姓名：杨梓超

职称：讲师

联系邮箱：zcyangchn@163.com

学习经历：

2021.09-2024.06：南方医科大学，药物化学，博士

2018.09-2021.06：南方医科大学，药学，硕士

2014.09-2018.06：南方医科大学，药学，学士

工作经历：

2024.07-2024.10, 南方医科大学坪山医院，博士后

2024.11至今, 南方医科大学, 药学院, 讲师

承担课程：

本科生课程：《有机化学》

研究方向：

1. 肿瘤免疫小分子调节剂的发现

2. 计算机辅助药物设计

主要科研课题：

暂无

代表性论文：

1.Yang Z^#, Liu Z^#, Wan S^#, Xu J, Huang Y, Liu T, He H, Li L, Ren Y, Zhang J, Chen J. Discovery of novel small molecule-based dual PD-L1/EGFR inhibitors with high druggability for glioblastoma immunotherapy. J Med Chem. 2024;67(10):7995-8019.

2.Yang Z^#, Liu Z^#, Xu C, Xu J, Liu T, He H, Li L, Ren Y, Chen J. Discovery of novel resorcinol biphenyl ether-based macrocyclic small molecules as PD-1/PD-L1 inhibitors with favorable pharmacokinetics for cancer immunotherapy. Bioorg Chem. 2023, 139:106740.

3.Yang Z^#, Ai Y^#, Wan S, Yang Z, Li H, Li Z, Huang C, Zhang L, Li M, Zhang J^*, Zhang T^*. Discovery of 4-methyl-3-(pyridin-2-ylamino)benzamide derivatives as C-Abl inhibitors with potential neuroprotective effect. Bioorg Med Chem. 2022, 74:117069.

4.Yang Z^#, Yang H^#, Ai Y, Zhang L, Li Z, Wan S, Xu X, Zhang H, Wu S^*, Zhang J^*, Zhang T^*. Computational studies of potent covalent inhibitors on wild type or T790M/L858R mutant epidermal growth factor receptor. Eur J Pharm Sci. 2020,152,105463.

5.Yang Z^#, Ai Y^#, Wu G, Guo F, Yang Z, Chen J, Zhang L, Li M, Chen J^*, Zhang J^*, Zhang T^*. Discovery of conformationally constrained c-Abl inhibitors with potential neuroprotective effects against Parkinson’s disease. Bioorg Med Chem. 2023, 96:117532.

6.Wu Y^#, Yang Z ^#, Cheng K^*, Bi H^*, Chen J^*. Small molecule-based immunomodulators for cancer therapy. Acta Pharm Sin B. 2022, 12(12):4287-4308.

7.Ai Y^#, Yang Z^#, Yang Z, Wan S, Huang C, Huang C, Li M, Li Z^*, Zhang J^*, Zhang T^*. Discovery and Computational Studies of Potent Covalent Kinase Inhibitors with α-Substituent Electrophiles Targeting Cysteine. J Chem Inf Model. 2023, 63(2):493-506.

8.Zhang L^#, Yang Z^#, Sang H, Jiang Y, Zhou M, Huang C, Huang C, Wu X, Zhang T, Zhang X, Wan S^*, Zhang J^*. Identification of imidazo[4,5-c]pyridin-2-one derivatives as novel Src family kinase inhibitors against glioblastoma. J Enzyme Inhib Med Chem. 2021, 36(1):1541-1552.

9.Jiang Y^#, Yang Z^#, Zhang L, Yan R, Liu S, Yang H, Wan S, Li Z, Zhu Z, Ye L^*, Zhang J^*. The cytochrome P450 metabolic profiling of SMU-B in vitro, a novel small molecule tyrosine kinase inhibitor. J Pharm Biomed Anal. 2020, 188, 113400.

10.Li, J ^#; Yang, Z^#; Liu, H; Qiu, M; Zhang, T; Li, W; Li, Z; Qi, T; Qiu, Y; Li, L; Zhou, X; Liu, S^*; Tan, S^*, ADS-J1 disaggregates semen-derived amyloid fibrils. The Biochemical journal 2019, 476 (6), 1021-1035.

11.Zhao Z^#, Liu J^#, Yuan L^#, Yang Z^#, Kuang P, Liao H, Luo J, Feng H, Zheng F, Chen Y, Wu T, Guo J, Cao Y, Yang Y, Lin C, Zhang Q^*, Chen J^*, Pang J^*. Discovery of novel benzbromarone analogs with improved pharmacokinetics and benign toxicity profiles as antihyperuricemic agents. Eur J Med Chem. 2022, 242:114682.