李艳

姓名：李艳

职称：实验师

联系邮箱：57690114@qq.com

联系电话：020-61648297

学习经历（学士、硕士、博士）：

2000.09-2004.07 北京工商大学，生物工程，学士

2005.09-2008.07 北京工商大学，生物化工，硕士

工作经历：

2012.10-2018.08 宁波大学海洋学院，助理实验师，实验师。

2018.09-2020.03 宁波大学食品与药学学院，实验师。

2020.04-今 南方医科大学生物医学工程学院，实验师。

研究方向：

1）天然产物分离纯化；2）色谱分析。

主要科研课题：

1. 国家重点研发计划课题：国产智能电动吻合器的配置方案及卫生经济学评价 (2023YFC2413706)，主要成员，在研，100万。

2. 广东省自然科学基金-面上项目：介孔超顺磁性氧化铁纳米粒及其乳腺癌诊疗应用研究 (2024A1515012639)，主要成员，在研，15万。

3. 广东省自然科学基金-面上项目：基于信息融合的乳腺癌放疗心脏放射损伤预测   (2024A1515012100)，主要成员，在研，15万。

代表性论文：

[1] Jing Yang, Bin Ren, Haobin Cai, Wei Xiong, Jie Feng, Qingdeng Fan, Zongheng Li, Lin Huang, Chenggong Yan, Yan Li*, Chaomin Chen*, Zheyu Shen*. Cyclic catalysis of intratumor Fe3+/2+ initiated by a hollow mesoporous iron sesquioxide nanoparticle for ferroptosis therapy of large tumors. Biomaterials 2025, 313, 122793.

[2]  Jiaoyang Zhu, Lin Huang*, Jing Yang, Zongheng Li, Lihe Wu, Wei Xiong, Jie Feng, Chenggong Yan, Chaomin Chen*, Yan Li*, Zheyu Shen*. A CIA strategy with eminent drug-loading capacities for tumor ferroptosis-gas synergistic therapy. Theranostics 2024, 14(19), 7349-7369.

[3]  Jing Yang, Jiaoyang Zhu, Bin Ren, Haobin Cai, Zongheng Li, Qingdeng Fan, Wei Xiong, Jie Feng, Chenggong Yan, Ge Wen, Yan Li,* Chaomin Chen,* Zheyu Shen*. A Hollow Mesoporous Iron Oxide Nanoparticle to Strengthen Fenton Reaction and Weaken Antioxidant Defense Systems for High Efficacy Tumor Ferroptosis Therapy. Chem. Eng. J. 2024, 497, 154470. (https://doi.org/10.1016/j.cej.2024.154470).

[4] Lin Huang, Jiaoyang Zhu, Guochao Wu, Wei Xiong, Jie Feng, Chenggong Yan, Jing Yang, Zongheng Li, Qingdeng Fan, Bin Ren, Yan Li, Chaomin Chen,* Xiangrong Yu,* Zheyu Shen*. A Strategy of “Adding Fuel to the Flames” Enables a Self-Accelerating Cycle of Ferroptosis-Cuproptosis for Potent Antitumor Therapy. Biomaterials 2024, 311, 122701. (https://doi.org/10.1016/j.biomaterials.2024.122701).

[5]  Lin Huang, Jie Feng*, Jiaoyang Zhu, Jing Yang, Wei Xiong, Xuanyi Lu, Sijin Chen, Sugeun Yang, Yan Li, Yikai Xu*, Zheyu Shen*. A strategy of Fenton reaction cycloacceleration for high performance ferroptosis therapy initiated by tumor microenvironment remodeling. Adv. Healthcare Mater. 2023, 12(18), 2203362. ( https://doi.org/10.1002/adhm.202203362)

[6] Lin Huang, Yudie Lu, Shuai Guo, Jing Yang, Zhiyu Liang, Qianqian Zhang, Peiwei Yi, Yanqiu Feng, Yan Li, Yikai Xu, Xiaozhong Qiu, Jie Feng, Zheyu Shen*. A strategy of limited-space controlled aggregation for generic enhancement of drug loading capability. Adv. Funct. Mater. 2023, 33(4), 2209278. ( https://doi.org/10.1002/adfm.202209278)

[7]  Yudie Lu, Zhiyu Liang, Jie Feng, Lin Huang, Shuai Guo, Peiwei Yi, Wei Xiong, Sijin Chen, Sugeun Yang, Yikai Xu, Yan Li, Xiaoyuan Chen, Zheyu Shen*. Facile synthesis of weakly ferromagnetic organogadolinium macrochelates-based T1-weighted magnetic resonance imaging contrast agents. Adv. Sci. 2023, 10, 2205109. (https://doi.org/10.1002/advs.202205109).

[8]  Yan Li, Chengxu Zhou, Xiaojun Yan, Jinrong Zhang, Jilin Xu*. Simultaneous analysis of ten phytohormones in Sargassum horneri by high-performance liquid chromatography with electrospray ionization tandem mass spectrometry. J. Sep. Sci. 2016, 39, 1804-1813.

[9] Lv Zhou, Jiao Chen, Jilin Xu*, Yan Li, Chengxu Zhou, Xiaojun Yan. Change of volatile components in six microalgae with different growth phases. J Sci Food Agric. 2016.

[10] 李艳, 徐继林, 郑立洋, 李敏, 严小军, 骆其君*.高效液相色谱-三重四极杆质谱法同时测定羊栖菜5个部位中10种植物激素含量. 色谱. 2014, 32 (8), 861-866.

[11] 李艳, 曹学丽*, 付鹏, 冯雪娇, 胡光辉. 贯叶金丝桃活性成分及其分离纯化与检测方法的研究进展. 药学进展. 2008 , 32 (1), 15-20.

授权发明专利

《一种用于反对比度磁共振成像的肿瘤微环境双重响应型复合纳米材料及其制备方法》，专利号：202210072698.2。