姓名：朱秋华

职称：教授，博士生导师

联系方式：南方医科大学药学院

Email:zhuqh@smu.edu.cn

 

工作经历：

2013.12-至今南方医科大学（原第一军医大学）药学院，教授

2004.7-2013.12南方医科大学（原第一军医大学）药学院，副教授

1982.07-2004.07第一军医大学 基础部化学教研室，教师

 

学习经历：

2006.09-2010.07华南理工大学，化学化工学院，应用化学，博士

1997.09-1999.07第一军医大学，药物研究所，硕士

1993.09-1996.07华南师范大学，化学系，化学教育，学士

2013.08.01-2014.1.30香港科技大学，化学科学院，唐本忠院士课题组，访问学者

 

研究方向：

1.温感范围可调荧光特性的产生机理及应用研究

2.新型杂环化合物的多组分反应合成方法研究

3.有机荧光小分子的设计、合成及其作为化学/生物荧光探针的研究

4.新型生物活性化合物的发现及构效关系研究

 

科研课题：

1.国家自然科学基金面上项目（61975074）：“荧光响应温度范围可调特性的产生机理及应用研究”，2020.1-2023.12，项目负责人

2.广州市科技计划项目（907193375068）“温感范围可调特性荧光探针的分子结构特征及开发应用研究”，2020.4-2022.3，项目负责人

3.国家自然科学基金面上项目（21272111）：“一类新颖荧光材料五取代四氢嘧啶的合成、光学特性以及结构-性质关系的研究”，2013.1-2016.12，项目负责人

4.广东省科技计划项目（2015A010105015）“首次实现快速测定CMC的试剂盒与试纸的开发研究”，2016.1-2017.12，项目负责人

5.广东省科技计划项目（2008B060600066）：“多取代四氢嘧啶衍生物的合成及其消炎止痛作用的研究”，2008.1～2010.12，项目负责人

 

代表性论文：

1.Wu, S.; Liang, F.; Hu, D.; Li, H.; Yang, W.;Zhu, Q.(通讯作者), Determining the Critical Micelle Concentration of Surfactants by a Simple and Fast Titration Method.Anal. Chem.2020,92(6), 4259-4265.

2.2. Wan, Y.; Wu, S.; Zheng, S.; Liang, E.; Liu, S.; Yao, X.;Zhu, Q.(通讯作者), A series of octahydroquinazoline-5-ones as novel inhibitors against dengue virus.Eur. J. Med. Chem.2020, 112318.

3.3. Liu, T.; Dai, C.; Sang, H.; Chen, F.; Huang, Y.; Liao, H.; Liu, S.;Zhu, Q.(通讯作者); Yang, J., Discovery of dihydropyrrolidones as novel inhibitors against influenza A virus.Eur. J. Med. Chem.2020,199, 112334.

4.Liao, H.;Zhu Q. H. (通讯作者). Water-DMSO-promoted one-pot synthesis of two new series of dihydropyrrolo[2,3-h]quinolinesOrg. Biomol. Chem.2019.

5.Lai, Y.; Huang, J.; Wu, S.;Zhu Q. H. (通讯作者); Liu, Y. Aggregation-induced emission and reversible mechanofluorochromic characteristics of tetra-substituted tetrahydropyrimidine derivativesDyes Pigments2019,166, 8.

6.Zhu Q. H. (通讯作者); Wu, S.; Zheng, S.; Ye, Z.; Huang, C.; Liu, Y. Insight into Structural Influences on the Optical Properties and Heteroenantiomeric Self-Assembly of Racemic C6-Unsubstituted Tetrahydropyrimidines with Strong Aggregation-Induced Emission.Dyes Pigments2019,162, 543-551.

7.Zheng S, Huang C, Zhao X, Zhang Y, Liu S,Zhu Q. H. (通讯作者). A hydrophobic organelle probe based on aggregation-induced emission: Nanosuspension preparation and direct use for endoplasmic reticulum imaging in living cells.Spectrochim. Acta. A.2018,189, 231-238.

8.Zhu Q. H. (通讯作者); Dai, C.; Huang, C.; Zheng, S.; Tian, Y. Racemates Have Much Higher Solid-State Fluorescence Efficiency Than Their Levo- and Dextrorotary Enantiomers.J. Phys. Chem. C2017,121, 25503-25508

9.Zhu Q. H. (通讯作者); Ziwei, Y.; Weijie, Y.; Xiaotie, C.; Ben Zhong, T., One-Pot Synthesis and Structure-Property-Relationship of Aminomaleimides: Fluorescence Efficiencies in Monomers and Aggregates Easily Tuned by Switch of Aryl and Alkyl.J. Org. Chem.2016,82(2):1096–1104.

10.Zhu Q. H. (通讯作者); Yang, W.; Zheng, S.; Sung, H. H. Y.; Williams, I. D.; Liu, S.; Tang, B. Z. Reversible Thermo-Stimulus Solid-State Fluorescence-Colour/on-Off Switching and Uses as Sensitive Fluorescent Thermometers in Different Temperature RangesJ. Mater. Chem. C2016,4, 7383-7386.

11.Zheng, S.; Zhong, S.; Chen, Z.; Chen, W.;Zhu Q. H. (通讯作者). Efficient Synthesis of a Series of Novel Octahydroquinazoline-5-Ones Via a Simple on-Water Urea-Catalyzed Chemoselective Five-Component ReactionACS Comb. Sci.2016,18, 475–481.

12.Zhu Q. H. (通讯作者), Zhang Y, Nie H, Zhao Z, Liu S, Wong KS, et al.Insight into the Strong Aggregation-Induced Emission of Low-Conjugated Racemic C6-Unsubstituted Tetrahydropyrimidines through Crystal-Structure-Property Relationship of Polymorphs.Chem Sci2015,6(8):4690-4697.

13.Cai X, Yang W, Huang L,Zhu Q. H.(通讯作者), Liu S. A series of sensitive and visible fluorescence-turn-on probes for CMC of ionic surfactants: Design, synthesis, structure influence on CMC and sensitivity, and fast detection via a plate reader and a UV light.Sensors and Actuators B2015,219(0):251-260.

14.Chen Z-P, Wang H-B, Wang Y-Q,Zhu Q. H.(通讯作者), Xie Y, Liu S-W. Synthesis of fused pyrrolo[3,4-d]tetrahydropyrimidine derivatives by proline-catalyzed multicomponent reaction.Tetrahedron2014,70(29):4379-4385.

15.Zhu, Q. H.; Huang, L.; Su, J.; Liu, S.,A Sensitive and Visible Fluorescence-Turn-on Probe for the CMC Determination of Ionic Surfactants.Chem. Comm.2014,50:1107-1109

16.Huang, L.;Su, J. Zhong, D. Wang, H.; Liu, R.; Yu, L.;Zhu, Q. H. (通讯作者);Liu, S.,Copper-Induced Fluorescence Enhancement and Particle-Size Decrease of a C-6 Unsubstituted Tetrahydropyrimidine Racemate.RSC Advances.2013,3:13286-13292.(IF = 2.562)

17.Lv, L.; Zheng, S.; Cai, X.; Chen, Z.;Zhu, Q. H. (通讯作者); Development of four-component synthesis of tetra- and pentasubstituted polyfunctional dihydropyrroles: Free permutation and combination of aromatic and aliphatic amines.ACS Comb. Sci.2013, 10.1021/co300148c.

18.Zhu, Q. H.; Huang, L.; Chen, Z.; Zheng, S.; Lv, L.; Zhu, Z.; Cao, D.; Jiang, H.; Liu, S., A new series of c-6 unsubstituted tetrahydropyrimidines: Convenient one-pot chemoselective synthesis, aggregation-induced and size-independent emission characteristics.Chem. Eur. J.2013,19, 1268 – 1280.

19.Zhu, Q. H.;Gao, L. X.; Chen, Z. P.; Li, J.; Jiang, H. F.; Liu, S. W. A novel class of small-molecule caspase-3 inhibitors prepared by multicomponent reactions.Eur. J. Med. Chem.2012,54(0), 232-238.

20.Zhu, Q. H.;Jiang, H. F.; Li, J. H.; Liu, S. W.; Xia, C. L.; Zhang, M.Concise and versatile multicomponent synthesis of multisubstituted polyfunctional dihydropyrroles.J. Comb. Chem.2009, 11 ( 4 ), 685−696.

21.Zhu, Q. H.;Jiang, H. F.; Li, J. H.; Liu, S. W.; Zhang, M.; Wang, X.J.; Qi, C. R. Practical synthesis and mechanistic study of polysubstituted tetrahydropyrimidines with use of domino multicomponent reactions.Tetrahedron2009, 65 ( 23 ), 4604−4613.

专利:

1.朱秋华、吴深根、杨伟杰、梁菲晴、胡丹娜、李昊.一种表面活性剂临界胶束浓度的荧光探针滴定法.中国发明专利201811613075.1

2.朱秋华;杨洁；戴晨舒;刘腾.二氢吡咯酮衍生物在制备流感病毒抑制剂上的应用及一种抗流感病毒的二氢吡咯类衍生物.中国发明专利2018106728773,2018.8.22

3.朱秋华、吴深根、姚新刚、刘叔文一种八氢喹唑啉-5-酮衍生物在作为登革热病毒抑制剂的应用.中国发明专利201810209962.6,2018.3.14

4.朱秋华,戴晨舒,杨伟杰.一种表面活性剂临界胶束浓度试纸及其制备方法.中国发明专利201810036450.4,2018.1.15

5.朱秋华,吴少瑜,黄翠红,张辉武.一种二氢吡咯酮衍生物及其在制备抗肿瘤药物中的应用. CN201710671141.X,2017.8.8

6.朱秋华,戴晨舒,杨伟杰.五取代四氢嘧啶化合物在滴定法测定表面活性剂临界胶束浓度中的应用.中国发明专利CN201610859727.4,2016

7.朱秋华,刘淑文,郑思超,赵旭燕.基于聚集诱导发光的五取代四氢嘧啶化合物作为内质网探针在细胞成像方面的应用.中国发明专利CN2016040800897810,2016(授权)

8.朱秋华,刘艳山,叶子威.具有聚集诱导发光特性的五取代四氢嘧啶的压致荧光变色性能及其应用.中国发明专利CN2016030800655670,2016(授权)

9.Qiuhua Zhu.APPLICATION OF PENTA-SUBSTITUTED TETRAHYDROPYRIMIDINES IN PREPARATION OF TEMPERATURE-SENSITIVE FLUORESCENT MATERIAL. PCT/CN2011/084601, WO2016/173386, US15518246 A1 (授权).

10.朱秋华.五取代四氢嘧啶在制备温度敏感荧光材料中的应用.中国发明专利201510212629.7.2015（授权）

11.朱秋华;刘叔文.一种1,3-二取代马来酰亚胺化合物及作为表面活性剂临界胶束浓度荧光探针的应用.中国发明专利CN201410368738.3,2014（授权）

12.朱秋华;刘叔文.一种测定表面活性剂临界胶束浓度灵敏的荧光点亮探针法.中国发明专利201310295311.02013（授权）

13.朱秋华;刘叔文.聚集诱导发光的五取代四氢嘧啶及其制备方法和应用.中国发明专利201110129857.x（授权）

14.Qiuhua Zhu, Shuwen Liu. Penta-substituted tetrahydropyrimidines with aggregation-induced emission characteristics and preparation method and use thereof US 2014 0051855 A1,2013（授权）

15.江焕峰;朱秋华;李佳;高盛.二氢吡咯酮衍生物作为caspase-3抑制剂.中国发明专利201010141256.62010（授权）

16.江焕峰;朱秋华;刘叔文;张珉. HIV-1抑制剂吡咯酮衍生物及其合成方法和应用.中国发明专利200910036539.1.2009（授权）