姓名：谢宝平
职务：药学院科研办主任
联系方式：南方医科大学药学院
Email: xiebp@smu.edu.cn
学习经历：
2003/09-2006/06，中山大学分析化学博士
1996/09-1999/06，江西农业大学植物学专业硕士
1992/09-1996/06，江西农业大学林学专业学士
工作经历：
2006/06-至 今，南方医科大学，药学院
2017/01-2018/01， 新加坡科技研究局材料工程研究院，访问学者
1999/07-2003/08，常熟理工学院，生物系
研究方向：
生化分析及生物传感器，纳米材料及生物医学应用
主持或参加科研项目：
1. 国家基金，21874064，同源细胞膜包裹P-DNA@MOF荧光/MRI双模态探针的构建及其癌症靶向诊断功能研究；
2. 国家基金，81871334，基于多模态磁共振成像定量监测KGN/USPIO双标记组织工程水凝胶诱导BMSCs定向分化促进软骨修复的实验研究；
3. 国家基金，81671709，超声激发载氧相变纳米滴-携iRGD肽载药肝素纳米粒复合物克服肿瘤多药耐药及其机制的研究；
4. 广东省医学基金，A2017195，两性三维金属有机骨架的构建及其登革热病毒核酸系列的检测功能研究。
近期代表性论文：
1. Qing-Xin Gao#, Li-Min Zhang#, Qian-Qian Wu, Fang-Fang Guo, Jun Chen, Min-Min Li, Yong-Yi Wu, Bao-Ping Xie*, Wen-Jun Duan*. A sodium-dependent split DNAzyme fluorescent sensor under butanol acceleration for ultrasensitive detection of PIWI-interacting RNAs and microRNAs. Sensors & Actuators: B. Chemical, 2023, 393, 134272.
2. Birong Liu, Mengxu Sun, Tong Li, Pengying Liang, Qianying Zhou, Mingqi Guo, Chunrong Li, Wen-Jun Duan, Min-Min Li, Jin-Xiang Chen*, Bao-Ping Xie*, Zong Dai, Jun Chen*. A ZIF-8@DNAzyme-based DNA walker nanosystem for microRNAs sensing in living cells with high accuracy. Sensors and Actuators B: Chemical, 2023, 387, 133812.
3. Birong Liu, Zizhong Yang, Ting Huang, Min-Min Li, Wenjun Duan, Baoping Xie*, Jin-Xiang Chen*, Zong Dai, Jun Chen*. Label-free and highly sensitive APE1 detection based on rolling circle amplification combined with G-quadruplex. Talanta, 2022, 123404.
4. Mengxu Sun, Birong Liu, Tong Li, Chunrong Li, Wen-Jun Duan, Baoping Xie, Min-Min Li*, Jin-Xiang Chen, Zong Dai, Jun Chen*. A universal rolling circle amplification for label-free and highly specific nucleic acid sensing. Chemical Communications, 2022, 58 (84), 11863-11866.
5. Zizhong Yang, Birong Liu, Ting Huang, Bao-Ping Xie, Wen-Jun Duan, Min-Min Li, Jin-Xiang Chen*, Jun Chen*, Zong Dai*. Smart Hairpins@MnO2 Nanosystem Enables Target-Triggered Enzyme-Free Exponential Amplification for Ultrasensitive Imaging of Intracellular MicroRNAs in Living Cells. Analytical Chemistry, 2022, 94, 22, 8014–8023.
6. Li-Min Zhang#, Qing-Xin Gao#, Bao-Ping Xie, Jun Chen*, Wen-Jun Duan*. Highly accelerated isothermal nucleic acid amplifications by butanol dehydration: simple, more efficient, and ultrasensitive, Chemical Communications, 2022, 58 (38) , 5793-5796.
7. Ting Huang, Guixun Chen, Birong Liu, Zizhong Yang, Yuanwei Huang, Baoping Xie, Min-Min Li, Jin-Xiang Chen*, Jun Chen*, Zong Dai. An intramolecular DNAzyme-based amplification for miRNA analysis with improving reaction kinetics and high sensitivity, Talanta, 2022, 239, 123137.
8. Jun Chen, Yanfei Zhang, Bao-Ping Xie, Bin Sun, Wen-Jun Duan, Min-Min Li, Jin-Xiang Chen*, Zong Dai*, Xiaoyong Zou. A protein triggering exponential amplification reaction enables label- and wash-free one-pot protein assay with high sensitivity.Talanta,2021,225,121980.
9. Bao-Ping Xie, Jin-Wei Chai, Cheng Fan,Ji-Hua Ouyang, Wen-Jun Duan, Bin Sun, Jun Chen, Li-Xia Yuan*, Xue-Qing Xu*, and Jin-Xiang Chen*. Water-Stable Silver-Based Metal–Organic Frameworks of Quaternized Carboxylates and Their Antimicrobial Activity. ACS Applied Bio Materials,2020,3,12,8525–8531.
10. Bao-Ping Xie, Gui-Hua Qiu, Bin Sun, Zi-Feng Yang, Wen-Hua Zhang*, Jin-Xiang Chen*, Zhi-Hong Jiang*. Synchronous sensing of three conserved sequences of Zika virus using a DNAs@MOF hybrid: experimental and molecular simulation studies. Inorganic Chemistry Frontiers, 2019, 6 (1), 148-152.
11. Rong-Tian Li, Zhen Liang, Meng-Chu Li, Yong Tan, Bao-Ping Xie, Wen-Jun Duan, Chun-Tao Ning, Jin-Xiang Chen*, Bin Sun*. Speedy, specific, synchronous sensing platforms with ruthenium complexes for multiplexed microRNA detection. Inorganic Chemistry, 2019, 58, 22, 15126–15137
12. Bao-Ping Xie#, Gui-Hua Qiu#, Pei-Pei Hu, Zhen Liang, Ye-Mei Liang, Bin Sun, Li-Ping Bai, Zhi-Hong Jiang, Jin-Xiang Chen*. Simultaneous detection of Dengue and Zika virus RNA sequences with a three-dimensional Cu-based zwitterionic metal–organic framework, comparison of single and synchronous fluorescence analysis. Sensors and Actuators B: Chemical, 2018,254, 1133-1140.
13. Pei-Pei Hu, Ning Liu, Ke-Yang Wu, Ling-Yan Zhai, Bao-Ping Xie, Bin Sun, Wen-Jun Duan, Wen-Hua Zhang*, Jin-Xiang Chen*. Successive and specific detection of Hg2+ and I– by a DNA@MOF biosensor: experimental and simulation studies. Inorganic Chemistry. 2018, 57, 14, 8382–8389
14. Bin Sun#, Zhen Liang#, Bao-Ping Xie, Rong-Tian Li, Lin-Ze Li, Zhi-Hong Jiang, Li-Ping Bai, Jin-Xiang Chen*. Fluorescence sensing platform based on ruthenium(II) complexes as high 3S (sensitivity, specificity, speed) and “on-off-on” sensors for the miR-185 detection. Talanta, 2018, 179, 658-667.
15. Gui-Hua Qiu, Zi-Hua Weng, Pei-Pei Hu, Wen-Jun Duan, Bao-Ping Xie, Bin Sun, Xiao-Yan Tang*, Jin-Xiang Chen*. Synchronous detection of ebolavirus conserved RNA sequences and ebolavirus-encoded miRNA-like fragment based on a zwitterionic copper (II) metal–organic framework. Talanta, 2018, 180, 396-402.
16. Bin Sun#, Hai-Qing Zhao#, Bao-Ping Xie, Li-Ping Bai, Zhi-Hong Jiang, Jin-Xiang Chen*. Sequence-specific fluorometric recognition of HIV-1 ds-DNA with zwitterionic zinc(II)-carboxylate polymers. Journal of Inorganic Biochemistry, 2017, 176, 17-23.
17. Ying Wang*, Yingjia Li, Dongxiao Wang, Shaofu Hong, Jianguo Wang, Baoping Xie, Qianbing Zhang, Xingmei Zhang, Hongfen Shen, Qian Xiao MM. Response of heterogeneous cancer cells on targeted nanoparticles. Nanomedicine: Nanotechnology, Biology and Medicine, 2016,12(7),2127-2137.
授权的发明专利
1. 谢宝平，陈金香，孙斌，杨水平，邱桂华，张茉莉，一种两性羧酸三维金属配位聚合物及其制备方法和应用，中国，专利号：ZL 201611077693.X
2. CHEN, Jin-Xiang;XIE, Bao-Ping;QIU, Gui-Hua; HU, Pei-Pei; LIANG, Zhen; LIANG, Ye-Mei; SUN, Bin; BAI, Li-Ping and JIANG, Zhi-Hong, CRYSTALLINE COPPER-BASED COORDINATION POLYMERS AND THEIR USE. AU: 2017100590
3. CHEN, Jin-Xiang; SUN, Bin; XIE, Bao-Ping; JIANG, Zhi-Hong and BAI, Li-Ping, CRYSTALLINE LANTHANUM-CARBOXYLATE COORDINATION POLYMERSAND THEIR USE, AU:2017100565
4. CHEN, Jin-Xiang; SUN, Bin, ZHAO, Hai-Qing; XIE, Bao-Ping; BAI, Li-Ping; JIANG, Zhi-Hong; ZWITTERIONIC ZINC(II) CARBOXYLATE COMPOUNDS AND THEIR USE,AU: 2016101528
