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继2019年成功举办第四届岭南国际DMPK论坛后，第五届岭南国际DMPK论坛将于2023年11月10-12日在广州再次召开。会议由中山大学药学院、南方医科大学药学院及广东省药理学会主办，中国药理学会药物代谢专业委员会、广东省药理学会药物代谢专业委员会协办。
论坛旨在建立一个DMPK学者学术交流和合作的平台，推动国内药物代谢与药代动力学相关领域的学术交流、合作与高质量发展。论坛将聚焦DMPK学科进展、研发前沿、科研新思路新方法，邀请海内外著名DMPK专家和学者作专题报告，分析研讨DMPK发展趋势和前沿动向，探讨中国DMPK发展的重大科学问题，交流展示DMPK研究新成果、新进展、新技术、新经验，以互相启迪科研思路，拓展研究视野，整合内外资源，共同促进DMPK学科发展。
这又将是一次DMPK领域的学术盛会，我们盛情邀请各高校、科研院所以及企事业单位的各界同仁参加2023年第五届岭南国际DMPK论坛。
诚挚相邀，汇智岭南！
一、 会议主题与内容
会议主题：DMPK研究交流——合作共赢
会议方式与内容：
1） 研讨会探讨DMPK研究的新科学问题；
2） 国内外DMPK专家作前沿学术报告；
3） 青年学者介绍或展示最新科研成果；
4） 国内外学者圆桌会议加强交流与合作。
学术报告包括但不限于如下内容：
1） DMPK的新进展；
2） 药物代谢与药理毒理机制；
3） 药物代谢调控与转化；
4） DMPK的其他科学问题
二、论坛组委会
国内召集人：黄 民 （中山大学）、毕惠嫦 （南方医科大学）
海外召集人：丁欣欣 （University of Arizona, USA）
委员（按拼音顺序）：
顾景凯 （吉林大学）
李 川 （中国科学院上海药物所）
林 鸽 （The Chinese University of Hong Kong）
谢 文 （University of Pittsburgh, USA）
喻爱明 （University of California at Davis, USA）
曾 苏 （浙江大学）
钟筱波 （University of Connecticut, USA）
左 中 （The Chinese University of Hong Kong）
三、会议时间和地点
时间：2023年11月10-12日
地点：中山大学东校园（广州市番禺区大学城外环东路132号）
四、会议日程安排
时 间 | 日 程 |
2023年11月10日 | 全天报到 |
2023年11月11日 | 上午：开幕式、大会报告、分会场报告 下午：分会场报告 晚上：组委会研讨会 |
2023年11月12日 | 上午：中大药学院20周年庆学术活动 下午：闭幕式 |
2023年11月13日 | 会后交流或离会 |
五、论文摘要投稿
会议接收符合本次会议议题的博士后或研究生论文摘要，并从中评选出优秀的摘要通过墙报等方式交流。论文摘要和墙报均使用英文，墙报展示安排在会议期间进行。论文英文摘要的格式请见附件1。
六、会议注册
1、本会议采用网上报名注册（请扫描下方二维码注册）。请拟参会人员于2023年11月9日前完成网上注册。会议注册二维码如下：
2、会务费及缴费 ：会务费包含会议资料费和午餐费（会议交通费及住宿自理)：
| 现场注册 | 提前注册（2023年10月31日前） |
一般代表 | 1200元人民币 | 1000元人民币 |
学生代表 | 800元人民币 | 500元人民币 |
付款方式： | 汇款方式汇至以下帐户； 现场注册者可选择刷卡或现金缴交注册费。 |
账户户名： | 广东省药理学会 |
账 号： | 101001516010010542 |
开户行： | 广发银行广州广发大厦支行 |
汇款注明： | 2023DMPK会务费（请注明参会人员姓名） |
汇款后请将汇款凭证上传至会议注册里 |
七、演讲嘉宾（按姓名首字母顺序，持续更新中）:
Aiming Yu (University of Califoria at Davis, USA)
Andrew Paterson (Penn State University, USA)
Baojian Wu (Guangzhou University of Chinese Medicine, China)
Benzhan Zhu (Chinese Academy of Sciences, China)
Chuan Li (Shanghai Institute of Material Medica, China)
Dafang Zhong (Shanghai Institute of Material Medica, China)
Eric Chan (National University of Singapore, Singapore)
Feng Zhu (Zhejiang University, China)
Ge Lin (The Chinese University of Hong Kong, China)
Grace L Guo (Rutgers University, USA)
Guangbo Ge (Shanghai University of Traditional Chinese Medicine, China)
Guofeng You (Rutgers University, USA)
Huichang Bi (Southern Medical University, China)
Huidi Jiang (Zhejiang University, China)
Hongbing Wang (University of Maryland, USA)
Herana K. Seneviratne (University of Maryland Baltimore Country, USA)
José E. Manautou (University of Connecticut, USA)
Jiang Zheng (Shenyang Pharmaceutical University/Guizhou Medical University, China)
Jingkai Gu (Jilin University, China)
Lauren Aleksunes (Rutgers University, USA)
Lirong Zhang (Zhengzhou University, China)
Lynn Ge (The Chinese University of Hong Kong, China)
Qingyu Zhang (University of Amrizona, USA）
Taosheng Chen (St. John's Children's Reseach Hospital, USA)
Wei Jia (Hongkong Baptist University, China)
Wei Yue (University of Oklahoma Health Sciences Center, USA)
Wen Xie (University of Pittsburgh, USA)
Xiaobo Zhong (University of Connecticut, USA)
Xiaochao Ma (University of Pittsburgh, USA)
Xinxin Ding (University of Arizona, USA)
Yan Shu (University of Maryland, USA)
Zhong Zuo (The Chinese University of Hong Kong, China)
八、秘书处
会务组负责人：方坚鸿、唐斓、杜笑娟
E-mail：lingnanDMPK2023@163.com
联系地址：广州大学城外环东路132号 中山大学药学院，510006
九、住宿指引
与会代表自行预定住宿，费用自理。
会议地址附近酒店推荐：
1、广州大学城新天地J精品酒店（广州番禺区大学城中二横路1号GOGO新天地）
2、广州大学城南国会国际会议中心（广州番禺区大学城外环东路280号）
3、广州华工大学城中心酒店（广州番禺区华工北路68号华南理工大学北门）
4、广州大学城雅乐轩酒店（广州番禺区大学城小谷围街立德街66号）
报“中大药学院会议”可享受协议价格，先到先得。
2023年第五届岭南国际DMPK论坛组委会
中山大学药学院
南方医科大学药学院
广东省药理学会
2023年9月8日
附件1 摘要模板：
Fenofibrate induced-hepatomegaly and liver regeneration is PPARα- dependent and partially related to the activation of YAP pathway
Shicheng Fan1, Yue Gao2, Min Huang2*, Huichang Bi1*
1 School of Pharmaceutical Sciences, Southern Medical University
2 School of Pharmaceutical Sciences, Sun Yat-sen University
Fenofibrate, an agonist of peroxisome proliferator-activated receptor α (PPARα), has been widely used as a lipid-regulating agent in clinical practice. Recent studies found that fenofibrate treatment induced hepatomegaly in mice, but the mechanisms involved remain unclear. YAP, the key effector of Hippo signaling pathway, plays an important role in manipulating the liver size and regeneration. The aim of this study is to identify the role of YAP in fenofibrate-induced hepatomegaly and liver regeneration. The effects of fenofibrate on liver enlargement and liver regeneration were investigated in wild-type, Pparafl/fl, and hepatocyte-specific Ppara-deficient (PparaΔHep) mice. The results showed that administration of fenofibrate significantly induced liver enlargement and promoted liver regeneration after partial hepatectomy, accompanied by hepatocyte hypertrophy around the central vein area and enhanced hepatocyte proliferation around the portal vein area. Mechanistically, fenofibrate regulated the expressions of YAP and its downstream targets. Fenofibrate activated YAP signaling via suppressing K48-linked ubiquitination and promoting K63-linked ubiquitination, and enhancing interaction and transcriptional activity of YAP-TEAD complex. Suppression of YAP using AAV-Yap shRNA in mice significantly attenuated fenofibrate-induced hepatomegaly, as well as hepatocyte hypertrophy and proliferation. Other factors might also participate in fenofibrate-induced hepatomegaly, including MYC, KRT23, RHOA, and RAS. These studies revealed a novel role of fenofibrate in promoting liver enlargement and regeneration partially through activating the YAP signaling pathway. These findings provide clinical implications of fenofibrate as a potential medication for promoting liver regeneration following PHx.
Key Words
Fenofibrate; peroxisome proliferator-activated receptor a; hepatomegaly; liver regeneration; yes-associated protein
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