姓名：郑镭

职称：讲师

联系邮箱：zhenglei2354@smu.edu.cn

个人简介

郑镭博士主要开展靶向PXR等核受体的创新药物研发及作用机制研究。现主持博士后面上基金项目1项，累计在相关领域期刊J Med Chem, Eur J Med Chem, Org Chem Front, Chem Comm等发表22篇SCI论文（第一/共同第一作者论文9篇）授权专利4项。

学习经历

2020.09-2024.06: 南方医科大学, 药物化学, 博士

2016.09-2019.06: 武汉工程大学, 制药化学, 硕士

2012.09-2016.06: 武汉工程大学, 化学工程与工艺, 本科

工作经历

2025.12-至今: 南方医科大学药学院, 讲师

2024.07-2025.11: 南方医科大学药学院, 博士后

2019.07-2019.11: 武汉药明康德新药开发有限公司, 有机合成研究员

近年主持科研基金项目

中国博士后科学基金-面上项目，2025

承担课程：

本科生课程：《有机化学》

研究方向

合成药物化学

代表性论文

[1] Lei Zheng#, Zulihuma Aimaiti#, Lu Long, Chuang Xia, Wenya Wang*, Zhong-Zhen Zhou*. Discovery of 4-Ethoxy-6-Chloro-5-Azaindazoles as Novel PDE4 Inhibitors for the Treatment of Alcohol Use Disorder and Alcoholic Liver Diseases. Journal of Medicinal Chemistry, 2024, 67, 728.

[2] Lei Zheng#, Kun Chen#, Yifan Xie, Jiaxi Huang, Chuang Xia, Ying-Xia Bao, Huichang Bi, Jigang Wang*, and Zhong-Zhen Zhou*. Discovery of Novel N2-indazole Derivatives as Phosphodiesterase 4 Inhibitors for the Treatment of Inflammatory Bowel Disease. European Journal of Medicinal Chemistry, 2024, 277, 116710.

[3] Lei Zheng, Zhong-Zhen Zhou*. An Overview of Phosphodiesterase 9 Inhibitors: Insights from Skeletal Structure, Pharmacophores, and Therapeutic Potential. European Journal of Medicinal Chemistry, 2023, 259, 115682.

[4] Lei Zheng, Tao Yi, Ruilin Fang, Zhongzhen Zhou, Can Wang*, Yunfeng Chen*. Cascade C-C Bond Cleavage/Reformation and Cycloaddition for the Synthesis of 4-Acyl 1,2,3-Triazoles from β-Alkyl Nitroalkenes and Organic Azides. Organic Chemistry Frontiers, 2023, 10, 5260.

[5] Lei Zheng, Ye Wang, Xianggao Meng, Yunfeng Chen*. Pyridinyl-Triazole Ligand Systems for Highly Efficient Cui-Catalyzed Azide- Alkyne Cycloaddition. Catalysis Communications, 2021, 148, 106165.

[6] Lei Zheng, Zhigang Zeng, Qiong Yan, Fengcheng Jia, Lihui Jia, Yunfeng Chen*. Copper-Catalyzed Synthesis of 3-NO2 Quinolines from o-Azidobenzaldehyde and Nitro-Olefins and Its Application in the Concise Synthesis of Quindolines. Advanced Synthesis & Catalysis, 2018, 360, 4037.

[7] Ruilin Fang#, Lei Zheng#, Xuyang Chen, Can Wang, Yunfeng Chen*. An FeCl3-Catalyzed Three-Component Reaction for the Synthesis of Beta-(1,2,3-Triazolyl)-Ketones Using DMF as a One-Carbon Source. Organic & Biomolecular Chemistry, 2024, 22, 3866.

[8] Jie Liu#, Lu Liu#, Lei Zheng#, Kai-Wen Feng, Hai-Tao Wang, Jiang-Ping Xu, Zhong-Zhen Zhou*. Discovery of Novel 2,3-dihydro-1H-inden-1-ones as Dual PDE4/AChE Inhibitors with More Potency against Neuroinflammation for the Treatment of Alzheimer's Disease. European Journal of Medicinal Chemistry, 2022, 238, 114503.

[9] Liangfeng Huang#, Lei Zheng#, Zhongzhen Zhou*, Yunfeng Chen*. Copper-Catalyzed Multiple Oxidation and Cycloaddition of Aryl-Alkyl Ketones (Alcohols) for the Synthesis of 4-Acyl- and 4-Diketo-1,2,3-Triazoles. Chemical Communications, 2022, 58, 3342.

[10] Ye Wang, Lei Zheng, Xiaodong Shi*, Yunfeng Chen*. 1,3-Difunctionalization of Beta-Alkyl Nitroalkenes via Combination of Lewis Base Catalysis and Radical Oxidation. Organic Letters, 2021, 23, 886.

[11] Miaomiao Li, Lei Zheng, Li Ma, Yunfeng Chen*. Transition Metal-Free Oxidative Cross-Coupling Reaction of Activated Olefins with N-Alkyl Amides. Journal of Organic Chemistry, 2021, 86, 3989.

[12] Qiong Yan, Lei Zheng, Miaomiao Li, Yunfeng Chen*. N,S-Chelating Triazole-Thioether Ligand for Highly Efficient Palladium-Catalyzed Suzuki Reaction. Journal of Catalysis, 2019, 376, 101.

[13] Yu-Wei Wang, Lei Zheng, Feng-Cheng Jia*, Yun-Feng Chen*, An-Xin Wu. Oxidative Ring-Opening of Isatins for the Synthesis of 2-Aminobenzamides and 2-Aminobenzoates. Tetrahedron, 2019, 75, 1497.

[14] Xue Lei, Lei Zheng, Chuanxin Zhang, Xiaodong Shi*, Yunfeng Chen*. Allylic C-S Bond Construction through Metal-Free Direct Nitroalkene Sulfonation. Journal of Organic Chemistry, 2018, 83, 1772.