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付卫明

 

 

名:付卫明
称:副教授,博士生导师
联系邮箱:fuweiming76@smu.edu.cn
联系电话:020-61648673

学习经历:
1994.09-1998.07
山东师范大学 ,食品科学与工程,学士
2001.07-2003.07
天津大学,生物化工,硕士
2010.08-2012.12
香港中文大学,生物医学,博士

工作经历:
1998.08-2001.06
山东省济南市轻工业学校,教师
2003.03-2006.12
天津天士力药业,研发主管
2007.01-2010.03 Veoliawater Solution and Technology
SH),技术经理
2012.03-2012.08
美国耶鲁大学药理学,访问学者
2012.12-2016.03
广州中国科学院先进技术研究所,实验室主任 ,副研究员
2016.03-
至今   南方医科大学药学院,副教授

研究方向:
1.
天然产物抗肿瘤作用的药理学研究;
2.  Non- coding RNA

3.
干细胞分化;

主要科研课题:
1.
国家自然科学基金。81773066。基于调控转录因子FOXA2的长链非编码RNA在肝癌转移复发中的作用及分子机制研究。2018.01-2021.12。主持人

2. 广东省自然科学基金。2015A030310139。长链非编码RNA H19调控结肠癌中甲氨蝶呤的耐药性及其分子机理的研究。2015.82018.7 主持人
3.
广州市科技计划项目。2014J410OO45。调控神经胶质瘤中Trail耐受性的microRNAs及其分子机制的研究。2014.12016.6 主持人
4.
国家自然科学基金项目。81372450MiRNA-133a调控神经胶质瘤中TRAIL耐受性及分子机制研究。2014.12017.12 第二参与人
5.
国家自然科学基金。81201699。沉默原癌基因Bmi-1microRNAs在原发性肝癌中的功能及分子机制研究。2013.12015.12 第二参与人
6.
教育部留学人员资助项目。20151312。主持人

代表性论文:

Liang WC, Ren JL, Wong CW, Chan SO, Waye MM, Fu WM, Zhang JF.2018

LncRNA-NEF antagonized epithelial to mesenchymal transition and cancer metastasis via cis-regulating FOXA2 and inactivating Wnt/β-catenin signaling.

Oncogene. 37(11):1445-1456.

Wang SS, Feng L, Hu BG, Lu YF, Wang WM, Guo W, Suen CW, Jiao BH, Pang JX, Fu WM, Zhang JF. (2017).  miR-133a Promotes TRAIL Resistance in Glioblastoma via Suppressing Death Receptor 5 and Activating NF-κB Signaling. Mol Ther Nucleic Acids, 15;8:482-492.

Liu Y, Wang WM, Lu YF, Feng L, Li L, Pan MZ, Sun Y, Suen CW, Guo W, Pang JX, Zhang JF, Fu WM.(2017) Usp5 functions as an oncogene for stimulating tumorigenesis in hepatocellular carcinoma. Oncotarget, 6;8(31):50655-50664.

Liu Y, Wang WM, Zou LY, Li L, Feng L, Pan MZ, Lv MY, Cao Y, Wang H, Kung HF, Pang JX, Fu WM, Zhang JF.(2017) Ubiquitin specific peptidase 5 mediates Histidine-rich protein Hpn induced cell apoptosis in hepatocellular carcinoma through P14-P53 signaling. Proteomics, 17(12).

Liu Y, Liang Y, Zhang JF, Fu WM. MicroRNA-133 mediates cardiac diseases: Mechanisms and clinical implications.2017 Exp Cell Res. 354(2):65-70.

Wu KF, Liang WC, Feng L, Pang JX, Waye MM, Zhang JF, Fu WM. 2017H19 mediates methotrexate resistance in colorectal cancer through activating Wnt/β-catenin pathway. Exp Cell Res. 350(2):312-317.

Liu MH, Zhang Q, Zhang YH, Lu XY, Fu WM, He JY.(2016)Chemical Analysis of Dietary Constituents in Rosa roxburghii and Rosa sterilis Fruits. Molecules, 9;21(9).

He JY, Zhang YH, Ma N, Zhang XL, Liu MH*, Fu WM*.2016 Comparative analysis of multiple ingredients in Rosa roxburghiiand R.sterilisfruits and their antioxidant activities. Journal of Functional Foods, 27, 29-41 .
 Liu MH, Ko CH, Ma N, Tan PW, Fu WM*, He JY*.
2016Chemical profiles, antioxidant and anti-obesity effects of extract of BambusatextilisMcClure leaves. Journal of Functional Foods, 22, 533-546.
 Wei-Cheng Liang#, Wei-Ming Fu#, Yu-Bing Wang, Yu-Xin Sun, Liang-Liang Xu, Cheuk-Wa Wong, Kaiming Chan, Gang Li, Mary Miu-Yee Waye, and Jin-Fang Zhang .
2016H19 activates Wnt signaling and promotes osteoblast differentiation by functioning as a competing endogenous RNA. Scientific Reports. 8;6:20121.

Liang WC, Liang PP, Wong CW, Ng TB, Huang JJ, Zhang JF, Waye MM, Fu WM*. 2016CRISPR/Cas9 Technology Targeting Fas Gene Protects Mice From Concanavalin-A Induced Fulminant Hepatic Failure. J Cell Biochem. 9999;1-7,
Wang B, Guo J, Feng L, Suen CW, Fu WM*, Zhang JF, Li G*.
2016MiR124 suppresses collagen formation of human tendon derived stem cells through targeting egr1. Exp Cell Res. 1;347(2):360-6.  

Wu KF, Liang WC, Feng L, Pang JX, Waye MM, Zhang JF, Fu WM*.(2016)H19 mediates methotrexate resistance in colorectal cancer through activating Wnt/β-catenin pathway. Exp Cell Res. 350(2):312-317

Fu WM, Wang WM, Jiang HQ, Qi W, Wan DC, Zhang JF (2016) Long Noncoding RNA Hotair Mediated Angiogenesis in Nasopharyngeal Carcinoma by Direct and Indirect Signaling pathways. Oncotarget. 26;7(4):4712-23.

Liang WC, Fu WM, Wang WM, Jiang HQ, Qi W, Wan DC, Zhang JF, Waye MM (2015) The LncRNA H19 Promotes Epithelial to Mesenchymal Transition by Functioning as miRNA sponges in Colorectal Cancer. oncotarget . 8;6(26):22513-25

Fu WM, Zhu X, Wang WM, Lu YF, Hu BG, Wang H, Liang WC, Wang SS, Ko CH, Waye MM, Kung HF, Li G, Zhang JF. (2015) Hotair Mediates Hepatocarcinogenesis through Suppressing MiRNA-218 Expression and Activating P14 and P16 Signaling. J Hepatology. 63(4):886-95.
Lu YF, Zhang L, Waye MM, Fu WM*, Zhang JF*. (2015) MiR-218 Mediates tumorigenesis and metastasis: Perspectives and implications. Exp Cell Res. 15;334(1):173-182. Review
HING-LOK WONG, WING-SUM SIU, CHAK-HEI FUNG, CHENG ZHANG, WAI-TING SHUM, XUE-LIN ZHOU, CLARA BIK-SAN LAU, JING-FANG ZHANG, PING-CHUNG LEUNG, WEI-MING FU* and CHUN-HAY KO*.
2015 Characteristics of stem cells derived from rat fascia: In vitro proliferative and multilineage potential assessment. Molecular Medicine Reports. 11(3):1982-90
Fu WM ,Tang LP, Zhu X, Lu YF, Zhang YL, Lee WY, Wang H, Yu Y, Liang WC, Ko CH, Xu HX, Kung HF, Zhang JF.
2015MiR-218-targeting-Bmi-1 mediates the suppressive effect of 1,6,7-trihydroxyxanthone on liver cancer cells. Apoptosis. 20(1):75-82
He JY, Ma N, Zhu S, Komatsu K, Li ZY, Fu WM*. (2015) The genus Codonopsis (Campanulaceae): a review of phytochemistry, bioactivity and quality control. J Nat Med. 69(1):1-21
Zhang ZL, Zhu XL, Gao ZL, Lin HL,Fu WM*. (2014) Efficiency of 10-year vaccination (2001-2010) on Hepatitis A in Tianjin, China. Hum Vaccin Immunother, 10(4).
Fu WM, Wang WM, Wang H, Zhang JF. (2014) Staphylococcal Enterotoxin C2 Promotes Osteogenesis and Stimulates Bone Fracture Healing. Exp Cell Res. 322(1):202-7
Fu WM, Wang WM, Wang H, Zhu X, Liang Y, Kung HF, Zhang JF.(2014) 1,3,5-Trihydroxy-13,13-dimethyl-2H-pyran [7,6-b] xanthone directly targets heat shock protein 27 in hepatocellular carcinoma. Cell Biol Int. 38(2):272-6
Mo LN, Fu WM, Shu XH, Li CG. (2013) miR-128 and its target genes in tumorigenesis and metastasis. Experimental Cell Research. Exp Cell Res. 319(20):3059-64
Fu WM, Zhang JF, Wang H, Xi ZC, Wang WM, Zhuang P, Chen SC, Chan TM, Leung KS, Lu G, Xu HX, Kung HF. (2012) Heat shock protein 27 mediates the effect of 1,3,5-trihydroxy-13,13-dimethyl-2H-pyran [7,6-b] xanthone on mitochondrial apoptosis in hepatocellular carcinoma. J proteomics, 75(15):4833-43.
 Fu WM, Zhang JF, Wang H, Tan HS, Wang WM, Chen SC, Zhu X, Chan TM, Tse CM, Leung KS, Lu G, Xu HX, Kung HF. (2012) Apoptosis induced by 1,3,6,7-tetrahydroxyxanthone in Hepatocellular carcinoma and proteomic analysis. Apoptosis. 17(8):842-51.
Zhang JF, He ML, Fu WM, Wang H, Chen LZ, Zhu X, Chen Y, Chen G, Lu G, Lin MC, Kung HF(2011). Primate-specific miRNA-637 Inhibits Tumorigenesis in Hepatocellular Carcinoma by disrupting Stat3 signaling. Hepatology. 54(6):2137-48.

授权专利:
1.
付卫明、张锦芳、梁岩。一种调控肿瘤对TRAIL耐受性的药物。中国。ZL201310089306.4
2.
付卫明、张锦芳。MicroRNA用于制备降低神经胶质瘤对TRAIL耐受性的药物的用途。中国。ZL201410165917.7 

3. 付卫明、梁伟铖。LincRNA在制备调控甲氨蝶呤肿瘤治疗耐药性的药物中的应用。2013.11。中国。Zl201310611737.2

 

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