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周中振



 

姓名:周中振
职称:副教授,硕士生导师
联系邮箱:zhouzz@smu.edu.cn
联系电话:020-61648549


受教育经历(从大学本科开始,按时间倒排序)
 2001/9 – 2007/7 华中师范大学,化学学院,农药与化学生物学教育部重点实验室,有机化学专业,博士(导师杨光富教授);
 1997/9 – 2001/6 武汉化工学院制药系,工业分析专业,学士;


研究工作经历(按时间倒排序)
 2012/1 ~至今 南方医科大学,药学院合成药物化学课题组,副教授;
 2010/1~ 2011/12 南方医科大学,药学院合成药物化学课题组,讲师;
 2007/7 ~ 2009/12 南方医科大学,药学院化学系,讲师;


研究方向:
 抗肿瘤、抗炎与抗老年痴呆药物分子设计、合成及性质研究;
 药物合成方法学研究;


主要学术任职:
 广东省药学会药物化学专业委员会委员,2009;


主要获奖情况:
 广东省高等学校“千百十工程”校级培养对象,广东省教育厅,2008;


主持或参加的项目:
1) 新型黄酮类肿瘤血管阻断剂的合成与生物活性研究(项目编号:21002048),国家自然科学基金,研究期限:2011.01-2013.12,项目负责人;
2) 基于多靶点的肿瘤血管阻断剂的设计与合成(9451051501002541),主持得广东省自然科学基金,研究期限:2009.10-2011.10,项目负责人;
3) 异黄酮乙酸类肿瘤血管抑制剂的设计、合成及其性质的研究(项目编号:B20081032008),广东省卫生厅医学科学技术研究基金,研究期限:2009.1-2010.12,项目负责人;
4) 抗军事认知能力损伤化学药1.1类新药磷酸二酯酶4抑制药ZX101的成药性研究(项目编号:2012ZX09J1211003C),“重大新药创制”科技重大专项(军口),研究期限:2012.01-2014.12,主要参与者(第二);


代表性论文:
1. Zhou, Z. –Z.; Gu, C. –P.; Deng, Y. –H.; Yan, G. –H.; Li, X. –F.; Yu, L.; Chen, W. –H. Synthesis, selective cytotoxicities and probable mechanism of action of 7-methoxy-3-arylflavone-8-acetic acids. Bioorg. Med. Chem. 2014, 22(5), 1539-1547.
2. Yang, H. –K.; You, W. –W.; Yan, G. –H.; Jiang, Z. –H.; Zhao, P. –L. *; Zhou, Z. –Z.* An efficient one-pot synthesis of 3-amino-7-azaindoles under microwave irradiation,Synth. Commun. 2014, DOI:10.1080/00397911.2013.858360.
3. Zhang, M. –Z.; Zhou, Z. –Z. (Co-first author); Yuan, X.; Cheng, Y. –F.; Bi, B. –T.; Gong, M. –F.; Chen, Y. P.; Xu, J. –P.* Chlorbipram: A novel PDE4 inhibitor with improved safety as a potential antidepressant and cognitive enhancer. Eur. J. Pharmacol. 2013, 721 (1-3), 56-63.
4. Zhou, Z. –Z.; Yan, G. –H.; Chen,W. –H.*; Yan, X. –M. Microwave-assisted efficient synthesis of 2-hydroxydeoxybenzoins from the alkali degradation of readily prepared 3-aryl-4-hydroxycoumarins in water. Chem. Pharm. Bull. 2013, 60(11), 1166-1172.
5. Lu, Y. –M.; Deng, L. –Q.; Huang, X.; Chen, J. –X.; Wang, B.; Zhou, Z. –Z.; Hu, G. –S.; Chen, W. –H.Synthesis and anionophoric activities of dimeric polyamine-sterol conjugates: the impact of rigid vs. flexible linkers. Org. Biomol. Chem., 2013, 11(47), 8221-8227.
6. Zhou, J.; Lu, Y. –M.; Deng, L. –Q.; Zhou, Z. –Z.; Chen, W. –H.Synthesis and ionophoric activities of functionalized bis(choloyl) conjugates with a rigid core. Bioorg. Med. Chem. Lett. 2013, 23 (11), 3145-3148.

7. Zhou, Z. Z.; Zou, M.; Zhou, J.; Zhou, C. Q.; Deng, Y. H.; Chen, M. H.; Gu, C. P.; Jiang, Z. H.; Chen, W.-H.*; Liu, S.-W.* Synthesis, cytotoxicities and DNA-binding affinities of benzofuran-3-ols and their fused analogs. Chem. Pharm. Bull. 2011, 59 (8), 1057-1061.
8. Zhang, L.; Ling, Y.; Zhou, Z. Z.* 3D-QSAR Studies of Flavone-8-acetic Acid Analoges Disrupting Tumour Blood Vessels. Acat Chim. Sinica, 2011, 69 (2), 231–238.
9. Zhou, Z. Z.; Deng, Y. H.; Jiang, Z. H.; Chen, W. H. * Microwave-Assisted dieckmannreaction: efficient one-step synthesis of 2-aroylbenzofuran-3-ols. Adv. Synth. Catal. 2010, 352, 1909–1913.
10. Zhao, P. L.; Zhou, Z. Z.* Synthesis and Crystal Structure of 2-Ethoxy carbonyl-methyl-8-chloro-3a, 4-dihydro-3a-methyl-chromeno [4, 3-c] pyrazol- 3(2H)-one. Chinese J. Struct. Chem. 2010, 29 (8), 1280–1283.
11. Zhou, Z. Z.; You, W. W.; Zhao, P. L. Synthesis and Crystal Structure of (Z)-Methyl -3- methoxy -2-{2-[(4-(E-3-ptolylacryloyl) phenoxy) methyl] phenyl} acrylate. Chinese J. Struct. Chem., 29 (10), 2010, 1574 – 1578.
12. Zhou, Z. Z.; Ding, M. W.; Yang, G. F. Construction of a combinatorial library of 2-(4-oxo-4H-1- benzopyran-3-yl)-4-thiazolidinones by microwave-assisted one-pot parallel syntheses. Heteroatom Chem., 2007, 18 (4) ,381 - 389.
13. Zhou, Z. Z.; Zhao, P. L.; Huang, W.; Yang, G. F. A Selective transformation of flavanones to 3-bromoflavones and flavones under microwave irradiation. Adv. Synth. Catal. 2006, 34 8 (1), 63 - 67.
14. Zhou, Z. Z.; Ji, F. Q.; Cao, M.; Yang, G. F. An efficient intramolecular stetter reaction in room temperature ionic liquids promoted by microwave irradiation. Adv. Synth. Catal. 2006, 348 (14), 1826 - 1830.
15. Zhou, Z. Z.; Yang, G. F. Insecticidal lead identification by screening benzopyrano [4, 3-c]-pyrazol-3(2H)-ones library constructed from multiple- parallel synthesis under microwave irradiation. Bioorg. Med. Chem., 2006, 14 (24), 8666 - 8674.
16. 周中振,陈琼,杨光富,3a, 4-二氢-苯并吡喃[4,3-c]吡唑-3(2H)-酮类衍生物的合成及其活性。有机化学,2009,29 (11), 1174 - 1783 .
17. 周中振,陈琼,杨光富。微波辅助下N-酰胺基-2-(4-氧代-4H-色烯-3-基)噻唑-4-酮类衍生物的平行合成及其杀虫活性。有机化学,2008,28(8),1385-1392.


专利:
1. 徐江平,周中振,一种能避免呕吐反应的磷酸二酯酶4抑制剂。专利号:CN 102603676(中国),WO 2013123766(国际),2012。
2. 徐江平,周中振,程玉芳,张明子,专利号:CN 102716110(中国),WO 2013143259(国际),2012。
3. 周中振,刘叔文,一种3-芳基黄酮乙酸,专利号:CN 103304531,2013。

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