一、基本信息
姓名：高毅
职称：教授、主任医师
联系邮箱：gaoyi6146@163.com
二、学习经历
1979.9—1984.7 第二军医大学，临床医学专业，学士
1987.9—1992.7 第二军医大学，外科学专业硕博连读，博士
三、拟招收博士后开展的研究方向
1. 干细胞与再生医学；
2. 生物材料与组织工程；
3. 类器官与肿瘤精准治疗；
4. 医学数据与临床研究。
四、主要学术任职
1. 中国生物医学工程学会，会员；
2. 国际肝胆胰协会中国分会，委员；
3. 国家干细胞与再生医学产业技术联盟，理事；
4. 中国研究型医院学会转化医学分会，理事；
5. 中国研究型医院学会微创外科学专业委员会，委员；
6. 广东省肝脏病学会，副会长；
7. 广东省临床医学会，监事长；
8. 广东省肝脏病学会肝衰竭及人工肝专业委员会，名誉主任委员；
9. 广东省医师协会胰腺外科分会，副主委；
10. 广东省行业管理协会肝胆胰外科分会，副主委；
11. 广东省医疗行业协会肝胆胰外科管理分会，副主委；
12. 广东省肝脏病学会外科手术学分会，副主委。
五、主要获奖情况
1. 广东省科技进步二等奖，广东省科技厅，2001；
2. 广东省科技进步三等奖，广东省科技厅，广东省教育厅，2003。
六、代表性论文
[1] Ting Li*, Jun Weng, Yue Zhang, Kangyan Liang, Gongbo Fu, Yang Li, Xiaochun Bai* and Yi Gao*. mTOR direct crosstalk with STAT5 promotes de novo lipid synthesis and induces hepatocellular carcinoma.Cell Death and Disease (2019) 10:619.
[2] Li Li, Hongyi Meng, Qingjian Zou, Jianmin Zhang, Lei Cai, Bin Yang, Jun Weng, Liangxue Lai*, Huaqiang Yang* and Yi Gao*.Establishment of gene-edited pigs expressing human bloodcoagulation factor VII and albumin for bioartificial liver use. Journal of Gastroenterology and Hepatology.2019. doi:10.1111/jgh.14666.
[3] Zhaoyuan Liu, Qing Peng, Yang Li, Yi Gao* .Resveratrol enhances cisplatin-induced apoptosis in human hepatoma cells via glutamine metabolism inhibition. BMB Rep. 2018; 51(9): 474-479.
[4] Zhang K, Chen R, Gong X, Gao Y*. Survival outcomes of liver transplantation versus liver resection among patients with hepatocellular carcinoma: A SEER-based longitudinal study. J Formos Med Assoc. 2018 Oct 25. pii: S0929-6646(17)30738-6.
[5] Han S , Wei S , Wang X , Han X , Zhang M , Su M , Li Y , Guo J , Zeng W , Liu J , Gao Y* , Shen L*. Enhanced intrinsic CYP3A4 activity in human hepatic C3A cells with optically controlled CRISPR/dCas9 activator complex. Integr Biol (Camb). 2018 Dec 19;10(12):780-790.
[6] Jiang X, Feng L, Pan M, Gao Y*. Optimizing Livers for Transplantation Using Machine Perfusion versus Cold Storage in Large Animal Studies and Human Studies: A Systematic Review and Meta-Analysis, Biomed Res Int. 2018 Sep 5;2018:9180757.
[7] Feng L, He GL, Cai L, Fu CY, Li Y, Weng J, Huo XL, Peng Q, Gao Y*. Artificial liver and renal support system for cynomolgus monkeys with surgery-induced acute renal failure: A preclinical study. Biomed Res Int, 2018; 2018: 7456898.
[8] ZHANG Bin-bin, LI Yang, WANG Gao-shang, Zhidong Jia, Haiyan Li, Qing Peng*, Yi Gao*. Fabrication of agarose concave petridish for 3D-culture microarray method for spheroids formation of hepatic cells[J]. Journal of Materials Science. Materials in Medicine, 2018, 29(5): 49.
[9] Huang R, Li T, Ni J, Bai X, Gao Y*, Li Y, Zhang P and Gong Y (2018) Different Sex-Based Responses of Gut Microbiota During the Development of Hepatocellular Carcinoma in Liver-Specific Tsc1-Knockout Mice.Front. Microbiol. 9:1008.doi: 10.3389/fmicb.2018.01008
[10] YIN Liang-chun, LUO Zhen-chao, GAO Yan-xin, Yang Li, Qing Peng, and Yi Gao*. Twist expression in circulating hepatocellular carcinoma cells predicts metastasis and prognoses[J]. Biomed Research International, 2018, 2018: 3789613.
[11] Huang Y, Peng Q, Li HY, Jia ZD, Li Y, Gao Y*. Novel sericin-based hepatocyte serum-free medium and sericin’s effect on hepatocyte transcriptome. World J Gastroenterol,2018; 24(30): 3398-3413
[12] Jue Tang, Dan Zhang, Wei Liu,Ji-Xiao Zeng, Jia-Kang Yu and Yi Gao*. Differentiation between cystic biliary atresia and choledochal cyst: A retrospective analysis. Journal of Paediatrics and Child Health,2017, 54 (4).
[13] He, G. L., Feng, L., Cai, L., Zhou, C. J., Cheng, Y., Jiang, Z. S., ... & Gao, Y*. (2017). Artificial liver support in pigs with acetaminophen-induced acute liver failure. World journal of gastroenterology, 23(18), 3262.
[14] Feng, L., Cai, L., He, G. L., Weng, J., Li, Y., Pan, M. X., ... & Gao, Y*. (2017). Novel D-galactosamine-induced cynomolgus monkey model of acute liver failure. World journal of gastroenterology, 23(42), 7572.
[15] Peng, G., Li, S., Peng, Q., Li, Y., Weng, J., Jia, Z., ... & Guifeng Zhang*, Gao, Y*. (2017). Immobilization of native type I collagen on polypropylene fabrics as a substrate for HepG2 cell culture. Journal of Biomaterials Applications, 0885328217709607.
[16] Qin, J., Mai, Y., Li, Y., Jiang, Z., & Gao, Y*. (2017). Effect of mild hypothermia preconditioning against low temperature (4 C) induced rat liver cell injury in vitro. PloS one, 12(4), e0176652.
[17] Peng Zhang, Peihua Cao, Xiaofeng Zhu, Mingxin Pan, Kebo Zhong, Rui He,Yang Li, Xingyuan Jiao*, Yi Gao*. (2017). Upregulation of long non-coding RNA HOXA-AS2 promotes proliferation and induces epithelial-mesenchymal transition in gallbladder carcinoma.Oncotarget, 8 (20), 33137-33143.
[18] Weng J, Li Y, Cai L, Li T, Peng G, Fu C, Han X, Li H, Jiang Z, Zhang Z, Du J, Peng Q*, Gao Y*. (2017). Elimination of Mycoplasma Contamination from Infected Human Hepatocyte C3A Cells by Intraperitoneal Injection in BALB/c Mice. Front Cell Infect Microbiol, 7:440. doi: 10.3389/fcimb.2017.00440
[19] Cai, L., Weng, J., Feng, L., He, G., Qin, J., Zhang, Z., ... & Gao, Y*. (2016). Establishment of a Novel Simplified Surgical Model of Acute Liver Failure in the Cynomolgus Monkey. BioMed research international, 2016
[20] Han, S., Guo, J., Liu, Y., Zhang, Z., He, Q., Li, P., ... &Gao, Y*., Li Shen*. (2015). Knock out CD44 in reprogrammed liver cancer cell C3A increases CSCs stemness and promotes differentiation. Oncotarget, 6(42), 44452.
[21] He, G. L., Feng, L., Duan, C. Y., Hu, X., Zhou, C. J., Cheng, Y., ... & Gao, Y*. (2015). Meta-analysis of survival with the molecular adsorbent recirculating system for liver failure. International journal of clinical and experimental medicine, 8(10), 17046
[22] Zhang Z, Zhao Y C, Cheng Y, Jian G D, Pan M X, Gao Y*. (2014). Hybrid bioartificial liver support in cynomolgus monkeys with D-galactosamine-induced acute liver failure[J]. World J Gastroenterol, 20(46): 17399-17406.
