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何坚



姓名 何 坚
职称 教 授
Tel 020-61648717
E-mail jianhe@smu.edu.cn


学习经历
1997/09-2000/06 中国医学科学院, 中国协和医科大学药物研究所,药物化学,博士
1994/09-1997/06 华中师范大学分析测试中心,有机化学,硕士


研究工作经历
2013/01 - 至今 南方医科大学药学院,教授
2008/04–2012/12 C3 Jian Inc.公司,研究员 (Scientist)
2007/12–2010/01 加洲大学洛山矶分校牙医学院,助理研究员 (Assistant researcher)
2004/01 -2007/11 加洲大学洛山矶分校牙医学院,博士后
2003/01 -2003/12 亚历桑那大学西南天然产物研究和商业化中心,博士后
2002/07 -2003/01 德国汉斯-克劳尔天然产物研究所,助理研究员 (Senior scientist)
2000/07 -2002/06 德国汉斯-克劳尔天然产物研究所,博士后


研究方向
1. 肽类药物分子设计、合成和活性研究
2. 天然药物化学


在研课题
1. 主持南方医科大学高层次人才引进科研项目
项目名称:以小分子肽和肽类似物为骨架的高活性抗菌化合物的设计,合成和活性研究,2014年1月,50万元

项目编号:B1040903
2. 主持广东省科技厅科研项目
项目名称:以血凝素蛋白为靶点的肽类流感病毒进入抑制剂的研究。 2015-2017,20万元
项目编号:2014A020210014
3. 主持广东省科技厅科研项目
项目名称:从放线菌Streptomyces sp SMU03中寻找抑制流感病毒进入宿主先导化合物的研究,2016-2018, 30 万元
项目编号:2015A020211010
4. 参与NSFC-广东联合基金重点项目 (排名第二)
项目名称:以血凝素蛋白保守功能区为新靶点的小分子天然来源流感病毒进入抑制剂研究 2014 -2017

项目编号:U1301224


承担课程
《天然药物化学》、《生物技术制药》


主要论著
2010-2015
1. Dongguo Lin, Fangfang Li, Qiuyi Wu, Xiangkun Xie, Wenjiao Wu, Jian He*, A “building block” approach to the new influenza A virus entry inhibitors with reduced cellular toxicities. (Submitted) (* refers to corresponding author)
2. Dongguo Lin, Ruxia Ren, Qianjing Tan, Qiuyi Wu, Fangfang Li, Lin Li, Shuwen Liu, Jian He*, A facile and rapid approach to the detection of peptide aggregation. (Submitted)
3. Wenjiao Wu, Dongguo Lin, Xintian Shen, Fangfang Li, Yuxin Fang, Kaiqun Li, Tianrong Xun, Guang Yang, Jie Yang, Shuwen Liu,* Jian He*, New influenza A virus entry inhibitors derived from the viral fusion peptides PLoS One 2015, 10(9): e0138426 (IF 3.23)
4. Jingyu Wang, Wenjing Zhong, Dongguo Lin, Fan Xia, Wenjiao Wu, Heyuan Zhang, Lv Lin, Shuwen Liu,* Jian He*, Antimicrobial peptides derived from fusion peptides of influenza A viruses, a promising approach to designing potent antimicrobial agents. Chemical Biology & Drug Design 2015; 86: 487-495 (IF 2.48)
5. Wenjiao Wu, Jingyu Wang, Dongguo Lin, Linqing Chen, Xiangkun Xie, Xintian Shen, Qingqing Yang, Qiuyi Wu, Jie Yang, Jian He*, Shuwen Liu*, Super short membrane-active lipopeptides inhibiting the entry of influenza A virus, Biochimica et Biophysica Acta (BBA) - Biomembranes 2015, 1848, 2344-2350 (IF 3.83)
6. Shao-Hua Wu*, Jian He*, Xiao-Nian Li, Rong Huang, Fei Song, You-Wei Chen, Cui-Ping Miao,Guaiane sesquiterpenes and isopimarane diterpenes from an endophytic fungus Xylaria sp. Phytochemistry 2014, 105, 197-204 (IF 2.54)
7. Yuxin Fang, Wenjing Zhong, Yue Wang, Tianrong Xun, Dongguo Lin, Wenjun Liu, Jingyu Wang, Lin Lv, Shuwen Liu*, Jian He*,Tuning the antimicrobial pharmacophore to enable discovery of super short lipopeptides with multiple modes of action, European Journal of Medicinal Chemistry, 2014, 83, 36-44 (IF 3.44)
8. Kai-Xia Ma, Xintian Shen, Rong Huang, Tang Wang, Xiao-Song Xie, Shuwen Liu, Shao-Hua Wu*, and Jian He*, Bioactive Metabolites Produced by the Endophytic Fungus Phomopsis sp YM355364 , Natural Product Communications, 2014, 9(5), 669-670 (IF 0.90)
9. Peter B. Lillehoj, Christopher W. Kaplan, Jian He, Wenyuan Shi, Chih-Ming Ho, Rapid, Electrical Impedance Detection of Bacterial Pathogens Using Immobilized Antimicrobial Peptides, Journal of Laboratory Automation. 2014, 19(1):42-49. (IF 1.87)
10. Hu CH, He J, Eckert R, Wu XY, Li LN, Tian Y, Lux R, Shuffer JA, Gelman F, Mentes J, Spackman S, Bauer J, Anderson MH, Shi WY., Development and evaluation of a safe and effective sugar-free herbal lollipop that kills cavity-causing bacteria, Int J Oral Sci., 2011, 3(1), 13-20 (IF 2.53)
11. Yarbrough DK, Eckert R, He J, Hagerman E, Qi F, Lux R, Wu B, Anderson MH, Shi W.,Rapid probing of biological surfaces with a sparse-matrix peptide library,PLoS One,2011, 6(8), e23551 (IF 3.23)
12. He, Xuesong; Hu, Wei; He, Jian; Guo, Lihong; Lux, Renate; Shi, Wenyuan,Community-based interference against integration of Pseudomonas aeruginosa into human salivary microbial biofilm, Molecular Oral Microbiology, 2011, 26(6), 337-52 (IF 2.78)
13. R. Sullivan, P. Santarpia, S. Lavender, E. Gittins, Z. Liu, M.H. Anderson, J. He, W. Shi, R. Eckert, Clinical Efficacy of a Specifically Targeted Antimicrobial Peptide Mouth Rinse: Targeted Elimination of Streptococcus mutans and Prevention of Demineralization, Caries Research, 2011, 45(5), 415-428 (IF 2.28)
14. Jian He, Daniel K. Yarbrough, Jens Kreth, Maxwell H. Anderson, Wenyuan Shi, and Randal Eckert, A systematic approach to optimizing specifically-targeted antimicrobial peptides against Streptococcus mutans, Antimicrobial Agents and Chemotherapy, 2010, 54(5), 2143-2151 (IF 4.47)
15. Lina Li, Jian He, Randal Eckert, Daniel Yarbrough, Renate Lux, Maxwell Anderson and Wenyuan Shi, Design and characterization of an acid-activated antimicrobial peptide, Chem Biol Drug Des., 2010, 75(1), 127-32 (IF 2.48)
16. Li LN, Guo LH, Lux R, Eckert R, Yarbrough D, He J, Anderson M, Shi WY., Targeted antimicrobial therapy against Streptococcus mutans establishes protective non-cariogenic oral biofilms and reduces subsequent infection, Int J Oral Sci., 2010, 2(2), 66-73 (IF 2.53)
17. Yarbrough DK, Hagerman E, Eckert R, He J, Choi H, Cao N, Le K, Hedger J, Qi F, Anderson M, Rutherford B, Wu B, Tetradis S, Shi W., Specific Binding and Mineralization of Calcified Surfaces by Small Peptides. Calcif Tissue Int., 2010, 86, 58–66 (IF 3.27)
2000-2009
18. Jian He, Maxwell Anderson,Wenyuan Shi, and Randal Eckert, Design and activity of a “dual-targeted” antimicrobial peptide, Internaional Journal of Antimicrobial Agents, 2009, 33(6), 532-537 (IF 4.29)
19. Huang X, He Jian, Niu X, Menzel K-D, Dahse H-M, Grabley S, Fiedler P, Sattler I, Hertweck C, Benzopyrenomycin, a Cytotoxic Bacterial Polyketide Metabolite with an Unprecedented Benzo[a]pyrene-Type Carbacyclic Ring System, Angew. Chem. Int. Ed., 2008, 47, 3995-3998 (IF 11.26)
20. He, Jian; Eckert, Randal; Yarbrough, Daniel K.; Qi, Fengxia; Anderson, Maxwell H.; Shi, Wenyuan, Novel synthetic antimicrobial peptides against Streptococcus mutans, Antimicrobial Agents and Chemotherapy, 2007, 51, 1351-1358 (IF 4.47)
21. Jian He, Ernst Roemer, Corinna Lange, Xueshi Huang, Armin Maier, Gerhard Kelter,, Yi Jiang, Li-hua Xu, Klaus-Dieter Menzel, Susanne Grabley, Heinz-Herbert Fiebig, Cheng-Ling Jiang, and Isabel Sattler, Structure, Derivatization, and Antitumor Activity of New Griseusins from Nocardiopsis sp., J. Med. Chem., 2007,50(21), 5168-5175 (IF 5.44)
22. Randal Eckert, Ian Mchardy, Daniel K. Yarbrough, Jian He, Fengxia Qi, Maxwell H. Anderson and Wenyuan Shi, Stability and activity in sputum of G10KHc, a potent anti-pseudomonas antimicrobial peptide. Chem Biol Drug Des., 2007, 70(5), 456-460 (IF 2.48)
23. Jian He, Li Chen, David Heber, Wenyuan Shi, Qingyi Lu, Antibacterial Compounds from Glycyrrhiza uralensis. J. Nat. Prod. 2006, 69(1), 121-124 (IF 3.79)
24. He, Jian; Feng, Xiao-Zhang; Ji, Teng-Fei; Lu, Yang; Zhao, Bin, Secondary metabolites from
fungus Fome Cajanderi, Natural Product Research, Part A: Structure and Synthesis, 2006, 20(6),
598-605 (IF 0.91)
25. Eckert, Randal; He, Jian; Yarbrough, Daniel K.; Qi, Fengxia; Anderson, Maxwell H.; Shi, Wenyuan, Targeted killing of Streptococcus mutans by a pheromone-guided "smart"antimicrobial peptide, Antimicrobial Agents and Chemotherapy, 2006, 50(11), 3651-3657 (IF 4.47)
26. Eckert, Randal, Qi, Fengxia, Yarbrough, Daniel K., He, Jian, Anderson, Maxwell H., Shi, Wenyuan, Adding selectivity to antimicrobial peptides: rational design of a multidomain peptide against Pseudomonas spp. Antimicrobial Agents and Chemotherapy, 2006, 50(4), 1480-1488 (IF 4.47)
27. Eckert, Randal, Brady, Keith M., Greenberg, E. Peter, Qi, Fengxia, Yarbrough, Daniel K., He, Jian, McHardy, Ian, Anderson, Maxwell H., Shi, Wenyuan, Enhancement of antimicrobial activity against Pseudomonas aeruginosa by coadministration of G10KHc and tobramycin, Antimicrobial Agents and Chemotherapy, 2006, 50(11), 3833-3838 (IF 4.47)
28. Jian He, Ulrich Lion , Isabel Sattler, Susanne Grabley, etc, Diastereomeric Quinolinone Alkaloids from marine-derived fungus Penicillium janczewskii Zalessky, J. Nat. Prod., 2005, 68(9), 1397-1399 (IF 3.79)
29. Jian He, E. M. Kithsiri Wijerane, Manping Liu, Jun Zhang, Elizabeth E. Pierson, Leland S. Pierson, III, Hans D. VanEtten, and A. A. Leslie Gunatilak, Cytotoxic and other Metabolites of Aspergillus inhabiting the rhizosphere of Sonoran desert plants, J. Nat. Prod., 2004, 67 (12), 1985 -1991 (IF 3.79)
30. Jian He*, Xiao Zhang Feng, Yang Lu, Bin Zhao, Fomlactones A-C, Three Novel Triterpene Lactones from Fomes cajanderi, J. Nat. Prod., 2003, 66(9), 1249-1251 (IF 3.79)
31. Jian He, Xiao Zhang Feng, Yang Lu, Bin Zhao, Three new Triterpenoids from Fuscoporia obliqua, Journal of Asian natural products Research, 2001, 3(1), 55-61 (IF 0.91)
32. Jian He, Xiao Zhang, Feng, The chemical constituents study on Fuscoporia obliqua, Chinese Traditional and Herbal Drugs, 2001, 32(1), 4-6
33. Jian He, Xiao Zhang Feng, Yang Lu, Bin Zhao, Triterpenoids from Fuscoporia obliqua, Chinese Chemical Letters, 2000, 1, 45 (IF 1.58)
34. Jian He, Xiao Zhang, Feng, The chemical constituents study on Phellinus yamanoi, Natural Products Research and Development, 2000, 12(6), 33-36
专利
1.何坚, 刘叔文, 林冬果, 方堉欣,王静瑜,具有抗菌抗病毒活性的小分子肽及其活性修饰物,中国,201410259060.5,2014
2.何坚, 刘叔文, 王静瑜,武文姣,林冬果, 一类兼具抗菌和抗流感病毒活性的融合肽衍生物,中国,201510045228.7,2015
3. Eckert, Randal H.; Yarbrough, Daniel K.; Shi, Wenyuan; Anderson, Maxwell H.; Qi, Fengxia; He, Jian; McHardy, Ian H. Selectively targeted antimicrobial peptides and the use thereof , 美国,
PCT Int. Appl.,WO 2008030988,2008
4. He, Jian; Eckert, Randal; Qi, Fengxia; Anderson, Maxwell H.; Shi, Wenyuan. Novel Antimicrobial peptides, 美国, PCT Int. Appl.,WO 2008140834, 2008
5. Yarbrough, Daniel; Eckert, Randal, Shi, Wenyuan; Qi, Fengxia; He, Jian Applying matrix design in discovery biological activity polypeptides (antimicrobial, bacterial binding, and protein binding peptides etc) , 美国, PCT Int. Appl. , WO 2009117524, 2009
6. Eckert, Randal H.; Yarbrough, Daniel K.; Shi, Wenyuan; Anderson, Maxwell; He, Jian;
Kaplan, Chris; Sim, Jee-Hyun New targeted antimicrobial peptides with peptide targeting Moieties,美国, PCT Int. Appl.,WO 2010091294, 2010
7. Eckert, Randal H.; Chris Kaplan, He, Jian; Yarbrough, Daniel K.; Maxwell H.; Jee-Hyun Sim; Antibacterial and antifungal peptides, 美国, PCT Int. Appl., WO 2010080836, 2010
8. Eckert, Randal H.; Kaplan, Chris; He, Jian; Anderson, Maxwell; Sim, Jee-Hyun,Chimeric multi-head specifically targeted antimicrobial peptides , 美国, PCT Int. Appl., WO 2010080819, 2010
9. Eckert, Randal H.; Kaplan, Chris; He, Jian; Yarbrough, Daniel K.; Anderson, Maxwell; Sim, Jee-Hyun Methods using selective permeabilization reagents and devices for the selective detection of microorganisms , 美国, U.S. Pat. Appl., US 20120003661,2012
10. Yarbrough, Daniel; Shi, Wenyuan; Hagerman, Elizabeth; Tetradis, Sotirios; Qi, Fengxia; He, Jian; Rutherford, Bruce; Eckert, Randal; Wu, Ben. Calcium binding peptides, 美国,PCT Int. Appl.,WO 2007038683, 2007
11. Grabley, Susanne; Sattler, Isabel; Roemer, Ernst; Huang, Xueshi; He, Jian; Fiebig, Heinz-Herbert; Maier, Armin; Kelter, Gerhard. Griseusin derivatives and their use as antitumor agents, 德国, Eur. Pat. Appl.,EP 1650209, 2006
12. Grabley, Susanne; Sattler, Isabel; Ulrich Lion; He, Jian, New secondary metabolites from marine fungi: 德国, Eur. Pat. Appl., 02 02 0606.6, 2002


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