[已阅读次]
谭穗懿


姓名:谭穗懿
职称:副教授
联系邮箱:suiyitan@smu.edu.cn
联系电话:020-61648590

学习经历
2007/09-2011/06   南方医科大学,药学院, 药理学博士
2004/09-2006/06 中山大学,生命科学学院, 药物分析硕士
2000/09-2004/06 中山大学,药学院, 药学学士

工作经历
2014.12-至今 南方医科大学,药学院,副教授
2008/12-2014/11 南方医科大学, 药学院,讲师
2009/03-2010/12 纽约血液中心,LFK研究所,访问学者
2006/07-2008/12 南方医科大学,药学院,助教

研究方向:
1. 抗病毒药物药理学的研究;
2. 预防HIV性传播的杀微生物剂研究;
3.HIV粘膜传播机制研究。

主要学术任职:
世界中联中医药免疫专业委员会,理事

主要获奖情况:
1. 2015/07,学院优秀共产党员
2. 2007、2014,南方医科大学教学优秀二等奖
3. 2015/04,第29届国际抗病毒研究大会奖学金
4. 2012/04,国际杀微生物剂大会奖学金

代表性论文:
1. Xuefeng Zhou#, Wei Fang#, Suiyi Tan#(共同第一), Xiuping Lin, Tianrong Xun, Bingjie Yang, Shuwen Liu*, Yonghong Liu*. Aspernigrins with Anti-HIV-1 Activities from the Marine-Derived Fungus Aspergillus niger SCSIO Jcsw6F30. Bioorg Med Chem Lett. 2016; 26(2):361-365.
2. Xun T, Li W, Chen J, Yu F, Xu W, Wang Q, Yu R, Li X, Zhou X, Lu L, Jiang S, Li L, Tan S* (共同通讯), Liu S*,ADS-J1 Inhibits Semen-Derived Amyloid Fibril Formation and Blocks Fibril-Mediated Enhancement of HIV-1 Infection. Antimicrob Agents Chemother. 2015; 59(9):5123-34.
3. Suiyi Tan, Heng Duan, Tianrong Xun, Jiayin Qiu, Fei Yu, Xuyan Zhao, Linxuan Wu, Lin Li, Lu Lu, Shibo Jiang, Shuwen Liu*, HIV-1 impairs human retinal pigment epithelial barrier function: possible association with the pathogenesis of HIV-associated retinopathy. Lab Invest, 2014; 94(7):777-787.
4. Suiyi Tan, Lin Li, Lu Lu, Chungen Pan, Hong Lu, Yelena Oksov, Xiaojuan Tang, Shibo Jiang*, Shuwen Liu*. Peptides derived from HIV-1 gp120 co-receptor binding domain form amyloid fibrils and enhane HIV-1 infection. FEBS Letters. 2014, 588(9):1515-1522.
5. Suiyi Tan, Lu Lu, Lin Li, Jixiang Liu, Yelena Oksov, Hong Lu, Shibo Jiang, Shuwen Liu. Polyanionic candidate microbicides accelerate the formation of semen-derived amyloid fibrils to enhance HIV-1 infection. PLOS ONE. 2013;8(3):e59777.
6. Suiyi Tan, Shuwen Liu*, Shibo Jiang*. Pathogenesis and Treatment of Human Immunodeficiency Virus (HIV)-Associated Human Cytomegalovirus (HCMV) Retinitis. Future Virology.2011; 6(4):503-520.
7. Suiyi Tan, Shuwen Liu, Shibo Jiang. HIV/AIDS and Ocular Complications. International Journal of Ophthalmology, 2009; 9(2): 203-213.
8. Chen J, Ren R, Tan S, Zhang W, Zhang X, Yu F, Xun T, Jiang S, Liu S, Li L. A Peptide Derived from the HIV-1 gp120 Coreceptor-Binding Region Promotes Formation of PAP248-286 Amyloid Fibrils to Enhance HIV-1 Infection. PLoS One. 2015; 10(12): e0144522.
9. Xiaojuan Li, Longgang He, Yiping Hu, Heng Duan, Xianglian Li, Suiyi Tan, Min Zou, Chunping Gu, Xiangzhou Zeng, Le Yu, Jiake Xu, Shuwen Liu*. Sinomenine Suppresses Osteoclast Formation and Mycobacterium tuberculosis H37Ra-Induced Bone Loss by Modulating RANKL Signaling Pathways. PLOS ONE. 2013; 8(9):e74274.
10. Wenjun Duan, Suiyi Tan, Jing Chen, Shuwen Liu, Shibo Jiang, Yang Xie*. Isolation of Anti-HIV Components from Canarium Album Fruits by High-Speed Countercurrent Chromatography. Analytical Letters. 2013; 46(7):1057-1068.
11. Jie Yang, Lin Li, Hong Jin, Suiyi Tan, Jiayin Qiu, Lei Yang, Yanqing Ding, Zhi-Hong Jiang, Shibo Jiang, Shuwen Liu*. Vaginal gel formulation based on theaflavin derivatives as a microbicide to prevent HIV sexual transmission. AIDS Res Hum Retroviruses. 2012; 28(11): 1498-508.
12. Jie Yang, Lin Li, Suiyi Tan, Hong Jin, Jiayin Qiu, Qinchao Mao, Runming Li, Chenglai Xia, Zhi-Hong Jiang, Shibo Jiang, Shuwen Liu*. A natural theaflavins preparation inhibits HIV-1 infection by targeting the entry step: Potential applications for preventing HIV-1 infection. Fitoterapia. 2012; 83(2):348-55.
13. Chang Zhou, Lu Lu, Suiyi Tan, Shibo Jiang, Ying-Hua Chen. HIV-1 Glycoprotein 41 EctodomainInduces Activation of the CD74 Protein-mediated Extracellular Signal-regulated Kinase/Mitogen-activated Protein Kinase Pathway to Enhance Viral Infection. J Biol Chem. 2011; 286(52):44869-77.
14. Xiaowen Yu, Lu Lu, Lifeng Cai, Pei Tong, Suiyi Tan, Peng Zou, Fanxia Meng, Ying-hua Chen, Shibo Jiang*. Mutations of Gln64 in the HIV-1 gp41 N-terminal heptad repeat render viruses resistant to peptide HIV fusion inhibitors targeting the gp41 pocket. J Virol. 2012; 86(1):589-93.
15. Shufeng Shang, Suiyi Tan, Kangbai Li, Jun Wu, Huina Lin, Shuwen Liu*, Yiqun Deng*. Glu659Leu substitution of recombinant HIV fusion inhibitor C52L induces soluble expression in E. coli with equivalent anti-HIV potency. Protein Engineering, Design & Selection, 2011; 24(7): 545-551.
16. Lin Li, Suiyi Tan, Hong Lu, Lu Lu, Jie Yang, Hong Jin, Shuwen Liu, Shibo Jiang*. Combinations of 3-Hydroxyphthalic Anhydride-modified Ovalbumin with Antiretroviral Drug-based Microbicide Candidates Display Synergistic and Complementary Effects against HIV-1 Infection. J. AIDS, 2011; 56(5): 384-392.
17. Lin Li, Pengyuan Qiao, Jie Yang, Lu Lu, Suiyi Tan, Hong Lu, Xiujuan Zhang, Xi Chen, Shuguang Wu, Shibo Jiang*, Shuwen Liu*. Maleic anhydride-modified chicken ovalbumin as an effective and inexpensive anti-HIV microbicide candidate for prevention of HIV sexual transmission. Retrovirology. 2010, 26; 7:37.
18. Lin Li, Lili He, Suiyi Tan, Xinhua Guo, Hong Lu, Zhi Qi, Chungen Pan, Xiuli An, Shibo Jiang*, Shuwen Liu*. 3-Hydroxyphthalic Anhydride-modified Chicken Ovalbumin Exhibits Potent and Broad Anti-HIV-1 Activity: a Potential Microbicide for Preventing Sexual Transmission of HIV-1. Antimicrobial Agents and Chemotherapy, 2010, 54:1700-1711.
19. Chungen Pan, Byron Cheung, Suiyi Tan, Chunling Li, Lin Li, Shuwen Liu, Shibo Jiang*. Genomic signature and mutation trend analysis of 2009 H1N1pdm influenza A virus. PLOS ONE, 2010, 2010, 5(3): e9549.

主要科研课题:
1. 广东省自然科学基金自由申请项目。HIV-1进入人血-视网膜外屏障及其传播的机制研究。项目编号2015A030313241,2015.08-2018.8,10万,主持,在研。
2. 广州市珠江科技新星。靶向病毒与精液淀粉样纤维的多功能新型杀微生物剂的研究。项目编号201610010132,2016.05-2019.04,30万,主持,在研。
3. 广东省高等学校优秀青年教师人才项目。新型多效杀微生物剂的合成、活性评价及机制研究。项目编号YQ2015039,2016.01-2018.12,30万,主持,在研。
4. 国家自然科学基金面上项目。南海深海放线菌中gp41为靶点的HIV进入抑制剂的筛选发现。项目编号41376162,2014.01-2017.12,联合申请(19.5万),在研。
5. 南方医科大学优秀青年教师培养计划。HIV-1进入人血-视网膜外屏障及其传播机制研究。2015.01-2017.12,5万,主持,在研。
6. 广东省医学科研基金。HIV-1进入人-血视网膜屏障的研究。项目编号B2014235,2014.06-2016.06,1万,主持,在研。
7. 国家自然科学基金青年科学基金项目。精液蛋白拮抗阴离子多聚物类杀微生物剂抗HIV活性的分子机制研究。项目编号81102482/H3106,2012.01-2014.12,主持(20万),已结题。 
 

上一条:蔡铮