一、基本信息
姓名:龙海波
职称:教授、主任医师
联系邮箱:longhb@smu.edu.cn,longhb1966@163.com
二、学习经历
1983.9-1988.7 第一军医大学,军医专业,学士
1993.9-1996.7 第一军医大学,内科学(肾病)专业,硕士
2004.9-2007.7 南方医科大学,中西医结合临床专业,博士
三、拟招收博士后开展的研究方向
1.自主合成的小白菊内酯系列衍生物在糖尿病肾病、IgA肾病、狼疮性肾炎中的作用及其机制;
2.自主合成的1.1类候选新药ACT001、ACT004等对肾脏、腹膜纤维化的影响及其机制;
3.自主开发研制的中药复方(肾康丸等)在糖尿病肾病中的作用及其机制。
四、主要学术任职
1.国家科学技术奖励评审专家;
2.国家自然科学基金评审专家;
3.中国中医药研究促进会肾病分会常务理事;
4.中国民族医药学会肾病分会常务理事;
5.中国医师协会肾脏内科医师分会第二届委员会委员;
6.中国中西医结合学会肾脏疾病专业委员会第四届委员会青年委员;
7.广东省中西医结合学会肾衰竭专业委员会副主任委员;
8.广东省医学教育协会肾脏病学专业委员会副主任委员;
9.广东省基层医药学会NCD慢病防治专业委员会副主任委员。
五、主要获奖情况
1.军队科技进步二等奖,解放军总后勤部,2001;
2.广东省科技进步三等奖,广东省科技厅,2002;
3.中国中西医结合学会科学技术奖二等奖,中国中西医结合学会,2008。
六、代表性论文
[1] Wu JY (#), Huang QY (#), Li PL (#), Wang YX, Zheng CH, Lei XH, Li ST, Gong WQ, Yin BH, Luo CW, Xiao J, Zhou WD, Xu ZZ, Chen YH (*), Peng FF(*), Long HB(*)(龙海波).MicroRNA-145 promotes the epithelial-mesenchymal transition in peritoneal dialysis-associated fibrosis by suppressing fibroblast growth factor 10[J].J BIOL CHEM,2019,DOI 10.1074/jbc.RA119.007404.
[2] Peng FF (#), Li HY (#),Li ST (#), Wang YX, Liu WT, Gong WQ, Yin BH, Chen SJ, Zhang Y, Luo CW, Zhou WD, Chen YH, Li PL, Huang QY, Xu ZZ(*), Long HB (*)(龙海波).Micheliolide ameliorates renal fibrosis by suppressing the Mtdh/BMP/MAPK pathway[J].LAB INVEST,2019, doi.org/10.1038/ s41374-019-0245-6.
[3] Li ST (#),Peng FF (#),Gong WQ (#),Wu JY, Wang YX, Xu ZZ, Liu WT, Li HY, Yin BH, Zhang Y, Chen SJ, Luo CW, Li PL, Chen YH, Huang QY, Zhou WD (*) ,Long HB (*)(龙海波).Dimethylaminomicheliolide ameliorates peritoneal fibrosis through the activation of autophagy[J]. J MOL MED,2019,doi.org/10.1007/s00109-019-01757-1.
[4] Peng FF (#), LinXX, Sun LZ, Zhou WD, Chen YH, Li PL,Chen T,Wu JY, Xu ZZ, Long HB (*)(龙海波).Exertional rhabdomyolysis in a 21-year-old healthy man resulting from lower extremity training A case report[J].MEDICINE, 2019, doi.org/10.1097/MD.0000000000016244.
[5] Zhong J,Gong WQ,Chen J,Qing Y,Wu SY,Li HB,Huang CX,Chen YH,Wang YX,Xu ZZ,Liu WT,Li HY,Long HB (*)(龙海波).Micheliolide Alleviates Hepatic Steatosis in db/db Mice by Inhibiting Inflammation and Promoting Autophagy via PPAR-γ-mediated NF-кB and AMPK/mTOR Signaling[J]. INT IMMUNOPHARMACOL, 2018,59:197-208.
[6] Zhu Y(#),Peng FF(#),Chen YH(#),Chen WJ, Zhou WD, Li PL, Niu HX, Long HB(*)(龙海波), Mean platelet volume/platelet count ratio and mortality in patients on peritoneal dialysis[J]. CLIN NEPHROL,2018, DOI 10.5414/CN109329.
[7] Zhong J,Gong WQ,Lu L,Chen J,Lu ZB,LiHY,Liu WT,Liu YY,Wang MQ,Hu R, Long HB(*)(龙海波),Wei LB(*).Irbesartan ameliorates hyperlipidemia and liver steatosis in type 2 diabetic db/db mice via stimulating PPAR-γ, AMPK/Akt/mTOR signaling and autophagy[J].INT IMMUNOPHARMACOL, 2017,42:176–184.
[8] Peng FF(#), Chen WJ(#), Zhou WD(#), Li PL, Niu HX, Chen YH, Zhu Y, Long HB(*)(龙海波).Low prognostic nutritional index associated with cardiovascular disease mortality in incident peritoneal dialysis patients[J].INT UROL NEPHROL,2017, 49(6):1095-1101,DOI: 10.1007/s11255-017-1531-0.
[9] Niu HX(#),Li SH(#),Li HY(#), Chen YH, Liu WW, Li PL, Long HB(*)(龙海波). Clinicopathologic features, diagnosis and treatment of IgA nephropathy with minimal change disease caused by exposure to mercury-containing cosmetics: a case report[J].CLIN NEPHROL,2017,87(4):196-201.
[10] Liu WT(#), Peng FF(#), Li HY(#), Chen XW, Gong WQ, Chen WJ, Chen YH, Li PL, Li ST, Xu ZZ, Long HB(*)(龙海波).Metadherin facilitates podocyte apoptosis in diabetic nephropathy[J]. CELL DEATH DIS,2016,doi:10.1038/cddis.2016.335.
[11] Chen XW(#),Liu WT(#),Wang YX(#),Chen WJ, Li HY, Chen YH, Du XY, Peng FF, Zhou WD, Xu ZZ, Long HB(*)(龙海波).Cyclopropanyldehydrocostunolide LJ attenuates high glucose-induced podocyte injury by suppressing RANKL/RANK-mediated NF-κB and MAPK signaling pathways[J].J DIABETES COMPLICAT,2016,30: 760-769
[12] Chen XW(#), Du XY(#), Wang YX, Wang JC, Liu WT, Chen WJ, Li HY, Peng FF, Xu ZZ, Niu HX, Long HB(*)(龙海波).Irbesartan ameliorates diabetic nephropathy by suppressing the RANKL-RANK-NF-κB pathway in type 2 diabetic db/db mice[J].MEDIATORS INFLAMM,2016(1405924)
[13] Zhao Y, Chen SJ, Wang JC, Niu HX, Jia QQ, Chen XW, Du XY, Lu L, Huang B, Zhang Q, Chen Y, Long HB(*)(龙海波).Sesquiterpene lactones inhibit advanced oxidation protein products-induced monocyte chemoattractant protein-1 expression in podocytes via an IKK/NF-κB dependent mechanism[J].OXID MED CELL LONGEV,2015(934058).
[14] Wang JC, Zhao Y, Chen SJ, Long J, Jia QQ, Zhai JD, Zhang Q, Chen Y, Long HB(*)(龙海波).AOPPs Induce MCP-1 Expression by Increasing ROS-mediated Activation of the NF-κB Pathway in Rat Mesangial Cells: Inhibition by Sesquiterpene Lactones[J].CELL PHYSIOL BIOCHEM,2013, 32(6):1867-1877.
[15] Jia QQ(#),Wang JC(#), Long J,Zhao Y, Chen SJ, Zhai JD, Wei LB, Zhang Q, Chen Y, Long HB(*)(龙海波).Sesquiterpene Lactones and Their Derivatives Inhibit High Glucose-Induced NF-κB Activation and MCP-1 and TGF-β1 Expression in Rat Mesangial Cells[J].MOLECULES,2013,18(10):13061-13077.