姓名:何 坚

职称:教 授

Tel:020-61648717

E-mail:jianhe@smu.edu.cn

主要招生方向：生物技术药物、工业药学

学习经历

1997/09-2000/06 中国医学科学院,中国协和医科大学药物研究所，药物化学，博士

1994/09-1997/06 华中师范大学分析测试中心，有机化学，硕士

研究工作经历

2013/01 -至今 南方医科大学药学院，教授

2008/04–2012/12 C3 Jian Inc.公司，研究员（Scientist）

2007/12–2010/01 加洲大学洛山矶分校牙医学院，助理研究员(Assistant researcher)

2004/01 -2007/11 加洲大学洛山矶分校牙医学院，博士后

2003/01 -2003/12 亚历桑那大学西南天然产物研究和商业化中心，博士后

2002/07 -2003/01 德国汉斯－克劳尔天然产物研究所，助理研究员(Senior scientist）

2000/07 -2002/06 德国汉斯－克劳尔天然产物研究所，博士后

研究方向

1.肽类药物分子设计、合成和活性研究

2.天然药物化学

在研课题

1.主持南方医科大学高层次人才引进科研项目

项目名称：以小分子肽和肽类似物为骨架的高活性抗菌化合物的设计，合成和活性研究

项目编号：B1040903

2. 主持广东省科技厅科研项目

项目名称：从放线菌Streptomyces sp SMU03中寻找抑制流感病毒进入宿主先导化合物的研究

项目编号：2015A020211010

3.主持NSFC面上项目

项目名称：以流感病毒血凝素酶为靶点兼具免疫调节功能的新型抗禽流感病毒肽类化合物的

研究项目编号：81773556

近五年主要论著

1. Xi Xie, Shengsheng Lu, Xiaoyan Pan, Min Zou, Fangfang Li, Haixing Lin, Jianan Hu, Sheng Fan,Jian He^*,Antiviral Bafilomycins from a Feces-inhabitingStreptomycessp.Journal of natural products, (accepted).

2. Shengsheng Lu, Xiaoyan Pan, Daiwei Chen, Xi Xie, Yan Wu，Weijuan Shang, Xiaming Jiang, Yuan Sun, Sheng Fan,Jian He^*,The broad-spectrum antivirals of protoporphyrins inhibiting the entry of highly pathogenic emerging viruses.Bioorganic Chemistry, (accepted).

3.范升，陆盛胜，吴秋艺，李芳芳，何坚^*，广东红冬蛇菰Balanophora Harlandi及其内生真菌Penicillium coprophilumMzz9的化学成分研究天然产物研究与开发, 2020，32: 1539-1544

4. Daiwei Chen, Shengsheng Lu, Guang Yang, Xiaoyan Pan, Sheng Fan, Xi Xie, Qi Chen, Fangfang Li, Zhonghuang Li, Shaohua Wu,Jian He^*, The seafoodMusculus senhouseishows anti-influenza A virus activity by targeting virion envelope lipids,Biochem Pharmacol.2020 Jul;177:113982.

5. Fangfang Li, Shengsheng Lu, Xi Xie, Sheng Fan, Daiwei Chen, Shaohua Wu^*,Jian He^*, Antiviral properties of extracts ofStreptomycessp. SMU 03 isolated from the feces ofElephasmaximusFitoterapia2020 Jun;143:104600.

6. Guang Yang, Jingyu Wang, Shengsheng Lu, Zhao Chen, Sheng Fan, Daiwei Chen, Huanxin Xue, Wenyuan Shi,Jian He*Short lipopeptides specifically inhibit the growth ofPropionibacterium acnesthrough antibacterial andanti-inflammatory dual action,British Journal of Pharmacology2019,176(13), 2321-2335.

7.Kai-Xuan Zheng, Yi Jiang, Ju-Xing Jiang, Rong Huang,Jian He, Shao-Hua Wu,A new phthalazinone derivative and a new isoflavonoid glycoside from lichen-associated Amycolatopsis sp.，Fitoterapia2019,135, 85-89.

8. Zhao Chen, Guang Yang, Shengsheng Lu, Daiwei Chen, Sheng Fan, Junyang Xu, Buling Wu*,Jian He*，Design and antimicrobial activities of LL-37 derivatives inhibiting the formation of Streptococcus mutansbiofilm,Chemical Biology and Drug Design2019, 93(6), 1175-1185.

9.Fangfang Li, Daiwei Chen, Shengsheng Lu, Guang Yang, Xiaoling Zhang, Zhao Chen, Sheng Fan, Shaohua Wu,Jian He*,Anti-influenza A Viral Butenolide fromStreoptomycessp Smu03 Inhabiting the Intestine ofElephas maximus,Viruses2018, 10, 356.

10. Rong Huang,Bo-Guang Jiang, Xiao-Nian Li, Ya-Ting Wang, Si-Si Liu, Kai-Xuan Zheng,Jian He,*and Shao-Hua Wu*, Polyoxygenated Cyclohexenoidswith Promisinga-Glycosidase Inhibitory Activity from the Endophytic FungusPhomopsissp.YE3250,Journal of Agricultural and Food Chemistry2018,66(5), 1140–1146.

11．Dongguo Lin, Yinzhu Luo, Guang Yang, Fangfang Li, Xiangkun Xie, Daiwei Chen, Lifang He, Jingyu Wang, Chunfeng Ye, Shengsheng Lu, Lin Lv, Shuwen Liu*,Jian He*, Potent influenza A virus entry inhibitors targeting a conserved region of hemagglutininBiochem Pharmacol.2017, 144, 35–51.

12.李芳芳,陆盛胜,吉腾飞,何坚*,动物来源放线菌的次级代谢产物及其生物活性研究进展,药学学报,2017, 52(7), 1091-1101.

13.Shou-Peng Zhang, Rong Huang,Fang-Fang Li, Xiao-Song Xie, Hong-Xia Wei, Xiao-Wei Fang,Dong-Guo Lin, Shao-Hua Wu*,Jian He*,Antiviral anthraquinones and azaphilones produced by an endophytic fungusNigrosporasp. fromAconitum carmichaeli,Fitoterapia2016, 112, 85-89.

14. Dongguo Lin, Fangfang Li, Qiuyi Wu, Xiangkun Xie, Wenjiao Wu, Jie Wu, Qing Chen, Shuwen Liu,Jian He^*,A “building block” approach to the new influenza A virus entry inhibitors with reduced cellular toxicities.Sci. Rep.2016, 6, 22790.

15. Dongguo Lin, Ruxia Ren, Qianjing Tan, Qiuyi Wu, Fangfang Li, Lin Li, Shuwen Liu,Jian He^*, A facile and dynamic assay for the detection of peptide aggregation.Analytical and Bioanalytical Chemistry2016, 408(6), 1609-1614.

专利

1.何坚，李芳芳，陆胜盛，陈黛蔚，大象肠道来源放线菌的丁烯酸内酯类化合物及其应用，中国，201810717849.9，2018

2.何坚，陈昭，一种具有抗菌及抗炎活性的多肽化合物，中国，201810378872.X

3.何坚，杨光，王静瑜，一种具有专一性抗痤疮丙酸杆菌作用及抗炎双重作用的短脂肽，中国, 201811034762.8，2018

4.何坚，林冬果，刘叔文，快速方便地检测淀粉样蛋白形成的荧光探针及方法，中国，201610027639.8，2016

5.何坚,刘叔文,王静瑜，武文姣，林冬果,一类兼具抗菌和抗流感病毒活性的融合肽衍生物，中国，ZL 201510045228.7，2015

6.何坚,刘叔文,林冬果,方堉欣，王静瑜，具有抗菌抗病毒活性的小分子肽及其活性修饰物，中国，201410259060.5，2014