姓名：毕惠嫦

职称：教授，博士生导师

联系邮箱：bihchang@smu.edu.cn

联系电话：020-61648530

主要招生方向：药理学、工业药学

国家杰青/优青获得者；南方医科大学药学院二级教授、博导、院长，广东省新药筛选重点实验室主任、粤港澳新药筛选联合实验室主任。专注于内/外源物代谢调控对疾病及合理用药影响的研究。主持国家各级课题20多项。已发表中英科研论文150多篇，以通讯作者或第一作者在Hepatology, Advanced Science, Cell Death Differ, Acta Pharm Sin B, Brit J Pharmacol等发表SCI论文100多篇。主编并出版专著5部，参编7部。

目前担任中国药理学会临床药理学专业委员会副主任委员、中国药理学会分析药理学专业委员会副主任委员、中国药理学会药物代谢专业委员会副主任委员；广东省药理学会候任理事长等学术兼职。担任5本SCI期刊编委。

获2014年中国药理学会-Servier优秀药理学者奖、2018年国际代谢学会（ISSX）亚太青年学者奖（2018 ISSX Asia Pacific New Investigator Award）、2021年美国药理与实验治疗学会（ASPET）Richard Okita Early Career Award in Drug Metabolism and Disposition、2023年第十七届广东省丁颖科技奖。

学习经历

1993.09 - 1997. 06：中国药科大学，获英语药学学士学位

2002.09 – 2007.06：中山大学药学院，获药理学博士学位

工作经历

2022 - 至今： 南方医科大学药学院，教授/博导/院长

2016 - 2021： 中山大学药学院，教授/博导/副院长

2010.06 - 2015.12： 中山大学药学院，副教授

2007.07 - 2010.05： 中山大学药学院，讲师

2018.07 - 2024.06： 美国匹兹堡大学药学院，兼职教授

2015.11 - 2018.06： 美国匹兹堡大学药学院，兼职副教授

2011.10 - 2012.11： 美国国立卫生研究院（NIH），访问学者（博士后）

研究方向

代谢调控与疾病及临床合理用药研究。

近年主持科研项目

1. 国家自然联合基金重点支持项目，2024.01～2027.12。

2. 国家自然科学基金杰出青年基金，2021.01～2025.12。

3. 国家自然科学基金（面上项目），2020.01～2023.12。

4. 国家重点研发计划国际合作重点专项，2018.07～2022.06。

5. 国家自然科学基金优秀青年基金，2016.01～2018.12。

6. 国家自然科学基金（面上项目），2016.01～2019.12。

代表性论文

1.Zhao Tingting#, Zhong Guoping#, Wang Ying, Cao Renjie, Song Shaofei, Li Yuan, Wan Guohui, Sun Haiyan, Huang Min*, Bi Huichang*, Jiang Yiming*. Pregnane X receptor activation in liver macrophages protects against endotoxin-induced liver injury. Advanced Science, 2024 Mar 13 online.

2.Li Xuan#, Fan Shicheng#, Cai Chenghui, Gao Yue, Wang Xinhui, Zhang Yifei, Liang Hangfei, Li Huilin, Yang Jie, Huang Min*, Bi Huichang*. YAP regulates the liver size during the fasting-refeeding transition in mice. Acta Pharm Sin B. 2023;13(4):1588-1599.

3.Zhang Shuaishuai#, Guo Manlan#, Jiang Xiaowen, Tang Lan, Wu Ting, Bi Guofang, Yang Xiao, Fan Shicheng, Bi Huichang*. PXR triggers YAP-TEAD binding and Sirt2-driven YAP deacetylation and polyubiquitination to promote liver enlargement and regeneration in mice. Pharmacol Res. 2023;188:106666.

4.Chen Panpan, Tian Jingyu, Zhou Yanying, Chen Yixin, Zhang Huizhen, Jiao Tingying, Huang Min, Zhang Hui*, Huang Peng, Yu Aiming, Gonzalez J Frank, Bi Huichang*. Metabolic Flux Analysis Reveals the Roles of Stearate and Oleate on CPT1C-mediated Tumor Cell Senescence. Int J Bio Sci, 2023; 19(7):2067-2080.

5.Fan Shicheng#, Gao Yue#, Qu Aijuan, Jiang Yiming, Li Hua, Xie Guomin, Yao Xinpeng, Yang Xiao, Zhu Shuguang, Yagai Tomoki, Tian Jianing, Wang Ruimin, Gonzalez Frank J, Huang Min, Bi Huichang*. YAP-TEAD mediates PPARα-induced hepatomegaly and liver regeneration in mice. Hepatology, 2022; 75(1): 74-88.

6.Gao Yue, Fan Shicheng, Li Hua, Jiang Yiming, Yao Xinpeng, Zhu Shuguang, Yang Xiao, Wang Ruimin, Tian Jianing, Gonzalez Frank J, Huang Min*, Bi Huichang*. Constitutive androstane receptor induced-hepatomegaly is partially via yes-associated protein activation. Acta Pharm Sin B. 2021; 11(3):727-737.

7.Fu Kaili#, Chen Pan#, Zhou Yanying, Jiang Yiming, Gao Yue, Zhang Huizhen, Guan Lihuan, Wang Conghui, Liu Junling, Huang Min*, Bi Huichang*. Hepatic Vps33b deficiency aggravates cholic acid-induced cholestatic liver injury in male mice. Acta Pharm Sin. 2021. doi: 10.1038/s41401-021-00723-3.

8.Zhao Yingyuan#, Yao Xinpeng, Jiao Tingying, Tian Jianing, Gao Yue, Fan Shicheng, Chen Panpan, Jiang Yiming, Zhou Yanying, Chen Yixin, Yang Xiao, Huang Min, Bi Huichang*. Schisandrol B promotes liver enlargement via activation of PXR and YAP pathways in mice. Phytomedicine. 2021; 84:153520.

9.Zhang Huizhen#, Wang Yongtao, Guan Lihuan, Chen Yixin, Chen Panpan, Sun Jiahong, Gonzalez Frank J., Huang Min, Bi Huichang*. Lipidomics reveals carnitine palmitoyltransferase 1C protects cancer cells from lipotoxicity and senescence. J Pharm Anal. 2021; 11:340-350.

10.Yao Xinpeng, Jiao Tingying, Jiang Yiming, Fan Shicheng, Zhao Yingyuan, Yang Xiao, Gao Yue, Li Fei, Zhou Yanying, Chen Panpan, Huang Min, Bi Huichang*. PXR mediates mifepristone-induced hepatomegaly in mice. Acta Pharmacol Sin. 2021. doi: 10.1038/s41401-021-00633-4.

11.Huang Wen#, Zhou Jin#, Guo Juanjuan#, Hu Wen, Chen Guanghui, Li Bin, Wen Yajie, Jiang Yimin, Fu Kaili, Bi Huichang*, Zhang Yuanzhen*, Wang Hui*. Dexamethasone induces an imbalanced fetal-placental-maternal bile acid circulation: involvement of placental transporters. BMC Med. 2021; 19:87.

12.Huang Dong#, Wang Ruimin#, Li Wei, Zhao Yingyuan, Yuan Fangyu, Yan Xuelong, Chen Ye, Tang Guihua, Bi Huichang*, Yin Sheng*. Lathyrane Diterpenoids as Novel hPXR Agonists: Isolation, Structural Modification, and Structure-Activity Relationships. ACS Med Chem Lett. 2021; 12(7):1159-1165.

13.Zhou Yanying#, Fan Xiaomei#, Jiao Tingying, Li Wenzhou, Chen Panpan, Jiang Yiming, Sun Jiahong, Chen Yixin, Chen Pan, Guan Lihuan, Wen Yajie, Huang Min, Bi Huichang*. SIRT6 as a key event linking p53 and NRF2 counteracts APAP-induced hepatotoxicity through inhibiting oxidative stress and promoting hepatocyte proliferation. Acta Pharm Sin B. 2021; 11(1):89-99.

14.Chen Yixin, Zhou Yanying, Han Fangwei, Zhao Yingyuan, Tu Meijuan, Wang Yongtao, Huang Can, Fan Shicheng, Chen Panpan, Yao Xinpeng, Guang Lihuan, Yu Ai-ming, Gonzalez J Frank, Huang Min, Bi Huichang*. A novel miR-1291-ERRα-CPT1C axis modulates tumor cell proliferation, metabolism and tumorigenesis. Theranostics. 2020; 10(16): 7193-7210.

15.Jiao Tingying#, Yao Xinpeng#, Zhao Yingyuan, Zhou Yanying, Gao Yue, Fan Shicheng, Chen Panpan, Li Xuan, Jiang Yiming, Yang Xiao, Gonzalez Frank J, Huang Min, Bi Huichang*. Dexamethasone-induced liver enlargement is related to PXR/YAP activation and lipid accumulation but not hepatocyte proliferation. Drug Metab Dispos. 2020; 48(9): 830-839.

16.Wang Yongtao#, Yu Tao#, Zhou Yanying, Wang Shike, Zhou Xunian, Wang Limin, Ou Tianmiao, Chen Yixin, Zhou Yawen, Zhang Huizhen, Wang Ying, Fan Xiaomei, Chen Pan, Gonzalez J Frank, Yu Aiming, Huang Peng, Huang Min, Bi Huichang*. Carnitine palmitoyltransferase 1C contributes to progressive cellular senescence. Aging. 2020; 12(8): 6733-6755.

17.Li Yuhua#, Meng Qiang#, Yang Mengbi#, Liu Dongyang#, Hou Xiangyu#, Tang Lan#, Wang Xin#, Lyu Yuanfeng, Chen Xiaoyan*, Liu Kexin*, Yu Ai-Ming*, Zuo Zhong*, Bi Huichang*. Current trends in drug metabolism and pharmacokinetics. Acta Pharm Sin B. 2019; 9(6): 1113-1144.

18.Jiang Yiming, Feng Dechun, Ma Xiaochao, Fan Shicheng, Gao Yue, Fu Kaili, Wang Ying, Sun Jiahong, Yao Xinpeng, Liu Conghui, Zhang Huizhen, Xu Leqian, Liu Aiming, Gonzalez J Frank, Yang Yingzi, Gao Bin, Huang Min, Bi Huichang*. Pregnane X receptor regulates liver size and liver cell fate via yes-associated protein activation. Hepatology, 2019; 69(1):343-358.

19.Wang Yongtao, Chen Yixin, Guan Lihuan, Zhang Huizheng, Huang Yaoyao, Johnson H Caroline, Wu Zeming, Gonzalez J Frank, Yu Aiming, Huang Peng, Wang Ying, Yang Shouhui, Chen Pan, Fan Xiaomei, Huang Min, Bi Huichang*. Carnitine palmitoyltransferase 1C regulates cancer cell senescence through mitochondria-associated metabolic reprograming. Cell Death Differ. 2018; 25(4):733-746.

20.Sun Jiahong#, Wen Yajie#, Zhou Yanying#, Jiang Yiming, Chen Yixin, Zhang Huizheng, Guan Lihuan, Yao Xinpeng, Huang Min*, Bi Huichang*. P53 attenuates acetaminophen-induced hepatotoxicity by regulating drug-metabolizing enzymes and transporter expression. Cell Death Dis. 2018; 9(5): 536-547.

21.Chen Pan#, Li Dongshun#, Chen Yixin#, Sun Jiahong, Fu Kaili, Guan Lihuan, Zhang Huizhen, Jiang Yiming, Li Xi, Zeng Xuezhen, Chen Xiao, Huang Min, Bi Huichang*. p53-mediated regulation of bile acid disposition attenuates cholic acid-induced cholestasis in mice. Br J Pharmacol. 2017; 174(23):4345-4361.

22.Zeng X, Li X, Xu C, Jiang F, Mo Y, Fan X, Li Y, Jiang Y, Li D, Huang M, Bi Huichang*. Schisandra sphenanthera extract (Wuzhi Tablet) protects against chronic-binge and acute alcohol-induced liver injury by regulating the NRF2-ARE pathway in mice. Acta Pharm Sin B. 2017; 7(5):583-592.

23.Chen Yixin, Wang Yongtao, Huang Yaoyao, Zeng Hang, Hu Bingfang, Guan Lihuan, Zhang Huizhen, Yu Aiming, Johnson H Caroline, Gonzalez J Frank, Huang Min, Bi Huichang*. PPARα regulates tumor cell proliferation and senescence via a novel target gene carnitine palmitoyltransferase 1C. Carcinogenesis. 2017; 38(4):474-483.

24.Zeng Hang#, Jiang Yiming#, Chen Pan, Fan Xiaomei, Li Dongshu, Liu Aiming, Ma Xiaochao, Xie Wen, Liu Peiqing, Gonzalez Frank J, Huang Min, Bi Huichang*. Schisandrol B protects against cholestatic liver injury through pregnane X receptor. Br J Pharmacol. 2017; 174(8):672-688.