姓名： 李媛媛
单位： 中国科学院上海药物研究所、中科中山药物创新研究院
职称： 教授，博士生导师
联系邮箱：liyuanyuan@simm.ac.cn
联系电话: 0760-85286866转8519
个人主页：https://www.zidd.ac.cn/headofresearchgroup/info.aspx?itemid=334
个人简介：
李媛媛博士，中国科学院上海药物研究所/中科中山药物创新研究院研究员、课题组长、博士生导师。入选中科院海外高层次人才引进计划、上海市浦江人才、上海市领军人才(海外)等多个人才计划。长期从事代谢性疾病（脂肪肝及肝纤维化、动脉粥样硬化、糖尿病肥胖等）的致病新机制研究。目前已发表学术论文25篇，包括在Nature Metabolism, Hepatology（2篇）, Arteriosclerosis, Thrombosis, and Vascular Biology等代谢领域权威杂志以第一作者发表9篇文章；在 Cell Metabolism, Nature Communications, Diabetes（3篇）以共同作者发表文章16篇。发表文章得到Nature Reviews Endocrinology、Hepatology、Diabetes 等杂志的高度评价和Faculty1000 肝病领域权威专家的推荐。文章总引用超过1100次，H-index 18。新药研发方面，作为主要参与人和骨干开发了多个新颖有潜力的糖尿病小分子化合物，申请PCT专利一项，已有参与新药项目拿到临床批件，实现成果转化。目前主持包括中科院海外高层次人才引进计划择优资助、上海市浦江人才项目、国家自然科学基金、广东省自然科学基金、中科中山药物创新研究院科研团队领军人才启动经费等多个科研基金项目。
学习经历：
2004.09–2010.01 中国科学院上海药物研究所，博士
2000.09–2004.06 华中科技大学同济医学院药学院，学士
工作经历：
2020.08–至今 中国科学院上海药物研究所/中科中山药物创新研究院，研究员，课题组长
2019.10–2020.06 美国贝勒医学院，博士后
2012.09–2018.04 美国东北俄亥俄医科大学，博士后
2010.09–2012.08 美国约翰霍普金斯大学医学院，博士后
研究方向：
本实验室针对各种代谢性疾病：非酒精性脂肪肝病、肝纤维化、动脉粥样硬化、炎症性肠病等，开展其致病新机制研究，新靶标发现、确证及新药开发。重点围绕在病理情况下的各种细胞的代谢紊乱（酶水平、转录水平、亚细胞器水平、亚细胞器互作等），细胞间及组织间相互通讯紊乱开展新机制的研究。
使用手段：转基因小鼠、基因递送载体、CRISPR-Cas9技术、类器官、代谢组及转录组学技术。
主要获奖情况：
2021年，中科院海外高层次人才引进计划
2021年，上海市浦江人才
2021年，上海市领军人才(海外)
2016年，美国肝病大会AASLD青年学者奖(Young Investigator Award)
2016年，美国肝病大会AASLD杰出海报奖 (Presidential Poster of Distinction)
2014年，美国心血管会议优秀口头报告奖
2010年，上海市高校优秀毕业生
近年主持或参加科研项目：
1. 代谢性疾病的新机制研究与新靶标发现，400万，2022.1-2024.12，中科院海外高层次人才引进计划择优资助
2. 非酒精性脂肪肝病的致病新机制发现、原创靶点鉴定与新药研发， 30万，2021.10-2023.09，上海市浦江人才计划
3. FOXA3抑制非酒精性脂肪肝炎(NASH)炎症与纤维化的机制研究与靶标验证， 30万，2022.01-2024.12，国家自然科学基金青年项目
4. 羧酸酯酶CES2调控肝星状细胞活化治疗非酒精性脂肪肝病与肝纤维化的机制研究与原创新药开发，10万，2022.01-2024.12，广东省自然科学基金面上项目
5. 中科中山药物创新研究院科研团队领军人才启动经费
代表性论文
1. Yanyong Xu#, Yuanyuan Li#, Kavita Jadhav#, Xiaoli Pan, Yingdong Zhu, Shuwei Hu, Shaoru Chen, Liuying Chen, Yong Tang, Helen H Wang, Ling Yang, David Q-H Wang, Liya Yin, Yanqiao Zhang. Hepatocyte ATF3 protects against atherosclerosis by regulating HDL and bile acid metabolism. Nature Metabolism, 2021, 3(1):59-74(# Co-first author) 发表时间：2021-01-18
2. Yuanyuan Li#, Yanyong Xu#, Kavita Jadhav, Liya Yin and Yanqiao Zhang. Hepatic forkhead box protein A3 regulates ApoA I expression, cholesterol efflux and atherogenesis. Arteriosclerosis, Thrombosis, and Vascular Biology, 2019, 39(8):1574-1587(# Co-first author) 发表时间：2019-07-11
3. Yuanyuan Li, Munaf Zalzala, Kavita Jadhav, Yang Xu, Takhar Kasumov, Liya Yin and Yanqiao Zhang. Carboxylesterase 2 Prevents Liver Steatosis by Modulating Lipolysis, ER stress and Lipogenesis and is regulated by Hepatocyte Nuclear Factor 4 Alpha in Mice. Hepatology, 2016, 63(6):1860-1874 此研究内容获得2016AASLD美国肝病大会学术海报主席特别奖与青年学者奖 发表时间：2016-06
4. Jiesi Xu #, Yuanyuan Li #, Wei Dong Chen #, Yang Xu #, Liya Yin, Xuemei Ge, Kavita Jadhav, Luciano Adorini, and Yanqiao Zhang. Hepatic Carboxylesterase 1 Is Essential for Both Normal and Farnesoid X Receptor Controlled Lipid Homeostasis. Hepatology, 2014, 59(5):1761-1771 (# Co-first author) 得到同期Hepatology的Editorial Comment 高度评价(Hepatology, 2014 59(5):1665-7)和被Faculty1000 Prime推荐 发表时间：2014-05
5. Yuanyuan Li, Kavita Jadhav, and Yanqiao Zhang. Bile acid receptors in non-alcoholic fatty liver disease. Biochemical Pharmacology, 2013, 86(11):1517-24 发表时间：2013-12-01
Yuan-Yuan Li#, Li-Fang Yu#, Li-Na Zhang, Bei-Ying Qiu, Ming-Bo Su, Fang Wu, Tao Pang, Min Gu, Wei Zhang, Da-Kai Chen,Wei-Ping Ma, Jing-Ya Li*, Fa-Jun Nan*, Jia Li*. Novel small-molecule AMPK activator orally exerts beneficial effects on diabetic db/db mice. Toxicology and Applied Pharmacology, 2013, 273(2):325-34(# Co-first author) 发表时间：2013-12-01
7. Li-Fang Yu#, Yuan-Yuan Li#, Ming-Bo Su, Mei Zhang , Wei Zhang , Li-Na Zhang , Tao Pang , Run-Tao Zhang , Bing Liu , Jing-Ya Li*, Jia Li*, and Fa-Jun Nan*. Development of Novel Alkene Oxindole Derivatives As Orally Efficacious AMP-Activated Protein Kinase Activators. ACS Med. Chem. Lett., 2013, 4 (5): 475–480 (# Co-first author) 发表时间：2013-03-25
8. Linrong Zhu#, Yuanyuan Li#, Qiu Ling, Mingbo Su, Xin Wang, Chunmei Xia, Yi Qu, Jingya Li, Jia Li*, Bin Xiong*, Jingkang Shen*. Design and Synthesis of 4-(2,4,5-Trifluorophenyl)butane-1,3-diamines as Dipeptidyl Peptidase IV Inhibitors. ChemMedChem, 2013, 8(7):1104-16 (# Co-first author) 发表时间：2013-07
9. Zhang Liu#, Qian Chai #, Yuanyuan Li #, Qiang Shen, Lanping Ma*, Lina Zhang, Xin Wang, Li Sheng, Jingya Li, Jia Li*, Jingkang Shen. Discovery of novel PTP1B inhibitors with antihyperglycemic activity. Acta Pharmacologica Sinica, 2010, 31(8):1005–1012 (# Co-first author) 发表时间：2010-08
10. Yanyong Xu#, Xiaoli Pan#, Shuwei Hu#, Yingdong Zhu, Fathima Cassim Bawa, Yuanyuan Li, Liya Yin, Yanqiao Zhang. Hepatocyte-specific Expression of Human Carboxylesterase 2 Attenuates Non-alcoholic Steatohepatitis in Mice. Am J Physiol Gastrointest Liver Physiol. 2021 Jan 1;320(2):G166-G174 发表时间：2021-01-01
11. Yanyong Xu, Yingdong Zhu, Kavita Jadhav, Yuanyuan Li, Huihui Sun, Liya Yin, Takhar Kasumov, Xiaoli Chen, Yanqiao Zhang. Lipocalin-2 Protects Against Diet-Induced Nonalcoholic Fatty Liver Disease by Targeting Hepatocytes. Hepatology Communications, 2019, 3(6):763-775 发表时间：2019-03-25
12. Kavita Jadhav#, Yang Xu#, Yanyong Xu#, Yuanyuan Li, Jiesi Xu, Yingdong Zhu, Luciano Adorini, Yoon Kwang Lee, Takhar Kasumov, Liya Yin, Yanqiao Zhang. Reversal of metabolic disorders by pharmacological activation of bile acid receptors TGR5 and FXR. Molecular Metabolism, 2018, 9:131-140 发表时间：2018-03
13. Jiesi Xu, Yang Xu, Yuanyuan Li, Kavita Jadhav, Min You, Liya Yin & Yanqiao Zhang (2016). Carboxylesterase 1 Is Regulated by Hepatocyte Nuclear Factor 4α and Protects Against Alcohol- and MCD diet-induced Liver Injury. Scientific Reports, 2016, 6:24277 发表时间：2016-04-14
14. Michael L. Multhaup, Marcus M. Seldin, Andrew E. Jaffe, Xia Lei, Henriette Kirchner, Prosenjit Mondal, Yuanyuan Li, Varenka Rodriguez, Alexander Drong, Mehboob Hussain, Cecilia Lindgren, Mark McCarthy, Erik Naslund, Juleen R. Zierath, G. William Wong, Andrew P. Feinberg. Mouse-Human Experimental Epigenetic Analysis Unmasks Dietary Targets and Genetic Liability for Diabetic Phenotypes. Cell Metabolism, 2015, 21(1):138-49 得到 Nature Reviews Endocrinology, 2015:11(5):261-2 的Editorial Comment 评论 发表时间：2015-01-06
15. Yang Xu#, Munaf Zalzala#, Jiesi Xu, Yuanyuan Li, Liya Yin, Yanqiao Zhang. A metabolic stress-inducible miR-34a-HNF4α pathway regulates lipid and lipoprotein metabolism. Nature communications, 2015, 6:7466 发表时间：2015-06-23
16. Prosenjit Mondal#, Woo-Jin Song#, Yuanyuan Li, Kil S. Yang, and Mehboob A. Hussain. Increasing β-Cell Mass Requires Additional Stimulation for Adaptation to Secretory Demand. Mol Endocrinol., 2015, 29(1):108-20 发表时间：2015-01
17. Ryan C. Riddle, Julie M. Leslie, Mathieu Ferron, Yuanyuan Li, Douglas J.Digirolamo, Marie-Claude Faugere, Mehboob A. Hussain, Gerard Karsenty and Thomas L. Clemens. Tsc2 Is a Molecular Checkpoint Controlling Osteoblast Development and Glucose Homeostasis. Molecular and Cellular Biology, 2014:34(10):1850-62 发表时间：2014-05
18. Jiesi Xu, Liya Yin, Yang Xu, Yuanyuan Li, Munaf Zalzala, Gang Cheng, Yanqiao Zhang. Hepatic Carboxylesterase 1 Is Induced by Glucose and Regulates Postprandial Glucose Levels. PLoS ONE, 2014, 9(10):e109663 发表时间：2014-10-06
19. Woo-Jin Song#, Prosenjit Mondal#, Yuanyuan Li, Suh Eun Lee and Mehboob A. Hussain. Pancreatic β-cell Response to Increased Metabolic Demand and to Pharmacologic Secretagogues Requires EPAC2A. Diabetes, 2013, 62(8):2796-807 得到同期Diabetes杂志的Editorial Comment 评论(Diabetes, 2013,62(8):2665-6)。 发表时间：2013-08
20. Li-Na Zhang, Hua-Yong Zhou, Yan-Yun Fu, Yuan-Yuan Li, Fang Wu, Min Gu, Ling-Yan Wu, Chun-Mei Xia, Tian-Cheng Dong, Jing-Ya Li*, Jing-Kang Shen*, and Jia Li*. Novel Small-Molecule PGC-1α Transcriptional Regulator With Beneficial Effects on Diabetic db/db Mice. Diabetes, 2013, 62(4):1297-307 发表时间：2013-04
21. Li-Na Zhang, Lei Xu, Hua-Yong Zhou, Ling-Yan Wu, Yuan-Yuan Li, Tao Pang, Chun-Mei Xia, Bei-Ying Qiu, Min Gu, Tian-Cheng Dong, Jing-Ya Li*, Jing-Kang Shen*, Jia Li*. Novel Small-Molecule AMP-Activated Protein Kinase Allosteric Activator with Beneficial Effects in db/db Mice. PLoS ONE, 2013, 8(8):e72092 发表时间：2013-08-20
22. Beiying Qiu, Turner N, Yuanyuan Li, Ming Gu, Mingwei Huang, Fang Wu, Tao Pang, Fajun Nan, Jiming Ye, Jingya Li*, Jia Li*. High-Throughput Assay for Modulators of Mitochondrial Membrane Potential Identifies a Novel Compound With Beneficial Effects on db/db Mice. Diabetes, 2010, 59(1):256–265 发表时间：2010-01
23. Zhe Cheng#, Anfeng Chen#, Fang Wu, Li Sheng, Hankun Zhang, Min Gu, Yuanyuan Li, Lina Zhang, Lihong Hu*, Jingya Li*, Jia Li*. 8,8-Dimethyldihydroberberine with improved bioavailability and oral efficacy on obese and diabetic mouse models. Bioorganic & Medicinal Chemistry, 2010, 18(16):5915–5924 发表时间：2010-08-15
24. Guanghui Deng, Deju Ye, Yuanyuan Li, Lingyan He, Yu Zhou, Jiang Wang, Jia Li, Hualiang Jiang, Hong Liu. Synthesis of (S)-, (R)-, and (rac)-2-amino-3,3-bis(4-fluorophenyl) propanoic acids and an evaluation of the DPP IV inhibitory activity of Denagliptin diastereomers. Tetrahedron, 2008, 64(46):10512-10516 发表时间：2008-11-10
25. Xiang Guang-ya, Liang Rong-bei, Li Yan-ping, Li Yuanyuan. Synthesis of NO-releasing oxaprozin and determination of NO-releasing activities in vitro. Central South Pharmacy, 2005, 3(4):206
发明专利：
李佳，南发俊，顾民，李静雅，易华，李媛媛。一类二肽酶四抑制剂及其制备方法和用途国际专利申请号：PCT/CN2006/001596
指导学生获奖：
袁晓燕 2022年上海药物所“新光闪药”研究生学术年会优秀奖
