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周春琼



姓名:周春琼
职称:讲师,博士
联系方式:南方医科大学药学院
Email: zcqlg@smu.edu.cn

工作经历:
2006.07 -至今 南方医科大学药学院,讲师

学习经历:
2003/09 – 2006/07,华南理工大学化工工程专业,博士
2000/09 – 2003/07,山西大学无机化学专业,硕士
1996/09 – 2000/06,三峡大学化学教育专业,学士

承担课程:
《物理化学》

科研课题:
1、 广东省自然科学基金(7300452),人工酶与肝靶向载体乳糖化壳聚糖偶联物的抗肝癌研究,2007.10-2010.10,项目负责人。
2、 绿色催化四川省高校重点实验室开放基金项目(LYJ11010),特异性识别和定位切割DNA的人工核酸酶的构筑,2011.11-2013.11,项目负责人。
3. 南方医科大学科研启动计划,以端粒DNA为靶点的抗肝癌药物的设计,2012.12-2014.12,项目负责人。
4. 广东省科技计划项目(2012B050100007),特异性识别和定位切割人端粒DNA的金属核酸酶技术的联合研究,2012.11-2015.11,项目负责人,排名第二。
5. 广东省教育厅项目(2012KJCX0024),高序列选择性的DNA定位切割剂的构筑,2012.12- 2015.12,参与,排名第二。

主要论著:
1. Zhou, C. Q.; Lin, Y. L.; Yang, J.-W.; Chen, J. X.; Chen, W. H.* Synthesis, DNA-cleaving and cytotoxicities of C2-symmetrical dipyrrole-polyamide dimer-based Cu(II) complexes: A comparative study, Eur. J. Med. Chem., 2013, 66, 508-515.
2. Wang,Y. M.; Zhou, C. Q. (Co-first author); Lin, Y. L.; Chen, J. X.; Kuang, B. C.; Fu, W. L.; Chen, W. H.* Facile synthesis of a polyether-tethered dimeric berberine as a highly effective DNA-cleaving agent in the presence of Cu(II) ion, Med. Chem. Comm., 2013, 4, 1400-1404.
3. Chen, M. Z.; Chen, M.; Zhou, C. Q.; Lin, W. E.; Chen, J. X.*; Chen, W. H.*; Jiang, Z. H. Synthesis, crystal structures and DNA-cleaving activities of [Cemp]2[MCl4] (Cemp = N-carbethoxymethyl-1, 10-phenanthrolinium, M=CuII, ZnII, CoII, NiII and MnII), Chem. Pharm. Bull., 2013, 61(7), 714-721.
4. Chen, M.; Chen, M. Z.; Zhou, C. Q.; Lin, W. E.; Chen, J. X.*; Chen, W. H.*; Jiang, Z. H. Towards polynuclear metal complexes with enhanced bioactivities: synthesis, crystal structures and DNA cleaving activities of CuII, NiII, ZnII, CoII and MnII complexes derived from 4-carboxy-1-(4- carboxybenzyl) pyridinium bromide, Inorg. Chim. Acta., 2013, 405, 461-469.
5. Wang,Y. M.; Zhou, C. Q.; Chen, J. X.; Chen, W. H.* Synthesis and DNA-binding properties of trehalose-tethered monomeric and dimeric berberines, Bull. Korean Chem. Soc., 2013, 34(3), 749-752.
6. Zhou, C. Q.; Lin, Y. L.; Chen, J. X.; Wang, L. S.; Yang, N. N.; Zeng, W.; Chen, W.-H.* Facile synthesis of a dimeric pipyrrole-polyamide and synergetic DNA-cleaving activity of its Cu(II) complex. Bioorg. Med. Chem. Lett., 2012, 22(18), 5853-5856.
7. Zhou, C. Q.; Lin, Y. L.; Chen, J. X.; Chen, W.-H.* Synergetic DNA-cleaving activities of metal complexes of a polyether-tethered pyrrole-polyamide dimer. Chem. Biodiv., 2012, 9(6), 1125-1132.
8. Chen, J. X.; Lin, W. E.; Chen, M. Z.; Zhou, C. Q.; Lin, Y. L.; Chen, M.; Jiang, Z. H.*; Chen, W.-H.* Synthesis, characterization and potent DNA-cleaving activity of copper(II)- complexed berberine carboxylate. Bioorg. Med. Chem. Lett., 2012, 22(23), 7056-7059.
9. Chen, J. X.; Lin, W. E.; Zhou, C. Q.; Yau, L. F.; Wang, J. R.; Wang, B.; Chen, W.-H.*; Jiang, Z. H. Synthesis, crystal structures and biological evaluation of water-soluble zinc complexes of zwitterionic carboxylates. Inorg. Chim. Acta., 2011, 376(1), 389-395.
10. Zhou, Z. Z.; Zou, M.; Zhou, J.; Zhou, C. Q.; Deng, Y. H.; Chen, M. H.; Gu, C. P.; Jiang, Z. H.; Chen, W.-H.*; Liu, S. W.* Synthesis, cytotoxicities and DNA-binding affinities of benzofuran-3-ols and their fused analogs. Chem. Pharm. Bull., 2011, 59(8), 1057-1061.
11.邹敏,刘叔文,周春琼*,一种新的吡咯多胺镍配合物的合成及其与DNA的作用研究, 化学学报,2010,68 (6): 481–486。
12. 周春琼,邹敏,游文玮,唐中坤,郭瑞芬,吡咯-多胺钴配合物的合成及与DNA的作用研究, 无机化学学报,2010,26 (2): 257–262。

专利:
1. 周春琼,周中振,一种对称的多胺与吡咯聚酰胺缀合物及其制备方法,2011.09,中国,ZL200910194140.6。

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