姓名：姚新刚

职称：副教授，博士，硕士研究生导师（学术型）

联系邮箱：yaoxingang@smu.edu.cn

联系电话：020-62789421

主要招生专业：药理学、工业药学

学习经历

2008/09–2014/01， 上海药物研究所， 药理学， 硕、博士，

2004/09–2008/09， 中山大学，

科研与学术工作经历

1.2019/12-2020/12, Wake Forest University, Visiting Scholar

2.2019/06, 南方医科大学，药学院，副教授

3.2015/08-2019/06，南方医科大学，药学院，讲师

研究方向

1.工程化外泌体用于疾病的治疗研究

2.CRISPR基因药物治疗和基因药物靶向递送研究

3.高通量药物筛选（黄病毒药物发现）和药理学机制研究

4.天然免疫机制在病毒感染及代谢性疾病中的机制研究

主持或参加科研项目项目情况

1.国家自然科学面上项目，批准号：82373873，GLP1R激动剂艾塞那肽抑制NLRP3炎症小体活化改善登革病毒诱导的血管渗漏作用及机制研究，2024.01-2027.12, 49万，国家自然科学基金委员会。主持

2.广东省自然科学基金项目（青年提升项目），批准号：2314070000176，RNA适配体介导的hfCas13d-RNP外泌体高效抑制登革病毒感染和耐药的机制研究，2023.01-2025.12, 30万，广东省基础与应用基础研究基金委员会。主持

3.广东省重点领域研发计划，海洋生物来源的感染性疾病创新药物研发，2023.10-2025.10， 500万，广东省科技厅。参与（第五）

4.广东省新药筛选重点实验室，2019.01-2022.01，参加，300万元，广东省科技厅。

5.广东省自然科学基金面上项目，VEGFR2抑制剂布立尼布通过AMPK/mTOR通路抑制登革病毒感染的机制研究，2019.10-2022.10，主持，10万元，广东省自然科学基金委员会, 2019A1515010681。结题

6.广州市珠江新星，噻吩酰胺类化合物改善胰岛b细胞功能的机制和靶标发现研究，2018.04-2021.3，主持，30万元，广州市科创委，201806010119。结题

7.国家自然科学青年基金项目，81603118，PKA/ERK介导噻吩酰胺类化合物BBT改善胰岛beta细胞炎症免疫的机制研究，2017.01-2019.12，主持，17.3万元，国家自然科学基金委员会。结题

8.广东省医学科研基金，A2016119，噻吩酰胺类化合物改善胰岛beta细胞功能的构效关系和机制研究，2016.7-2018.6，主持，1万元，广东省卫计委。结题

教学改革项目

1.“课程思政”视域下高校《药理学》课程与思政教育融合研究，2019，校级，主持

2.微信“雨课堂”平台在《药理学》教学中的实践应用和效果评价，2018，院级项目立项编号，2018YXYJG02，主持

获奖情况

1.广东省药理学会科技成果奖，岭南新发与再发现病毒防治药物筛选模式的建立及新药研发，二等奖，南方医科大学，杨洁，刘叔文，姚新刚 （2020）003号

2.第十五届“全国大学生药苑论坛”药学科学组，特等奖，2023.10.19, 沈阳药科大学南校区（本溪），项目成员为我院2020级临床药学本科生陈炳林、吴非、2019级临床药学本科生曾海峰、郭绍燊。

代表性研究成果

(1) Yuanda Wan, Liren Li , Ruilin Chen, Jiajia Han, Qiyun Lei, Zhipeng Chen, Xiaodong Tang, Wenyu Wu, Shuwen Liu, Xingang Yao, Engineered extracellular vesicles efficiently deliver CRISPR-Cas9 ribonucleoprotein (RNP) to inhibit herpes simplex virus1 infection in vitro and in vivo，Acta Pharmaceutica Sinica B, 2023 https://doi.org/10.1016/j.apsb.2023.10.004.

(2) Yifei Feng, Yan Yang, Shuting Zou, Shuqi Qiu, Hao Yang, Yi Hu, Guifen Lin, Xingang Yao, Shuwen Liu, Min Zou, Identification of alpha-linolenic acid as a broad-spectrum antiviral against zika, dengue, herpes simplex, influenza virus and SARS-CoV-2 infection, Antiviral Research 2023, 216, 105666

(3) Haifeng Zeng, Shaoshen Guo, Xuancheng Ren, Zhenkun Wu, Shuwen Liu, Xingang Yao，Current Strategies for Exosome Cargo Loading and Targeting Delivery, Cells, 2023,12 (10), 1416

(4) Qiwen Gao, Jinhong Tian, Kangmei Wen, Chen Chen, Xingang Yao, Jianxin Pang, Xiaodong Tang，Copper-Mediated C4-Benzylations of 5-Aminopyrazoles with 3-Indoleacetic Acids， The Journal of Organic Chemistry, 2023

(5) Xin Qi, Weihao Chen, Liurong Chen, Yiwei Hu, Xueni Wang, Wenrong Han, Jiao Xiao, Xiaoyan Pang, Xingang Yao, Shuwen Liu, Yong Li, Jie Yang, Junfeng Wang, Yonghong Liu, Structurally various p-terphenyls with neuraminidase inhibitory from a sponge derived fungus Aspergillus sp. SCSIO41315， Bioorganic Chemistry, 2023, 132, 106357

(6) Wenyu Wu, Ruilin Chen, Yuanda Wan, Liren Li, Jiajia Han, Qiyun Lei, Zhipeng Chen, Shuwen Liu, Xingang Yao, Acetyl-CoA Carboxylase (ACC) Inhibitor, CP640186, Effectively Inhibited Dengue Virus (DENV) Infection via Regulating ACC Phosphorylation, Molecules, 2022, 27 (23), 8583

(7) Shijun He, Yuanda Wan, Liren Li, Xiaodong Tang, Wenyu Wu, Shuwen Liu, Xingang Yao, PKCβ Inhibition Promotes TXNIP Degradation to Ameliorate Pancreatic β-Cell Dysfunction, Pharmacology, 2022, 107 (11-12), 584-600

(8) Yihong Wan, Wenyu Wu, Yuanda Wan, Liren Li, Jiawen Zhang, Xiaodong Tang, Xiaoguang Chen, Shuwen Liu, Xingang Yao. Tenovin-1 inhibited dengue virus replication through SIRT2, European Journal of Pharmacology, 33, 13138-13149. Available online 17 June 2021, https://doi.org/10.1016/j.ejphar.2021.174264

(9) YihongWan, WenyuWu, YuandaWan, LirenLi, JiawenZhang, XiaoguangChen, ShuwenLiu, XingangYao. Brivanib alaninate inhibited dengue virus proliferation through VEGFR2/AMPK pathway. Pharmacological Research, Available online 8 June 2021, 105721, https://doi.org/10.1016/j.phrs.2021.105721

(10) Xingang Yao, Pin Lyu, Kyung Yoo, Manish Kumar Yadav, Ravi Singh, Anthony Atala, Baisong Lu, Engineered Extracellular Vesicles as Versatile Ribonucleoprotein Delivery Vehicles for Efficient and Safe CRISPR Genome Editing, Journal of extracellular vesicles, 2021, 10 (5), e12076

(11) Zuyan Lu^#, Xingang Yao^#, Pin Lyu, Manish Yadav, Kyung Yoo, Anthony Atala, Baisong Lu, Lentiviral Capsid-Mediated Streptococcus pyogenes Cas9 Ribonucleoprotein Delivery for Efficient and Safe Multiplex Genome Editing, The CRISPR Journal, 2021 DOI: 10.1089/crispr.2020.0106

(12) Jiewen Chen, En Liang, Jie Shi, Yinrong Wu, Kangmei Wen, Xingang Yao, Xiaodong Tang, Metal-free synthesis of 1, 4-benzodiazepines and quinazolinones from hexafluoroisopropyl 2-aminobenzoates at room temperature, RSC Advances 2021, 11 (9), 4966-4970

(13) Wenyu Wu, Shijun He, Yuli Shen, Jiawen Zhang, Yihong Wan, Xiaodong Tang, Shuwen Liu, Xingang Yao, Natural Product Luteolin Rescues THAP-Induced Pancreatic β-Cell Dysfunction through HNF4α Pathway, The American Journal of Chinese Medicine, 2020, 48 (06), 1435-1454

(14) Yinrong Wu, Jiewen Chen, Lu Li, Kangmei Wen, Xingang Yao, Jianxin Pang, Ting Wu, Xiaodong Tang, Copper-Mediated Decarboxylative Sulfonylation of Arylacetic Acids with Sodium Sulfinates, Organic Letters, 2020, 22 (18), 7164-7168

(15) Yihong Wan, Shengen Wu, Sichao Zheng, En Liang, Shuwen Liu, Xingang Yao, Qiuhua Zhu, A series of octahydroquinazoline-5-ones as novel inhibitors against dengue virus, European Journal of Medicinal Chemistry, 2020, 200, 112318

(16) Jianjiao Wang, Qingyun Peng, Xingang Yao, Yonghong Liu, Xuefeng Zhou, New pestallic acids and diphenylketone derivatives from the marine alga-derived endophytic fungus Pestalotiopsis neglecta SCSIO41403 The Journal of antibiotics, 2020, 73 (8), 585-588

(17) Chao Jiang, Xingang Yao, Yulin Zhao, Jianmin Wu, Pan Huang, Chunhua Pan, Shuwen Liu, Chungen Pan, Comparative review of respiratory diseases caused by coronaviruses and influenza A viruses during epidemic season. Microbes and infection, 2020, 22 (6-7), 236-244

(18) Min Zou, Hongmiao Liu, Jingyan Li, Xingang Yao, Yi Chen, Changwen Ke, Shuwen Liu, Structure-activity relationship of flavonoid bifunctional inhibitors against Zika virus infection, Biochemical Pharmacology, 2020, 177, 113962

(19) Yi hong Wan, Wen yu Wu, Song xin Guo, Shi jun He, Xiao dong Tang, Xiao yun Wu, Kutty Selva Nandakumar, Min Zou, Lin Li, Xiao guang Chen, Shu wen Liu*, Xin gang Yao*. [1,2,4] Triazolo[1,5-a]pyrimidine derivative (Mol-5) is a new NS5-RdRp inhibitor of DENV2 proliferation and DENV2-induced inflammation, Acta Pharmacologica Sinica, 2020, 41, 706–718, https://doi.org/10.1038/s41401-019-0316-7

(20) Shijun He, Wenyu Wu, Yihong Wan, Kutty Selva Nandakumar, Xiuchao Cai, Xiaodong Tang, Shuwen Liu, Xingang Yao. GLP-1 Receptor Activation Abrogates β-Cell Dysfunction by PKA Cα-Mediated Degradation of Thioredoxin Interacting Protein, Frontiers in Pharmacology, 2019, 25, 10:1230.

(21) Zhiyuan Fang, Li Ban, Yanan Li, Wenchang Yuan, Zhihua Liu, Ting Liu, Xiaomei Li, Kwok-yin Wong, Yujing Lu, Ning Sun, Xingang Yao. A quinoline-based FtsZ inhibitor for the study of antimicrobial activity and synergistic effects with b-lactam antibiotics, Journal of Pharmacological Sciences, 2018, 137, 283–289.

(22) Xingang Yao^#, Songxin Guo^#, Wenyu Wu, Jinan Wang, Shengen Wu, Shijun He, Yihong Wan, Kutty Selva Nandakumar, Xiaoguang Chen, Ning Sun, Qiuhua Zhu, Shuwen Liu. Q63, a novel DENV2 RdRp non-nucleoside inhibitor, inhibited DENV2 replication and infection, Journal of Pharmacological Sciences, 2018, 138, 247–256.

(23) Xingang Yao^#, Yun Ling^#, Songxin Guo^#, Wenyu Wu, Shijun He, Qing Zhang, Min Zou, Kutty Selva Nandakumar, Xiaoguang Chen, Shuwen Liu. Tatanan A from the Acorus calamus L. root inhibited dengue virus proliferation and infections, Phytomedicine, 2018, 42, 258–267.

(24) Xingang Yao^#, Yun Ling^#, Songxin Guo^#, Shijun He, Jinan Wang, Qing Zhang, Wenyu Wu, Min Zou, Tingting Zhang, Kutty Selva Nandakumar, Xiaoguang Chen, Shuwen Liu. Inhibition of dengue viral infection by diasarone-I is associated with 2'Omethyltransferase of NS5, Eur J Pharmacol, 2018, 821, 11-20.

(25) Lili Shi, Le Yu, Desheng Zhong, Chunping Gu, Longyun Lv, Xiaoyun Zeng, Xingang Yao, Lin Li, Shuwen Liu. TMC120 displayed potent cytotoxic effect on human cervical carcinoma through enhancing the polymerization of microtubules, AIDS, 2018, doi: 10.1097/QAD.0000000000001808.

(26) Chengqian Xiao, Yunan Tian, Min Lei, Fanglei Chen, Xianwen Gan, XingangYao, Xu Shen, Jing Chen, Lihong Hu. Synthesis and glucose-stimulate insulin secretion (GSIS) evaluation of vindoline derivatives. Bioorg Med Chem Lett, 2017, 27, 1316-1318.

(27) Xingang Yao^#, Xin Xu^#, Gaihong Wang, Min Lei, Lingling Quan, Yanhua Cheng, Ping Wan, Jinpei Zhou, Jing Chen, Lihong Hu, Xu Shen. BBT improves glucose homeostasis by ameliorating beta-cell dysfunction in type 2 diabetic mice. J Endocrinol, 2015, 224, 327-341.

(28) Xingang Yao, Fanglei Chen, Ping Li, Lingling Quan, Jing Chen, Liang Yu, Hong Ding, Chenjing Li, Lili Chen, Zhaobing Gao, Ping Wan, Lihong Hu, Hualiang Jiang, Xu Shen. Natural product vindoline stimulates insulin secretion and efficiently ameliorates glucose homeostasis in diabetic murinemodels, J Ethnopharmacol, 2013, 150, 285-297.

(29) Gaihong Wang, Xing Xu, Xingang Yao, Zhiyuan Zhu, Liang Yu, Lili Chen, Jing Chen, Xu Shen. Latanoprost effectively ameliorates glucose and lipid disorders in db/db and ob/ob mice. Diabetologia, 2013, 56, 2702-2712.

(30) Rong Zhou, Xingang Yao, Xing Xu, Gaihong Wang, Zhiyuan Zhu, Jing Chen, Lili Chen, Xu Shen. Blockage of progesterone receptor effectively protects pancreatic islet beta cell viability. Steroids, 2013, 78, 987-995.

(31) Zhiyuan Zhu, Jianming Yan, Wei Jiang, Xingang Yao, Jing Chen, Lili Chen, Chenjing Li, Lihong Hu, Hualiang Jiang, Xu Shen. Arctigenin effectively ameliorates memory impairment in Alzheimer's diseasemodel mice targeting both beta-amyloid production and clearance. J Neurosci, 2013, 33, 13138-13149.

(32) Yu Zhang, Haitao Zhang, Xingang Yao, Hong Shen, Jing Chen, Chenjing Li, Lili Chen, Mingyue Zheng, Jiming Ye, Lihong Hu, Xu Shen, Hualiang Jiang. (+)-Rutamarin as a dual inducer of both GLUT4 translocation and expression efficiently ameliorates glucose homeostasis ininsulin-resistant mice. Plos One, 2012, 7, e31811-e31811.

授权发明专利

(1) 双细辛酮I作为治疗登革病毒感染的药物及其要用途，国家发明专利201710094600.2（姚新刚，凌 云，郭颂欣，刘叔文）CN106860437 B，2019年08月02日

(2) Tatanan A 作为治疗登革病毒感染的药物及其制药用途，国家发明专利201710093605.3，（姚新刚，凌 云，郭颂欣，刘叔文）CN106983736 B，2019年08月27日

(3) 一种N-芳基-2-噻吩酰胺类衍生物机器制备方法和用途，国家发明专利201710361230.4，（姚新刚，陈之朋，吴文玉，刘叔文）CN107033122B，2017年05月19日

(4) 布立尼布作为治疗登革病毒感染的药物及其制药用途，国家发明专利201910110917.X, (姚新刚，万毅虹，唐晓冬，刘叔文) CN109602749 B，2021年03月12日

(5) 细菌DNA促旋酶抑制剂BRD7716作为治疗和/或预防登革病毒感染的药物及其制药用途，国家发明专利2020101128510（姚新刚，刘叔文）CN111346079 B，2023年06月20日

(6) ACC酶抑制剂CP640184作为治疗和/或预防登革病毒感染的药物及其制药用途，国家发明专利2020101128309（姚新刚，刘叔文）CN111317737B，2023年02月17日

(7) 尼罗替尼作为治疗登革病毒感染的药物及其制药用途8治疗登革病毒感染的药物及其制药用途，国家发明专利2017106703697（姚新刚，刘叔文）CN107441094B，2020年05月22日

(8) 治疗登革病毒感染的药物及其制药用途，国家发明专利2017106703697（姚新刚，万毅虹，唐晓冬，刘叔文）CN109602746 B，2020年07月10日

教学论文(题目, 发表, 年月, 刊物名称, 刊号, 刊物主办出版单位, 期刊影响因子或重要指标等, 他引次数)

(1) “课程思政”背景下药理学课程与思政教育融合研究 2021-06-25 广东化工 1007-1865 广东省科学院化工研究院 0.429 3

(2) 雨课堂在药理学“化学治疗药物”章节课程改革应用中的探讨 2020-01-29 教育现代化 2095-8420 中华人民共和国工业和信息化部 0

(3) 药理学课后小论文在提高药理学教学成绩中的研究 2018-02-15 中国高等医学教育 1002-1701 浙江大学;全国高等医学教育学会 0.443 3

(4) 大学生中抗菌药物认知、使用习惯和应用态度的调查 2018-01-17 卫生职业教育 1671-1246 甘肃省医学科学研究院 0.257 0

(5) 多元化教学模式在提高内分泌药理学教学效果中的应用探讨 2017-03-01 教育教学论坛 1674-9324 河北教育出版社有限责任公司 0.283 8

(6) “四新”理念下实验教学改革新路径和创新人才培养新模式探索” 中国医药远程杂志