一、基本信息
姓名:瞿少刚
职称:教授
联系邮箱:sgq9528@163.com
二、学习经历
1990.9-1995.6 湖北医科大学(现武汉大学医学院),临床医学专业,学士
2002.9-2005.6 武汉大学医学院,免疫学专业,硕士
2006.12-2010.12 以色列希伯来大学,生物化学与分子生物学专业,博士
三、拟招收博士后开展的研究方向
神经退行性疾病发病机制及防治
四、主要学术任职
1. 中国医药生物技术协会生物诊断技术分会委员会,委员;
2. 广东省医学教育协会生物化学与分子生物学专业委员会,副主任委员;
3. 广东省老年保健协会神经系统疑难疾病专业委员会,副主任委员;
4. 广东省中西医结合学会帕金森病及运动障碍专业委员会,常委;
5. 广东省卒中学会卒中后认知障碍分会,常委;
6. 广东省医学会临床输血学分会,委员;
7. 广东省医学会医学科研实验室建设与管理学分会,委员
五、主要获奖情况
广东省海外高层次留学人才,广东省外国专家局,2011
六、代表性论文
1.Qu S*, Meng X, Liu Y, Zhang X, Zhang Y*. Ginsenoside Rb1 prevents MPTP-induced changes in hippocampal memory via regulation of the α-synuclein/PSD-95 pathway. Aging (Albany NY). 2019 Apr 4;11(7):1934-1964. doi: 10.18632/aging.101884. (第一作者兼共同通讯作者,IF: 5.1);
2.Qu S*, Zhang W, He S, Zhang X. Paired-cysteine scanning reveals conformationally sensitive proximity between the TM4b-4c loop and transmembrane domain 8 of the glutamate transporter EAAT1.ACS Chem Neurosci.2019 May 15;10(5):2541-2550. doi: 10.1021/acschemneuro.9b00048. (第一作者兼通讯作者,IF: 4.2);
3. Wu X#, Meng X#, Tan F#, Jiao Z, Zhang X, Tong H, He X, Luo X*, Xu P*,Qu S*. Regulatory Mechanism of miR-543-3p on GLT-1 in a Mouse Model of Parkinson's Disease.ACS Chem Neurosci.2019;10(3):1791-1800.(*通讯作者,IF: 4.2);
4. Zhang W, Zhang X, Qu S*. Substrate-Induced Motion between TM4 and TM7 of the Glutamate Transporter EAAT1 Revealed by Paired Cysteine Mutagenesis. Mol Pharmacol.2019;95(1):33-42.(*通讯作者,IF: 3.9);
5. Tong H, Zhang X, Meng X, Lu L, Mai D, Qu S*. Simvastatin Inhibits Activation of NADPH Oxidase/p38 MAPK Pathway and Enhances Expression of Antioxidant Protein in Parkinson Disease Models.Front Mol Neurosci.2018;11:165. (*通讯作者,IF=3.9);
6. Zhang W, Zhang X,Qu S*. Cysteine Scanning Mutagenesis of TM4b-4c Loop of Glutamate Transporter EAAT1 Reveals Three Conformationally Sensitive Residues.Mol Pharmacol. 2018;94(1):713-721. (*通讯作者,IF=3.9);
7. Lu L, Zhang X, Tong H, Zhang W, Xu P* and Qu S*. Central administration of 5Z-7-oxozeaenol protects experimental autoimmune encephalomyelitis mice by inhibiting microglia activation.Frontiers in Pharmacology. 2017; 8:789. (*共同通讯作者,IF=3.8);
8. Zhang Y#, He X#, Wu X, Lei M, Wei Z, Zhang X, Wen L, Xu P*, Li S*, and Qu S*.Rapamycinupregulates glutamate transporter and IL-6 expression in astrocytes in a mouse model of Parkinson’s disease.Cell Death and Disease 2017;8(2):e2611. (共同通讯作者,IF=5.6);
9. Zhang Y, He X, Meng X, Wu X, Tong H, Zhang X and Qu S*. Regulation of glutamate transporter trafficking by Nedd4-2 in a Parkinson’s disease model.Cell Death and Disease2017;8(2):e2574. (通讯作者,IF=5.6);
10. Tong H#, Zhang X#, Meng X, Xu P*, Zou X* and Qu S*. Amyloid-beta peptide decreases expression and function of glutamate transporters in nervous system cells.The International Journal of Biochemistry & Cell Biology.2017, 85:75-84.(*共同通讯作者,IF=3.2);
11. Zhang Y, Zhang X, and Qu S*.Ceftriaxone Protects Astrocytes from MPP+ Neurotoxicity via Suppression of NF-κB/JNK/c-Jun Signaling.Molecular Neurobiology 2015;52(1):78-92. (*通讯作者,IF=5.3);
12. Rong X, Zhang X, andQu S*.A complex relative motion between HP2 and TM5 in the glutamate transporter GLT-1.The International Journal of Biochemistry & Cell Biology.2015;60:1-7. (*通讯作者,IF=3.9);
13. Rong X, Zomot Elia, Zhang X, andQu S*.Investigating substrate-induced motion between the scaffold and transport domains in the glutamate transporter EAAT1. Mol Pharmacol 2014;86(6):657-664.(*通讯作者,IF=4.1);
14. Crisman T#, Qu S#, Kanner BI, Forrest L*. Inward-facing conformation of glutamate transporters as revealed by their inverted-topology structural repeats.Proc Natl Acad Sci U S A.2009; 106(49):20752-757.(#共同第一作者,IF=9.4);
15. Teichman S#, Qu S#, Kanner BI*. The equivalent of a thallium binding residue from an archeal homolog controls cation interactions in brain glutamate transporters.Proc Natl Acad Sci U S A. 2009;106(34):14297-302.(#共同第一作者,IF=9.4);
16. Qu S, Kanner BI*.Substrates and non-transportable analogues induce structural rearrangements at the extracellular entrance of the glial glutamate transporter GLT-1/EAAT2.J Biol Chem.2008;283(39):26391-400. (第一作者,IF=5.5);