一、基本信息
姓名：任蕙苹
职称：特聘教授
联系邮箱：judyyam@pathology.hku.hk
二、学习经历
1989.9-1992.12 美国华盛顿大学，理学院，生物化學专业，理学士
1993.9-1995.7 香港科技大学，生物学系，生物技术专业，硕士
1995.9-1999.7 香港科技大学，生物学系，分子生物专业，哲学博士
2000.9-2004.11 香港大学，医学院病理学系，博士后
三、拟招收博士后开展的研究方向
1. 细胞外囊泡介導肝癌轉移的分子機制
2. 腫瘤微環境對於肝癌的影響
3. 肝癌的生物指標和治療靶點
四、主要获奖情况
香港大学2008-2009 年度著名优秀青年研究员，2010
五、代表性论文
1. Leung Z, Ko FCF, Tey SK, Kwong EML, Mao XW, Liu BMH, Ma APY, Fung YMF, Che CM, Wong DKH, Lai CL, Ng IOL, Yam JWP. 2019. Galectin-1 promotes hepatocellular carcinoma and the combined therapeutic effect of OTX008 galectin-1 inhibitor and sorafenib in tumor cells. J Exp Clin Cancer Res (Accepted)
2. Mao XW, Tey SK, Ko FCF, Kwong EML, Y Gao, Ng IOL, ST Cheung, XY Guan, Yam JWP. 2019. C-terminal truncated HBx protein activates caveolin-1/LRP6/ β-catenin/FRMD5 axis in promoting hepatocarcinogenesis. Cancer Lett 444:60-69.
3. Tey SK, Tse EYT, Mao XW, Ko ECF, AST Wong, Lo RCL, Ng IOL, Yam JWP. 2017. Nuclear Met promotes hepatocellular carcinoma tumorigenesis and metastasis by upregulation of TAK1 and activation of NF-κB pathway. Cancer Lett 411:150-161.
4. Mao XW, Wong SYS, Tse EYT, Ko FCF, Tey SK, Yeung YS, Man K, Lo RCL, Ng IOL, Yam JWP. 2016. Mechanisms through which hypoxia-induced caveolin-1 drives tumorigenesis and metastasis in hepatocellular carcinoma. Cancer Res 76:7242-7253.
5. Ko FCF, Chan LK, Sze KMF, Yeung YS, Tse EYT, Lu P, Yu MH, Ng IOL, Yam JWP. 2013. PKA-induced dimerization of the RhoGAP DLC1 promotes its inhibition of tumorigenesis and metastasis. Nat Commun 4:1618. [selected as featured article in NPG journals in cancer]
6. Tse EYT, Ko FCF, Tung EKK, Chan LK, Lee TKW, Ngan ESW, Man K, Wong AST, Ng IOL, Yam JWP. 2012. Caveolin-1 is overexpressed and associated with hepatocellular carcinoma tumorigenesis and metastasis. J Pathol 226:645-653.
7. Ko FCF, Chan LK, Tung EKK, Lowe SW, Ng IOL, Yam JWP. 2010. Akt phosphorylation of Deleted in Liver Cancer 1 deregulates its suppression of liver cancer tumorigenesis and metastasis. Gastroenterology 139:1397-1407.
8. Yam JWP, Ko FCF, Chan CY, Yau TO, Tung EKK, Leung THY, Jin DY, Ng IOL. 2006. Tensin2 variant 3 is associated with aggressive tumor behavior in human hepatocellular carcinoma. Hepatology 44:881-890.
9. Yam JWP, Ko FCF, Chan CY, Jin DY, Ng IOL. 2006. Interaction of DLC1-tensin2 complex with caveolin-1 and implications in tumor suppression. Cancer Res 66:8367-8372.
10. Wong CM*, Yam JWP*, Ching YP, Yau TO, Leung HY, Jin DY, Ng IOL. 2005. Rho GTPase activating protein DLC1 (deleted in liver cancer 1) suppresses cell proliferation and invasion in hepatocellular carcinoma. Cancer Res 65:8861-8868. *Contributed equally
11. Yam JWP, Jin DY, So CW, Chan LC. 2004. Identification and characterization of EBP, a novel EEN binding protein that inhibits ras signaling and is recruited into the nucleus by the MLL-EEN fusion protein. Blood 103:1445-1453.
12. Yam JWP, Chan KW, Hsiao WLW. 2003. Transcriptional regulation of rat frizzled related protein gene promoter by CREB. Oncogene 22:3901-3910.
13. Yam JWP, Chan KW, Hsiao WLW. 2001. Suppression of the tumorigenicity of mutant p53-transformed rat embryo fibroblasts through expression of a newly cloned rat nonmuscle myosin heavy chain-B. Oncogene 20:58-68.
