蔡道章教授

【 发布日期: 11-21 】 【 浏览次数: 】 【 作者: 】

 

 

 

一、基本信息

姓名:蔡道章                                

职称:主任医师、教授

联系邮箱:daozhang@medmail.com.cn

 

二、学习经历

1979.9-1984.7    安徽医学院,医疗系专业,学士

1986.9-1989.8   中山大学,临床医学系专业,硕士

1989.9-1991.6   中山大学,临床医学系专业,博士

 

三、拟招收博士后开展的研究方向

1.骨与软骨退行性变的临床与基础研究

2. 3D打印技术在人工关节置换中的应用研究

3.智慧化医疗的应用研究

 

四、主要学术任职

1. 中国医师协会运动医疗分会学会,副主任委员;

2. 中国医学会运动医疗分会,委员;

3. SICOT中国部运动医学学会,副主任委员;

4. SICOT中国部关节外科学会,常务委员;

5. 中国医师协会内镜医师分会,常务委员;

6. 中国医师协会内镜医师分会关节镜专业委员会,常务委员;

7. 广东省医学会关节外科学分会,主任委员;

8. 广东省医学会运动医学分会,名誉主任委员;

9. 广东省医学会骨科学分会,副主任委员;

10. 广东省医学会关节外科学分会青年委员会,主任委员;

11. 广东省医学教育协会骨科专业委员会,主任委员;

12. 广东省医院协会临床科主任管理分会,副主任委员;

13. 广东省3D打印产业技术创新联盟,副会长;

14. 广东省临床医学学会,副会长;

15. 广东省医师协会,常务理事

 

五、主要获奖情况

1. “国之名医卓越建树奖”,2018

2. 广东省好医生好故事“仁心”奖,2018

3. 首届“广东医师奖”,2018

4. 全国卫生计生系统先进工作者,2017

5. 岭南名医,2017

6. 天晴杯广东医院优秀管理干部,2018

7. 广东省抗非英雄,2003

8. 广东省白求恩式先进工作者,2003

 

六、代表性论文

1. Zhang H#, Lin C#, Zeng C#, Wang Z, Wang H, Lu J, Liu X, Shao Y, Zhao C, Pan J, Xu S, Zhang Y, Xie D, Cai D*, Bai X*. Synovial macrophage M1 polarisation exacerbates experimental osteoarthritis partially through R-spondin-2. Ann Rheum Dis. 2018. Oct; 77(10): 1524-1534.;

2. Lin C#, Liu L#, Zeng C#, Cui ZK, Chen Y, Lai P, Wang H, Shao Y, Zhang H, Zhang R, Zhao C, Fang H, Cai D*, Bai X*. Activation of mTORC1 in subchondral bone preosteoblasts promotes osteoarthritis by stimulating bone sclerosis and secretion of CXCL12. Bone Res. 2019 Feb 20;7:5.;

3. Zhang H#, Wang H#, Zeng C#, Yan B, Ouyang J, Liu X, Sun Q, Zhao C, Fang H, Pan J, Xie D, Yang J, Zhang T, Bai X*, Cai D*. mTORC1 activation downregulates FGFR3 and PTH/PTHrP receptor in articular chondrocytes to initiate osteoarthritis. Osteoarthritis Cartilage. 2017 Jun; 25(6):952-963.;

4. Liu X#, Liu L, Zhang H, Shao Y, Chen Z, Feng X, Fang H, Zhao C, Pan J, Zhang H*, Zeng C*, Cai D*. MiR-146b accelerates osteoarthritis progression by targeting alpha-2-macroglobulin. Aging (Albany NY). 2019 Aug 17;11. doi: 10.18632/aging.102160.

5. Lin C#, Shao Y#, Zeng C, Zhao C, Fang H, Wang L, Pan J, Liu L, Qi W, Feng X, Qiu H, Zhang H, Chen Y, Wang H, Cai D*, Xian CJ. Blocking PI3K/AKT signaling inhibits bone sclerosis in subchondral bone and attenuates post-traumatic osteoarthritis. J Cell Physiol. 2018 Aug;233(8):6135-6147.

6. Wang H#, Zhang H#, Sun Q, Wang Y, Yang J, Zhang T, Luo S, Wang L, Jiang Y, Zeng C*, Cai D*, Bai X*. Intra-articular delivery of antago-miR-483-5p Inhibits Osteoarthritis by Modulating Matrilin-3 and Tissue Inhibitor of Metalloproteinase-2. Mol Ther. 2017 Mar 1; 25(3):715-727.

7. Lu J#, Zhang H#, Cai D#, Zeng C, Lai P, Shao Y, Fang H, Li D, Ouyang J, Huang B, Zhao C, Xie D, Yang J, Jiang Y, Bai X*. Positive-feedback regulation of subchondral H-type vessel formation by chondrocyte promotes osteoarthritis development in mice. J Bone Miner Res. 2018 May; 33(5): 909-920.

8. Wang H#, Zhang H#, Sun Q, Yang J, Zeng C, Ding C, Cai D, Liu A, Bai X*. Chondrocyte mTORC1 activation stimulates miR-483-5p Via HDAC4 in osteoarthritis progression. J Cell Physiol. 2019 Mar;234(3):2730-2740.

9. Lin XC#, Liu X#, Li K, Zhao C, Xu S, Zhang Y, Bai XC, Cai DZ*. B-cell-specific mammalian target of rapamycin complex 1 activation results in severe osteoarthritis in mice. Int Immunopharmacol. 2018 Dec;65:522-530.

10. Zhao C, Shao Y, Lin C, Zeng C, Fang H, Pan J, Cai D*. Myostatin serum concentrations are correlated with the severity of knee osteoarthritis. J Clin Lab Anal. 2017 Sep;31(5) doi: 10.1002/jcla.22094.

11. Zhao C, Lin C, Wang W, Zeng C*, Fang H, Pan J, Cai D*. Kinematics of anterior cruciate ligament-deficient knees in a Chinese population during stairascent. J Orthop Surg Res. 2016 Aug 8;11(1):89.

12. Ma ZP, Liao JC, Zhao C, Cai DZ*. Effects of the 1, 4-dihydropyridine L-type calcium channel blocker benidipine on bone marrow stromal cells. Cell Tissue Res. 2015 Aug; 361(2): 467-76.

13. Chen Y#, Zeng C#, Zeng H, Zhang R, Ye Z, Xing B, Hu K, Li M, Cai DZ*. Comparative serum proteome expression of the steroid-induced femoral head osteonecrosis in adults. Exp Ther Med. 2015 Jan;9(1):77-83.

14. Ye Z#, Chen Y#, Zhang R, Dai H, Zeng C, Zeng H, Feng H, Du G, Fang H, Cai D*. c-Jun N-terminal kinase-c-Jun pathway transactivates Bim to promote osteoarthritis. Can J Physiol Pharmacol. 2014; 92(2):132-9.

15. Zhang R#, Fang H#, Chen Y, Shen J, Lu H, Zeng C, Ren J, Zeng H, Li Z, Chen S, Cai D*, Zhao Q. Gene Expression Analyses of Subchondral Bone in Early Experimental Osteoarthritis by Microarray. PLoS One. 2012;7(2):e32356.

16. Huang B#, Wang W#, Li Q#, Wang Z, Yan B, Zhang Z, Wang L, Huang M, Jia C, Lu J, Liu S, Chen H, Li M, Cai D, Jiang Y, Jin D*, Bai X*. Osteoblasts secrete Cxcl9 to regulate angiogenesis in bone. Nat Commun. 2016 Dec 14; 7: 13885.

17. Yan B#, Zhang Z#, Jin D, Cai C, Jia C, Liu W, Wang T, Li S, Zhang H, Huang B, Lai P, Wang H, Liu A, Zeng C, Cai D, Jiang Y, Bai X*. mTORC1 regulates PTHrP to coordinate chondrocyte growth, proliferation and differentiation. Nat Commun. 2016 Apr 4; 7: 11151.

18. Huang B#, Wang Y, Wang W, Chen J, Lai P, Liu Z, Yan B, Xu S, Zhang Z, Zeng C, Rong L, Liu B, Cai D, Jin D, Bai X*. mTORC1 Prevents Preosteoblast Differentiation through the Notch Signaling Pathway. PLoS Genet. 2015 Aug 4;11(8):e1005426.

19. Xiao CY, Pan YF, Guo XH, Wu YQ, Gu JR, Cai DZ. Expression of β-catenin in rheumatoid arthritis fibroblast-like synoviocytes[Article]. Scand J Rheumatol. 2011 Jan;40(1):26-33.

20. Gao W#, Zeng C#, Cai D*, Liu B, Li Y, Wen X, Chen Y. Serum concentrations of s elected endogenous estrogen and estrogen metabolites in pre- and post-menopau sal Chinese women with osteoarthritis. J Endocrinol Invest. 2010 Oct;33(9):644-9.

21. Shi DH, Qi JA, Li DH, Zhu L, Jin WT, Cai DZ. Fingertip replantation at or beyond the nail base in children. Microsurgery 2010; 30 (5): 380-85.

22. Wang K, Zhu L, Cai D, Zeng C, Lu H, Xu G, Guo X, Lin S, Cheng S. Artificial biological ligament: its making, testing, and experimental study on animals. Microsurgery. 2008;28(1):44-53.

23. Cai DZ, Zeng C, Quan DP, Bu LS, Wang K, Lu HD, Li XF. Biodegradable chitosan scaffolds containing microspheres as carriers for controlled transforming growth factor-beta1 delivery for cartilage tissue engineering. Chin Med J (Engl). 2007 Feb 5;120(3):197-203.

24. Cai DZ, Zeng C, Quan DP, Bu LS, Wang K, Lu HD, Li XF. Biodegradable chitosan scaffolds containing microspheres as carriers for controlled transforming growth factor-β1 delivery for cartilage tissue engineering. Chinese Medical Journal (Engl). 2007 Feb 5;120(3):197-203.

25. Tan X, Cai D, Wu Y, Liu B, Rong L, Chen Z, Zhao Q. Comparative analysis of serum proteomes: discovery of proteins associated with osteonecrosis of the femoral head. Transl Res. 2006 Sep;148(3):114-9.

26. Shi DH, Cai DZ, Zhou CR, Rong LM, Wang K, Xu YC. Development and potential of a biomimetic chitosan/type II collagen scaffold for cartilage tissue engineering. Chin Med J (Engl). 2005 Sep 5;118(17):1436-43.

27. Cai D, Marty-Roix R, Hsu HP, Spector M. Lapine and Canine Bone Marrow Stromal Cells Contain Smooth Muscle Actin and Contract a Collagen-Glycosaminoglycan Matrix Tissue engineering, 2001, Dec;7(6): 829-8412.