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刘利红

发布时间:2017年10月17日 浏览次数:

药学院 刘利红蓝白底

姓名:刘利红

职称:教授,博士生导师

联系邮箱:lhliu02@126.com

联系电话:020-61648595

学习经历:

1995.09-1999.07 河北科技大学, 染整工程, 学士

2002.09-2007.06,兰州大学,分析化学,博士

2013.12-2014.12,美国麻省理工学院, 电子工程系,访问学者

2018.01-2018.03新加坡-麻省理工学院科研中心(SMART),访问学者

工作经历:

2007.07-2010.12 南方医科大学药学院,讲师

2010.12- 2015.12 南方医科大学药学院,副教授

2015.12-至今 南方医科大学药学院,教授

承担课程:

《分析化学》,《高等药物分析》

研究方向:

1. 药物分析及筛选新方法的研究及应用。

2. 微流控芯片及毛细管电泳在临床用药及疾病诊断中的研究及应用

3. 纳米材料在临床诊断中的研究

承担的课题:

1. 微流控芯片在循环肿瘤细胞研究中的应用, 广东省海外名师深度交流与合作项目:5 万,2024

2. 快速、低成本检测细胞治疗产品中微生物的便携式装置研究(2024B03J0007),广州市科技计划项目(重点研发计划),2024.01-2026.12,主持

3. 基于 cDNA@AuNPs 联合微流控芯片 ICP 在线富集技术的病原菌鉴定和药敏试验新方法研究(2023A1515010996),广东省基础与应用基础研究基金,10 万,2023.01-2025.12,主持

4. 基于DNaseI-Ap-GO联合多靶标平行在线富集微流控芯片的原发性肝癌早期诊断新方法研究(2021A1515011493),广东省基础与应用基础研究基金,10 万,2021.01-2023.12,主持

5. 基于集成微流控芯片的血小板功能检测新方法研究(81973282),国家自然科学基金面上项目,55万,2020.01-2023.12,主持

6. 毛细管电泳柱端GNPas-Ap-Ber微反应器间接超灵敏检测CRP新方法的研究(2018A030313843),广东省科技创新战略专项资金,10万,2018.05-2021.04,主持

7. 基于微流控芯片在线检测生物药中内毒素含量的新方法研究(2016A040403052),广东省科技计划项目(协同创新与平台环境建设,30万,2016.01-2018.12,主持

8. 基于微流控芯片在线检测全血中内毒素的新方法研究(81470161),国家自然科学基金面上项目,30万,2015/01~2016/12,主持

9. N/C-多肽与纳米金层层自组装微反应器在HIV gp41抑制剂筛选中的应用(2012045),广州市珠江科技新星专项,30万,2012/07~2015/07,主持

10. 基于毛细管电泳柱端微反应器筛选HIV gp41融合抑制剂的研究(30901826),国家自然科学基金青年项目,20万,2010/01~2012/12,主持

11. 毛细管电泳柱端多肽微反应器在HIV gp41融合抑制剂筛选中的研究(9451051501002526),广东省自然科学基金博士启动项目,3万,2009/10~2011/10,主持

12. (C108310003)刘利红-引进人才科研启动经费主持

13. (K911310002)刘利红-天睿生物公司科研合作经费,主持

14. 基于微流控芯片在线检测生物药中内毒素含量的新方法(“一带一路”培育项目,YD2017N002),2017年度“科研启动计划”,主持

学术论文:

1. Qing Tang, Hanren Chen, Bihong Diao, Zuoyan Qin, Huaze Shao, Runhui Zhang, Lihong Liu*, PCR-free and visual detection of antibiotic resistance gene in feces genome of aquatic products by coupling CuO nanoparticles concatemers-Au@Fe3O4 and 3D DNA walker based on a portable blue light gel imager, Chemical Engineering Journal 499 (2024) 156311

2. Hanren Chen, Shiquan Zheng, Yitong Zhang, Qing Tang, Runhui Zhang, Yue Chen, Meiming Wu, and Lihong Liu*Visual Detection of LPS at the Femtomolar Level Based on Click Chemistry-Induced Gold Nanoparticles Electrokinetic AccumulationAnalytical Chemistry, 2024, 96, 6995−7004.

3. Huaze Shao , Hong Yan , Qing Tang , Shiquan Zheng , Hanren Chen , Lihong Liu *,Enzyme-free and label-free detection of HER2 in human serum based on Ag+-released hybridization chain reaction signal amplification Sensors & Actuators: B. Chemical, 2024, 413, 135919.

4. Yue Chen#; Jieqi Deng#; Runhui Zhang; Huaze Shao; Dan Xu; Lihong Liu*; Rapid and Nondestructive Evaluation of Platelet Function in Whole Blood by Microfluidic Deterministic Cytometry,Analytical Chemistry, 2024, 96(1): 145-153.

5. Siqi Wei#; Qing Tang#; Xiumei Hu#; Wei Ouyang; Huaze Shao; Jincheng Li; Hong Yan; Yue Chen; Lihong Liu*; Rapid, Ultrasensitive, and Visual Detection of Pathogens Based on Cation Dye-Triggered Gold Nanoparticle Electrokinetic Agglutination Analysis,ACS Sensors, 2024, 9(1): 325-336. 2024.1.12出版

6. Qing Tang#; Zhijie Li#; Jincheng Li; Hanren Chen; Hong Yan; Jieqi Deng; Lihong Liu*; PCR-Free, Label-Free, and Centrifugation-Free Diagnosis of Multiplex Antibiotic Resistance Genes by Combining mDNA-Au@Fe3O4 from Heating Dry and DNA Concatamers with G-Triplex, Analytical Chemistry, 2024, 96(1): 292-300.

7. Runhui Zhang#; Jun Xu#; Jieqi Deng; Wei Ouyang; Hanren Chen; Qing Tang; Shiquan Zheng; Lihong Liu*; High-Performance Cation Electrokinetic Concentrator based on a γ-CD/QCS/PVA Composite and Microchip for Evaluating the Activity of P-Glycoprotein without any Interference from Serum Albumin, Lab on a Chip, 2024, 24(1): 127-136.

8. Runhui Zhang#; Qing Tang; Hanren Chen; Jieqi Deng; Yongyin Li*; Lihong Liu*; Simultaneous Detection of Multiplex Biomarkers Related with Hepatocellular Carcinoma by Coupling DNase I-Assisted Recycling Amplification and Microfluidic Electrokinetic Stacking Chip with Parallel Multi-Channels, Sensors and Actuators: B. Chemical, 2024, 400: 134885.

9. Yue Chen#; Zhen Liu#; Huaze Shao; Jun Xu; Jincheng Li; Haoyi Chen; Chunqiong Zhou; Lihong Liu*; Heterogeneity of Red Blood Cell Deformability Caused by Lipopolysaccharide based on a Microfluidic Chip, Current Pharmaceutical Biotechnology, 2023, 24(14): 1795-1802.

10. Hong Yan#; Xiumei Hu#; Huaze Shao#; Jincheng Li; Jieqi Deng; Lihong Liu*; Low-Cost Full-Range Detection of C-Reactive Protein in Clinical Samples by Aptamer Hairpin Probes and Coprecipitation of Silver Ions and Gold Nanoparticles, Analytical Chemistry, 2023, 95(32): 11918-11925.

11. Jun Xu#; Qing Tang; Runhui Zhang; Haoyi Chen; Bee Luan Khoo; Xinguo Zhang; Yue Chen; Hong Yan; Jincheng Li; Huaze Shao; Lihong Liu*; Sensitive Detection of MicroRNAs using Polyadenine-Mediated Fluorescent Spherical Nucleic Acids and a Microfluidic Electrokinetic Signal Amplification Chip, Journal of Pharmaceutical Analysis, 2022, 12(5): 808-813.

12. Yue Chen#; Qiong Zhan#; Jian Zhang#; Wei Wang#; Bee Luan Khoo; Zhen Liu; Siqi Wei; Junxin Niu; Jun Xu; Chia-Chen Yu; Xiumei Hu; Yanhui Liu; Jongyoon Han; Shuwen Liu*; Lihong Liu*; Accurate Prediction of Drug-Induced Heterogeneous Response of Red Cell in Vivo using a Gravity-Driven Flow Cytometry based on a Microfluidic Chip, Analytica Chimica Acta, 2022, 1221: 340151.

13. Qing Tang#; Jun Xu; Siqi Wei; Haoyi Chen; Jiapeng Chen; Huilin Zhang; Lihong Liu*; Label-Free and Highly Sensitive Detection of CRP Based on the Combination of Nicking Endonuclease-Assisted Signal Amplification and Capillary Electrophoresis-UV Assay, Analytica Chimica Acta, 2022, 1221: 340131.

14. Yue Chen#; Kerwin Kwek Zeming#; Xiumei Hu#; Siqi Wei; Jun Xu; Hong Yan; Lihong Liu*; Deterministic Flow Cytometry: Rapid Erythrocyte Rheological Profiling from a Drop of Whole Blood, Sensors and Actuators: B. Chemical, 2022, 362: 131783.

15. Niu, J.X., Hu, X.M., Ouyang, W., Chen, Y., Liu, S.W., Han, J.Y.*, Liu, Lihong*, 2019. Femtomolar Detection of Lipopolysaccharide in Injectables and Serum Samples Using Aptamer-Coupled Reduced Graphene Oxide in a Continuous Injection-Electrostacking Biochip.Analytical Chemistry, 2019, 91, 2360-2367.

16. Liu, Z., Hettihewa, M., Shu, Y., Zhou, C., Wan, Q., Liu, Lihong*, 2018. The mechanism of the adsorption of dsdna on citrate-stabilized gold nanoparticles and a colorimetric and visual method for detecting the v600e point mutation of the braf gene. Microchimica Acta, 185(4), 240.

17. Xu, X.Y.#, Li, L.#, Liu, Z., Yao, X.J., Zhang, X.X., Liu, S.W.*, Liu, Lihong*, 2018. Investigation of the inhibition effect of arachidonic acid on the core structure of the HIV-1 gp41, Journal of Pharmaceutical and Biomedical Analysis 161:377-382, 2018, 377-382

18. Wan, Q., Liu, Y.H., Yang, C.L., Liu, Lihong*, 2017. On-line double focusing of atenolol and metoprolol in human urine using capillary electrophoresis with the aid of β-cyclodextrin. Analytica Chimica Acta, 978:61-67.

19. Liu, Lihong*, Wan, Q, Xu, X.Y., Duan, S.S, Yang, C.L., 2017. Combination of micelle collapse and field-amplified sample stacking in capillary electrophoresis for determination of trimethoprim and sulfamethoxazole in animal-originated foodstuffs. Food Chemistry, 219: 7-12.

20. Liu, Lihong#, Xu, X.Y#., Liu, Y.H., Zhang, X.X., Li, L.*, Jia, Z.M.*, 2016. Screening HIV-1 fusion inhibitors based on capillary electrophoresis head-end microreactor targeting to the core structure of gp41. Journal of Pharmaceutical and Biomedical Analysis 120:153-157.

21. Liu, Lihong#, Huang, S.#, Xu, X.Y., Han, J.Y.*, 2016. Study of Individual erythrocyte deformability susceptibility to INFeD and ethanol using a microfluidic chip. Scientific Reports, 6, 22929.

22. Shu, Y., Xue, W.W., Xu, X.Y., Jia, Z.M., Yao, X.J., Liu, S.W., Liu, Lihong*, 2015. Interaction of erucic acid with bovine serum albumin using a multi-spectroscopic method and molecular docking technique.Food Chemistry 173: 31-37.

23. Xu, X.Y., Liu, Lihong*, Jia, Z.M., Shu, Y., 2015, Determination of enrofloxacin and ciprofloxacin in foods of animal origin by capillary electrophoresis with field amplified sample stacking-sweeping technique, Food Chemistry 176: 219-225.

24. Xu, X.Y., Jia, Z.M., Shu, Y., Liu, Lihong*, 2015. Dynamic pH junction-sweeping technique for on-line concentration of acidic amino acids in human serum by capillary electrophoresis with indirect UV detection. Journal of Chromatography B 980: 25-26, 30.

25. Liu, Lihong *, You, W.W., Zheng, L.J., Chen,F.Y., Jia, Z.M., 2012. Determination of peimine and peiminine in Bulbus Fritillariae Thunbergii by capillary electrophoresis by indirect UV detection using N-(1-naphthyl)ethylenediamine dihydrochloride as probe. Electrophoresis 33: 2152-2158. (IF2014 = 3.028)

26. Liu, Lihong *, Deng, X.X., Chen, X.G., 2010. Micelle to trapping solution stacking in micellar electrokinetic chromatography. J. Chromatogr. A 1217: 175-178. (IF2009 = 4.169)

27. Liu, Lihong *, Chen, X.G., Liu, J.L., Deng, X.X., Duan, W.J., Tan, S.Y., 2010. Determination of capsaicin and dihydrocapsaicin in Capsicum anuum and related products by capillary electrophoresis with a mixed surfactant system. Food Chemistry 119: 1228-1232. (IF2014 = 3.391)

28. Liu, Lihong, Chen, X.G. *, Hu, Z.D., 2007. Separation and determination of alpinetin and cardamonin in Alpinia Katsumadai Hayata by flow injection-micellar electrokinetic chromatography. Talanta 71: 155-159. (IF2009 = 3.29)

29. Liu, Lihong, Chen, X.G. *, Hu, Z.D., 2007. On-line concentration by head-column field amplified sample injection for the analysis of berberine, palmatine and jatrorrhizine in herbal medicine by flow injection-micellar electrokinetic chromatography. Microchim. Acta 159: 125-131. (IF2009 = 2.648)

30. Liu, Lihong, Wu, X.A., Fan, L.Y., Chen, X.G. *, Hu, Z.D., 2006. Separation and determination of honokiol and magnolol in herbal medicines by flow injection-capillary electrophoresis. Anal. Bioanal. Chem. 384: 1533-1539. (IF2009 = 3.48)

31. Liu, Lihong, Liu, X.M., Chen, X.G. *, Hu, Z.D., 2005. Separation and determination of tetrandrine and fangchinoline in herbal medicines by flow injection-micellar electrokinetic capillary chromatography with internal standard method. J. Chromatogr. A 1098: 177-182. (IF2009 = 4.101)

32. Liu, Lihong, Chen, X.G. *, Hu, Z.D., 2005. Online concentration by field-amplified sample injection in acidic buffer for analysis of fangchinoline and tetrandrine in herbal medicine by flow injection-micellar electrokinetic capillary chromatography. Electrophoresis 26: 4456-4464. (IF2009 = 3.077)

33. Liu, Lihong, Fan, L.Y., Chen, H.L., Chen, X.G. *, Hu, Z.D., 2005. Separation and determination of four active anthraquinones in Chinese herbal preparations by flow injection-capillary electrophoresis. Electrophoresis 26: 2999-3006. (IF2009 = 3.077)

34. Fan, L.Y., Liu, Lihong, Chen, H.L., Chen, X.G. *, Hu, Z.D., 2005. Continuous on-line concentration based on dynamic pH junction for trimethoprim and sulfamethoxazole by microfluidic capillary electrophoresis combined with flow injection analysis system. J. Chromatogr. A 1062: 133-137. (IF2009 = 4.101)

35. Fan, L.Y., Cheng, Y.Q., Chen, H.L., Liu, Lihong, Chen, X.G. *, Hu, Z.D., 2004. Continuous on-line derivatization and selective separation of D-aspartic acid by a capillary electrophoresis system with a continuous sample introduction interface. Electrophoresis 25: 3163-3167. (IF2009 = 3.077)

36. Liu, X.M., Liu, Lihong, Chen, H.L., Chen, X.G. *, 2007. Separation and determination of four active components in medicinal preparations by flow injection-capillary electrophoresis. J. Pharm. Biomed. Anal. 43: 1700-1705. (IF2009 = 2.453)

37. Sun, J.F., Liu, Lihong, Ren, C.L., Chen, X.G. *, Hu, Z.D., 2008. A feasible method for the sensitive and selective determination of vitamin B1 with CdSe quantum dots. Microchim. Acta 163: 271-276. (IF2009 = 2.648)

38. Sun, J.F., Ren, C.L., Liu, Lihong, Chen, X.G. *, 2008. CdTe quantum dots as fluorescence sensor for the determination of vitamin B6 in aqueous solution. Chinese Chemical Letters (中国化学快报). 19: 855-859. (IF2007 = 0.643)

39. 刘利红*, 刘居理. 2010. 胶束电动色谱法测定辣椒中的辣椒碱. 现代仪器 16(1): 25-26, 30.

40. 刘利红*. 2009. 毛细管电泳柱上富集技术原理及应用. 广州化工 37(9): 13-15.

41. 徐小英,刘利红*,舒阳. 2015. 毛细管电泳柱端酶微反应器研究进展. 化学教育36(4): 1-5.

42. 刘利红, 陈飞瑜. 2013. 纳米材料的应用及其生物安全性评价. 广东化工40(19): 56.

近五年参编教材:

《医用化学实验》,科学出版社,2022 年,副主编。

《分析化学》,高等教育出版社,拟2024 年 6 月出版,编委。

近五年主持教学项目:

(1)高等教育教学改革立项项目(校级),微视频及雨课堂在分析化学线下教学中的应用研究与探索,2020。

(2)教学质量与教学改革工程建设项目(校级),基于爱课平台的《体内药物分析》课程混合式教学改革,2022。

(3)教学质量与教学改革工程建设项目(校级),以职业胜任力为导向的体内药物分析教学改革,2024。

教学论文:

1. 刘利红. 基于职业胜任的体内药物分析混合式教学改革 [J]. 基础医学教育, 2023, 25(03): 194-197.

2. 刘利红, 田园新, 张勇. 特色微视频及雨课堂在分析化学教学中的应用 [J]. 化工管理, 2023, 27,39-41,46.

3. 刘利红. 2019. 药学专业分析化学实验课堂教学思考. 广州化工, 2019(16):154-155.

4. 刘利红. 2015. 浅谈混合碱液实验教学中如何引导学生理论与实验相结合. 广州化工 43(12): 210-211.

5. 刘利红, 贾志敏,田元新,张勇. 2012. 药学专业开设分析化学综合性实验研究. 山西医科大学学报(基础医学教育版) 14(1): 210-212.

6. 刘利红, 贾志敏, 谭穗懿, 张群, 田元新. 2010. 药学专业分析化学课程绪论教学的设计与实践. 山西医科大学学报(基础医学教育版) 12(3): .

7. 刘利红, 慈薇, 吴少瑜. 2010. 药物分析实验教学思考 山西医科大学学报(基础医学教育版) 12(1): .

8. 刘利红, 张勇. 2009. 分析化学实验在药学专业教学改革中的思路与实践. 山西医科大学学报(基础医学教育版) 11(2): 210-212.

9. 杨洁, 谢宝平, 田园新, 刘利红. 2010. 针对执业药师资格考试优化成人教育课程的探索. 山西医科大学学报(基础医学教育版) 12(2): .

10.谭穗懿, 田元新, 张 勇, 刘利红. 2008. 多媒体技术应用于专科分析化学教学探讨. 山西医科大学学报(基础医学教育版) 10(2): 225-227.

专利情况:

1. 刘利红,陈悦,邓洁淇,一种快速无损测定血小板功能的新方法,专利申请号:202311288948.7,审核中。

2. 刘利红,陈悦,一种检测红细胞变形性及尺寸变化的方法,专利号:ZL202210247890.0,授权。

3. 刘利红,魏思奇,一种快速菌种鉴定及药敏检测方法,专利申请号:202211301704.3,审核中。

4. 刘利红,闫宏,一种用于检测 Ag + 的试剂及其在 C 反应蛋白检测中的应用,专利申请号:202310259106.2,审核中。

5. 刘利红,唐庆,一种基于适配体检测 C- 反应蛋白的方法,专利申请号:202210085686.3,审核中。

6. 刘利红,章润辉,一种基于 DNase I/Apt/rGO 联合多通道微流控芯片检测方法与应用,专利申请号:202311461029.5,审核中。

1. 刘利红,牛俊心,一种检测内毒素的方法,专利申请号:201811061693.X,授权。

2. 刘利红,刘贞,一种基于微流控芯片检测己酮可可碱对冠心病患者红细胞变形能力及生物化学指标的影响,专利申请号:201810144124.5,授权终止。

3. 刘利红,刘贞,己酮可可碱对蛋白激酶C的抑制作用及其应用,专利申请号:201810915533.0,授权终止。

4. 刘利红,刘贞,体外检测脂多糖对红细胞变形能力影响的方法及应用,专利申请号:201810466533.7,授权终止。

5. 刘利红,徐小英,李琳,张萱萱,花生四烯酸在制备抗HIV疫苗或药物中的应用,中华人民共和国国家知识产权局,201410339752.0,授权终止。

6. 刘利红,徐小英,李琳,张萱萱,一种抗HIV中药的有效部位及其制备方法,中华人民共和国国家知识产权局,201410166156.7,授权。

7. 刘利红,舒阳,基于未修饰纳米金与双链DNA相互作用的比色法检测DNA,中华人民共和国国家知识产权局,ZL 201510590912.3,授权终止。