姓名：刘理涵
职称：副教授，硕士生导师
联系邮箱：liulihan@smu.edu.cn
主要招生方向：药剂学、工业药学
学习经历：
2008.9-2012.7 武汉大学，化学基地班，学士
2012.9-2014.7 武汉大学，高分子化学与物理，硕士
2014.9-2017.7 武汉大学，高分子化学与物理，博士
工作经历：
2017.8-至今 南方医科大学药学院，副教授
承担课程：
1. 本科生课程：《药剂学》、《化工原理》、《药用高分子材料》
2. 研究生课程：《抗肿瘤纳米药物传递系统》
研究方向：
1. 靶向多肽前药自组装纳米药物用于肿瘤光疗研究；
2. 多组分药物自组装及其抗肿瘤研究。
3. 多功能纳米药物系统的构建及其在癌症诊疗中的应用；
近年主持的科研项目：
1. 国家自然科学基金青年基金项目，51803087，细胞膜靶向药物自运载系统用于抗炎增强肿瘤光热治疗，2019. 01-2021.12；
2. 广东省自然科学基金-青年提升项目，2023A1515030109，内质网靶向自组装纳米药物多策略增强肿瘤光动力学治疗及抗肿瘤免疫，2023.01-2025.12；
3. 广东省基础与应用基础研究基金面上项目，2021A1515010302，逆转耐热型自递送纳米药物用于增强肿瘤低温光热治疗，2021.01-2023.12；
4. 广州市科技计划基础与应用基础研究项目（博士青年科技人员类），202102021126，新型肿瘤和内质网双重靶向自组装纳米药物用于高效光动力学肿瘤治疗，2021.04-2023.03；
5. 广东省自然科学基金-博士启动纵向协同项目，2018030310486，实时疗效反馈型诊疗一体化细胞膜靶向光动力学治疗药物系统的设计及其抗肿瘤研究，2018.05- 2021.04；
6. 南方医科大学高层次人才引进科研启动项目, 基于自组装多肽骨架的光动力学-化学联合治疗系统的制备及其抗肿瘤行为研究，2017.09-2020.12。
代表性论文：
1. Huang P.-Y., Liang S.-Y., Xiang Y., Li M.-R., Wang M.-R., Liu L.-H.*, Endoplasmic Reticulum-Targeting Self-Assembly Nanosheets Promote Autophagy and Regulate Immunosuppressive Tumor Microenvironment for Efficient Photodynamic Immunotherapy, Small 2024, https://doi.org/10.1002/smll.202311056.
2. Chen Y., Shu X., Guo J.-Y., Xiang Y., Liang S.-Y., Lai J.-M., Zhou J.-Y., Liu L.-H. *, Wang P.*, Nanodrugs mediate TAMs-related arginine metabolism interference to boost photodynamic immunotherapy, Journal of Controlled Release, 2024, 367: 248–264.
3. Zhu Y.-Y., Huang C.-J., Zhong H., Shi Q.-Y., Lai J.-M., Liu J.-H., Liu L.-H.*, A drug ligand based bimetallic coordination-driven self-assembly nanodrug for high-efficiency tumor chemodynamic therapy, Materials Today Chemistry, 2024, 36: 101977.
4. Lai J., Shi Q., Xie Y., Zhu Y., Liang S., Chen Y., Yuan J., Liu L.*, Self-Delivery Nanomedicines Reverse Thermal Resistance to Enhance Tumor Mild-Temperature Photothermal Therapy, Molecular Pharmaceutics 2024, 21(3): 1526–1536.
5. Liu L.-H., Zhang X.-Z.*, Carrier-free nanomedicines for cancer treatment, Progress in Materials Science, 2022, 125: 100919.
6. Chen P.-L., Huang P.-Y., Chen J.-Y., Shi Q.-Y., Zhu Y.-Y., Chen Y., Liu L.-H.*, Zhang, X. Z., A Self-Delivery Chimeric Peptide for High Efficient Cell Membrane-Targeting Low-Temperature Photothermal/Photodynamic Combinational Therapy and Metastasis Suppression of Tumor, Biomaterials, 2022, 286: 121593.
7. Shu X., Chen Y., Yan P., Xiang Y., Shi Q.-Y., Yin T.*, Wang P.*, Liu L.-H.*, Shuai X., Biomimetic nanoparticles for effective mild temperature photothermal therapy and multimodal imaging, Journal of Controlled Release, 2022, 347: 270–281.
8. Huang P.-Y., Zhu Y.-Y., Zhong H., Chen P.-L., Shi Q.-Y., Chen J.-Y., Lai J.-M., Tu Y.-F.*, Liu S.-W.*, Liu L.-H.*, Autophagy-inhibiting biomimetic nanodrugs enhance photothermal therapy and boost antitumor immunity, Biomaterials Science, 2022, 5(10): 1267–1280.
9. Zhong H. #, Huang P.-Y. #, Yan P., Chen P.-L., Shi Q.-Y., Zhao Z.-A., Chen J.-X., Shu X., Wang P., Yang B., Zhou Z.-Z., Chen J.-J., Pang J.-X., Tu Y.-F., Liu L.-H.*, Zhang X.-Z., Versatile Nanodrugs Containing Glutathione and Heme Oxygenase 1 Inhibitors Enable Suppression of Antioxidant Defense System in a Two-pronged Manner for Enhanced Photodynamic Therapy, Advanced Healthcare Materials, 2021, 10(19): 2100770.
10. Yan P., Shu X., Zhong H., Chen P., Gong H., Han S., Tu Y., Shuai X., Li J.*, Liu L.-H.*, Wang P.*, A Versatile Nanoagent for Multimodal Imaging-Guided Photothermal and Anti-Inflammatory Combination Cancer Therapy, Biomaterials Science, 2021, 9(14): 5025–5034.
11. Ma W., Sha S. N., Chen P. L., Yu M., Chen J. J., Huang C. B., Yu B., Liu Y., Liu L.-H.*, Yu Z. Q.*, A Cell Membrane-Targeting Self-Delivery Chimeric Peptide for Enhanced Photodynamic Therapy and In Situ Therapeutic Feedback. Advanced Healthcare Materials, 2020, 9(1): 1901100.
12. Chen P.-L. #, Shi Q.-Y. #, Chen T., Wang P., Liu Y., Liu L.-H.*, A dual-usage near-infrared (NIR) cell membrane targeting chimeric peptide for cancer cell membrane imaging and photothermal ablation. Journal of Materials Science, 2020, 55(18): 7843–7856.
13. Chen P.-L., Peng S.-L., Wu L.-T., Fan M.-M., Wang P.*, Liu L.-H.*, Amphiphilic tumor-targeting chimeric peptide-based drug self-delivery nanomicelles for overcoming drug resistance in cancer by synergistic chemo-photodynamic therapy, Journal of Materials Science, 2020, 55(31): 15288–15298.
14. Yan P., Liu L.-H.*, Wang P.*, Sonodynamic Therapy (SDT) for Cancer Treatment: Advanced Sensitizers by Ultrasound Activation to Injury Tumor. ACS Applied Bio Materials, 2020, 3(6): 3456–3475.
15. Liu L.-H.#, Qiu W. X.#, Zhang Y. H., Li B., Zhang C., Gao F., Zhang, X. Z.*, A Charge Reversible Self-Delivery Chimeric Peptide with Cell Membrane-Targeting Properties for Enhanced Photodynamic Therapy. Advanced Functional Materials, 2017, 27(25): 1700220.
16. Liu L.-H.#, Zhang Y. H.#, Qiu W. X., Zhang L., Gao F., Xu L., Fan J. X., Li Z. H., Zhang X. Z.*, Dual-Stage Light Amplified Photodynamic Therapy against Hypoxic Tumor based on an O2 Self-sufficient Nano-platform. Small, 2017, 13(37): 1701621.
17. Liu L.-H., Qiu W.-X., Li B., Zhang C., Sun L.-F., Wan S.-S., Rong L., Zhang X.-Z.*, A Red Light Activatable Multifunctional Prodrug for Image-Guided Photodynamic Therapy and Cascaded Chemotherapy. Advanced Functional Materials, 2016, 26(34): 6257–6269.
18. Li S.-Y. #, Liu L.-H. #, Rong L., Qiu W.-X., Jia H.-Z., Li B., Li F., Zhang X.-Z.*, A Dual-FRET-Based Versatile Prodrug for Real-Time Drug Release Monitoring and In Situ Therapeutic Efficacy Evaluation. Advanced Functional Materials, 2015, 25, 7317–7326.
19. Li S.-Y. #, Liu L.-H. #, Cheng H., Li B., Qiu W.-X., Zhang X.-Z.*, A dual-FRET-based fluorescence probe for the sequential detection of MMP-2 and caspase-3. Chemical Communications, 2015, 51, 14520–14523.
20. Li S.-Y. #, Liu L.-H. #, Jia H.-Z., Qiu W.-X., Rong L., Cheng H., Zhang X.-Z.*, A pH-responsive prodrug for real-time drug release monitoring and targeted cancer therapy. Chemical Communications, 2014, 50, 11852–11855.
21. Liu L.-H., Li Z.-Y., Rong L, Qin S.-Y., Lei Q., Cheng H., Zhou X., Zhuo R.-X., Zhang X.-Z.*, Self-Assembly of Hybridized Peptide Nucleic Acid Amphiphiles. ACS Macro Letters, 2014, 3, 467−471.
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