一、基本信息
姓名：蔡道章
职称：主任医师、教授
联系邮箱：daozhang@medmail.com.cn
二、学习经历
1979.9-1984.7 安徽医学院，医疗系专业，学士
1986.9-1989.8 中山大学，临床医学系专业，硕士
1989.9-1991.6 中山大学，临床医学系专业，博士
三、拟招收博士后开展的研究方向
1.骨与软骨退行性变的临床与基础研究
2. 3D打印技术在人工关节置换中的应用研究
3.智慧化医疗的应用研究
四、主要学术任职
1. 中国医师协会运动医疗分会学会，副主任委员；
2. 中国医学会运动医疗分会，委员；
3. SICOT中国部运动医学学会，副主任委员；
4. SICOT中国部关节外科学会，常务委员；
5. 中国医师协会内镜医师分会，常务委员；
6. 中国医师协会内镜医师分会关节镜专业委员会，常务委员；
7. 广东省医学会关节外科学分会，主任委员；
8. 广东省医学会运动医学分会，名誉主任委员；
9. 广东省医学会骨科学分会，副主任委员；
10. 广东省医学会关节外科学分会青年委员会，主任委员；
11. 广东省医学教育协会骨科专业委员会，主任委员；
12. 广东省医院协会临床科主任管理分会，副主任委员；
13. 广东省3D打印产业技术创新联盟，副会长；
14. 广东省临床医学学会，副会长；
15. 广东省医师协会，常务理事
五、主要获奖情况
1. “国之名医卓越建树奖”，2018；
2. 广东省好医生好故事“仁心”奖，2018；
3. 首届“广东医师奖”，2018
4. 全国卫生计生系统先进工作者，2017
5. 岭南名医，2017
6. “天晴杯”广东医院优秀管理干部，2018
7. 广东省抗非英雄，2003
8. 广东省白求恩式先进工作者，2003
六、代表性论文
1. Zhang H#, Lin C#, Zeng C#, Wang Z, Wang H, Lu J, Liu X, Shao Y, Zhao C, Pan J, Xu S, Zhang Y, Xie D, Cai D*, Bai X*. Synovial macrophage M1 polarisation exacerbates experimental osteoarthritis partially through R-spondin-2. Ann Rheum Dis. 2018. Oct; 77(10): 1524-1534.；
2. Lin C#, Liu L#, Zeng C#, Cui ZK, Chen Y, Lai P, Wang H, Shao Y, Zhang H, Zhang R, Zhao C, Fang H, Cai D*, Bai X*. Activation of mTORC1 in subchondral bone preosteoblasts promotes osteoarthritis by stimulating bone sclerosis and secretion of CXCL12. Bone Res. 2019 Feb 20;7:5.；
3. Zhang H#, Wang H#, Zeng C#, Yan B, Ouyang J, Liu X, Sun Q, Zhao C, Fang H, Pan J, Xie D, Yang J, Zhang T, Bai X*, Cai D*. mTORC1 activation downregulates FGFR3 and PTH/PTHrP receptor in articular chondrocytes to initiate osteoarthritis. Osteoarthritis Cartilage. 2017 Jun; 25(6):952-963.；
4. Liu X#, Liu L, Zhang H, Shao Y, Chen Z, Feng X, Fang H, Zhao C, Pan J, Zhang H*, Zeng C*, Cai D*. MiR-146b accelerates osteoarthritis progression by targeting alpha-2-macroglobulin. Aging (Albany NY). 2019 Aug 17;11. doi: 10.18632/aging.102160.
5. Lin C#, Shao Y#, Zeng C, Zhao C, Fang H, Wang L, Pan J, Liu L, Qi W, Feng X, Qiu H, Zhang H, Chen Y, Wang H, Cai D*, Xian CJ. Blocking PI3K/AKT signaling inhibits bone sclerosis in subchondral bone and attenuates post-traumatic osteoarthritis. J Cell Physiol. 2018 Aug;233(8):6135-6147.
6. Wang H#, Zhang H#, Sun Q, Wang Y, Yang J, Zhang T, Luo S, Wang L, Jiang Y, Zeng C*, Cai D*, Bai X*. Intra-articular delivery of antago-miR-483-5p Inhibits Osteoarthritis by Modulating Matrilin-3 and Tissue Inhibitor of Metalloproteinase-2. Mol Ther. 2017 Mar 1; 25(3):715-727.
7. Lu J#, Zhang H#, Cai D#, Zeng C, Lai P, Shao Y, Fang H, Li D, Ouyang J, Huang B, Zhao C, Xie D, Yang J, Jiang Y, Bai X*. Positive-feedback regulation of subchondral H-type vessel formation by chondrocyte promotes osteoarthritis development in mice. J Bone Miner Res. 2018 May; 33(5): 909-920.
8. Wang H#, Zhang H#, Sun Q, Yang J, Zeng C, Ding C, Cai D, Liu A, Bai X*. Chondrocyte mTORC1 activation stimulates miR-483-5p Via HDAC4 in osteoarthritis progression. J Cell Physiol. 2019 Mar;234(3):2730-2740.
9. Lin XC#, Liu X#, Li K, Zhao C, Xu S, Zhang Y, Bai XC, Cai DZ*. B-cell-specific mammalian target of rapamycin complex 1 activation results in severe osteoarthritis in mice. Int Immunopharmacol. 2018 Dec;65:522-530.
10. Zhao C, Shao Y, Lin C, Zeng C, Fang H, Pan J, Cai D*. Myostatin serum concentrations are correlated with the severity of knee osteoarthritis. J Clin Lab Anal. 2017 Sep;31(5) doi: 10.1002/jcla.22094.
11. Zhao C, Lin C, Wang W, Zeng C*, Fang H, Pan J, Cai D*. Kinematics of anterior cruciate ligament-deficient knees in a Chinese population during stairascent. J Orthop Surg Res. 2016 Aug 8;11(1):89.
12. Ma ZP, Liao JC, Zhao C, Cai DZ*. Effects of the 1, 4-dihydropyridine L-type calcium channel blocker benidipine on bone marrow stromal cells. Cell Tissue Res. 2015 Aug; 361(2): 467-76.
13. Chen Y#, Zeng C#, Zeng H, Zhang R, Ye Z, Xing B, Hu K, Li M, Cai DZ*. Comparative serum proteome expression of the steroid-induced femoral head osteonecrosis in adults. Exp Ther Med. 2015 Jan;9(1):77-83.
14. Ye Z#, Chen Y#, Zhang R, Dai H, Zeng C, Zeng H, Feng H, Du G, Fang H, Cai D*. c-Jun N-terminal kinase-c-Jun pathway transactivates Bim to promote osteoarthritis. Can J Physiol Pharmacol. 2014; 92(2):132-9.
15. Zhang R#, Fang H#, Chen Y, Shen J, Lu H, Zeng C, Ren J, Zeng H, Li Z, Chen S, Cai D*, Zhao Q. Gene Expression Analyses of Subchondral Bone in Early Experimental Osteoarthritis by Microarray. PLoS One. 2012;7(2):e32356.
16. Huang B#, Wang W#, Li Q#, Wang Z, Yan B, Zhang Z, Wang L, Huang M, Jia C, Lu J, Liu S, Chen H, Li M, Cai D, Jiang Y, Jin D*, Bai X*. Osteoblasts secrete Cxcl9 to regulate angiogenesis in bone. Nat Commun. 2016 Dec 14; 7: 13885.
17. Yan B#, Zhang Z#, Jin D, Cai C, Jia C, Liu W, Wang T, Li S, Zhang H, Huang B, Lai P, Wang H, Liu A, Zeng C, Cai D, Jiang Y, Bai X*. mTORC1 regulates PTHrP to coordinate chondrocyte growth, proliferation and differentiation. Nat Commun. 2016 Apr 4; 7: 11151.
18. Huang B#, Wang Y, Wang W, Chen J, Lai P, Liu Z, Yan B, Xu S, Zhang Z, Zeng C, Rong L, Liu B, Cai D, Jin D, Bai X*. mTORC1 Prevents Preosteoblast Differentiation through the Notch Signaling Pathway. PLoS Genet. 2015 Aug 4;11(8):e1005426.
19. Xiao CY, Pan YF, Guo XH, Wu YQ, Gu JR, Cai DZ. Expression of β-catenin in rheumatoid arthritis fibroblast-like synoviocytes[Article]. Scand J Rheumatol. 2011 Jan;40(1):26-33.
20. Gao W#, Zeng C#, Cai D*, Liu B, Li Y, Wen X, Chen Y. Serum concentrations of s elected endogenous estrogen and estrogen metabolites in pre- and post-menopau sal Chinese women with osteoarthritis. J Endocrinol Invest. 2010 Oct;33(9):644-9.
21. Shi DH, Qi JA, Li DH, Zhu L, Jin WT, Cai DZ. Fingertip replantation at or beyond the nail base in children. Microsurgery 2010; 30 (5): 380-85.
22. Wang K, Zhu L, Cai D, Zeng C, Lu H, Xu G, Guo X, Lin S, Cheng S. Artificial biological ligament: its making, testing, and experimental study on animals. Microsurgery. 2008;28(1):44-53.
23. Cai DZ, Zeng C, Quan DP, Bu LS, Wang K, Lu HD, Li XF. Biodegradable chitosan scaffolds containing microspheres as carriers for controlled transforming growth factor-beta1 delivery for cartilage tissue engineering. Chin Med J (Engl). 2007 Feb 5;120(3):197-203.
24. Cai DZ, Zeng C, Quan DP, Bu LS, Wang K, Lu HD, Li XF. Biodegradable chitosan scaffolds containing microspheres as carriers for controlled transforming growth factor-β1 delivery for cartilage tissue engineering. Chinese Medical Journal (Engl). 2007 Feb 5;120(3):197-203.
25. Tan X, Cai D, Wu Y, Liu B, Rong L, Chen Z, Zhao Q. Comparative analysis of serum proteomes: discovery of proteins associated with osteonecrosis of the femoral head. Transl Res. 2006 Sep;148(3):114-9.
26. Shi DH, Cai DZ, Zhou CR, Rong LM, Wang K, Xu YC. Development and potential of a biomimetic chitosan/type II collagen scaffold for cartilage tissue engineering. Chin Med J (Engl). 2005 Sep 5;118(17):1436-43.
27. Cai D, Marty-Roix R, Hsu HP, Spector M. Lapine and Canine Bone Marrow Stromal Cells Contain Smooth Muscle Actin and Contract a Collagen-Glycosaminoglycan Matrix Tissue engineering, 2001, Dec;7(6): 829-8412.
