叶玲，博士，教授，博士生导师（药剂学与中药学），国家优青、广东省杰青、广州市珠江科技新星项目获得者，南医优秀教师，美国休斯敦大学、香港浸会大学和中国药科大学访问学者。主要研究方向为宿主-肠道菌群共代谢系统调控的中药有效性与毒性研究。作为项目负责人先后主持国家自然科学基金（5项）、广东省自然科学基金及广州市科技计划等科研项目10余项。以第一／通讯作者在Nature communications、Gut microbes、Acta Pharmaceutica Sinica B、Pharmacology＆Therapeutics等期刊发表SCI论文30余篇。现担任中国药理学会药物代谢专委会青年常委、中国药理学会抗炎免疫药理专委会委员，广东省药理学会毒理专委会常委等学术职务。

姓名: 叶玲

职称: 教授，博士生（后）导师

邮箱:  lotus623@126.com

主要招生方向：药剂学、工业药学、中药学

教育经历

2007.09-2012.06，南方医科大学，药理学，博士

2011.01-2011.09，美国休斯顿大学，药学院，博士联合培养

2009.08-2010.02，香港浸会大学，中医药学院，合作交流

2009.03-2009.05，沈阳药科大学，药学院，合作交流

2003.09-2007.06，南方医科大学，药学，学士

研究工作经历

2021.10-至今，南方医科大学，药学院，教授

2016.01-2021.10，南方医科大学，药学院，副教授

2012.07-2015.12，南方医科大学，药学院，讲师

2016.07-2017.07，中国药科大学，药学院，访问学者

研究方向

1.中药体内过程与代谢机制研究

2.肠道菌群介导的药物代谢研究

3.疾病状态下药物代谢酶和转运体的变化与调控机制

承担课程

1.本科生课程：《生物药剂学与药物动力学》、《药剂学》、《药物制剂工程》、《制剂设计学》

2.研究生课程：《分子生物药剂学》、《制剂设计学》、《药学前言》

主要学术任职

1.中国药理学会药物代谢专业委员会，青年常委

2.中国药理学会抗炎免疫药理专业委员会，委员

3.广东省药理学会药物毒理专业委员会，常务委员

4.广东省药理学会药物代谢专业委员会，常务委员

5.世界中联中医药免疫专业委员会，理事

6.中华中医药学会中药制剂委员会，委员

7.广东省中医药学会中药药剂与药理专业委员会，委员

主持科研项目

1.国家自然科学基金优秀青年项目，中药代谢及其调控机制，2025-01至2027-12，200万，在研，主持。

2.国家自然科学基金面上项目，宿主-菌群共代谢转运系统调控附子心脏毒性的作用及其机制研究，2023-01至2026-12，52万，在研，主持。

3.国家自然科学基金面上项目，基于“肠道菌群调控CYP3A4酶活性”研究抑郁诱发钩吻神经毒性的作用，2021-01至2024-12，55万，在研，主持。

4.国家自然科学基金面上项目，肠道菌群介导的内酯类组分C-位磺酸化代谢在穿心莲保肝利胆中的作用，2019-01至2022-12，57万，在研，主持。

5.国家自然科学基金青年项目，基于细胞色素P450酶代谢研究中药钩吻的毒性及配伍减毒机制，2016-01至2018-12，18万，已结题，主持。

6.广东省自然科学基金杰出青年项目，基于宿主-肠道菌群共代谢的雷公藤肝毒性的分子机制及减毒研究，2024.01-2026.12，100万，在研，主持。

7.广东省自然科学基金面上项目，甘草调控肝脏CYP450酶抵御中药钩吻化学应激的“配伍减毒”机制，2016-06至2019-06，10万，已结题，主持。

8.广东省自然科学基金博士启动项目，生物利用度屏障在防止附子毒性发生中的作用及其机制，2013-10至2015-10，3.0万，已结题，主持。

9.广州市科技计划项目珠江新星专项，穿心莲内酯经肠道菌群代谢激活FXR-BSEP/MRPs抗胆汁淤积的机理研究，2019-04至2021-03, 30万，已结题，主持。

10.天然药物活性组分与药效国家重点实验室（中国药科大学）开放课题，具有镇痛抗炎活性的钩吻生物碱的P450酶代谢与其毒效的调控研究，2017-01至2018-12，10万，已结题，主持。

发表通讯/第一作者SCI论文

1.Dafu Tang, Wanyu Hu, Bingxuan Fu, Xiaojie Zhao, Guoquan You, Cong Xie, Hong yu Wang, Xueni Guo, Qianbing Zhang, Zhongqiu Liu*, Ling Ye*, Gut microbiota-mediated C-sulfonate metabolism impairs the bioavailability and anti-cholestatic efficacy of andrographolide, Gut microbe, 2024 Jan-Dec;16(1):2387402.

2.Ye L ; Yuanlong Hou; Wanyu Hu; Hongmei Wang; Ruopeng Yang; Qihan Zhang; Qiaoli Feng; Xiao Zheng; Guangyu Yao; Haiping Hao*; Repressed Blautia-acetate immunological axis underlies breast cancer progression promoted by chronic stress, Nat Commun, 2023 Oct 3;14(1):6160.

3.Ling Ye*, Shicheng Fan, Pengfei Zhao, Chenghua Wu, Menghua Liu, Shuang Hu, Peng Wang, Hongyu Wang, Huichang Bi, Potential herb-drug interactions between anti-C0VID-19 drugs and traditional Chinese medicine. Acta Pharm Sin B, 2023 Jun 5;13(9):3598–637.

4.Tan J, Fu B, Zhao X, Ye L*. Novel Techniques and Models for Studying the Role of the Gut Microbiota in Drug Metabolism. Eur J Drug Metab Pharmacokinet. 2024 Mar;49(2):131-147. doi: 10.1007/s13318-023-00874-0. Epub 2023 Dec 21.

5.Yang R, Hu W, Xie C, Tang D, Zhao X, Fu B, Wu J, Ye L*, Liao R*. A Sensitive Liquid Chromatography-Mass Spectrometry Method for Determination of 14-Deoxy-12(R)-Sulfo Andrographolide Concentration in Rat Plasma and its Application to a Pharmacokinetic Study. Curr Drug Metab. 2022;23(11):905-911.

6.You G, Yang R, Wei Y, Hu W, Gan L, Xie C, Zheng Z, Liu Z, Liao R*, Ye L*. The detoxification effect of cytochrome P450 3A4 on gelsemine-induced toxicity. Toxicol Lett. 2021 Oct 7; S0378-4274(21)00850-X. doi: 10.1016/j.toxlet.2021.10.003.

7.Chen M, You G, Xie C, Yang R, Hu W, Zheng Z, Liu S*, Ye L*. Pharmacokinetics of metformin in collagen-induced arthritis rats. Biochem Pharmacol. 2021 Jan 9; 185:114413.

8.Ye L#, Zhang J#, Xiao W*, Liu S*. Efficacy and mechanism of actions of natural antimicrobial drugs. Pharmacol Ther. 2020 Dec; 216:107671.

9.Gan L#, Ma J#, You G, Mai J, Wang Z, Yang R, Xie C, Fei J, Tang L, Zhao J, Cai Z, Ye L*. Glucuronidation and its effect on the bioactivity of amentoflavone, a biflavonoid from Ginkgo biloba leaves. J Pharm Pharmacol. 2020 Dec;72(12):1840-1853.

10.Jiang Y, Yang Z, Zhang L, Yan R, Liu S, Yang H, Wan S, Li Z, Zhu Z, Ye L*, Zhang J*. The Cytochrome P450 Metabolic Profiling of SMU-B in Vitro, a Novel Small Molecule Tyrosine Kinase Inhibitor. J Pharm Biomed Anal. 2020 Jun 3; 188:113400.

11.Sun R#, Chen M#, Hu Y, Lan Y, Gan L, You G, Yue M, Wang H, Xia B, Zhao J, Tang L, Cai Z, Liu Zhongqiu*, Ye L*. CYP3A4/5 mediates the metabolic detoxification of humantenmine, a highly toxic alkaloid from Gelsemium elegans Benth. J Appl Toxicol. 2019 Sep;39(9):1283-1292.

12.Wang Z#, Lan Y#, Chen M, Wen C, Hu Y, Liu Z*, Ye L*. Eriodictyol, Not Its Glucuronide Metabolites, Attenuates Acetaminophen-Induced Hepatotoxicity. Mol Pharm. 2017 Sep 5;14(9):2937-2951.

13.Hu Y#, Chen M#, Wang Z, Lan Y, Tang L, Liu M, Zhao J, Hu M, Zhang L*, Ye L*. Development of a validated UPLC-MS/MS method for determination of humantenmine in rat plasma and its application in pharmacokinetics and bioavailability studies. Biomed Chromatogr. 2017 Dec;31(12).

14.Ye L#, Miao M#, Li S*, Hao K*. Nanosuspensions of a new compound, ER-β005, for enhanced oral bioavailability and improved analgesic efficacy. Int J Pharm. 2017 Oct 5;531(1):246-256.

15.Ye L, Hou C, Liu S*. The Role of Metabolizing Enzymes and Transporters in Antiretroviral Therapy. Curr Top Med Chem. 2017;17(3):340-360.

16.Hu Y, Wang Z, Huang X, Xia B, Tang L, Zheng Z, Ye L*. Oxidative metabolism of koumine is mainly catalyzed by microsomal CYP3A4/3A5. Xenobiotica. 2016 Aug 8:1-8.

17.Ye L, Yang X, Guo E, Chen W, Lu L, Wang Y, Peng X, Yan T, Zhou F, Liu Z. Sorafenib metabolism is significantly altered in the liver tumor tissue of hepatocellular carcinoma patient. PLoS One. 2014 May 5;9(5).

18.Ye L#, Yang X#, Lu L, Chen W, Zeng S, Yan T, Dong L, Peng X, Shi J, Liu Z*. Monoester-Diterpene Aconitum Alkaloid Metabolism in Human Liver Microsomes: Predominant Role of CYP3A4 and CYP3A5. Evid Based Complement Alternat Med. 2013;2013:941093.

19.Ye L#, Shi J#, Wan S, Yang X, Wang Y, Zhang J, Zheng D, Liu Z*. Development and validation of a liquid chromatography-tandem mass spectrometry method for topotecan determination in beagle dog plasma and its application in a bioequivalence study. Biomed Chromatogr. 2013 Nov;27(11).

20.Ye L#, Lu L#, Li Y, Zeng S, Yang X, Chen W, Feng Q, Liu W, Tang L, Liu Z*. Potential role of ATP-binding cassette transporters in the intestinal transport of rhein. Food Chem Toxicol. 2013 Aug;58:301-5.

21.Ye L, Yang X, Yang Z, Gao S, Yin T, Liu W, Wang F, Hu M*, Liu Z*. The role of efflux transporters on the transport of highly toxic aconitine, mesaconitine, hypaconitine, and their hydrolysates, as determined in cultured Caco-2 and transfected MDCKII cells. Toxicol Lett. 2013 Feb 4;216(2-3).

22.Ye L, Liang F, Yang X, Shi J, Wang F, Liu W, Zhao J, Liu Z*. [Oral bioavailability and intestinal disposition of dehydroandrographolide in rats]. Nan Fang Yi Ke Da Xue Xue Bao. 2012 Aug;32(8):1074-81.

23.Ye L, Gao S, Feng Q, Liu W, Yang Z, Hu M*, Liu Z*. Development and validation of a highly sensitive UPLC-MS/MS method for simultaneous determination of aconitine, mesaconitine, hypaconitine, and five of their metabolites in rat blood and its application to a pharmacokinetics study of aconitine, mesaconitine, and hypaconitine. Xenobiotica. 2012 Jun;42(6):518-25.

24.Ye L, Wang T, Tang L, Liu W, Yang Z, Zhou J, Zheng Z, Cai Z, Hu M*, Liu Z*. Poor oral bioavailability of a promising anticancer agent andrographolide is due to extensive metabolism and efflux by P-glycoprotein. J Pharm Sci. 2011 Nov;100(11):5007-17.

25.Ye L, Wang T, Yang C, Tang L, Zhou J, Lv C, Gong Y, Jiang Z, Liu Z*. Microsomal cytochrome P450-mediated metabolism of hypaconitine, an active and highly toxic constituent derived from Aconitum species. Toxicol Lett. 2011 Jul 4;204(1):81-91.

26.Ye L, Tang L, Gong Y, Lv C, Zheng Z, Jiang Z, Liu Z*. Characterization of metabolites and human P450 isoforms involved in the microsomal metabolism of mesaconitine. Xenobiotica. 2011 Jan;41(1).