦门大学，动物学专业，学士
1993.9-1996.7 中山大学，动物学专业，硕士
2000.9-2003.7 中山大学，生化与分子生物学专业，博士
2006.11-2009.9 Virginia Polytechnic Institute and State University，博士后
三、拟招收博士后开展的研究方向
1.病原-宿主互作机制研究；
2.重要蚊媒传染病防控研究
四、主要学术任职
1.广东省教学名师；
2.广东省健康科普促进会副会长；
3.中国动物学会寄生虫学专业委员会理事；
4.广东省热带医学学会常务理事；
5.广东省寄生虫学会常务理事。
五、主要获奖情况
1. 广东省“珠江学者”特聘教授，广东省教育厅，2014；
2. 彭鸿娟，刘全，袁子国，朱兴全，范泉水. 弓形虫病流行特征、致病机制与防治基础研究. 中华医学科技奖三等奖（2021.03）, 排名1.
3. 彭鸿娟，刘全，袁子国，朱兴全，范泉水，张秀香，王泽东、何成、魏海霞。弓形虫病流行特征、致病机制与防治基础研究. 广东省医学科技奖二等奖（2021.01），排名1
4. 日本血吸虫病新基因的鉴定、筛选及应用，广东省科技进步三等奖 （2005），排名1
5. 广东省教育教学成果一等奖“慕课时代《医学寄生虫学》在线精品课程建设与改革实践”（排名1，2018年）
6. 广东省教育教学成果奖一等奖“公共卫生协同创新育人模式的研究与实践“（排名9，2018年）
7. 国家发明专利名称：一种生物杀虫剂筛选模型及其制备方法和应用；发明人：彭鸿娟，陈晓光，顾金保；专利号：ZL 2006 1 0122057.4； 专利授权时间：2010.8；专利申请国：中国
8. 国家发明专利名称：一种毒杀蚊幼虫的双价重组球孢白僵菌及其制备方法；发明人：彭鸿娟、廖启彬, 等。专利号：201510176572X; 专利授权时间：2018.5；专利申请国：中国
六、代表性论文
1.Chen M #, Yao L #, Zhou L, Yang P, Zou W, Xu L, Li S, Peng HJ*. Toxoplasma gondii ROP18I Inhibits Host Innate Immunity through cGAS-STING Signaling. The FASEB Journal. 2022 Feb;36(2):e22171. doi: 10.1096/fj.202101347R. PMID: 35084749.
2.Zhou LJ, Peng J, Chen M, Yao LJ, Zou WH, He CY, Peng HJ*. Toxoplasma gondii SAG1 targeting host cell S100A6 for parasite invasion and host immunity. iScience. 2021 Nov 26;24(12):103514. doi: 10.1016/j.isci.2021.103514. PMID: 34950858; PMCID: PMC8671940.
3.Xu L, Yao L, Jiang D, Zhou L, Chen M , Liao W, Zou W, Peng H*. A uracil auxotroph Toxoplasma gondii exerting immunomodulation to inhibit breast cancer growth and metastasis. Parasites & Vectors. 2021 Dec 11;14(1):601. DOI: 10.1186/s13071-021-05032-6
4.Jiang D, Wu S; Xu L, Xie G, Peng H*. Anti-Infection Roles of mir155-5p Packaged in Exosomes Secreted by Dendritic Cells Infected with Toxoplasma gondii. Parasites & Vectors.Parasites Vectors. 2022 Jan 6;15(1):3. DOI: 10.1186/s13071-021-05003-x
5.Yao LJ, Xu LQ, Zhou LJ, Wu SZ, Zou WH, Chen M, Chen JT, Peng HJ*. Toxoplasma gondii Type-I ROP18 Targeting Human E3 Ligase TRIM21for Immune Escape. Front. Cell Dev. Biol.2021, May 26; 9:685913. doi: 10.3389/fcell.2021.685913.
6.Kong L, Peng H*. Current epidemic situation of human toxocariasis in China.Adv Parasitol. 2020;109:433-448. doi: 10.1016/bs.apar.2020.01.016. Epub 2020 Feb 5. PMID: 32381211.
7.Kong L#, Jiang D#, He C, Xia J, Wei H, Zhou L, Peng H*.TgROP18 targets IL20RB for host-defense-related-STAT3 activation during Toxoplasma gondii infection.Parasit Vectors. 2020 Aug 7;13(1):400. doi: 10.1186/s13071-020-04251-7. PMID: 32767999; PMCID: PMC7412674.
8.Xia J, Blank ML, Zhou LJ, Wu SZ, Peng HJ*, Boyle JP*. Strain-specific disruption of interferon-stimulated N-myc and STAT interactor (NMI) function by Toxoplasma gondii type I ROP18 in human cells. Parasitology. 2020 Nov;147(13):1433-1442. doi: 10.1017/S0031182020001249. Epub 2020 Jul 30. PMID: 32729455.
9.He C，Xu MZ， Pan S，Wang H， Peng HJ*，Liu ZZ *. iTRAQ-Based Phosphoproteomic Analysis of Toxoplasma gondii Tachyzoites Provides Insight Into the Role of Phosphorylation for its Invasion and Egress. Frontiers in Cellular and Infection Microbiology, 2020 Nov 26;10:586466. doi: 10.3389/fcimb.2020.586466. PMID: 33363051; PMCID: PMC7756149.
10.Deng SQ, Peng HJ*. Characteristics of and Public Health Responses to the Coronavirus Disease 2019 Outbreak in China. Journal of Clinical Medicine. J Clin Med. 2020 Feb 20;9(2):575. doi: 10.3390/jcm9020575. PMID: 32093211; PMCID: PMC7074453.
11.Deng SQ, Yang X, Wei Y, Chen JT, Wang XJ, Peng HJ*. A Review on Dengue Vaccine Development.Vaccines. 2020 Feb 2;8(1):63. doi: 10.3390/vaccines8010063.
12.Xia J, Kong L, Zhou LJ, Wu SZ, Yao LJ, He C, He CY, Peng HJ*. Genome-Wide Bimolecular Fluorescence Complementation- Based Proteomic Analysis of Toxoplasma gondii ROP18’s Human Interactome Shows Its Key Role in Regulation of Cell Immunity and Apoptosis. Front. Immunol. 2018 Feb 5;9:61. doi: 10.3389/fimmu.2018.00061. PMID: 29459857; PMCID: PMC5807661.
13.Wu S#, Wei H#, Jiang D, Li S, Zou W, Peng HJ* . Genome-Wide CRISPR Screen Identifies Host Factors Required by Toxoplasma gondii Infection. Front. Cell. Infect. Microbiol. 2020 Jan 22;9:460. doi: 10.3389/fcimb.2019.00460. PMID: 32039045; PMCID: PMC6987080.
14.Li DL, Zou WH, Deng SQ, Peng HJ*. Analysis of the Dierential Exosomal miRNAs of DC2.4 Dendritic Cells Induced by Toxoplasma gondii Infection. Int. J. Mol. Sci. 2019 Nov 5; 20(21): 5506. doi: 10.3390/ijms20215506. PMID: 31694199; PMCID: PMC6862309.
15.Wei H, Zhou L, Wu S, Li D, Deng S, Peng H*. Host cell Rac1 GTPase facilitates Toxoplasma gondii invasion. Sci China Life Sci. 2020 Apr; 63(4):610-612. doi: 10.1007/s11427-019-9564-0. Epub 2019 Jun 17. PMID: 31222548.
16.Zhou LJ, Chen M, Puthiyakunnon S, He C, Xia J, He C, Deng SQ，Peng H*. Toxoplasma gondii ROP18 inhibits human glioblastoma cell apoptosis through a mitochondrial pathway by targeting host cell P2X1. Parasit Vectors. 2019 Jun 4;12(1):284. doi: 10.1186/s13071-019-3529-1. PMID: 31164145; PMCID: PMC6547611.
17.He C, Kong L, Puthiyakunnon S, Wei HX, Zhou LJ, Peng H-J*. iTRAQ-based phosphoproteomic analysis reveals host cell's specific responses to Toxoplasma gondii at the phases of invasion and prior to egress. Biochim Biophys Acta Proteins Proteom. 2019 Mar;1867(3):202-212. doi: 10.1016/j.bbapap.2018.12.004. Epub 2018 Dec 18. PMID: 30576742.
18.He C, Kong L, Zhou L, Xia J, Wei H, Liu M, Peng H* .Host Cell Vimentin Restrains Toxoplasma gondii Invasion and Its hosphorylation Is Partly Regulated by TgROP18 Interaction. Int J Biol Sci. 2017 Sep 5;13(9):1126-1137. doi: 10.7150/ijbs.21247. PMID: 29104504; PMCID: PMC5666328.
19.Wei H, Jiang S, Chen L, He C, Wu S, Peng H*. Characterization of Cytosine Methylation and the DNA Methyltransferases of Toxoplasma gondii. Int J Biol Sci. 2017 Mar 11;13(4):458-470. doi: 10.7150/ijbs.18644. PMID: 28529454; PMCID: PMC5436566.
20.He C, Chen AY, Feng XS, Wei HX, Jiang SC, Xia J, Deng SQ, Wang XJ, Peng HJ* Phosphoproteome of Toxoplasma gondii Infected Host Cells Reveals Specific Cellular Processes Predominating in Different Phases of Infection. Am J Trop Med Hyg. 2017 Jul;97(1):236-244. doi: 10.4269/ajtmh.16-0901. PMID: 28719319; PMCID: PMC5508905.
21.Na RH, Zhu GH, Luo JX, Meng XJ, Cui L, Peng HJ*, Chen XG*, Gomez – Cambronero J. Enzymatically active Rho and Rac small-GTPases are involved in the establishment of the vacuolar membrane after Toxoplasma gondii invasion of host cells. BMC Microbiol. 2013 May 30;13:125. doi: 10.1186/1471-2180-13-125. PMID: 23721065; PMCID: PMC3681593.
22.Xia J, Cheng XY, Wang XJ, Peng HJ* Association between Toxoplasma gondii types and outcomes of human infection: a review and meta-analysis. Acta Microbiologica et Immunologica Hungarica. 2017 Sep 1;64(3):229-244. doi: 10.1556/030.64.2017.016. Epub 2017 Jun 20. PMID: 28629230.
23.Deng SQ, Zou WH, Li DL, Chen JT, Huang Q, Zhou LJ, Tian XX, Chen YJ, Peng HJ*. Expression of Bacillus thuringiensis toxin Cyt2Ba in the entomopathogenic fungus Beauveria bassiana increases its virulence towards Aedes mosquitoes. PLoS Negl Trop Dis. 2019 Jul 15;13(7):e0007590. doi: 10.1371/journal.pntd.0007590. PMID: 31306427; PMCID: PMC6667155.
24.Deng SQ, Chen JT, Li WW, Chen M, Peng HJ. Application of the Scorpion Neurotoxin AaIT against Insect Pests. Int J Mol Sci. 2019 Jul 15;20(14):3467. doi: 10.3390/ijms20143467. PMID: 31311095; PMCID: PMC6678123.
25.Deng S, Huang Q, Wei H, Zhou L, Yao L, Li D, Wu S, Chen J, Peng H*. Beauveria bassiana infection reduces the vectorial capacity of Aedes albopictus for the Zika virus. Journal of Pest Science. 2019, 92（2）:781-789.26.Li XL, Wei HX, Zhang H, Peng HJ*, Lindsay DS*. A Meta Analysis on Risks of Adverse Pregnancy Outcomes in Toxoplasma gondii Infection. PLoS One. 2014 May 15;9(5):e97775. doi: 10.1371/journal.pone.0097775. PMID: 24830795; PMCID: PMC4022675.
27.Wei HX, Wei SS, Lindsay DS*, Peng HJ*. A Systematic Review and Meta-Analysis of the Efficacy of Anti-Toxoplasma gondii Medicines in Humans. PLoS One. 2015 Sep 22;10(9):e0138204. doi: 10.1371/journal.pone.0138204. PMID: 26394212; PMCID: PMC4578932.
28.Shen SQ, Wei HX, Fu YH, Zhang H, Mo QY, Wang XJ, Deng SQ, Zhao W, Liu Y, Feng XS, Chen W, Peng HJ*. Multiple Sources of Infection and Potential Endemic Characteristics of the Large Outbreak of Dengue in Guangdong in 2014.Scientific Reports. 2015 Nov 23;5:16913. doi: 10.1038/srep16913. PMID: 26593240; PMCID: PMC4655357.
29.Zhou LJ，Xia J，Wei HX，Liu XJ，Peng HJ* Risk of drug resistance in Plasmodium falciparum malaria therapy-a systematic review and meta-analysis.Parasitol Res. 2017 Feb;116(2):781-788. doi: 10.1007/s00436-016-5353-2. Epub 2016 Dec 27. PMID: 28028628.
30.Xia J, Jiang SC, Peng HJ*. Association between Liver Fluke Infection and Hepatobiliary Pathological Changes: A Systematic Review. PLOS one. 2015 Jul 17;10(7):e0132673. doi: 10.1371/journal.pone.0132673. PMID: 26186510; PMCID: PMC4506038.
31.Wang XJ, Jiang SC, Wei HX, Deng SQ, He C, Peng HJ*. The Differential Expression and Possible Function of Long Noncoding RNAs in Liver Cells Infected by Dengue Virus.Am J Trop Med Hyg. 2017 Dec;97(6):1904-1912. doi: 10.4269/ajtmh.17-0307. Epub 2017 Sep 28. PMID: 29016307; PMCID: PMC5805055.
32.Wang XJ, Wei HX, Jiang SC, He C, Xu XJ, Peng HJ*. Evaluation of aminotransferase abnormality in dengue patients: A meta analysis.Acta Trop. 2016 Apr;156:130-6. doi: 10.1016/j.actatropica.2015.12.013. Epub 2015 Dec 29. PMID: 26739659.
33.Deng SQ, Cai QD, Deng MZ, Huang Q, Peng HJ*. Scorpion neurotoxin AaIT-expressing Beauveria bassiana enhances the virulence against Aedes albopictur mosquitoes. AMB Express. 2017 Dec;7(1):121. doi: 10.1186/s13568-017-0422-1. Epub 2017 Jun 9. PMID: 28605881; PMCID: PMC5466577.
34.Huang Q, Hu L, Liao QB, Xia J, Wang QR, Peng HJ*. Spatiotemporal analysis of the malaria epidemic in mainland China, 2004-2014. Am J Trop Med Hyg. 2017 Aug;97(2):504-513. doi: 10.4269/ajtmh.16-0711. PMID: 28829728; PMCID: PMC5544075.
35.Zhang H. He Z, Zeng W*, Peng HJ*. Roles of Interferons in Pregnant Women with Dengue Infection: Protective or Dangerous Factors.Canadian Journal of Infectious Diseases and Medical Microbiology, 17:1671607. 2017; 2017:1671607. doi: 10.1155/2017/1671607. Epub 2017 Sep 7. PMID: 29081814; PMCID: PMC5610849.
36.Wu XB, Na RH, Wei SS, Zhu JS, Peng HJ*(2013) Distribution of Tick-borne Diseases in China.Parasites Vectors. 2013 Apr 23;6:119. doi: 10.1186/1756-3305-6-119. PMID: 23617899; PMCID: PMC3640964.
37.Wu XB, Na RH, Wei SS, Zhu JS, Peng HJ* Distribution of Tick-borne Diseases in China. Parasites & Vectors. 2013, 6:119 doi:10.1186/1756-3305-6-119. PMID: 23617899; PMCID: PMC3640964.
