一、基本信息

姓名：李祖国                      

职称：教授

联系邮箱：lizg@smu.edu.cn

 

二、学习经历

1983.9-1986.7  衡阳医学院零陵分院医疗专业，学士

1994.9-1997.7  第一军医大学，病理学专业，硕士

2003.9-2006.7  第一军医大学，病理学专业，博士

2008.9-2010.5  美国乔治城大学，博士后

 

三、拟招收博士后开展的研究方向

1. 肿瘤免疫逃逸机制；

2. 肿瘤转移机制

 

四、主要学术任职

1. 广东省医师协会病理学分会，常务委员

2. 深圳市医学会病理学分会，副主任委员

3. 深圳市医师协会学会病理学分会，副主任委员

 

五、主要获奖情况

国家科技进步奖 二等奖一项，中华人民共和国国务院，2003

 

六、代表性论文

1. Xu C, Yang MH, Tian J, Wang XY,Li ZG (Corresponding author). MALAT-1: A long non-coding RNA and its important function motif of the 3’ end in colorectal cancer metastasis. Int J Oncol； 2011， 39: 169-175.

2. Huang WY, Li ZG, Rus H, Wang X, Jose PA, Chen SY. RGC-32 mediates transforming growth factor-beta-induced epithelial-mesenchymal transition in human renal proximal tubular cells. J Biol Chem. 2009 Apr 3;284 (14): 9426-32.(IF:4.6)

3. Xie WB, Li ZG, Miano JM, Long XC, Chen SY.Smad3-mediated Myocardin Silencing A Novel Mechanism Governing the Initiation of Smooth Muscle Differentiation  J Biol Chem. 2011 Apr 29;286 (7): 15050-57. (IF:4.6)

4. Li ZG, Xie WB, Escano CS, Asico LD, Xie Q, Jose PA, Chen SY.Response gene to complement 32 is essential for fibroblast activation in renal fibrosis。J Biol Chem. 2011 Dec 2;286 (48): 41323-30. 

5. Li ZG, Wang XY, Chang JL, Xie WB, Liu TF, Deng YJ, Ding YQ. The establishment of supramolecular immunobead real-time PCR and the identification of Cox-2 as a metastasis-related marker in colorectal carcinoma. Oncol Rep. 2012 Sep; 28(3):977-84.  

6. Wei-Bing Xie, Zuguo Li(Co-first author), Ning Shi, Xia Guo, Junming Tang, Wenjun Ju, Jun Han, Tengfei Liu, Erwin，P. Bottinger, Yang Chai, Pedro A. Jose, Shi-You Chen. Smad2 and MRTFB Cooperatively Regulate Vascular Smooth Muscle Differentiation from Neural Crest Cells. Circulation Research. 2013Sep; 113(8):1-22. e76-e86. 

7.  Xie LY, Hu Zhiyan, Wang XY, Li ZG(Corresponding author). Expression of long noncoding RNA MALAT1 gene in human nasopharyngeal carcinoma cell lines and its biological significance. J South Med Univ, 2013,33(5):692-697 

8. Min-Hui Yang , Zhi-Yan Hu,Chuan Xu, Lin-Ying Xie, Xiao-YanWang, Shi-You Chen , Zu-Guo Li(Corresponding author). MALAT1 promotes colorectal cancer cell proliferation/migration invasion via PRKA kinase anchor protein 9. Biochimica et Biophysica Acta-Molecular Basis of Disease. 2015 Jan; 1852(1): 166–174 

9. Fang Yang, Tengfei Liu,  Haiyan Zhao,  Zhiyan Hu, Liwei Xiao, Yanping Liu,  Xiaoyan Wang, Zuguo Li (Corresponding author).Indolent T-lymphblastic proliferation: report of a case involving the upper aerodigestive tract. Int J Clin Exp Pathol. 2014;7(9):6350-6356。

10. Zhi-Yan Hu, Wei-Bing Xie , Fang Yang, Li-Wei Xiao, Xiao-Yan Wang, Shi-You Chen,  Zu-Guo Li(Corresponding author). NDRG1 attenuates epithelial-mesenchymal transition of nasopharyngeal cancer cells via blocking Smad2 signaling. Biochimica et Biophysica Acta-Molecular Basis of Disease.2015 Sep;1852(9):1876-86.

11. Zhi-Yan Hu, Xiao-Yan Wang, Wen-bin Guo, Lin-Ying Xie, Yu-qi Huang,Yan-Ping Liu, Li-Wei Xiao, Sheng-Nan Li, Hui-Fang Zhu, Zu-Guo Li( Co-corresponding author) , Heping Kan. Long non-coding RNA MALAT1 increases AKAP-9 expression by promoting SRPK1-catalyzed SRSF1 phosphorylation in colorectal cancer cells. Oncotarget. 2016 Feb;7(10):11733-11743. Received: September 24, 2015 Accepted: January 23, 2016 Published: February 13, 2016 

12. Zhi-Yan Hu ,Yan-Ping Liu, Lin-Ying Xie, Xiao-YanWang, Fang Yang,,Shi-You Chen, Zu-Guo Li(Corresponding author). AKAP-9 promotes colorectal cancer development by regulating Cdc42 interacting protein 4. Biochimica et Biophysica Acta-Molecular Basis of Disease.2016 April;1862(6):1172-81.  

13. Yan-Ping Liu，Hui-Fang Zhu，Ding-li Liu，Zhi-Yan Hu，Sheng-Nan Li，He-Ping Kan，Xiao-Yan Wang，Zu-Guo L(Corresponding author). DcR3 induces epithelial-mesenchymal transition through activation of the TGF-β3/SMAD signaling pathway in CRC. Oncotarget. 2016 October;10(47):77306-77318. Received: May 30, 2016 Accepted: September 28, 2016. October 13, 2016  

14. Xiao-yan Wang, Shen-nan Li, Jie-Tian, Teng-fei Liu, Zu-guo Li(Corresponding author).RGC32 induces epithelial transition by activating the Samd/Sip1 signaling pathway in CRC. Scientific Reports. 2017 May 4;7:46078. doi: 10.1038/srep46078.）

15. Chuan-sha Gu,Xiao-yan Wang ,Ting Long,Xia Wang, Yan Zhong, Yidan Ma, Zhi-yan Hu, Zu-guo Li(Corresponding author). FSTL1 interacts with VIM and promotes colorectal cancer metastasis via activating, the focal adhesion signalling pathway. Cell Death & Disease. 2018 may 29;9(6):654  (1-14). Received: 3 January 2018 Revised: 30 April 2018 Accepted: 10 May 2018 published online: 29 May 2018      

16. Hui-Fang Zhu, Xu-Hui Zhang,Chuan-Sha Gu,Yan Zhong,Ting Long,Yi-Dan Ma,Zhi-Yan Hu,Zu-Guo Li(Corresponding author),Xiao-Yan Wang (Corresponding author). Cancer-associated fibroblasts promote colorectal cancer progression by secreting CLEC3B. Cancer Biol THer. 2019 may 20:1-12.  doi: 10.1080/15384047.2019.1591122. [Epub ahead of print]  Received 26 Oct 2018, Accepted 23 Feb 2019, Published online: 20 Mar 2019   

17. Hui-fang Zhu, Yan-ping Liu , Ding-li Liu , Yi-dan Ma , Zhi-yan Hu , Xiao-yan Wang , Chuan-sha Gu, Yan Zhong , Ting Long , He-ping Kan, Zu-guo Li(Corresponding author). Role of TGFβ3-Smads-Sp1 axis in DcR3-mediated immune escape of hepatocellular carcinoma. Oncogenesis. 2019 Aug; 8(8): 43.