一、基本信息

姓名：郭琳琅                                 

职称：教授、主任医师

联系邮箱：linlangg@yahoo.com

 

二、拟招收博士后开展的研究方向

1. 小细胞肺癌分子分型；

2. 小细胞肺癌化疗耐药机制。

 

三、主要学术任职

广东省医学会病理学分会数字与分子病理学组副组长

 

四、代表性论文

1. Zeng F, Wang Q, Wang S, Liang S, Huang W, Guo Y, Peng J, Li M, Zhu W, Guo L.Linc00173 promotes chemoresistance and progression of small cell lung cancer by sponging miR-218 to regulate Etk expression. Oncogene. 2019 Sep 2. doi: 10.1038/s41388-019-0984-2.

2. Wang Q, Zeng F, Sun Y, Qiu Q, Zhang J, Huang W, Huang J, Huang X, Guo L. Etk Interaction with PFKFB4 Modulates Chemoresistance of Small-cell Lung Cancer by Regulating Autophagy. Clin Cancer Res. 2018; 24(4); 950–62

3. Sun Y, Zhou Y, Bai Y, Wang Q, Bao J, Luo Y, Guo Y, Guo L. A long non-coding RNA HOTTIP expression is associated with disease progression and predicts outcome in small cell lung cancer patients. Mol Cancer. 2017;16(1):162.

4. Niu Y, Ma F, Huang W, Fang S, Li M, Wei T, Guo L. Long non-coding RNA TUG1 is involved in cell growth and chemoresistance of small cell lung cancer by regulating LIMK2b via EZH2. Mol Cancer. 2017;16(1):5.

5. Tang R, Lei Y, Hu B, Yang J, Fang S, Wang Q, Li M, Guo L. WW domain binding protein 5 induces multidrug resistance of small cell lung cancer under the regulation of miR-335 through the Hippo pathway. Br J Cancer. 2016 115(2):243-51.

6. Liu H, Huang J, Peng J, Wu X, Zhang Y, Zhu W, Guo L. Upregulation of the inwardly rectifying potassium channel Kir2.1 (KCNJ2) modulates multidrug resistance of small-cell lung cancer under the regulation of miR-7 and the Ras/MAPK pathway. Mol Cancer. 2015; 14(1):298.

7. Huang J, Peng J, Guo L. Non-Coding RNA: A New Tool for the Diagnosis, Prognosis, and Therapy of Small Cell Lung Cancer. J Thor Oncol, 2015; 10(1): 28-37.

8.  Xiao F, Bai Y, Chen Z, Li Y, Luo L, Huang J, Yang J, Liao H, Guo L. Downregulation of HOXA1 gene affects small cell lung cancer cell survival and chemoresistance under the regulation of miR-100. Eur J Cancer. 2014; 50(8):1541-54.