姓名：陈之朋

职称：副教授、硕士生导师

Email: czpwyq@smu.edu.cn

联系电话：020-62789490

主要招生方向：药物化学、工业药学

工作经历：

2005–2020南方医科大学药学院，讲师

2020-至今 南方医科大学药学院，副教授

学习经历：

2000.9–2005.7中山大学，有机化学，硕博连读

1996.9–2000.7曲阜师范大学，化学教育，学士

承担课程：

药物化学，高等有机化学

研究方向：

肿瘤免疫治疗研究

抗病毒药物研究

科研课题：

1、国家自然科学基金，81973183，2020.1-2023.12，项目负责人。

2、国家自然科学基金，81202544，2013.1~2015.12，项目负责人。

3、广州市科技计划项目，2007J1-C0251，2007.1~2009.12，项目负责人。

3、广东省医学科研基金，B2006091，2006.1~2007.12，项目负责人。

发表论文

1.Zhipeng Chen, Xiaohong Cen, Junjie Yang, Zhiman Lin, Meihuan Liu, Synthesis of urea analogues bearing N-alkyl-N’-(thiophen-2-yl) scaffold and evaluation of their innate immune response to toll-like receptors,Eur J Med Chem, 2019, 169: 42-52.

2.Zhipeng Chen, Xiaohong Cen, Junjie Yang, Xiaoshan Tang, Kai Cui, Kui Cheng. Structure-based discovery of a specific TLR1–TLR2 small molecule agonist from the ZINC drug library database.Chem Commun, 2018, 54, 11411-11414.

3.Zhipeng Chen, HaiBo Wang, YuQin Wang, QiuHua Zhu, Yang Xie , ShuWen Liu. Synthesis of fused pyrrolo[3,4-d]tetrahydropyrimidine derivatives by proline-catalyzed multicomponent reaction.Tetrahedron, 2014, 70: 4379-4385.

4. Suiyi Tan, Jinqing Li, Hongyan Cheng, Zhaofeng Li, Yan Lan, Tingting Zhagn, Zichao Yang, Wenjuan Li, Tao Qi, Yurong Qiu,Zhipeng Chen, Lin Li, Shuwen Liu. The anti-parasitic drug suramin potently inhibits formation of seminal amyloid fibrils and their interaction with HIV-1.J Biol Chem, 2019, 294(37): 13740-13754.

5. Yao Xu, Shujun Chen, Ying Cao, Pingzheng Zhou,Zhipeng Chen, Kui Cheng. Discovery of novel small molecule TLR4 inhibitors as potent anti-inflammatory agents.Eur J Med Chem,2018,154, 253-266.

6. Sichao Zheng, Shufang Zhong,Zhipeng Chen, Wenhua Chen, Qiuhua Zhu. Efficient synthesis of a series of novel octahydroquinazoline-5-ones via a simple on-water urea-catalyzed chemoselective five-component reaction,ACS Comb Sci, 2016, 18, 475-481.

7. Qiuhua Zhu, Lan Huang,Zhipeng Chen, Sichao Zheng, Longyun Lv, Zhibo Zhu, Derong Cao, Huanfeng Jiang, Shuwen Liu, A New Series of C-6 Unsubstituted Tetrahydropyrimidines: Convenient One-Pot Chemoselective Synthesis, Aggregation-Induced and Size-Independent Emission Characteristics,Chemistry-A European Journal,2013, 19(4): 1268-1280.

8. Qiuhua Zhu, Lixin Gao,Zhipeng Chen, Sichao Zheng, Huafei Shu, Jia Li, Huanfeng Jiang, Shuwen Liu, A novel class of small-molecule caspase-3 inhibitors prepared by multicomponent reactions,Eur J Med Chem, 2012, 54: 232-238.

9. Zhibo Zhu, Runming Li, Gaokeng Xiao,Zhipeng Chen, Jie Yang, Qiuhua Zhu, Shuwen Liu, Design, synthesis and structure-activity relationship of novel inhibitors against H5N1 hemagglutinin-mediated membrane fusion,Eur J Med Chem, 2012, 57: 211-216.