一、基本信息
姓名：王起
职称：副教授
联系邮箱：17098907712@126.com
二、学习经历
1999.9-2004.7 中国医科大学，法医学专业，学士
2004.9-2007.7 中国医科大学，法医学专业，硕士
2008.4-2012.3 大阪市立大学，法医学专业，博士
三、拟招收博士后开展的研究方向
1. 肠道微生物在甲基苯丙胺诱导的神经毒性中的作用及机制研究；
2. 微小RNA-155在甲基苯丙胺所致神经毒性中的作用；
3. 甲基苯丙胺的遗传毒性研究。
四、主要学术任职
Forensic Science International海外编委
五、代表性论文（第一或通讯作者）
1. Qu D, Tan XH, Zhang KK, Wang Q, Wang HJ: ATF3 mRNA, but not BTG2, as a possible marker for vital reaction of skin contusion. Forensic Sci Int 2019, 303:109937.
2. Xie XL, Zhou WT, Zhang KK, Yuan Y, Qiu EM, Shen YW, Wang Q: PCB52 induces hepatotoxicity in male offspring through aggravating loss of clearance capacity and activating the apoptosis: Sex-biased effects on rats. Chemosphere 2019, 227:389-400.
3. Huang E, Huang H, Guan T, Liu C, Qu D, Xu Y, Yang J, Yan L, Xiong Y, Liang T, Wang Q, Chen L: Involvement of C/EBPbeta-related signaling pathway in methamphetamine-induced neuronal autophagy and apoptosis. Toxicol Lett 2019, 312:11-21.
4. Xue Y, He JT, Zhang KK, Chen LJ, Wang Q, Xie XL: Methamphetamine reduces expressions of tight junction proteins, rearranges F-actin cytoskeleton and increases the blood brain barrier permeability via the RhoA/ROCK-dependent pathway. Biochem Biophys Res Commun 2019, 509:395-401.
5. Xie XL, Zhou WT, Zhang KK, Chen LJ, Wang Q: METH-Induced Neurotoxicity Is Alleviated by Lactulose Pretreatment Through Suppressing Oxidative Stress and Neuroinflammation in Rat Striatum. Front Neurosci 2018, 12:802.
6. Lyu H-P, Cheng M, Liu J-C, Ye M-Y, Xu D, He J-T, Xie X-L, Wang Q: Differentially expressed microRNAs as potential markers for vital reaction of burned skin. Journal of Forensic Science and Medicine 2018, 4:135-141.
7. Ye MY, Xu D, Liu JC, Lyu HP, Xue Y, He JT, Huang HY, Zhang KK, Xie XL, Wang Q: IL-6 and IL-20 as potential markers for vitality of skin contusion. J Forensic Leg Med 2018, 59:8-12.
8. Sun KJ, He JT, Huang HY, Xue Y, Xie XL, Wang Q: Diagnostic role of serum tryptase in anaphylactic deaths in forensic medicine: a systematic review and meta-analysis. Forensic Sci Med Pathol 2018, 14:209-215.
9. He JT, Huang HY, Qu D, Xue Y, Zhang KK, Xie XL, Wang Q: CXCL1 and CXCR2 as potential markers for vital reactions in skin contusions. Forensic Sci Med Pathol 2018, 14:174-179.
10. Wang Q, Wei LW, Zhou WT, Wang ZT, Xie XL: PCB28 and PCB52 induce hepatotoxicity by impairing the autophagic flux and stimulating cell apoptosis in vitro. Toxicol Lett 2018, 289:28-41.
11. Xie XL, He JT, Wang ZT, Xiao HQ, Zhou WT, Du SH, Xue Y, Wang Q: Lactulose attenuates METH-induced neurotoxicity by alleviating the impaired autophagy, stabilizing the perturbed antioxidant system and suppressing apoptosis in rat striatum. Toxicol Lett 2018, 289:107-113.
12. Xu J, Zhao R, Xue Y, Xiao H, Sheng Y, Zhao D, He J, Huang H, Wang Q, Wang H: RNA-seq profiling reveals differentially expressed genes as potential markers for vital reaction in skin contusion: a pilot study. Forensic Sciences Research 2018, 3:153-160.
13. Wang Q, Wei LW, Xiao HQ, Xue Y, Du SH, Liu YG, Xie XL: Methamphetamine induces hepatotoxicity via inhibiting cell division, arresting cell cycle and activating apoptosis: In vivo and in vitro studies. Food Chem Toxicol 2017, 105:61-72.
14. Du Y, Xu JT, Jin HN, Zhao R, Zhao D, Du SH, Xue Y, Xie XL, Wang Q: Increased cerebral expressions of MMPs, CLDN5, OCLN, ZO1 and AQPs are associated with brain edema following fatal heat stroke. Sci Rep 2017, 7:1691.
15. Du SH, Tan XH, Zhao R, Zhao D, Xue Y, Wang HJ, Xie XL, Wang Q: Molecular pathology of cerebral TNF-alpha, IL-1beta, iNOS and Nrf2 in forensic autopsy cases with special regard to deaths due to environmental hazards and intoxication. Forensic Sci Med Pathol 2017, 13:409-416.
16. Xue Y, Zhao R, Du SH, Zhao D, Li DR, Xu JT, Xie XL, Wang Q: Decreased mRNA levels of cardiac Cx43 and ZO1 in sudden cardiac death related to coronary atherosclerosis: a pilot study. Int J Legal Med 2016, 130:915-922.
17. Du Y, Jin HN, Zhao R, Zhao D, Xue Y, Zhu BL, Guan DW, Xie XL, Wang Q: Molecular Pathology of Pulmonary Edema in Forensic Autopsy Cases with Special Regard to Fatal Methamphetamine Intoxication. J Forensic Sci 2016, 61:1531-1537.
18. Wang Q, Ishikawa T, Michiue T, Zhu BL, Guan DW, Maeda H: Molecular pathology of brain matrix metalloproteases, claudin5, and aquaporins in forensic autopsy cases with special regard to methamphetamine intoxication. Int J Legal Med 2014, 128:469-474.
19. Wang Q, Ishikawa T, Michiue T, Zhu BL, Guan DW, Maeda H: Molecular pathology of pulmonary edema in forensic autopsy cases with special regard to fatal hyperthermia and hypothermia. Forensic Sci Int 2013, 228:137-141.
20. Wang Q, Ishikawa T, Michiue T, Zhu BL, Guan DW, Maeda H: Molecular pathology of brain edema after severe burns in forensic autopsy cases with special regard to the importance of reference gene selection. Int J Legal Med 2013, 127:881-889.
21. Wang Q, Ishikawa T, Michiue T, Zhu BL, Guan DW, Maeda H: Stability of endogenous reference genes in postmortem human brains for normalization of quantitative real-time PCR data: comprehensive evaluation using geNorm, NormFinder, and BestKeeper. Int J Legal Med 2012, 126:943-952.
22. Wang Q, Ishikawa T, Michiue T, Zhu BL, Guan DW, Maeda H: Molecular pathology of pulmonary edema after injury in forensic autopsy cases. Int J Legal Med 2012, 126:875-882.
23. Wang Q, Ishikawa T, Michiue T, Zhu BL, Guan DW, Maeda H: Quantitative immunohistochemical analysis of human brain basic fibroblast growth factor, glial fibrillary acidic protein and single-stranded DNA expressions following traumatic brain injury. Forensic Sci Int 2012, 221:142-151.
24. Wang Q, Ishikawa T, Michiue T, Zhu BL, Guan DW, Maeda H: Intrapulmonary aquaporin-5 expression as a possible biomarker for discriminating smothering and choking from sudden cardiac death: a pilot study. Forensic Sci Int 2012, 220:154-157.
25. Wang Q, Ishikawa T, Michiue T, Zhu BL, Guan DW, Maeda H: Evaluation of human brain damage in fatalities due to extreme environmental temperature by quantification of basic fibroblast growth factor (bFGF), glial fibrillary acidic protein (GFAP), S100beta and single-stranded DNA (ssDNA) immunoreactivities. Forensic Sci Int 2012, 219:259-264.
26. Wang Q, Michiue T, Ishikawa T, Zhu BL, Maeda H: Combined analyses of creatine kinase MB, cardiac troponin I and myoglobin in pericardial and cerebrospinal fluids to investigate myocardial and skeletal muscle injury in medicolegal autopsy cases. Leg Med (Tokyo) 2011, 13:226-232.
27. Wang Q, Ishikawa T, Michiue T, Zhu BL, Maeda H: Evaluation of human brain damage in fire fatality by quantification of basic fibroblast growth factor (bFGF), glial fibrillary acidic protein (GFAP) and single-stranded DNA (ssDNA) immunoreactivities. Forensic Sci Int 2011, 211:19-26.
28. Wang Q, Ishikawa T, Michiue T, Maeda H: Fatal facial-intracranial impalement injury in an accidental fall from a height: an autopsy case report with a review of the literature. Forensic Sci Int 2010, 200:e21-24.
29. Wang Q, Ishikawa T, Quan L, Zhao D, Li DR, Michiue T, Chen JH, Zhu BL, Maeda H: Immunohistochemical distribution of basic fibroblast growth factor (bFGF) in medicolegal autopsy. Leg Med (Tokyo) 2009, 11 Suppl 1:S161-164.
