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蔡铮



姓名:蔡铮
职称:副教授,博士,硕士生导师
联系邮箱:caizheng2002@sina.com
联系电话:020-61648597

学习经历:
2005.09 ~ 2008.06 四川大学华西药学院,药剂学,博士
1999.09 ~ 2002.06 云南中医学院中药学院,中药学,硕士
1995.09 ~ 1999.06 沈阳药科大学药学院,药物制剂,学士

工作经历:
2012.01至今 南方医科大学药学院,副教授
2008.07 ~ 2011.12 南方医科大学药学院,讲师
2002.07 ~ 2005.08 昆明制药集团药物研究所,项目组长

承担课程:
1. 本科生课程:《药剂学》、《生物药剂学与药物动力学》、《药物制剂工程》、《制剂设计学》;
2. 研究生课程:《分子生物药剂学》。

研究方向:
1. 黏膜给药系统的研究;
2. 基于药物ADME特性的新剂型的设计与开发。

主要学术任职:
1. 世界中医药学会联合会中药药剂专业委员会,理事;
2. 中华中医药学会制剂分会,委员;
3. 广东省中药药剂与药理专业委员会,委员。

主要科研课题:
1. 中药天麻活性成分经鼻入耳转运机理及给药系统的研究(国家自然科学基金,No. 30902009,2010.01 ~ 2012.12,项目负责人)
2. 基于Fe2+增效机理的青蒿素类药物抗肿瘤纳米脂质体的研究(南方医科大学引进人才科研启动项目,2010.01 ~ 2011.12,项目负责人)
3. 天麻素时辰给药制剂的研发(企业合作项目,2011.01 ~ 2013.12,项目负责人)
4. 乙酰天麻素口服吸收与代谢机理研究(企业合作项目,2013.01 ~ 2014.12,项目负责人)
5. 影响中药有效性的生物利用度屏障分子机制研究(国家自然科学基金国际(地区)合作重大项目,No. 81120108025,2012.01 ~ 2016.12,主研人员)
6. 岭南复方中药三九胃泰有效部位的筛选及其口服原位凝胶剂的研制(广东省高等学校科技创新重点项目,No. CXZD1121,2012.01 ~ 2014.12,主研人员)
7. 从中药毛冬青抗炎组分中开发心脑血管疾病新药(广州市科技计划项目,No. CXZD1131,2011.09 ~ 2013.10,主研人员)

代表性论文:
1. Cai Zheng, Huang Juan, Luo Hui, Lei Xiaolu, Yang Zhaoxiang, Mai Yang, Liu Zhongqiu*. Role of glucose transporters in the intestinal absorption of gastrodin, a highly water-soluble drug with good oral bioavailability. Journal of Drug Targeting, 2013; 21(6): 574-580.
2. Cai Zheng, Lei Xiaolu, Lin Zhufen, Zhao Jie, Wu Feizhen, Yang Zhaoxiang, Pu Junxue, Liu Zhongqiu*. Preparation and evaluation of sustained-release solid dispersions co-loading gastrodin with borneol, an oral brain-targeting enhancer. Acta Pharmaceutica Sinica B, 2013; http://dx.doi.org/10.1016/j.apsb.2013.12.012.
3. Cai Zheng, Song Xiangrong, Sun Feng, Yang Zhaoxiang, Hou Shixiang, Liu Zhongqiu*. Formulation and evaluation of in situ gelling systems for intranasal administration of gastrodin. AAPS PharmSciTech, 2011; 12 (4): 1102-1109.
4. Cai Zheng, Wang Yan, Zhu Lijun, Liu Zhongqiu*. Nanocarriers: a general strategy for enhancement of oral bioavailability of poorly absorbed or pre-systemically metabolized drugs. Current Drug Metabolism, 2010; 11 (2): 197-207.
5. Cai Zheng, Hou Shixiang*, Li Yuanbo, Zhao Binbin, Yang Zhaoxiang, Xu Shuguang, Pu Junxue. Effect of borneol on the distribution of gastrodin to the brain in mice via oral administration. Journal of Drug Targeting, 2008; 16 (2): 178-184.
6. Sun Feng, Cai Zheng, Ishtiaq Chaudhary Muhammad, Xiao Peigen, Cheng Yiyu*. Distribution of the triterpenoid saponins and chemotaxonomy of the genus Clematis L. by high-performance liquid chromatography–mass spectrometry. Biochemical Systematics and Ecology, 2010; 38 (5): 1018-1025.
7. Sun Feng, Cai Zheng, Yang Depo, Xiao Peigen, Cheng Yiyu*. Determination of triterpenoid saponins in radix clematidis and related Clematis species by high performance liquid chromatography-mass spectrometry. Chinese Journal of Analytical Chemistry, 2010; 38 (9): 1293-1298.
8. Zheng Yu, Cai Zheng, Song Xiangrong, Chen Qiuhong, Bi Yueqi, Li Yuanbo, Hou Shixiang*. Preparation and characterization of folate conjugated N-trimethyl chitosan nanoparticles as protein carrier targeting folate receptor: in vitro studies. Journal of Drug Targeting, 2009; 17 (4): 294-303.
9. Song Xiangrong, Cai Zheng, Zheng Yu, He Gu, Cui Fengyu, Gong Daoqiong, Hou shixiang*, Xiong Sijing, Lei Xiangjie, Wei Yuquan. Reversion of multidrug resistance by co-encapsulation of vincristine and verapamil in PLGA nanoparticles. European Journal of Pharmaceutical Sciences, 2009; 37 (3): 300-305.
10. Zheng Yu, Cai Zheng, Song Xiangrong, Yu Bo, Bi Yueqi, Chen Qiuhong, Zhao Dong, Xu Jiapeng, Hou Shixiang*. Receptor mediated gene delivery by folate conjugated N-trimethyl chitosan in vitro. International Journal of Pharmaceutics, 2009; 382 (1-2): 262-269.
11. Zheng Yu, Song Xiangrong, He Gu, Cai Zheng, Zhou Yan, Yu Bo, Xu Jiapeng, Wei Yuquan, Hou Shixiang*. Receptor-mediated gene delivery by folate-poly (ethylene glycol)-grafted –trimethyl chitosan in vitro. Journal of Drug Targeting, 2011; 19 (8): 647-656.
12. Liu Wei, Tang Lan, Ye Ling, Cai Zheng, Xia Bijun, Zhang Jiajie, Hu Ming*, Liu Zhongqiu*. Species and gender differences affect the metabolism of emodin via glucuronidation. The AAPS Journal, 2010; 12 (3): 424-436.

申请专利:
1. 刘中秋, 蔡 铮, 黄 娟, 吴 越. 一种治疗中枢神经系统疾病的天麻苷元凝胶剂(专利授权号:ZL201010109013.4)
2. 蔡 铮, 刘中秋, 杨兆祥, 黄 娟, 普俊学, 龚 耘, 罗 辉. 一种天麻素时辰给药制剂(专利申请号:CN201110175929)
3. 蔡 铮, 刘中秋, 杨兆祥, 张国丽, 张 琪, 黄 娟, 龚 耘, 罗 辉, 唐琪晶. 一种天麻素两次脉冲释药制剂(专利申请号:CN201210064044.1)
4. 刘中秋, 蔡 铮, 罗 辉, 麦 扬, 钟天恒, 李绪乾, 雷晓璐, 伍飞臻. 治疗慢性胃炎中药在制备防治胃溃疡的药物中的应用(专利申请号:201310301077.8)
5. 蔡 铮, 刘中秋, 罗 辉, 麦 扬, 钟天恒, 李绪乾, 雷晓璐, 伍飞臻. 一种防治胃溃疡的口服原位凝胶剂(专利申请号:201310409522.2)

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