成红

姓名：成红

职称：教授

联系邮箱：chengh@smu.edu.cn

学习经历（学士、硕士、博士）：

2008.09-2012.06 中南大学，应用化学，学士

2012.09-2017.06 武汉大学，高分子化学与物理，博士

工作经历：

2017.07-2022.01 南方医科大学生物医学工程学院，副教授

2022.01-至今    南方医科大学生物医学工程学院，教授

研究方向：

癌症由于其难以治愈、易转移复发、死亡率高等特点，已经成为威胁人类生命健康的主要疾病之一。但传统肿瘤治疗方式在实际应用过程中面临着诸多问题，如何将药物安全有效地递送至病灶部位，在提高药效的同时降低其对正常组织的毒副作用，一直是该领域研究人员致力于解决的关键问题之一。基于此，我们长期关注生物医用材料应用于肿瘤诊断和治疗的相关研究及动态，通过结合材料科学、生命科学、医学等学科，开发了一系列适应于肿瘤微环境的多功能药物载体，实现药物的可控释放，用于肿瘤的靶向治疗。

主要科研课题：

1、国家自然科学基金-面上项目,《用于原发瘤和转移瘤精准协同治疗的靶向纳米级联药物的研究》（52073140）,主持，2021.01-2024.12；

2、国家自然科学基金-青年项目,《肿瘤微环境响应逐级靶向型光控释金属有机框架纳米药物的构建及生物医学应用》（51803086）,主持，2019.01-2021.12；

3、广东省自然科学基金-博士启动纵向协同项目,《肿瘤微酸环境响应型光控释纳米药物载体的构建及其在肿瘤精准治疗中的研究》（2018030310283）,主持，2018.01-2021.04；

4、广东省普通高校特色创新项目,《双靶向自传递嵌合肽的制备及生物医学应用》,主持，2019.01-2020.12；

5、广州市科技计划-一般项目，《光控细胞核靶向自传递纳米药物用于肿瘤精准协同治疗》（202002030178），主持，2020.04-2023.03；

6、南方医科大学优青培育计划，《用于肿瘤靶向精准治疗的多功能生物医用材料》 （G619309590），主持，2020. 01-2021. 12。

代表性论文：

(1) Linping Zhao ^#, Rongrong Zheng ^#, Jiaqi Huang, Xiayun Chen, Fuan Deng, Yibin Liu, Chuyu Huang, Xiyong Yu, Hong Cheng*, Shiying Li*, Self-delivery photo-immune stimulators for photodynamic sensitized tumor immunotherapy, ACS Nano, 2020, doi: org/10.1021/acsnano.0c06765.

(2) Linping Zhao #, Rongrong Zheng #, Huaqing Chen, Lingshan Liu, Xiaoya Zhao, Houhe Liu, Xiaozhong Qiu, Xiyong Yu*, Hong Cheng*, Shiying Li*, Self-delivery nanomedicine for O2-economized photodynamic tumor therapy. Nano Letters, 2020, 20, 2062-2071.

(3) Ping Yuan, Guiling Fan, Linping Zhao, Lingshan Liu, Fuan Deng, Xueyan Jiang, Aihua Hu, Xiyong Yu, Ali Chen*, Hong Cheng*, Shiying Li*, Tumor targeted self-synergistic nanoplatforms for arsenic-sensitized photodynamic therapy, Acta Biomaterialia, 2020, 117, 349-360.

(4) Hong Cheng #, Guiling Fan#, Jinghao Fan, Ping Yuan, Fuan Deng, Xiaozhong Qiu, Xiyong Yu, Shiying Li*, Epigenetics-inspired photosensitizer modification for plasma membrane-targeted photodynamic tumor therapy. Biomaterials, 2019, 224, 119497.

(5) Hong Cheng#, Jinghao Fan#, Linping Zhao, Guiling Fan, Rongrong Zheng, Xiaozhong Qiu, Xiyong Yu*, Shiying Li*, Xianzheng Zhang, Chimeric peptide engineered exosomes for dual-stage light guided plasma membrane and nucleus targeted photodynamic therapy, Biomaterials, 2019, 211, 14-24.

(6) Hong Cheng*, Xueyan Jiang, Rongrong Zheng, Shengjia Zuo, Linping Zhao, Guiling Fan, Boru Xie, Xiyong Yu, Shiying Li*, Xianzheng Zhang, A biomimetic cascade nanoreactor for tumor targeted starvation therapy amplified chemotherapy, Biomaterials, 2019, 195, 75-85.

(7) Hong Cheng#, Rongrong Zheng#, Guiling Fan, Jinghao Fan, Linping Zhao, Xueyan Jiang, Bin Yang, Xiyong Yu*, Shiying Li*, Xianzheng Zhang, Mitochondria and plasma membrane dual-targeted chimeric peptide for single-agent synergistic photodynamic therapy, Biomaterials, 2019, 188, 1-11.

(8) Hong Cheng#, Ping Yuan#, Guiling Fan, Linping Zhao, Rongrong Zheng, Bin Yang, Xiaozhong Qiu, Xiyong Yu, Shiying Li*, Xianzheng Zhang, Chimeric peptide nanorods for plasma membrane and nuclear targeted photosensitizer delivery and enhanced photodynamic therapy, Applied Materials Today, 2019, 16, 120-131.

(9) Hong Cheng#, Guiling Fan#, Jinghao Fan, Linping Zhao, Rongrong Zheng, Xiyong yu, Shiying Li*, A ratiometric theranostic nanoprobe for pH imaging-guided photodynamic therapy, Nanoscale, 2019, 11, 9008-9014.  

(10)  Shiying Li#, Xueyan Jiang#, Rongrong Zheng, Shengjia Zuo, Linping Zhao, Guiling Fan, Jinghao an, Yonghua Liao, Xiyong Yu*, Hong Cheng*, An azobenzene-based heteromeric prodrug for hypoxia-activated chemotherapy by regulating subcellular localization, Chemical Communications, 2018, 54, 7983-7986.

(11)  Hong Cheng, Shiying Li, Haoran Zheng, Chuxin Li, Boru Xie, Kewei Chen, Bin Li, Xianzheng Zhang. Multi-forster resonance energy transfer-based fluorescent probe for spatiotemporal matrix metalloproteinase-2 and caspase-3 imaging. Analytical Chemistry, 2017, 89, 4349-4354.

(12)  Shiying Li#, Hong Cheng#, Wenxiu Qiu, Lu Zhang, Shuangshuang Wan, Jingyue Zeng, Xianzheng Zhang. Cancer cell membrane-coated biomimetic platform for tumor targeted photodynamic therapy and hypoxia-amplified bioreductive therapy. Biomaterials, 2017, 142, 149-161.

(13)  Hong Cheng, Jingyi Zhu, Shiying Li, Jingyue Zeng, Qi Lei, Kewei Chen, Chi Zhang, Xianzheng Zhang*, An O2 self-sufficient biomimetic nanoplatform for highly specific and efficient photodynamic therapy, Advanced Functional Materials, 2016, 26, 7847-7860.

(14)  Shiying Li#, Hong Cheng#, Boru Xie, Wenxiu Qiu, Lilin Song, Xianzheng Zhang. A ratiometric theranostic beacon for tumor targeting therapy and self-therapeutic monitoring. Biomaterials, 2016, 104, 297-309.