一、基本信息
姓名：刘志刚
职称：主任医师
联系邮箱：Zhigangliu1983@hotmail.com
二、学习经历
2006.9-2011.6 中山大学肿瘤防治中心，肿瘤学，博士（硕博连读）
2009.6-2011.4 美国贝勒医学院，分子肿瘤学，联合培养博士
三、拟招收博士后开展的研究方向
1. 硼中子俘获抗脑胶质瘤/头颈部肿瘤治疗转化研究；
2. 肿瘤辐射抗拒机制及逆转，正常组织放射防护。
3. 新型材料在抗肿瘤中的应用。
四、主要学术任职
1. 中华医学会肿瘤学分会第十一届委员会全国青年委员；
2. 中国抗癌协会神经肿瘤专业委员会委员；
3. 广东省抗癌协会鼻咽癌专业委员会青委副主任委员；
4. 广东省医师协会放射治疗医师委员会头颈肿瘤组副组长。
五、主要获奖情况
广东省杰出青年医学人才
六、代表性论文
1. Liu Z#, Wang Y, Huang Y, Kim BYS, Shan H, Wu D, Jiang W. Tumor Vasculatures: A New Target for Cancer Immunotherapy. Trends Pharmacol Sci. 2019 Sep; 40 (9): 613-623. (IF: 17.64)
2. Zhigang Liu#, Xiumei Zhao, Yue Wang, Hua Mao, Yulun Huang, Mari Kogiso, Lin Qi, Patricia A. Baxter, Tsz-Kwong Man, Adekunle Adesina, Jack M. Su, Daniel Picard, King Ching Ho, Annie Huang, Laszlo Perlaky, Ching C. Lau, Murali Chintagumpala, Xiao-Nan Li. A Patient Tumor-derived Orthotopic Xenograft Mouse Model Replicating the Group 3 Supratentorial Primitive Neuroectodermal Tumor in Children. Neuro Oncol. 2014 Jun;16(6):787-799. （IF: 13.03）
3. Zhigang Liu#, Xiumei Zhao, Hua Mao, Patricia A. Baxter, Yulun Huang, Litian Yu, Lalita Wadhwa, Jack MF Su, Adekunle Adesina, Lazlo Perlaky, Mary Hurwitz, Neeraja Idamakanti, Seshidhar Reddy Police, Paul L. Hallenbeck, Richard L. Hurwitz, Ching C. Lau, Murali Chintagumpala, Susan M. Blaney, Xiao-Nan Li. Intravenous Injection of oncolytic picornavirus SVV-001 prolongs animal survival in a panel of primary tumor-based orthotopic xenograft mouse models of pediatric glioma. Neuro Oncol. 2013 Sep;15(9):1173-1185. （IF: 13.03）
4. Liu Zhigang#, Jiang W, Nam J, Moon JJ, Kim BYS. Immunomodulating Nanomedicine for Cancer Therapy. Nano Lett. 2018 Nov;18(11):6655-6659. （IF: 12.26）
5. Yifan Wang, Zhigang Liu#, Hengfeng Yuan, Weiye Deng, Jing Li, Yuhui Huang, Betty Y.S. Kim, Michael D Story, Wen Jiang. The reciprocity between radiotherapy and cancer immunotherapy. Clinical Cancer Research. 2019 Mar; 25(6):1709-1717. （IF: 13.80）
6. Wei Xu, Hao Liu, Zhi-Gang Liu#, Hong-Sheng Wang, Fan Zhang, Hao Wang, Ji Zhang, Jing-Jing Chen, Hong-Jun Huang, Yuan Tan, Meng-Ting Cao, Jun Du, Qiu-Gui Zhang, Guan-Min Jiang. Histone deacetylase inhibitors upregulate Snail via Smad2/3 phosphorylation and stabilization of Snail to promote metastasis of hepatoma cells. Cancer Lett. 2018 Apr 28; 420:1-13. （IF: 9.76）
7. Yao JJ, Jin YN, Liu ZG#, Liu QD, Pei XF, Zhou HL, Zhang WJ, Zhang F, Lin L, Lawrence WR, Wang SY, Ma J, Zhou GQ, Sun Y. Do all patients with advanced N-stage nasopharyngeal carcinoma benefit from the addition of induction chemotherapy to concurrent chemoradiotherapy? Ther Adv Med Oncol. 2019 Mar; 11:1-14. （IF: 5.49）
8. Ji-Jin Yao, Zhen-Yu Qi, Zhi-Gang Liu#, Guan-Min Jiang, Xi-Wei Xu, Shao-Yi Chen, Feng-Ting Zhu, Wang-Jian Zhang, Wayne R. Lawrence, Jun Ma, Guan-Qun Zhou, Ying Sun. Clinical features and survival outcomes between ascending and descending types of nasopharyngeal carcinoma in the intensity-modulated radiotherapy era: A big-data intelligence platform-based analysis. Radiother Oncol, 2019. 137: p. 137-144. （IF: 6.90）
9. Shunli Peng#, Rong Wang#, Yuling Zhou#, Wei Wei, Guihua Zhong, Xiaotao Huang, Shuai Yang, Qiaodan Liu, Zhigang Liu*. Insight of a metabolic prognostic model to identify tumor environment and drug vulnerability for lung adenocarcinoma. Frontiers in Immunology. 2022 Jun 23;13:872910. (IF=8.79)
10. Li Y, Liao Z, Wang R, Liang Z, Lin Z, Deng S, Chen L, Liu Z*, Feng S. Long non-coding RNA SPRY4-IT1 promotes proliferation and metastasis in nasopharyngeal carcinoma cell. PeerJ. 2022 Mar 30;10:e13221.（IF: 3.06）
11. Zhou YL, Peng YP, Liu QD, Chen XZ, He J, Wei W, Zhong GH, Zhang YQ, Liu Y, Pan JY, Feng SY, Liu ZG*. Clinical Characteristics and Prognosis of Small Cell Carcinoma in the Nasopharynx: A Population-Based Study. Cancer Control. 2022 Jan-Dec;29:10732748221087075. （IF: 2.34）
12. Lei Chen, Yang Yan, Fangen Kong, Jikai Wang, Jia Zeng, Zhen Fang, Zheyan Wang, Zhigang Liu*, Fei Liu. Contribution of Oxidative Stress Induced by Sonodynamic Therapy to the Calcium Homeostasis Imbalance in Glioma Cells. Cancers (Basel). 2022 Apr 18; 14(8):2036. （IF: 6.58）
13. Guihua Zhong#, Wei Wei#, Wei Liao#, Rong Wang, Yingpeng Peng, Yuling Zhou, Xiaotao Huang, Shiping Xian, Shunli Peng, Zhaoyuan Zhang, Shaoyan Feng, Ye Liu, Haiyu Hong, Yunfei Xia, Yan Yan, Qiaodan Liu, and Zhigang Liu*. Tumor Microbiome in Nasopharyngeal Carcinoma and Its Association with Prognosis. Frontiers in Oncology. 2022 May 23;12:859721.（IF: 5.74）
14. Peng Y#, Wang R#, Liu Q#, Xu X, Wei W, Huang X, Peng X, Liu Z*. Combination of TMB and specific gene mutations stratifies outcome to immunotherapy across recurrent and metastatic head and neck squamous cell carcinoma. Frontiers in Genetics. 2021 Nov 16;12.（IF: 4.77）
15. Shuo Li, Peng He, Zhiwei Wang, Meng Liang, Wei Liao, Yili Huang, Mengshi Chi, Fei Liu, Nan Zen, Rongfei Su, Shulin Chen, Zhigang Liu*, Haiyu Hong. RNAi-mediated knockdown of PFK1 decreases the invasive capability and metastasis of nasopharyngeal carcinoma cell line, CNE-2. Cell Cycle. 2021; 20(2): 154–165（IF: 5.17）
16. Peng Y#, Liu Q#, Lin Y#, Peng S, Wang R, Xu X, Wei W, Zhong G, Zhou Y, Zhang Y, Liu Y, Wang S, Hong H*, Liu Z*. Pathological and genomic phenotype of second neuroendocrine carcinoma during long-term follow-up after radical radiotherapy for nasopharyngeal carcinoma. Radiat Oncol. 2021 Oct 11;16(1):198.（IF: 4.31）
17. Deng Z, Liao W, Wei W, Zhong G, He C, Zhang H, Liu Q, Xu X, Liang J, Liu Z*. Anlotinib as a promising inhibitor on tumor growth of oral squamous cell carcinoma through cell apoptosis and mitotic catastrophe. Cancer Cell Int. 2021 Jan 9; 21(1):37. （IF: 6.43）
18. Wei Wei, Hao Jiang, Weipeng Chen, Yuling Zhou, Shuanshuan Guo, Guihua Zhong, Huaili Zhou, Siyang Wang, Hongyu Zhang, Wen Jiang, Zhi-Gang Liu*. How should we implement radiotherapy for cancer patients in China during the endemic period of COVID-19? Radiother Oncol. 2020 Jun; 147:100-102. （IF: 6.90）
19. Liang Jun, Liu Jingang, Deng Zhaoming, Liu Zhigang*, Liang Lizhong*. DLX6 promotes cell proliferation and survival in oral squamous cell carcinoma. Oral Diseases. 2022 Jan;28(1):87-96.（IF: 3.5）
20. Zhi-Gang Liu#*, Jiao Tang, Zhenghu Chen, Huiyuan Zhang, Hui Wang, Jianhua Yang, Hong Zhang. The novel mTORC1/2 dual inhibitor INK128 enhance radiosensitivity of breast cancer cell line MCF-7. International Journal of Oncology. 2016 Sep ;49(3):1039-1045. （IF: 5.88）
