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叶玲

发布时间:2017年10月17日 浏览次数:

 

 

 

职称: 教授,博士生导师

邮箱: lotus623@126.com

电话:020-61648597


教育经历:

2007.09-2012.06,南方医科大学,药理学,博士

2003.09-2007.06,南方医科大学,药学,学士


研究工作经历:

2021.12-至今,南方医科大学,药学院,教授

2016.01-2021.10,南方医科大学,药学院,副教授

2012.07-2015.12,南方医科大学,药学院,讲师

2016.07-2017.07,中国药科大学,药学院,博士后

2011.01-2011.09,美国休斯顿大学,药学院,博士联合培养

2009.08-2010.02,香港浸会大学,中医药学院,博士联合培养

2009.03-2009.05,沈阳药科大学,药学院,合作交流


研究方向:

1. 肠道菌群介导岭南中药的代谢及调控机制

2. 疾病状态下肠道菌群与宿主代谢酶/转运蛋白的互作及其对药物的药效/毒性的影响

3. 肠道菌群与疾病发生发展的关系研究


承担课程:

1. 本科生课程:《生物药剂学与药物动力学》、《药剂学》、《药物制剂工程》、《制剂设计学》

2. 研究生课程:《分子生物药剂学》


主要学术任职:

1. 中国药理学会药物代谢专业委员会,青年委员

2. 广东省药理学会药物代谢专业委员会,常务委员

3. 中国药理学会抗炎免疫药理专委会,青年委员


获奖或称号

1. 2019年广州市“珠江科技新星”

2. 广东省高等学校“千百十人才培养工程”校级培养对象(第8批)


近年主持主要科研项目:

1. 国家自然科学基金(面上项目),82074110, 2021.01-2024.12

2. 国家自然科学基金(面上项目),81873080, 2019.01-2022.12

3. 国家自然科学基金(青年项目),81503336, 2016.01-2018.12

4. 广东省自然科学基金(面上项目),2016A030313576,2016.06-2019.06

5. 广东省自然科学基金(青年项目),S2013040012007, 2013.10-2015.10

6. 广州市科技计划项目(珠江新星专项),201906010010, 2019.04-2021.03

7. 天然药物活性组分与药效国家重点实验室(中国药科大学)开放课题(SKLNMKF201705),2017.01-2018.12

8. 广东省农业生物蛋白质功能与调控重点实验室开放课题,2018.07-2020.12

9. 广东省中药药效物质基础和创新药物研究重点实验室开放课题, 2017.11-2018.10

10. 广东省农业生物蛋白质功能与调控重点实验室开放课题, 2015.01-2016.12


发表通讯/第一作者SCI论文:

1. You G, Yang R, Wei Y, Hu W, Gan L, Xie C, Zheng Z, Liu Z, Liao R*, Ye L*. The detoxification effect of cytochrome P450 3A4 on gelsemine-induced toxicity. Toxicol Lett. 2021 Oct 7; S0378-4274(21)00850-X. doi: 10.1016/j.toxlet.2021.10.003.

2. Chen M, You G, Xie C, Yang R, Hu W, Zheng Z, Liu S*, Ye L*. Pharmacokinetics of metformin in collagen-induced arthritis rats. Biochem Pharmacol. 2021 Jan 9; 185:114413.

3. Ye L#, Zhang J#, Xiao W*, Liu S*. Efficacy and mechanism of actions of natural antimicrobial drugs. Pharmacol Ther. 2020 Dec; 216:107671.

4. Gan L#, Ma J#, You G, Mai J, Wang Z, Yang R, Xie C, Fei J, Tang L, Zhao J, Cai Z, Ye L*. Glucuronidation and its effect on the bioactivity of amentoflavone, a biflavonoid from Ginkgo biloba leaves. J Pharm Pharmacol. 2020 Dec;72(12):1840-1853.

5. Jiang Y, Yang Z, Zhang L, Yan R, Liu S, Yang H, Wan S, Li Z, Zhu Z, Ye L*, Zhang J*. The Cytochrome P450 Metabolic Profiling of SMU-B in Vitro, a Novel Small Molecule Tyrosine Kinase Inhibitor. J Pharm Biomed Anal. 2020 Jun 3; 188:113400.

6. Sun R#, Chen M#, Hu Y, Lan Y, Gan L, You G, Yue M, Wang H, Xia B, Zhao J, Tang L, Cai Z, Liu Zhongqiu*, Ye L*. CYP3A4/5 mediates the metabolic detoxification of humantenmine, a highly toxic alkaloid from Gelsemium elegans Benth. J Appl Toxicol. 2019 Sep;39(9):1283-1292.

7. Wang Z#, Lan Y#, Chen M, Wen C, Hu Y, Liu Z*, Ye L*. Eriodictyol, Not Its Glucuronide Metabolites, Attenuates Acetaminophen-Induced Hepatotoxicity. Mol Pharm. 2017 Sep 5;14(9):2937-2951.

8. Hu Y#, Chen M#, Wang Z, Lan Y, Tang L, Liu M, Zhao J, Hu M, Zhang L*, Ye L*. Development of a validated UPLC-MS/MS method for determination of humantenmine in rat plasma and its application in pharmacokinetics and bioavailability studies. Biomed Chromatogr. 2017 Dec;31(12).

9. Ye L#, Miao M#, Li S*, Hao K*. Nanosuspensions of a new compound, ER-β005, for enhanced oral bioavailability and improved analgesic efficacy. Int J Pharm. 2017 Oct 5;531(1):246-256.

10. Ye L, Hou C, Liu S*. The Role of Metabolizing Enzymes and Transporters in Antiretroviral Therapy. Curr Top Med Chem. 2017;17(3):340-360.

11. Hu Y, Wang Z, Huang X, Xia B, Tang L, Zheng Z, Ye L*. Oxidative metabolism of koumine is mainly catalyzed by microsomal CYP3A4/3A5. Xenobiotica. 2016 Aug 8:1-8.

12. Ye L, Yang X, Guo E, Chen W, Lu L, Wang Y, Peng X, Yan T, Zhou F, Liu Z. Sorafenib metabolism is significantly altered in the liver tumor tissue of hepatocellular carcinoma patient. PLoS One. 2014 May 5;9(5).

13. Ye L#, Yang X#, Lu L, Chen W, Zeng S, Yan T, Dong L, Peng X, Shi J, Liu Z*. Monoester-Diterpene Aconitum Alkaloid Metabolism in Human Liver Microsomes: Predominant Role of CYP3A4 and CYP3A5. Evid Based Complement Alternat Med. 2013;2013:941093.

14. Ye L#, Shi J#, Wan S, Yang X, Wang Y, Zhang J, Zheng D, Liu Z*. Development and validation of a liquid chromatography-tandem mass spectrometry method for topotecan determination in beagle dog plasma and its application in a bioequivalence study. Biomed Chromatogr. 2013 Nov;27(11).

15. Ye L#, Lu L#, Li Y, Zeng S, Yang X, Chen W, Feng Q, Liu W, Tang L, Liu Z*. Potential role of ATP-binding cassette transporters in the intestinal transport of rhein. Food Chem Toxicol. 2013 Aug;58:301-5.

16. Ye L, Yang X, Yang Z, Gao S, Yin T, Liu W, Wang F, Hu M*, Liu Z*. The role of efflux transporters on the transport of highly toxic aconitine, mesaconitine, hypaconitine, and their hydrolysates, as determined in cultured Caco-2 and transfected MDCKII cells. Toxicol Lett. 2013 Feb 4;216(2-3).

17. Ye L, Liang F, Yang X, Shi J, Wang F, Liu W, Zhao J, Liu Z*. [Oral bioavailability and intestinal disposition of dehydroandrographolide in rats]. Nan Fang Yi Ke Da Xue Xue Bao. 2012 Aug;32(8):1074-81.

18. Ye L, Gao S, Feng Q, Liu W, Yang Z, Hu M*, Liu Z*. Development and validation of a highly sensitive UPLC-MS/MS method for simultaneous determination of aconitine, mesaconitine, hypaconitine, and five of their metabolites in rat blood and its application to a pharmacokinetics study of aconitine, mesaconitine, and hypaconitine. Xenobiotica. 2012 Jun;42(6):518-25.

19. Ye L, Wang T, Tang L, Liu W, Yang Z, Zhou J, Zheng Z, Cai Z, Hu M*, Liu Z*. Poor oral bioavailability of a promising anticancer agent andrographolide is due to extensive metabolism and efflux by P-glycoprotein. J Pharm Sci. 2011 Nov;100(11):5007-17.

20. Ye L, Wang T, Yang C, Tang L, Zhou J, Lv C, Gong Y, Jiang Z, Liu Z*. Microsomal cytochrome P450-mediated metabolism of hypaconitine, an active and highly toxic constituent derived from Aconitum species. Toxicol Lett. 2011 Jul 4;204(1):81-91.

21. Ye L, Tang L, Gong Y, Lv C, Zheng Z, Jiang Z, Liu Z*. Characterization of metabolites and human P450 isoforms involved in the microsomal metabolism of mesaconitine. Xenobiotica. 2011 Jan;41(1).