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唐斓


 

姓名:唐斓
职称:教授,博士生导师
邮箱:tl405@smu.edu.cn
电话:020-61648596

受教育经历
2007/09-2010/07, 南方医科大学药学院,药理学博士
2003/09-2006/07, 华中科技大学同济医学院,药剂学硕士
1999/09-2003/07, 华中科技大学同济医学院,学士


研究工作经历
2016/12-今, 南方医科大学药学院,药剂学,教授,博士生导师
2015/12-今, 南方医科大学药学院,生物药剂学,PI
2012/12-2016/11, 南方医科大学药学院,药剂学,副教授
2009/12-2012/11, 南方医科大学药学院,药剂学,讲师
2008/02-2009/01, 美国休斯顿大学,药学院药理与药剂学系,博士联合培养
2006/08-2009/11, 南方医科大学药学院,药剂学,助教


研究方向:
1. 基于基因组学的药物代谢研究
2. 创新药物的药代动力学研究


承担课程:
1. 本科生课程:《药剂学》、《生物药剂学与药物动力学》、《药物制剂工程》、《制剂设计学》
2. 研究生课程:《分子生物药剂学》


主要学术任职:
[1]. 世界中联中医药免疫专业委员会第一届理事会,理事
[2]. 广东省药理学会第一届治疗药物监测研究专业委员会,常务委员
[3]. 中华中医药学会中药制剂委员会,委员
[4]. 中国药理学会肾脏药理专业委员会,委员
[5]. 广东省中医药学会中药药剂与药理专业委员会,委员


获奖或称号:
[1]. 2016年广东省“百千万工程青年拔尖人才”
[2]. 2014年“广东省高等学校优秀青年教师培养计划” 专项资助
[3]. 2012年广州市“珠江科技新星”
[4]. 2011年广东省优秀博士学位论文


主持科研课题:
[1]. 国家自然科学基金面上项目 [81673677],2017.1-2020.12
[2]. 广东省自然科学基金面上项目[2016A030313592],2016.6-2019.6
[3]. 国家自然科学基金重点项目-新疆联合基金,合作单位课题负责人[U1203204],2013.1-2016.12
[4]. 广东省教育厅优秀青年教师培养计划项目[Yq2013037], 2014.1-2016.12
[5]. 广州市珠江科技新星专项 [2012J2200048],2012.7-2015.06
[6]. 广东省研究生创新培养计划项目[Sybzzxm201224],2013.1-2014.12
[7]. 广东高校优秀青年创新人才培育项目[YM11039],2011.7-2013.12
[8]. 国家自然科学基金青年项目[81001690],2011.1-2013.12


发表论文(#为共同第一,*为通讯作者)
[1]. Zhong S, Han W, Hou C, Liu J, Wu L, Liu M, Liang Z, Lin H, Zhou L, Liu S, Tang L*. Relation of Transcriptional Factors to the Expression and Activity of Cytochrome P450 and UDP-Glucuronosyltransferases 1A in Human Liver: Co-Expression Network Analysis. AAPS J, 2017 Jan;19(1):203-214.
[2]. Liu J, Yu X, Zhong S, Han W, Liang Z, Ye L, Zhao J, Liu M, Liu S, Wei Q, Tang L*. Hepatic and Renal Metabolism of Genistein: an Individual-based Model to Predict Glucuronidation Behavior of Genistein in Different Organs. Journal of Pharmaceutical and Biomedical Analysis. 2017. doi: 10.1016/j.jpba.2017.02.020.
[3]. Mo H, Wu Q, Miao J, Luo C, Hong X, Wang Y, Tang L, Hou FF, Liu Y, Zhou L. Chemokine Receptor CXCR4 Plays a Crucial Role in Mediating Oxidative Stress-Induced Podocyte Injury. Antioxid Redox Signal. 2016 Dec 13. DOI: 10.1089/ars.2016.6758.
[4]. Liu JE#, Ren B#, Tang L#, Tang QJ, Liu XY, Li X, Bai X, Zhong WP, Meng JX, Lin HM, Wu H, Chen JY, Zhong SL*.The independent contribution of miRNAs to the missing heritability in CYP3A4/5 functionality and the metabolism of atorvastatin. Scientific Reports. 2016 May 23;6:26544. doi: 10.1038/srep26544.
[5]. Zhong WP, Wu H3 Chen JY, Li XX, Lin HM, Zhang B, Zhang ZW, Ma DL, Sun S, Li HP, Mai LP, He GD, Wang XP, Lei HP, Zhou HK, Tang L, Liu SW, Zhong SL. A genome-wide association study identifies novel genetic loci that modify antiplatelet effects and pharmacokinetics of clopidogrel. Clin Pharmacol Ther. 2016 Dec 16. doi: 10.1002/cpt.589.
[6]. Chen R, He J, Tong X, Tang L, Liu M*. A Review on Phytochemistry, Pharmacology, Quality Control and Pharmacokinetics. Molecules. 2016 May 30;21(6). pii: E710.
[7]. Hu Y, Wang Z, Huang X, Xia B, Tang L, Zheng Z, Ye L. Oxidative metabolism of koumine is mainly catalyzed by microsomal CYP3A4/3A5. Xenobiotica. 2016 Aug 8:1-8.
[8]. Tang QJ, Lin H, He G, Liu J, Wu H, Li X, Zhong W, Tang L, Meng J, Zhang M, Li H, Chen J, Zhong S*, Wang L*. Plasma miR-142 accounting for the missing heritability of CYP3A4/5 functionality is associated with pharmacokinetics of clopidogrel. Pharmacogenomics.2016.Aug 24.
[9]. Zhong W, Wang X, Tang L, Mai L, Chen XP, He G, Zheng Z, Zhong S*.Simultaneous Determination of Ticagrelor and Its Metabolites in Human Plasma and Urine Using Liquid Chromatography-Tandem Mass Spectrometry. Journal of Analytical Toxicology 2016 May 10. pii: bkw039.
[10]. Wu L, Liu J, Han W, Zhou X, Yu X, Liu S, Tang L*. Time-dependent metabolism of luteolin by human UDP-glucuronosyltransferases (UGTs) and its intestinal first-pass glucuronidation in mice. Journal of Agricultural and Food Chemistry. 2015, 63, 8722-8733.
[11]. Wu L, Zhong W, Liu J, Han W, Zhong S, Wei Q, Liu S, Tang L*. Human microsomal cytochrome P450-mediated reduction of oxysophocarpine, an active and highly toxic constituent derived from Sophora flavescens species, and its intestinal absorption and metabolism in rat. Fitoterapia. 2015 Sep;105:26-36.
[12]. Tang L, Li Y, Chen W, Zeng S, Dong L, Peng X, Jiang W, Hu M, Liu Z*. Breast cancer resistance protein-mediated efflux of luteolin glucuronides in HeLa cells overexpressing UDP-glucuronosyltransferase 1A9. Pharmaceutical Research. 2014,31,847-860.
[13]. Tang L, Dong L, Peng X, Shi J, Zhou F, Liu Z*.Pharmacokinetic characterization of oxymatrine and matrine in rats after oral administration of radix Sophorae tonkinensis extract and oxymatrine by sensitive and robust UPLC-MS/MS method. Journal of Pharmaceutical and Biomedical Analysis, 2013, 83,179–185.
[14]. Fan Y#, Tang L#, Zhou J, Feng Q, Xia B, Liu Z*. Simultaneous determination of sulfation and glucuronidation of flavones in FVB/N mouse intestine in vitro and in vivo. Journal of Applied Toxicology, 2013, 33(4), 273-280.
[15]. Ye L, Lu L, Li Y, Zeng S, Yang X, Chen W, Feng Q, Liu W, Tang L, Liu Z*, Potential role of ATP-binding cassette transporters in the intestinal transport of rhein. Food Chemistry Toxicology. 2013, 58: p. 301-305.
[16]. Tang L#, Feng Q#, Zhao J, Dong L, Liu W, Yang C, Liu Z*. Involvement of UDP-glucuronosyltranferases and sulfotransferases in the liver and intestinal first-pass metabolism of seven flavones in C57 mice and humans. Food and Chemical Toxicology, 2012, 50(5):1460-7.
[17]. Tang L, Yang C, Zhou J, Xia B, Hu M, Liu Z*. Systematic studies of sulfation and glucuronidation of 12 flavonoids in the mouse liver S9 fraction reveals both unique and shared positional preferences. Journal of Agricultural and Food Chemistry. 2012,28; 60(12):3223-33.
[18]. Zhu L, Yang X, Zhou J, Tang L, Xia B, Hu M, Zhou FY, Liu Z*. The exposure of highly toxic aconitine does not significantly impact the activity and expression of cytochrome P450 3A in rats determined by a novel ultra-performance liquid chromatography-tandem mass spectrometric method of a specific probe buspirone. Food and Chemical Toxicology. 2012 Oct 22; 51:396-403.
[19]. Zhao J, Su C, Yang CP, Tang L, Su WW, Liu ZQ*. Determination of ginsenosides Rb1, Rb2, and Rb3 in rat plasma by a rapid and sensitive liquid chromatography tandem mass spectrometry method: Application in a pharmacokinetic study. Journal of Pharmaceutical and Biomedical Analysis. 2012; 64-65:94-7.
[20]. Zheng ZJ, Yan TM, Chen WY, Ye L, Tang L, Liu ZQ *, Pharmacokinetic determination of ephedrine in Herba Ephedrae and Wu Tou Tang decoctions in rats using ultra performance liquid chromatography tandem mass spectrometry. Xenobiotica. 2012, 42(8):775-83.
[21]. Tang L, Gong Y, Lv C, Ye L, Liu L, Liu Z*. Pharmacokinetics of aconitine as the targeted marker of Fuzi (Aconitum carmichaeli) following single and multiple oral administrations of Fuzi extracts in rat by UPLC/MS/MS. Journal of Ethnopharmacology, 2012 Jun 1;141(2):736-41.
[22]. Tang L, Ye L, Lv C, Zheng Z, Gong Y, Liu Z*. Involvement of CYP3A4/5 and CYP2D6 in the metabolism of aconitine using human liver microsomes and recombinant CYP450 enzymes. Toxicology Letters, 2011, 202, 47–54.
[23]. Singh R, Wu B, Tang L, Hu M*. Uridine diphosphate glucuronosyltransferase isoform-dependent regiospecificity of glucuronidation of flavonoids. Journal of Agricultural and Food Chemistry. 2011, 59(13), 7452-64.
[24]. Ye L, Wang T, Tang L, Liu W, Zhen Y, Zhou J, Zheng Z, Cai Z, Hu M *, Liu Z*. Poor oral bioavaibility of a promising anticancer gent andrographolide is due to extensive metabolism and efflux by P-glycoprotein. Journal of Pharmaceutical Sciences. 2011; 100(11):5007-17.
[25]. Ye L, Wang T, Yang C, Tang L, Zhou J, Lv C, Gong Y, Jiang Z, Liu Z*. Microsomal cytochrome P450 mediated metabolism of hypaconitine, an active and highly toxic constituent derived from Aconitum species. Toxicology Letters, 2011; 204: 81-91.
[26]. Yang C, Tang L, Lv C, Ye L, Xia B, Hu M, Liu Z* . Sulfation of selected mono-hydroxyflavones by sulfotransferases in vitro: a species and gender comparison. Journal of pharmacy and pharmacology. 2011, 63: 967–970.
[27]. Ye L, Tang L, Gong Y, Lv C, Zheng Z, Jiang Z, Liu Z*. Characterization of metabolites and human P450 isoforms involved in the microsomal metabolism of mesaconitine. Xenobiotica. 2011 Jan;41(1):46-58.
[28]. Tang L, Ye L, Singh R, Wu B., Lv C., Zhao J, Liu Z, Hu M. Use of glucuronidation fingerprinting to describe and predict mono- and dihydroxyflavone metabolism by recombinant UGT isoforms and human intestinal and liver microsomes. Molecular Pharmaceutics. 2010, 7, 664-679.
[29]. Liu W#, Tang L#, Ye L, Cai Z, Xia B, Zhang J, Hu M, Liu Z. Species and gender differences affect the metabolism of emodin via glucuronidation. The AAPS Journal. 2010, 12, 424-436.
[30]. Singh R, Wu B, Tang L, Liu Z, Hu M*. Identification of the position of mono-O-glucuronide of flavones and flavonols by analyzing shift in online UV spectrum (lambdamax) generated from an online diode array detector. Journal of Agricultural and Food Chemistry. 2010, 58, 9384-9395.
[31]. Zhou Q, Zheng Z, Xia B, Tang L, Lv C, Liu W, Liu Z*, Hu M*. Use of isoform-specific UGT metabolism to determine and describe rates and profiles of glucuronidation of wogonin and oroxylin A by human liver and intestinal microsomes. Pharmaceutical Research. 2010, 27, 1568-1583.
[32]. Yang Z, Zhu W, Gao S, Xu H, Wu B, Kulkarni K, Singh R, Tang L, Hu M. Simultaneous determination of genistein and its four phase II metabolites in blood by a sensitive and robust UPLC-MS/MS method: Application to an oral bioavailability study of genistein in mice. Journal of Pharmaceutical and Biomedical Analysis. 2010, 53, 81-89.
[33]. Wang S, Kulkarni K, Tang L, Wang J, Yin T, Daidoji T, Yokota H, Hu M. Disposition of flavonoids via enteric recycling: UDP-glucuronosyltransferase (UGT) 1As deficiency in Gunn rats is compensated by increases in UGT2Bs activities. Journal of Pharmacology and Experimental Therapeutics. 2009, 329, 1023-1031.
[34]. Zhou X, Tang L*, Liu Y. An isomeric mixture of novel cerebrosides isolated from Impatiens pritzellii reduces lipopolysaccharide-induced release of IL-18 from human peripheral blood mononuclear cells. Lipids. 2009, 44, 759-763.
[35]. Tang L, Singh R, Liu Z, Hu M. Structure and concentration changes affect characterization of UGT isoform-specific metabolism of isoflavones. Molecular Pharmaceutics. 2009, 6, 1466-1482.

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