一、基本信息
姓名：郭洪波
职称：教授
联系邮箱：guohongbo911@126.com
二、学习经历
2012/10–2012/12，美国匹兹堡大学，神经医学研究所，高级访问学者
2002/09–2005/07，南方医科大学，神经生物学，博士
1999/09–2002/07，南方医科大学，神经生物学，硕士
1988/09–1994/07，南方医科大学，临床医学系，本科
三、拟招收博士后开展的研究方向
1. 神经肿瘤发病机制及肿瘤耐药机制；
2. 干细胞治疗及临床转化。
四、主要学术任职
1.中国神经科学学会 理事
2.中国神经科学学会 神经损伤与修复分会 委员
3.中国医师协会脑胶质瘤专委会基础研究与转化专委会 副主委
4.广东省医学会科研管理分会 副主委
5.中国医药生物技术协会组织生物样本库分会 委员
6.《中华神经医学杂志》 编辑部主任、编委
五、主要获奖情况
1.脑血管病血管内诊治技术的疗效评价及应用推广 (2012) 中华医学科技三等奖 （7/13）
2.体温正副调节中枢在发热自稳态中的电生理研究 (A04-0-3-04) 广东省科技进步三等奖 （2/7）
六、代表性论文
1. Xu N#, Liu B#, Lian C, Doycheva DM, Fu Z, Liu Y, Zhou J, He Z, Yang Z, Huang Q, Zeng H, Guo H. Long noncoding RNA AC003092.1 promotes temozolomide chemosensitivity through miR-195/TFPI-2 signaling modulation in glioblastoma. Cell Death Dis. 2018.9(12):1139.
2. Xu N#, Zhang Y, Doycheva DM, Ding Y, Zhang Y, Tang J, Guo H, Zhang JH. Adiponectin attenuates neuronal apoptosis induced by hypoxia-ischemia via the activation of AdipoR1/APPL1/LKB1/AMPK pathway in neonatal rats. Neuropharmacology. 2018 May 1; 133:415-428.
3. Zeng HJ#, Yang Z#, Xu NB, Liu BY, Fu Z, Lian CL, Guo HB*. Connective tissue growth factor promotes temozolomide resistance in glioblastoma through TGF-β1-dependent activation of Smad/ERK signaling. Cell Death & Disease (2017) 8, e2885;
4. Zeng HJ#, Xu NB#, Liu YT, Liu BY, Yang Z, Fu Z, Lian CL, Guo HB*. Genomic profiling of long non-coding RNA and mRNA expression associated with acquired temozolomide resistance in glioblastoma cells. International Journal of Oncology (2017):445-455.
5. Liu YT#, Xu NB#, Liu BY, Huang YR, Zeng HJ, Yang Z, He ZY, Guo HB*. Long noncoding RNA RP11-838N2.4 enhances the cytotoxic effects of temozolomide by inhibiting the functions of miR-10a in glioblastoma cell lines. Oncotarget. 2016.7(28): 43835-43851.
6. Liao HZ#, Bai YF#, Qiu SC, Zheng L, Huang LY, Liu TZ, Wang X, Liu YT, Xu NB, Yan XH, Guo HB*. MiR-203 downregulation is responsible for chemoresistance in human glioblastoma by promoting epithelial-mesenchymal transition via SNAI2. Oncotarget. 2015.6(11): 8914-8928.
7. Bai YF#, Liao HZ#, Liu TZ, Zeng XP, Xiao FM, Luo LQ, Guo HB*, Guo LL*. MiR-296-3p regulates cell growth and multi-drug resistance of human glioblastoma by targeting ether-a-go-go (EAG1). Eur J Cancer. 2013.49(3): 710-724.
8. Liu TZ#, Wang X#, Bai YF, Liao HZ, Qiu SC, Yang YQ, Yan XH, Chen J, Guo HB*, Zhang SZ*. The HIF-2alpha dependent induction of PAP and adenosine synthesis regulates glioblastoma stem cell function through the A2B adenosine receptor. Int J Biochem Cell B. 2014.49: 8-16.
9. Wang X#, Liu TZ#, Bai YF, Liao HZ, Qiu SC, Chang ZH, Liu YT, Yan XH, Guo HB*. Polymerase I and Transcript Release Factor Acts As an Essential Modulator of Glioblastoma Chemoresistance. Plos One. 2014.9(4).
10. Liu TZ#, Wang X, Yin ZL, Pan J, Guo HB*, Zhang SZ*. Extracts from Glioma Tissues following Cryoablation Have Proapoptosis, Antiproliferation, and Anti-Invasion Effects on Glioma Cells. BioMed research international. 2014.
11. Hu HY#, Li KP, Wang XJ, Liu Y, Lu ZG, Dong RH, Guo HB*, Zhang MX*. Set9, NF-kappaB, and microRNA-21 mediate berberine-induced apoptosis of human multiple myeloma cells. Acta pharmacologica Sinica. 2013.34(1): 157-166.
12. Meng W#, Jiang L, Lu L, Hu HY, Yu HL, Ding DP, Xiao K, Zheng WL, Guo HB*, Ma WL*. Anti-miR-155 oligonucleotide enhances chemosensitivity of U251 cell to taxol by inducing apoptosis. Cell biology international. 2012.36(7): 653-659.
