一、基本信息
姓名：张宏征
职称：主任医师、副教授
联系邮箱：zhang_hongzheng@yeah.net
二、学习经历
1996.09—2003.07，第一军医大学临床医学系，七年制硕研/硕士
2006.09—2009.07，中山大学 耳鼻咽喉科学，博士研究生/博士
2012.09—2013.08，美国Oregon Health Science University (OHSU), Oregon Hearing Research Center耳蜗生理与人工耳蜗植入 博士后
三、拟招收博士后开展的研究方向
1. 听觉障碍机制；
2. 人工耳蜗植入创伤机制及康复；
3. 内耳药物载体。
四、主要学术任职
1. 中国医药教育协会眩晕专委会常委
2. 中国中西医结合耳鼻咽喉科专业委员会人工耳蜗专家委员会委员
3. 中国医疗保健国际交流促进会耳内科学分会委员
4. 中国医疗保健国际交流促进会人工听觉分会委员
5. 中国优生科学协会听觉医学分会委员
6. 中国医师协会青春期医学耳鼻咽喉保健学组委员
7. 中国医师协会整合医学整合耳鼻咽喉头颈外科委员会委员
8. 国家人工耳蜗救助项目广东省专家组成员及项目负责人
9. 广东省精准医学应用学会听觉与前庭障碍分会主任委员
10. 广东省医学会耳鼻咽喉科学分会耳科学组副组长
11. 广东省医师协会耳鼻咽喉科分会耳科学组副组长
12. 广东省临床医学会耳内镜分会副主任委员
13. 广东省康复医学会听力及言语康复分会听力康复专业委员会常委
14. 广东省防聋治聋技术指导专家组成员
15. 广东省生物医学工程学会耳鼻咽喉科分会委员
16. 广东省生物医学工程学会医用生物材料分会委员
17. 《Journal of Otology》编委
18. 《中华耳科学杂志》编委
19. 《听力学及言语疾病杂志》编委
20. 《中国耳鼻咽喉颅底外科杂志》编委
五、主要获奖情况
1.多导人工耳蜗植入治疗全聋临床应用研究，2007，广东省科学技术二等奖（4/9）
2.叶酸分子靶向磁性纳米抗癌药物载体的研制及其应用，2015，广州市科技进步三等奖（4/5）
3.南医优秀教师，2018年，南方医科大学
六、代表性论文
Tan X, Pan J, Cai J, Jiang S, Shu F, Xu M, Peng H*, Tang J*, Zhang H*. Relevant research of inflammatory cytokines spectrum in peripheral blood of sudden hearing loss. The Laryngoscope, 2024.
Chen A, Wang Z, Chen H, Pang B, Cai H, Chen Z, Ning C*, Ma D*, Tang J*, Zhang H*. Zwitterion modified cochlear implants resist postoperative infection and inflammation, Materials Today Bio, 2023,100856. doi.org/10.1016/j.mtbio.2023.100856.
Xu M, Chen A, Chen D, Wu S, Deng Z, Wen H, Zhong H, Lu K, Tang J*, Ma D*, Zhang H*. Preparation, characterization, and in vitro/vivo evaluation of a multifunctional electrode coating for cochlear implants. Biomater Adv. 2023. 157: 213736.
Zhang, D, Chen, D, Wang, K, Pan, J, Tang J*, Zhang H*. Electrical stimulation of cochlear implant promotes activation of macrophages and fibroblasts under inflammation. Laryngoscope Investigative Otolaryngology. 2023; 1-11. doi:10.1002/lio2.1149.
Chen A, Chen D, Lv K, Li G, Pan J, Ma D*, Tang J*, Zhang H*. Zwitterionic Polymer/Polydopamine Coating of Electrode Arrays Reduces Fibrosis and Residual Hearing Loss After Cochlear Implantation. Advanced Healthcare Materials. 2023. 12(1): e2200807. DOI: 10.1002/adhm.202200807 (1区 IF11.092)
Chen A, Chen Y, Liu S, Ma D, Tang J, Zhang H*. Mesoporous silica nanoparticle-modified electrode arrays of cochlear implants for delivery of siRNA-TGFβ1 into the inner ear. Colloids Surf B Biointerfaces. 2022. 218: 112753. (2区 IF5.999)
Fan Shu, Mingyun Yao, Yimeng Liu, Jieqing Cai, Muqing Xu, Shanshan Jiang, Xinyuan Tan, Jie Tang* and Hongzheng Zhang*. Delayed-onset swelling around the implant after cochlear implantation: A series of 26 patients. European Archives of Oto-Rhino-Laryngology. 2022. https://doi.org/10.1007/s00405-022-07537-x. (3区 IF3.236)
Xuexin Tian, Yimeng Liu, Zengzhi Guo, Jieqing Cai, Jie Tang* , Fei Chen* and Hongzheng Zhang*. Cerebral Representation of Sound Localization Using Functional Near-Infrared Spectroscopy. Frontiers in Neuroscience. 2021,15:739706. DOI: 10.3389/fnins.2021.739706. (3区 IF5.152)
Dongxiu Chen, Yanjing Luo, Jing Pan, Anning Chen, Dong Ma, Muqing Xu, Jie Tang* and Hongzheng Zhang*. Long-term release of dexamethasone with a polycaprolactone-coated electrode alleviates fibrosis in cochlear implantation. Frontiers in Cell and Developmental Biology. 2021. DOI: 10.3389/fcell.2021.740576. (小类2区 IF6.081)
Wenlu Pan, Jing Pan, Yan Zhao, Hongzheng Zhang* and Jie Tang*. Serotonin transporter defect disturbs structure and function of the auditory cortex in mice. Frontiers in Neuroscience. 2021. 15:749923. doi: 10.3389/fnins.2021.749923 (3区 IF5.152)
Luo Y, Chen A, Xu M, Chen D, Tang J, MA D, Zhang H*. Preparation, characterization, and in vitro/vivo evaluation of dexamethasone/poly(ε-caprolactone)-based electrode coatings for cochlear implants. Drug Deliv. 2021. 28(1): 1673-1684. (小类2区 IF6.819)
Qi X, Lyu K, Meng L, Li C, Zhang H, Niu L, Lin Z, Zheng H*, Tang J*. Low-Intensity Ultrasound Causes Direct Excitation of Auditory Cortical Neurons[J]. Neural Plast, 2021, 2021:8855055. DOI: 10.1155/2021/8855055. (3区 IF3.144)
Jieqing Cai, Yimeng Liu, Minyun Yao, Muqing Xu, Hongzheng Zhang*. A Neurophysiological Study of Musical Pitch Identification in Mandarin-Speaking Cochlear Implant Users. Neural Plasticity, vol. 2020. Article ID 4576729, 11 pages, https://doi.org/10.1155/2020/4576729 (3区 IF3.144)
Pan W, Lyu K, Zhang H, Li C, Chen P, Ying M, Chen F, Tang J*. Attenuation of auditory mismatch negativity in serotonin transporter knockout mice with anxiety-related behaviors. Behav Brain Res. 2020 Feb 3;379:112387. doi: 10.1016/j.bbr.2019.112387. Epub 2019 Nov 26. PMID: 31783087. (2区 IF3.352)
Muqing Xu, Dong Ma, Dongxiu Chen, Jieqing Cai, Qiaofang He, Fan Shu, Jie Tang, Hongzheng Zhang*. Preparation, characterization and application research of a sustained dexamethasone releasing electrode coating for cochlear implantation. Materials Science & Engineering C-Materials for Biological Applications, 2018. 90: 16-26. (2区 IF7.328)
Aoshuang Chang, Peng Chen, Shasha Guo, Nana Xu, Wenlu Pan, Hongzheng Zhang, Cuixian Li, and Jie Tang. Specific Influences of Early Acoustic Environments on Cochlear Hair Cells in Postnatal Mice, Neural Plasticity, vol. 2018, Article ID 5616930, 13 pages, 2018. https://doi.org/10.1155/2018/5616930. (3区 IF3.599)
Zhang H.*, G. Stark,, and L. Reiss, Changes in gene expression and hearing thresholds after cochlear implantation[J]. Otology and Neurotology, 2015, 36(7): 1157-1165. （2区IF2.311）
Reiss, L.A., G. Stark, A.T. Nguyen-Huynh, K.A. Spear, H. Zhang, C. Tanaka, and H. Li, Morphological correlates of hearing loss after cochlear implantation and electro-acoustic stimulation in a hearing-impaired Guinea pig model. Hear Res, 2015. 327: p. 163-74. (1区 IF2.906)
Xie, M., H. Zhang, Y. Xu, T. Liu, S. Chen, J. Wang, and T. Zhang, Expression of folate receptors in nasopharyngeal and laryngeal carcinoma and folate receptor-mediated endocytosis by molecular targeted nanomedicine[J]. International journal of nanomedicine, 2013. 8: 2443. （2区IF4.3）
Xie, M., Y. Xu, J. Liu, T. Zhang, and H. Zhang, Preparation and characterization of folate targeting magnetic nanomedicine loaded with cisplatin[J]. Journal of Nanomaterials, 2012. 2012: 32.(4区IF2.986)
