姓名：刘利红
职称：教授，博士生导师
联系邮箱：lhliu02@126.com
联系电话：020-61648595
学习经历：
1995.09-1999.07 河北科技大学， 染整工程， 学士
2002.09-2007.06，兰州大学，分析化学，博士
2013.12-2014.12，美国麻省理工学院， 电子工程系，访问学者
2018.01-2018.03新加坡-麻省理工学院科研中心（SMART）,访问学者
工作经历：
2007.07-2010.12 南方医科大学药学院，讲师
2010.12- 2015.12 南方医科大学药学院，副教授
2015.12-至今 南方医科大学药学院，教授
承担课程：
《分析化学》，《高等药物分析》
研究方向
1. 药物分析及筛选新方法的研究及应用。
2. 微流控芯片及毛细管电泳在临床用药及疾病诊断中的研究及应用
3. 纳米材料在临床诊断中的研究
承担的课题
1. 微流控芯片在循环肿瘤细胞研究中的应用， 广东省海外名师深度交流与合作项目：5 万，2024，主持
2. 快速、低成本检测细胞治疗产品中微生物的便携式装置研究（2024B03J0007），广州市科技计划项目（重点研发计划），2024.01-2026.12，50 万，主持
3. 基于 cDNA@AuNPs 联合微流控芯片 ICP 在线富集技术的病原菌鉴定和药敏试验新方法研究（2023A1515010996），广东省基础与应用基础研究基金，10 万，2023.01-2025.12，主持
4. 基于DNaseI-Ap-GO联合多靶标平行在线富集微流控芯片的原发性肝癌早期诊断新方法研究（2021A1515011493），广东省基础与应用基础研究基金，10 万，2021.01-2023.12，主持
5. 基于集成微流控芯片的血小板功能检测新方法研究(81973282)，国家自然科学基金面上项目，55万，2020.01-2023.12,主持。
6. 毛细管电泳柱端GNPas-Ap-Ber微反应器间接超灵敏检测CRP新方法的研究（2018A030313843）, 广东省科技创新战略专项资金，2018.05-2021.04，主持
7. 基于微流控芯片在线检测生物药中内毒素含量的新方法研究,广东省科技计划项目(协同创新与平台环境建设（2016A040403052）, 2016.01-2018.12，主持
8. 基于微流控芯片在线检测全血中内毒素的新方法研究（81470161），国家自然科学基金面上项目，2015/01~2016/12，主持
9. N/C-多肽与纳米金层层自组装微反应器在HIV gp41抑制剂筛选中的应用（2012045），广州市珠江科技新星专项，2012/07~2015/07，主持
10. 基于毛细管电泳柱端微反应器筛选HIV gp41融合抑制剂的研究（30901826），国家自然科学基金青年项目，2010/01~2012/12，主持
代表论文：
1. Hanren Chen, Shiquan Zheng, Yitong Zhang, Qing Tang, Runhui Zhang, Yue Chen, Meiming Wu, and Lihong Liu*，Visual Detection of LPS at the Femtomolar Level Based on Click Chemistry-Induced Gold Nanoparticles Electrokinetic Accumulation，Analytical Chemistry, 2024, 96, 6995−7004.
2. Huaze Shao , Hong Yan , Qing Tang , Shiquan Zheng , Hanren Chen , Lihong Liu *，Enzyme-free and label-free detection of HER2 in human serum based on Ag+-released hybridization chain reaction signal amplification, Sensors & Actuators: B. Chemical, 2024, 413, 135919.
3. Yue Chen#; Jieqi Deng#; Runhui Zhang; Huaze Shao; Dan Xu; Lihong Liu*; Rapid and Nondestructive Evaluation of Platelet Function in Whole Blood by Microfluidic Deterministic Cytometry,Analytical Chemistry, 2024, 96(1): 145-153.
4. Siqi Wei#; Qing Tang#; Xiumei Hu#; Wei Ouyang; Huaze Shao; Jincheng Li; Hong Yan; Yue Chen; Lihong Liu*; Rapid, Ultrasensitive, and Visual Detection of Pathogens Based on Cation Dye-Triggered Gold Nanoparticle Electrokinetic Agglutination Analysis, ACS Sensors, 2024, 9(1): 325-336.
5. Qing Tang#; Zhijie Li#; Jincheng Li; Hanren Chen; Hong Yan; Jieqi Deng; Lihong Liu*; PCR-Free, Label-Free, and Centrifugation-Free Diagnosis of Multiplex Antibiotic Resistance Genes by Combining mDNA-Au@Fe3O4 from Heating Dry and DNA Concatamers with G-Triplex, Analytical Chemistry, 2024, 96(1): 292-300.
6. Runhui Zhang#; Jun Xu#; Jieqi Deng; Wei Ouyang; Hanren Chen; Qing Tang; Shiquan Zheng; Lihong Liu*; High-Performance Cation Electrokinetic Concentrator based on a γ-CD/QCS/PVA Composite and Microchip for Evaluating the Activity of P-Glycoprotein without any Interference from Serum Albumin, Lab on a Chip, 2024, 24(1): 127-136.
7. Runhui Zhang#; Qing Tang; Hanren Chen; Jieqi Deng; Yongyin Li*; Lihong Liu*; Simultaneous Detection of Multiplex Biomarkers Related with Hepatocellular Carcinoma by Coupling DNase I-Assisted Recycling Amplification and Microfluidic Electrokinetic Stacking Chip with Parallel Multi-Channels, Sensors and Actuators: B. Chemical, 2024, 400: 134885.
8. Yue Chen#; Zhen Liu#; Huaze Shao; Jun Xu; Jincheng Li; Haoyi Chen; Chunqiong Zhou; Lihong Liu*; Heterogeneity of Red Blood Cell Deformability Caused by Lipopolysaccharide based on a Microfluidic Chip, Current Pharmaceutical Biotechnology, 2023, 24(14): 1795-1802.
9. Hong Yan#; Xiumei Hu#; Huaze Shao#; Jincheng Li; Jieqi Deng; Lihong Liu*; Low-Cost Full-Range Detection of C-Reactive Protein in Clinical Samples by Aptamer Hairpin Probes and Coprecipitation of Silver Ions and Gold Nanoparticles, Analytical Chemistry, 2023, 95(32): 11918-11925.
10. Chen Y., Zhan Q., Zhang J., Wang W., Bee L. K., Liu Z., Wei S.Q., Niu J.X., Xu J., Chia-Chen Y., Hu X.M., Liu Y.H., Han J.Y., Liu S.W.*, and Lihong Liu*, Accurate prediction of drug-induced heterogeneous response of red cell in vivo using a gravity-driven flow cytometry based on a microfluidic chip. Analytica Chimica Acta, 1221, 340151 (2022).
11. Tang Q., Xu J., Wei S.Q., Chen H.Y., Chen J.P., Zhang H.L., and Lihong Liu*, Label-free and highly sensitive detection of CRP based on the combination of nicking endonuclease-assisted signal amplification and capillary electrophoresis-UV assay. Analytica Chimica Acta, 2022, 1221, 340131.
12. Xu J., Tang Q., Zhang R.H., Chen H.Y., Bee L.K., Zhang X.G., Chen Y., Yan H., Li J.C., Shao H.Z., and Lihong Liu*, Sensitive detection of microRNAs using polyadenine-mediated fluorescence spherical nucleic acids and a microfluidic electrokinetic signal amplification chip. Journal of Pharmaceutical Analysis, 2022 (DOI: https://doi.org/10.1016/j.jpha. 2022.05.009).
13. Chen Y., Kerwin K. Z., Hu X.M., Wei S.Q., Xu J., Yan H., and Lihong Liu*, Deterministic flow cytometry: Rapid erythrocyte rheological profiling from a drop of whole blood. Sensors and Actuators: B. Chemical, 2022, 362, 131783.
14. Niu, J.X., Hu X.M., Ouyang W., Chen Y., Liu S.W., Han J.Y. *, and Lihong Liu*, 2019. Femtomolar Detection of Lipopolysaccharide in Injectables and Serum Samples Using Aptamer-Coupled Reduced Graphene Oxide in a Continuous Injection-Electrostacking Biochip. Analytical Chemistry, 2019, 91, 3, 2360-2367.
15. Liu, Z., Hettihewa, M., Shu, Y., Zhou, C., Wan, Q., & Liu Lihong*, 2018. The mechanism of the adsorption of dsdna on citrate-stabilized gold nanoparticles and a colorimetric and visual method for detecting the v600e point mutation of the braf gene. Microchimica Acta, 185(4), 240.
16. Xu, X.X., Li, L., Liu, Z., X.J. Yao, Zhang, X.X., Liu, S.W.*, Liu, Lihong*, 2018. Investigation of the inhibition effect of arachidonic acid on the corestructure of the HIV-1 gp41, Journal of Pharmaceutical and Biomedical Analysis 161:377-382.
17. Liu Lihong *, Wan, Q, Xu, X.Y., Duan, S.S, Yang, C.L., 2017, Combination of micelle collapse and field-amplified sample stacking in capillary electrophoresis for determination of trimethoprim and sulfamethoxazole in animal-originated foodstuffs. Food Chemistry, 219: 7-12.
18. Wan Q, Liu Y, Yang C, Liu Lihong *. 2017, On-line double focusing of atenolol and metoprolol in human urine using capillary electrophoresis with the aid of β-cyclodextrin[J]. Analytica Chimica Acta, 978:61-67.
19. Lihong Liu, S. Huang., X.Y. Xu J.Y. Han, Study of Individual erythrocyte deformability susceptibility to INFeD and ethanol using a microfluidic chip. Scientific Reports, 2016, 6, 22929; doi: 10.1038/srep22929.
20. Liu, Lihong, Xu, X.X., Liu, Y.H., Zhang, X.X., Li, L., Jia, Z.M., Screening HIV-1 fusion inhibitors based on capillary electrophoresis head-end microreactor targeting to the core structure of gp41. Journal of Pharmaceutical and Biomedical Analysis 2016, 120:153-157.
21. Xu, X.Y., Jia, Z.M., Shu, Y., Liu, Lihong*, Dynamic pH junction-sweeping technique for on-line concentration of acidic amino acids in human serum by capillary electrophoresis with indirect UV detection. Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Science , 2015, 980: 20-27.
文章列表见：http://www.researcherid.com/rid/F-1512-2010
专利情况：
1、刘利红，牛俊心，一种检测内毒素的方法，专利申请号：201811061693.X。
2、刘利红，刘贞，一种基于微流控芯片检测己酮可可碱对冠心病患者红细胞变形能力及生物化学指标的影响，专利申请号：201810144124.5。
3、刘利红，刘贞，己酮可可碱对蛋白激酶C的抑制作用及其应用，专利申请号：201810915533.0。
4、刘利红，刘贞，体外检测脂多糖对红细胞变形能力影响的方法及应用，专利申请号：201810466533.7。
5、刘利红，徐小英，李琳，张萱萱,花生四烯酸在制备抗HIV疫苗或药物中的应用,中华人民共和国国家知识产权局，201410339752.0（已授权）。
6、刘利红，徐小英，李琳，张萱萱，一种抗HIV中药的有效部位及其制备方法，中华人民共和国国家知识产权局，201410166156.7（已授权）。
7、 刘利红，舒阳，基于未修饰纳米金与双链DNA相互作用的比色法检测DNA，中华人民共和国国家知识产权局，ZL 201510590912.3（已授权）
