一、基本信息
姓名：王慧君
职称：教授，主任法医师
联系邮箱：hjwang@smu.edu.cn
二、学习经历
1975.09-1978.07 同济医科大学，临床医学专业，学士
1978.09-1980.07 同济医科大学，全国病理学高师班，硕士
1994.07-1996.06 德国埃森（ESSEN）大学，法医学专业，博士
1997.07-1999.09 同济医科大学基础医学博士后流动站，博士后
三、拟招收博士后开展的研究方向
1. 甲基苯丙胺心脑损伤机制及应用研究；
2. 心血管疾病猝死的分子病理机制研究
四、主要学术任职
1. 广东省司法鉴定协会会长
2. 司法部司法鉴定高级专业技术职务任职资格评审委员会委员
3. 公安部法医病理重点实验室特聘专家
4. 广东省人大常委会聘任立法咨询专家
5. 广东省医疗事故处理委员会特聘专家
6. 广州市白云区人民检察院专家咨询组委员
7. 《Forensic Sciences Research》编委
8. 《Journal of Forensic Science and Medicine》编委
9. 《法医学杂志》编委
10. 《法庭科学与法医学杂志》编委
五、主要获奖情况
1. 2018年获南粤优秀教师称号（省级）
2. 2017年获南方医科大学优秀教师、十佳导师
3. 2016年获南方医科大学2015-2016年度教学优秀一等奖
4.2009年被司法部评为“法律服务主题实践活动”先进个人（国家级）
5. 2005年被评为广东省精神文明先进个人（省级）
6. 2005年获中华医学科技奖一等奖一项（排名第四）（国家级）
7. 2004年获得军队科技进步二等奖（排名第二）一项（部级）
8. 2004年荣立中国人民解放军总后勤部三等功一次（部级）
9. 2004年被广州市（市级）评为防“非典”先进个人（获金质奖章）
10. 2003年荣获中国人民解放军总后勤部《育才银奖》（部级）
六、代表性论文
1. Xiang Xu, Enping Huang, Baoying Luo, Dunpeng Cai, Xu Zhao, Qin Luo, Yili Jin, Ling Chen, Qi Wang, Chao Liu, Zhoumeng Lin, Wei-Bing Xie, and Huijun Wang ,Methamphetamine exposure triggers apoptosis and autophagy in neuronal cells by activating the C/EBPb-related signaling pathway，FASEB J. 2018.32（12）：6737-6759. （IF:5.391）
2. Du SH, Zhang W, Yue X, Luo XQ, Tan XH, Liu C, Qiao DF, Wang H.Role of CXCR1 and Interleukin-8 in Methamphetamine-Induced Neuronal Apoptosis. Front Cell Neurosci. 2018 Aug 3;12:230. （IF:4.3）
3. Wei-Qi Hao,Jing Liu,Li Jiang,Jun-Ping Han,Ling Wang,Jiu-Ling Li,Quan Ma,Chao Liu,Hui-Jun Wang,Cai-Xia Li,Exploring the ancestry differentiation and inference capacity of the 28-plex AISNPs, International Journal of Legal Medicine,07 June 2018 （IF:2.382）
4. Ning, X., Fu, Z., Zhu, B., Chao, L., Lin, Z., & Wang, H., et al. Cdk5-mediated tau accumulation triggers methamphetamine-induced neuronal apoptosis via endoplasmic reticulum-associated degradation pathway. Toxicol Lett.2018 Aug;292:97-107 （IF:3.86）
5. Lizeng Li, Si Chen, Yue Wang,Xia Yue,Jingtao Xu,Weibing Xie,Pingming Qiu,Chao Liu,AiFeng Wang*and Huijun Wang*,Role of GSK3β/α-synuclein axis in methamphetamine-induced neurotoxicity in PC12 cells, Toxicol Res., 2017 Dec 22;7(2):221-234(IF:1.89）
6. Si-Hao Du, Dong-Fang Qiao, Chuan-Xiang Chen, Si Chen, Chao Liu, Zhoumeng Lin, Huijun Wang, Weibing Xie,Toll-like receptor 4 mediates methamphetamine-induced neuroinflammation through Caspase-11 signaling pathway in astrocytes. Front Mol Neurosci. 2017 Dec 12;10:409.(IF:3.902）
7. Xiang Xu, Enping Huang, Yunchun Tai, Xu Zhao, Xuebing Chen, Chuanxiang Chen, Rui Chen, Chao Liu, Zhoumeng Lin, Huijun Wang Weibing Xie. Nupr1 modulates methamphetamine-induced dopaminergic neuronal apoptosis and autophagy through CHOP-Trib3-mediated endoplasmic reticulum stress signaling pathway. Front Mol Neurosci. 2017 Jun 26;10:203 (IF:3.902）
8. Cai D, Huang E, Luo B, Yang Y, Zhang F, Liu C, Lin Z, Xie WB, Wang H.Nupr1/Chop signal axis is involved in mitochondrion-related endothelial cell apoptosis induced by methamphetamine. Cell Death Dis. 2016 Mar 31;7:e2161. （IF 5.965）
9. Chen R, Wang B, Chen L, Cai D, Li B, Chen C, Huang E, Liu C, Lin Z, Xie WB, Wang H.DNA damage-inducible transcript 4 (DDIT4) mediates methamphetamine-induced autophagy and apoptosis through mTOR signaling pathway in cardiomyocytes. Toxicol Appl Pharmacol. 2016 Mar 15;295:1-11（IF 3.847）
10. Li B, Chen R, Chen L, Qiu P, Ai X, Huang E, Huang W, Chen C, Liu C, Lin Z, Xie WB, Wang H. Effects of DDIT4 in Methamphetamine-Induced Autophagy and Apoptosis in Dopaminergic Neurons. Mol Neurobiol. 2017 Apr;54(3):1642-1660.（IF 6.19）
11. Chen C, Qincao L, Xu J, Du S, Huang E, Liu C, Lin Z, Xie WB, Wang H.Role of PUMA in methamphetamine-induced neuronal apoptosis. Toxicol Lett. 2016 Jan 5;240(1):149-60.（IF 3.522）
12. Huang W, Xie WB, Qiao D, Qiu P, Huang E, Li B, Chen C, Liu C, Wang Q, Lin Z, Wang H. Caspase-11 plays an essential role in methamphetamine-induced dopaminergic neuron apoptosis. Toxicol Sci. 2015 May;145(1):68-79.(IF:4.478)
13. Tai Y, Chen L, Huang E, Liu C, Yang X, Qiu P, Wang H. Protective effect of alpha-synuclein knockdown on methamphetamine-induced neurotoxicity in dopaminergic neurons. Neural Regen Res. 2014 May 1;9(9):951-8.(IF:0.234)
14. Wang J, Zou D, Li Z, Huang P, Li D, Shao Y, Wang H, Chen Y. Mechanical properties of cranial bones and sutures in 1-2-year-old infants. Med Sci Monit. 2014 Oct 3;20:1808-13.(IF:1.216)
15. Leung KP, Qu YH, Qiao DF, Xie WB, Li DR, Xu JT, Wang HJ, Yue X. Critical role of insulin like growth factor binding protein 5 in methamphetamine induced apoptosis in cardiomyocytes. MOLECULAR MEDICINE REPORTS. 2014 Nov;10(5):2306-12 (IF: 1.484)
16. Wu XF, Wang AF, Chen L, Huang EP, Xie WB, Liu C, Huang WY, Chen CX, Qiu PM, Wang HJ. S-Nitrosylating protein disulphide isomerase mediates α-synuclein aggregation caused by methamphetamine exposure in PC12 cells. Toxicol Lett. 2014 Oct 1;230(1):19-27. (IF:3.355)
17. Qiao D, Xu J, Le C, Huang E, Liu C, Qiu P, Lin Z, Xie WB, Wang H. Insulin-like growth factor binding protein 5 (IGFBP5) mediates methamphetamine-induced dopaminergic neuron apoptosis. Toxicol Lett 2014 Nov 4;230(3):444-53. (IF:3.355)
18. Qu YH, Leung KP, Qiao DF, Li DR, Liu C, Yue X, Wang HJ. Remodeling of ion channel expression may contribute to electrophysiological consequences caused by methamphetamine in vitro and in vivo. Biochem Biophys Res Commun. 2014 Jan 10;443(2):441-6. (IF:2.281)
19. Yang X, Liu Y, Liu C, Xie W, Huang E, Huang W, Wang J, Chen L, Wang H, Qiu P, Xu J, Zhang F, Wang H. Inhibition of ROCK2 expression protects against methamphetamine-induced neurotoxicity in PC12 cells. Brain Res. 2013 Oct 2;1533:16-25. (IF: 2.879)
20. Zhang F, Chen L, Liu C, Qiu P, Wang A, Li L, Wang H. Up-regulation of protein tyrosine nitration in methamphetamine-induced neurotoxicity through DDAH/ADMA/NOS pathway. Neurochem Int. 2013 Jun;62(8):1055-64. (IF:2.659)
21. Weixia Weng，Hong Liu，Shuanglin Li，Jianye Ge，Huijun Wang ,Chao Liu. Mutation rates at 16 Y-chromosome STRs in the South China Han population. Int J Legal Med. 2013 Mar;127(2):369-72 (IF:2.686)
22. Dong-Ri Li，Fu Zhang , Yao Wang , Hui-Jun Wang, Quantitative analysis of GFAP- and S100 protein-immunopositive astrocytes to investigate the severity of traumatic brain injury. Legal Medicine 2012 Mar;14(2):84-92. (IF:1.238)
23. Xia YUE, Dongfang QIAO, Aifeng WANG, Xiaohui TAN, Yanhong LI, Chao LIU，Huijun WANG.CD200 Attenuates Methamphetamine-induced Microglial Activation and Dopamine Depletion*. J Huazhong Univ Sci Technolog Med Sci. 2012 Jun;32(3):415-421 (IF: 0.385)
24. Xuefeng Li, Huijun Wang, Pingming Qiu, Hong Luo. Proteomic profiling of proteins associated with methamphetamine-induced neurotoxicity in different regions of rat brain. Neurochemistry International 2008 Jan;52(1-2):256-64. (IF:3.228)
25. Chao liu,Changhui Liu,Huijun Wang. Genetic diversity at 15 STR Loci in two tribal populations in Southern China.Forensic Science International. Forensic Sci Int. 2006 Oct 16;162(1-3):28-32 (IF:2.307)
26. Chao liu,Changhui Liu,Huijun Wang. STR data for the 15 Loci from three minority populations in Guabgxi municipality in South China .Forensic Science International. Forensic Sci Int. 2006 Oct 16;162(1-3):49-52. (IF:2.307)
27. Wang Huijun ,Ding Yanqing, Xujun etal. Death of a SARS case from secondary aspergilus Infection. 117. 2004 Aug;117(8):1278-80. (SCI收录)
28. Wang.Huijun, Ding, Yanqing, Pei Guoxian, et al . A preliminary pathological study on human allotransplantation. Chin J Traumatol. 2003 Oct;6(5):284-7. (SCI收录)
29. Wang.Huijun, Ding, Yanqing, Li Xin, Yang lei, Zhang wenli, Kang Wei. Fatal Aspergillosis in a Patient with SARS Who Was Treated with Corticosteroids. N Engl J Med. 2003 Jul 31;349(5):507-8. (IF=34.833)
30. Ding Yanqing,Wang Huijun，Shen Hong et al.Clinical pathology of severe acute respiratory syndrome, a report from China. J. of Pathology,2003;200（3）：282 (IF=5.6)
七、在研课题
1. 国家自然科学基金面上项目，81871528， METH激活胶质细胞经NF-κB-LCN2/焦亡通路致脑神经毒性损伤作用机制研究，2019.01-2022.12,57万，在研，主持
2. 广州市科技计划项目，201803010005,C/EBPβ在METH导致的主动脉夹层中的作用机制，2018.04.01-2021.03.31,100万，在研，主持
3. 国家自然科学基金重点项目,81430045,内质网应激在甲基苯丙胺诱导的神经毒性中的作用及分子病理机制, 2015.01-2019.12,320万，在研，主持
