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何坚

F35CB

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职称:教 授

Tel:020-61648717

E-mail:jianhe@smu.edu.cn


学习经历:

1997.09-2000.06  中国医学科学院, 中国协和医科大学药物研究所,药物化学,博士

1994.09-1997.06  华中师范大学分析测试中心,有机化学,硕士

 

研究工作经历:

2013.01-至今      南方医科大学药学院,教授

2008.04-2012.12   C3 Jian Inc.公司,研究员 (Scientist)

2007.12-2010.01   加洲大学洛山矶分校牙医学院,助理研究员 (Assistant researcher)

2004.01-2007.11   加洲大学洛山矶分校牙医学院,博士后

2003.01-2003.12   亚历桑那大学西南天然产物研究和商业化中心,博士后

2002.07-2003.01   德国汉斯-克劳尔天然产物研究所,助理研究员 (Senior scientist)

2000.07-2002.06   德国汉斯-克劳尔天然产物研究所,博士后

 

研究方向:

1. 肽类药物分子设计、合成和活性研究

2. 天然药物化学

 

在研课题:

1. 主持南方医科大学高层次人才引进科研项目

项目名称:以小分子肽和肽类似物为骨架的高活性抗菌化合物的设计,合成和活性研究  

项目编号:B1040903

2. 主持广东省科技厅科研项目

项目名称:从放线菌Streptomyces sp SMU03中寻找抑制流感病毒进入宿主先导化合物的研究

项目编号:2015A020211010

3. 主持NSFC面上项目

项目名称:以流感病毒血凝素酶为靶点兼具免疫调节功能的新型抗禽流感病毒肽类化合物的研究  

项目编号:81773556

 

主要论著:

1. Guang Yang, Jingyu Wang, Shengsheng Lu, Zhao Chen, Sheng Fan, Daiwei Chen, Huanxin Xue, Wenyuan Shi, Jian He* Short lipopeptides specifically inhibit the growth of Propionibacterium acnes through antibacterial and anti-inflammatory dual action, British Journal of Pharmacology 2019, 176(13), 2321-2335.

2. Kai-Xuan Zheng, Yi Jiang, Ju-Xing Jiang, Rong Huang, Jian He, Shao-Hua Wu, A new phthalazinone derivative and a new isoflavonoid glycoside from lichen-associated Amycolatopsis sp.Fitoterapia 2019, 135, 85-89.

3. Zhao Chen, Guang Yang, Shengsheng Lu, Daiwei Chen, Sheng Fan, Junyang Xu, Buling Wu*, Jian He*

Design and antimicrobial activities of LL-37 derivatives inhibiting the formation of  Streptococcus mutans biofilm, Chemical Biology and Drug Design 2019, 93(6), 1175-1185.

4. Fangfang Li, Daiwei Chen, Shengsheng Lu, Guang Yang, Xiaoling Zhang, Zhao Chen, Sheng Fan, Shaohua Wu, Jian He*, Anti-influenza A Viral Butenolide from Streoptomyces sp Smu03 Inhabiting the Intestine of Elephas maximus, Viruses 2018, 10, 356.  

5. Rong Huang, Bo-Guang Jiang, Xiao-Nian Li, Ya-Ting Wang, Si-Si Liu, Kai-Xuan Zheng, Jian He,* and Shao-Hua Wu*, Polyoxygenated Cyclohexenoids with Promising a-Glycosidase Inhibitory Activity from the Endophytic Fungus Phomopsis sp. YE3250, Journal of Agricultural and Food Chemistry 2018, 66 (5), 1140–1146.  

6Dongguo Lin, Yinzhu Luo, Guang Yang, Fangfang Li, Xiangkun Xie, Daiwei Chen, Lifang He, Jingyu Wang, Chunfeng Ye, Shengsheng Lu, Lin Lv, Shuwen Liu*, Jian He*, Potent influenza A virus entry inhibitors targeting a conserved region of hemagglutinin Biochem Pharmacol. 2017, 144, 35–51.  

7. 李芳芳, 陆盛胜, 吉腾飞, 何坚*, 动物来源放线菌的次级代谢产物及其生物活性研究进展,药学学报, 2017, 52(7), 1091-1101.

8. Shou-Peng Zhang, Rong Huang, Fang-Fang Li, Xiao-Song Xie, Hong-Xia Wei, Xiao-Wei Fang, Dong-Guo Lin, Shao-Hua Wu*, Jian He*, Antiviral anthraquinones and azaphilones produced by an endophytic fungus Nigrospora sp. from Aconitum carmichaeli, Fitoterapia 2016, 112, 85-89.  

9. Dongguo Lin, Fangfang Li, Qiuyi Wu, Xiangkun Xie, Wenjiao Wu, Jie Wu, Qing Chen, Shuwen Liu, Jian He*, A “building block” approach to the new influenza A virus entry inhibitors with reduced cellular toxicities. Sci. Rep. 2016, 6, 22790.

10. Dongguo Lin, Ruxia Ren, Qianjing Tan, Qiuyi Wu, Fangfang Li, Lin Li, Shuwen Liu, Jian He*, A facile and dynamic assay for the detection of peptide aggregation. Analytical and Bioanalytical Chemistry 2016, 408(6), 1609-1614.

 

专利:

1. 何坚,李芳芳,陆胜盛,陈黛蔚,大象肠道来源放线菌的丁烯酸内酯类化合物及其应用,中国,201810717849.9, 2018

2. 何坚,陈昭,一种具有抗菌及抗炎活性的多肽化合物,中国,201810378872.X

3. 何坚,杨光,王静瑜,一种具有专一性抗痤疮丙酸杆菌作用及抗炎双重作用的短脂肽,中国, 201811034762.8, 2018

4. 何坚,林冬果,刘叔文,快速方便地检测淀粉样蛋白形成的荧光探针及方法,中国,201610027639.8,2016

5. 何坚, 刘叔文, 王静瑜,武文姣,林冬果, 一类兼具抗菌和抗流感病毒活性的融合肽衍生物,中国,ZL 201510045228.7,2015

6. 何坚, 刘叔文, 林冬果, 方堉欣,王静瑜,具有抗菌抗病毒活性的小分子肽及其活性修饰物,中国,201410259060.5,2014

 

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