一、基本信息
姓名：徐世元
职称：教授、主任医师
联系邮箱：xushiyuan355@163.com
二、学习经历
1989.9-1993.7 第一军医大学，研究生班，硕士
三、拟招收博士后开展的研究方向
1.麻醉药物神经毒性机制与防治研究；
2.阿片类药物耐受与痛敏机制与防治研究；
3.围术期器官损伤保护与器官血流动力学及氧合代谢研究。
四、主要学术任职
1. 中国高教育学会医学高等教育分会麻醉学高等教育学会常务理事；
2. 中华医学会麻醉学分会九至十二届委员；
3. 广东省医学会麻醉学分会第九届主任委员、前任主任委员。
五、代表性论文
1. Liu ZJ, Zhao W, Lei HY, Xu HL, Lai LY, Xu R, Xu SY: High Glucose Enhances Bupivacaine-Induced Neurotoxicity via MCU-Mediated Oxidative Stress in SH-SY5Y Cells. Oxid Med Cell Longev 2019; 2019: 7192798
2. Mo K, Xu H, Gong H, Lei H, Wang Y, Guo W, Xu S, Tu W: Dorsal Root Ganglia Coactivator-associated Arginine Methyltransferase 1 Contributes to Peripheral Nerve Injury-induced Pain Hypersensitivities. Neuroscience 2018; 394: 232-242
3. Lu A, Lei H, Li L, Lai L, Liang W, Xu S: Role of mitochondrial Ca(2+) uniporter in remifentanil-induced postoperative allodynia. Eur J Neurosci 2018; 47: 305-313
4. Hong P, Li FX, Gu RN, Fang YY, Lai LY, Wang YW, Tao T, Xu SY, You ZJ, Zhang HF: Inhibition of NLRP3 Inflammasome Ameliorates Cerebral Ischemia-Reperfusion Injury in Diabetic Mice. Neural Plast 2018; 2018: 9163521
5. Deng HB, Li FX, Cai YH, Xu SY: Waste anesthetic gas exposure and strategies for solution. J Anesth 2018; 32: 269-282
6. Zhang JB, Wang XQ, Lu GL, Huang HS, Xu SY: Adipose-derived mesenchymal stem cells therapy for acute kidney injury induced by ischemia-reperfusion in a rat model. Clin Exp Pharmacol Physiol 2017
7. Zhang HF, Li FX, Lei HY, Xu SY: Rising sudden death among anaesthesiologists in China. Br J Anaesth 2017; 119: 167-169
8. Wang H, Dong Y, Cai Y: Alanylglutamine prophylactically protects against lipopolysaccharideinduced acute lung injury by enhancing the expression of HSP70. Mol Med Rep 2017; 16: 2807-2813
9. Liu Z, Ma C, Zhao W, Zhang Q, Xu R, Zhang H, Lei H, Xu S: High Glucose Enhances Isoflurane-Induced Neurotoxicity by Regulating TRPC-Dependent Calcium Influx. Neurochem Res 2017; 42: 1165-1178
10. Ji ZH, Liu ZJ, Liu ZT, Zhao W, Williams BA, Zhang HF, Li L, Xu SY: Diphenyleneiodonium Mitigates Bupivacaine-Induced Sciatic Nerve Damage in a Diabetic Neuropathy Rat Model by Attenuating Oxidative Stress. Anesth Analg 2017; 125: 653-661
11. Zhao W, Liu Z, Yu X, Lai L, Li H, Liu Z, Li L, Jiang S, Xia Z, Xu SY: iTRAQ proteomics analysis reveals that PI3K is highly associated with bupivacaine-induced neurotoxicity pathways. Proteomics 2016; 16: 564-75
12. Zhang H, Xiong X, Liu J, Gu L, Li F, Wan Y, Xu S: Emulsified Isoflurane Protects Against Transient Focal Cerebral Ischemia Injury in Rats via the PI3K/Akt Signaling Pathway. Anesth Analg 2016; 122: 1377-84
13. Zhang H, Li F, Li WW, Stary C, Clark JD, Xu S, Xiong X: The inflammasome as a target for pain therapy. Br J Anaesth 2016; 117: 693-707
14. Xiong W, Xu S, Li H, Liang K: Moderate hypothermia ameliorates enterocyte mitochondrial dysfunction in severe shock and reperfusion. J Surg Res 2016; 200: 250-9
15. Wen X, Xu S, Zhang Q, Li X, Liang H, Yang C, Wang H, Liu H: Inhibitory gene expression of the Cav3.1 T-type calcium channel to improve neuronal injury induced by lidocaine hydrochloride. Eur J Pharmacol 2016; 775: 43-9
16. Li H, Cheng Y, Simoncini T, Xu S: 17beta-Estradiol inhibits TNF-alpha-induced proliferation and migration of vascular smooth muscle cells via suppression of TRAIL. Gynecol Endocrinol 2016; 32: 581-6
17. Hong QX, Xu SY, Dai SH, Zhao WX: Expression profiling of spinal genes in peripheral neuropathy model rats with type 2 diabetes mellitus. Int J Clin Exp Med 2016; 9: 6376-6384
18. Hao W, Chen L, Wu LF, Yang F, Niu JX, Kaye AD, Xu SY: Tanshinone IIA Exerts an Antinociceptive Effect in Rats with Cancer-induced Bone Pain. Pain Physician 2016; 19: 465-76
19. Fan YL, Li HC, Zhao W, Peng HH, Huang F, Jiang WH, Xu SY: Curcumin Attenuated Bupivacaine-Induced Neurotoxicity in SH-SY5Y Cells Via Activation of the Akt Signaling Pathway. Neurochem Res 2016; 41: 2425-32
20. Zhou L, Wang L, Yang B, Zeng J, Zhang Q, Lei H, Xu S: Protective effect of pretreatment with propofol against tumor necrosis factor-alpha-induced hepatic insulin resistance. Exp Ther Med 2015; 10: 289-294
21. Liu Z, Zhao W, Zhang Q, Lai L, Jiang S, Zhang J, Xu S: Increased Oxidative Damage and Reduced DNA Repair Enzyme XPD Involvement in High Glucose-Mediated Enhancement of Levobupivacaine-Induced Neurotoxicity. Neurochem Res 2015; 40: 1919-28
22. Li F, Guo CJ, Huang CC, Yu G, Brown SM, Xu S, Liu Q: Transient receptor potential A1 activation prolongs isoflurane induction latency and impairs respiratory function in mice. Anesthesiology 2015; 122: 768-75
23. Li L, Ye XP, Lu AZ, Zhou SQ, Liu H, Liu ZJ, Jiang S, Xu SY: Hyperglycemia magnifies bupivacaine-induced cell apoptosis triggered by mitochondria dysfunction and endoplasmic reticulum stress. J Neurosci Res 2013; 91: 786-98
24. Lu J, Xu SY, Zhang QG, Lei HY: Bupivacaine induces reactive oxygen species production via activation of the AMP-activated protein kinase-dependent pathway. Pharmacology 2011; 87: 121-9
