一、基本信息
姓名：于清宏
职称：教授，主任医师
联系邮箱：yuqinghonghome@163.com
二、学习经历
1982.9-1987.7 辽宁中医药大学，临床医学，学士
1987.9-1990.7 辽宁中医药大学，免疫学，硕士
1994.9-1997.7 解放军总医院，风湿病学，博士
1997.9-1999.9 军事医学科学院基础医学研究所，免疫学博士后
三、拟招收博士后开展的研究方向
1. 类风湿关节炎蛋白瓜氨酸化抗原参与发病机制研究；
2. 病理性自身抗体产生和参与发病机制研究；
3. 中药来源抗炎免疫调节小分子筛选及作用机制研究
四、主要学术任职
1、亚太医学生物免疫学会风湿免疫分会副主任委员
2、中国康复医学会风湿病分会副主任委员
3、中国医师学会免疫吸附分会常委
4、中国中西医结合风湿病学会常委
5、中华中医药学会风湿病分会委员
6、广东省精准医学应用学会自身免疫病学会主任委员
7、广东省药理学会炎症与免疫分会副主任委员
8、广东省中医药学会风湿病学会副主任委员
五、主要获奖情况
省科技进步2等奖一作1次
六、代表性论文
1.Qu Y, Zhang YP, Wu J, Jie LG, Deng JX, Zhao DB, Yu QH. Downregulated microRNA-135a ameliorates rheumatoid arthritis by inactivation of the phosphatidylinositol 3-kinase/AKT signaling pathway via phosphatidy- linositol 3-kinase regulatory subunit 2. J Cell Physiol. 2019 Aug;234(10): 17663-17676.
2.Wu J, Zhang YP, Qu Y, Jie LG, Deng JX, Yu QH. Efficacy of uric acid-lowering therapy on hypercholesterolemia and hypertriglyceridemia in gouty patients. Int J Rheum Dis. 2019 Aug;22(8):1445-1451.
3.Du H, Yu Q, Jie L. A Novel Phytochemical，DIM, Inhibits Proliferation, Migration, Invasion and TNF-α Induced Inflammatory Cytokine Production of Synovial Fibroblasts From Rheumatoid Arthritis Patients by Targeting MAPK and AKT/mTOR Signal Pathway. Front Immunol. 2019 Jul 23;10:1620.
4.Wu J, Li Q, Jin L, Qu Y, Liang BB, Zhu XT, Du HY, Jie LG, Yu QH. Kirenol Inhibits the Function and Inflammation of Fibroblast-like Synoviocytes in Rheumatoid Arthritis in vitro and in vivo.Front Immunol.2019 Jun 6;10: 1304.
5.Wu J, Qu Y, Zhang YP, Deng JX, Yu QH. RHAMM induces progression of rheumatoid arthritis by enhancing the functions of fibroblast-like synoviocytes. BMC Musculoskelet Disord. 2018 Dec 26;19(1):455.
6.Qu Y, Wu J, Deng JX, Zhang YP, Liang WY, Jiang ZL, Yu QH, Li J. micro RNA-126 affects rheumatoid arthritis synovial fibroblast proliferation and apoptosis by targetingPIK3R2 and regulating PI3K-AKT signal pathway. Oncotarget. 2016 Oct 6.
7.Jing Wu, Yuan Qu, Jia-Xin Deng, Wan-Yi Liang, Zhen-Lan Jiang, Rong Lai, Qing-Hong Yu. Resveratrol inhibition of TNF-ɑ and IL-1 for treatment of rheumatoid arthritis: from In-Silico to In-vitro elucidation，Int J Clin Exp Med,2016,9(2),745-752
8. Wu J. Qu Y. Deng J X. Liang WY. Jiang ZL. Lai R. Yu QH. Molecular docking studies of kirenol a traditional Chinese medicinal compound against rheumatoid arthritis cytokine drug targets (TNF-ɑ, IL-1 and IL-6). Biomedical Research, 2017,28(5), 1992-1995.
