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刘叔文

 

姓名:刘叔文
职称:教授(二级岗),博士生导师
联系邮箱:liusw@smu.edu.cn
联系电话:020-61648538

学习经历:
1989.9-1993.7 南昌大学 ,食品化学,学士
1993.9-1996.4 华南理工大学,发酵工程,硕士
1999.9-2002.7 第一军医大学,药理学,博士
2002.4-2014.12 纽约血液中心 ,博士后(Research Fellow)

工作经历:
1996.4-1998.9 第一军医大学药物研究所,助教
1998.9-2004.8 第一军医大学药物研究所,讲师
2004.8-2005.12 南方医科大学药学院,讲师
2005.1-2005.5 纽约血液中心,助理研究员(Assistant Member)
2005.12- 南方医科大学药学院,教授
2008.10-2009.1 德国乌尔姆大学,访问教授
2009.6-2009.10 英国伦敦大学,高级研究学者
2010.1- 南方医科大学药学院,免疫与生化药理学科主任
2012.12- 南方医科大学药学院,院长

研究方向:
1. 病毒进入抑制剂的高通量药物筛选研究;
2. 膜融合的作用机理及膜融合抑制剂的作用机制研究;
3. 预防HIV性传播的杀微生物剂研究;
4. 病毒感染的免疫药理学研究。

主要学术任职:
1. 中国药理学会,理事
2. 中国药理学会抗炎免疫药理专业委员会,副主任委员;
3. 广东省药理学会,副理事长;
4. 广东省新药筛选重点实验室,主任;
5. 广东省青年科学家学会,理事;
6. 广东省高性能计算学会生物医药专业委员会,主任委员;
7. Acta Pharmacologica Sinica, 编委;
8. 中国药理学通报,编委。

主要获奖情况:
1. 广东省高等学校“珠江学者”特聘教授,广东省教育厅,2010;
2. Young Research New Star Scientist Award,Pfizer/科学新闻/Elsvier,2010;
3. 广东省科技进步二等奖。B17-0-2-01。广东省科学技术委员会,2008;
4. 广东省高等学校“千百十工程”国家级培养对象,广东省教育厅,2008;
5. 中国药理学会青年药理学工作者奖,中国药理学会,2007年;
6. “新世纪优秀人才”,国家教育部,2007。

主要科研课题:
1. 国家自然科学基金-广东联合基金重点项目。U1301224。以血凝素蛋白保守功能区为新靶点的小分子天然来源流感病毒进入抑制剂研究。2014.1~2017.12。
2. 国家重大新药创制专项课题。2014ZX09509001-004。中药祛毒增宁胶囊及与HAART联合治疗HIV/AIDS的临床研究。2014.1~2016.12。
3. 国家自然科学基金项目。31370781。HIV包膜蛋白gp120降解多肽形成淀粉样纤维结构促进HIV感染的研究。2014.1~2017.12。
4. 国家自然科学基金-广东省联合基金重点项目。U0832001。以HIV包膜蛋白为靶点的病毒进入抑制剂及其分子机制。2009.1~2012.12。
5. 国家科技重大专项课题。2009ZX09103-011。以HIV gp41为靶点的四氮唑芳基杂环类新型抗艾滋病药物研究。2009.1~2010.12。
6. 国家自然科学基金委海外、港澳青年合作基金(国内合作者)。30729001。2008.1~2010.12。
7. 国家自然科学基金项目。30772602。靶向血凝素跨膜亚基HA2的H5N1禽流感病毒进入抑制剂的研究。2008.1~2010.12。
8. 国家自然科学基金项目。30672496。基于T-20新作用机制的HIV融合抑制剂药物新靶点的研究。2007.1~2009.12。
9. 教育部高等学校科技创新工程重大项目培育基金。706047。多酚类小分子化合物预防和治疗艾滋病的研究。2007.1~2008.12。
10. 教育部新世纪优秀人才计划。NCET-06-0753。2007.1~2009.12。

代表性论文:
1.Tan SY, Duan H, Xun TR, Ci W, Qiu JY, Yu F, Zhao XY, Wu LX, Li L, Lu L, Jiang SB, Liu SW*. HIV-1 Impairs Human Retinal Pigment Epithelial Barrier Function: Possible Association with the Pathogenesis of HIV-associated Retinopathy. Laboratory Investigation.2014, in press.
2.Tan SY, Li L, Lu L, Pan CG, Lu H, Oksov Y, Tang XJ, Jiang SB*, Liu SW*. Peptides Derived from HIV-1 gp120 Co-receptor Binding Domain Form Amyloid Fibrils and Enhance HIV-1 Infection. FEBS Letters. 2014, in press.
3.Yu F, Lu L, Liu Q, Yu XW, Wang LL, He E, Zou P,Du LY, Sanders RW, Liu SW*, Jiang SB*. ADS-J1 inhibits HIV-1 infection and membrane fusion by targeting the highly conserved pocket in the gp41 NHR-trimer. Biochimica et Biophysica Acta-Biomembrane, 2014;1838(5):1296-1305.
4.Gu CP, Yu FL, Yu L, He XY, Zhong DS, He LG, Lv LY, Xie L, Liu SW*. A novel synthetic dibenzocyclooctadiene lignan analog XLYF-104-6 attenuates lipopolysaccharide-induced inflammatory response in RAW264.7 macrophage cells and protects BALB/c mice from sepsis. European Journal of Pharmacology,2014; 729(1): 22-29
5.Zhou ZZ, Gu CP, Deng YH, Yan GH, Li XF, Yu L, Chen WH*, Liu SW*. Synthesis, selective cytotoxicities and probable mechanism of action of 7-methoxy-3-arylflavone-8-acetic acids. Bioorganic & Medicinal Chemistry, 2014; 22(5): 1539-1547
6.He LG, Li XL, Zeng XZ, Duan H, Wang S, Lei LS, Li XJ*, Liu SW*. Sinomenine induces apoptosis in RAW 264.7 cell-derived osteoclasts via caspase-3 activation. Acta Pharmacologica Sinica. 2014; 35(2): 203-10
7.Yu FL, He XY, Gu CP, Ohkoshi E, Wang LT, Lai CY, Yu L, Wang SB, Morris-Natschke SL, Lee KX, Liu SW*, Xi L*. Discovery of Novel Antitumor Dibenzocyclooctatraene Derivatives and Related Biphenyls as Potent Inhibitors of NF-kappaB Signaling Pathway. Bioorganic & Medicinal Chemistry, 2014; 22(1): 325-33.
8.ZhuQH, HuangL, SuJR, Liu SW*. A sensitive and visible fluorescence-turn-on probe for the CMC determination of ionic surfactants. Chemical Communications, 2014; 50(9): 1107-1109
9.Yu L, Liu SW*. Autophagy contributes to modulating the cytotoxicities of Bcl-2 homology domaim-3 mimetics.Seminars in Cancer Biology, 2013, 23(6 Pt B):553-60
10.Song DS, Xu HH*, Liu SW*. Theoretical Studies of the Interactions between Hemagglutinin of the Influenza Virus and its Small Molecule Ligands. Journal of Molecular Modeling, 2013; 19(12): 5561-8.
11.Qiu J, Ashkenazi A, Liu S, Shai Y. Structural and Functional Properties of the Membranotropic HIV-1 Gp41 Loop Region are Modulated by its Intrinsic Hydrophobic Core. Journal of Biological Chemistry.2013, 288(40):29143-29150
12.Li XJ, He LG, Hu YP, Duan H, Li XL, Tan SY, Zou M, Gu CP, Yu L, Xu JK, Liu SW*. Sinomenine suppresses osteoclast formation and Mycobacterium tuberculosis H37Ra-induced bone loss by modulating RANKL signaling pathways. PLoS One, 2013, 8(9): e74274
13.Huang L, Su JR, Zhong DS, Liu RY, Wang HB, Yu L, ZhuQH*, Liu SW*.Copper-Induced Fluorescence Enhancement and Particle-Size Decrease. RSC Advances,2013, 3 (32), 13286-13292
14.Lv LY, ZhengSC, CaiXT, ChenZP, Zhu QH*, Liu SW*. Development of four-component synthesis of tetra- and pentasubstituted polyfunctional dihydropyrroles: free permutation and combination of aromatic and aliphatic Amines. ACS Combinatorial Science. 2013; 15(4):183-92
15.Tan SY, Lu L, Li L, Liu JX, Oksov Y, Lu L, Jiang SB*, Liu SW*. Polyanionic candidate microbicides accelerate the formation of semen-derived amyloid fibrils to enhance HIV-1 infection. PLoS One,2013, 8(3): e59777 IF: 3.730
16.Li L, Qiu JY, LuL, An SL, Qiao P, Jiang SB, Liu SW*. 3-Hydroxyphthalic anhydride-modified human serum albumin as a microbicide candidate inhibits HIV infection by blocking viral entry. Journal of Antimicrobial Chemotherapy. 2013; 68(3): 573-576
17.Yang J, Li MM, Shen XT, Liu SW*. Influenza A virus entry inhibitors targeting the hemagglutinin. Viruses, 2013; 5(1): 352-373.
18.Bai Y, Xue HF, Wang K, Cai LF, Qiu JY, Bi SY, Lai LH, Chen MS, Liu SW*, Liu KL*. Covalent fusion inhibitors targeting HIV-1 gp41 deep pocket. Amino Acids, 2013; 44(2): 701-713
19.Chen MH, Yu L, Gu CP, Zhong DS, Wu SG, Liu SW*. Celecoxib antagonizes the cytotoxic effect of cisplatin in human gastric cancer cells by decreasing intracellular cisplatin accumulation. Cancer Letters, 2013; 329: 189-196
20.Zhu QH, Huang L, Chen ZP, Zheng SC, Lv LY, Zhu ZB, Cao DL, Jiang HF*, Liu SW*. A Novel Series of C-6 Unsubstituted Tetrahydropyrimidines: Convenient One-Pot Chemoselective Synthesis, Aggregation-Induced and Size-Independent Emission Characteristics. Chemistry: A European Journal. 2013; 19(4): 1268-1280
21.Yang J, Li L, Jin H, Tan SY, Qiu JY, Yang L, Ding YQ, Jiang ZH, Jiang SB,Liu SW*. Vaginal gel formulation based on theaflavin derivatives as a microbicide to prevent HIV sexual transmission. AIDS Research and Human Retroviruses,2012, 28(11):1498-508
22.Zhu ZB, Li RM, Xiao GK, Chen ZP, Yang J, Zhu QH,Liu SW*. Design, synthesis and structure-activity relationship of novel inhibitors against H5N1 hemagglutinin-mediated membrane fusion.European Journal of Medicinal Chemistry.2012, 57: 211-6.
23.Li RM, Song DS, Zhu ZB, Xu HH, Liu SW*. An induced pocket for the binding of potent fusion inhibitor CL-385319 with H5N1 influenza virus hemagglutinin. PLoS One,2012, 7(8): e41956
24.Zhu QH, Gao LX, Chen ZP, Zheng SC, Su HF, Li J*, Jiang HF*, Liu SW*. A novel class of small-molecule caspase-3 inhibitors prepared by multicomponent reactions. European Journal of Medicinal Chemistry. 2012, 54: 232-238.
25.Zeng YL, Li W, Li JT, Wang JJ, Zhou B, Zhang J, Liu SW*, Wu YS, Hou JL, Zhou YP*. Hepatitis C virus amino acid sequence diversity correlates with the outcome of combined interferon/ribavirin therapy in Chinese patients with chronic hepatitis C. Archive of Virology. 2012, 157(1): 1113-1121.
26.Jia QY, Jiang XF, Yu F, Qiu JY, Kang XY, Cai LF, Li L, Shi WG, Liu SW*, Jiang SB*, Liu KL*. Short cyclic peptides derived from the C-terminal sequence of α1-antitrypsin exhibit significant anti-HIV-1 activity. Bioorganic & Medicinal Chemistry Letters.2012, 22(7): 2393-5.
27.Li XJ, Hu YP, He LG, Wang S, Zhou H, Liu SW*. Icaritin inhibits T cell activation and prolongs skin allograft survival in mice. International Immunopharmacology.2012; 13(1): 1-7.
28.Yang J, Li L, Tan SY, Jin H, Qiu JY, Mao QC, Li RM, Xia CL, Jiang ZH, Jiang SB, Liu SW*. A natural theaflavins preparation inhibits HIV-1 infection by targeting the entry step: potential applications for preventing HIV-1 infection. Fitoterapia, 2012; 83(2): 348-355
29.Yu L, Chen MH, Li ZJ, Wen J, Fu JH, Guo G, Jiang Y, Wu SW, Cho CH, Liu SW*. Celecoxib antagonizes the cytotoxicity of cisplatin in human esophageal squamous cell carcinoma cells by reducing intracellular cisplatin accumulation. Molecular Pharmacology, 2011; 79(3): 608-617
30.Li L, Tan SY, Lu H, Lu L, Yang J, Jin H, Liu SW*, Jiang S*. Combinations of 3-Hydroxyphthalic Anhydride-modified Ovalbumin with Antiretroviral Drug-based Microbicide Candidates Display Synergistic and Complementary Effects against HIV-1 Infection. Journal of Acquired Immune Deficiency Syndromes,2011; 56(5): 384-392
31.Liu SW*, Li RM, Zhang RT, Chan C, Xi BM, Zhu ZB, Yang J, Poon V, Zhou J, Chen M, Münch J, Kirchhoff F, Pleschka S, Haarmann T, Dietrich U, Pan CG, Du LY, Jiang SB, Zheng BJ*. CL-385319 inhibits H5N1 avian influenza A virus infection by blocking viral entry. European Journal of Pharmacology, 2011; 660(2-3): 460-467
32.Shang SF, Tan SY, Li KB, Wu J, Lin HN, Liu SW*, DengYQ*. Glu659Leu substitution of recombinant HIV fusion inhibitor C52L induces soluble expression in E. coli with equivalent anti-HIV potency. Protein Engineering, Design & Selection, 2011; 24(7): 545-551
33.Xia CL, Luo DX, Yu XL, Jiang SB*, Liu SW*.HIV-associated dementia in the era of highly active antiretroviral therapy (HAART). Microbes and Infection, 2011; 13: 419-425
34.Zhou ZZ, Zou M, Zhou J, Zhou CQ, Deng YH, Chen MH, Gu CP, Jiang ZH, Chen WH*, Liu SW*. Synthesis, Cytotoxicities and DNA-Binding Affinities of Benzofuran-3-ols and Their Fused Analogs. Chemical and Pharmaceutical Bulletin,2011; 59(8): 1057-1061.
35.Li L, Qiao P, Yang J, Tan S, Lu H, Zhang X, Chen X, Wu S, Jiang S*, Liu S*. Maleic anhydride-modified chicken ovalbumin as an effective and inexpensive anti-HIV microbicide candidate for prevention of HIV sexual transmission. Retrovirology, 2010, 7(1): 37
36.Li L, He L, Tan S, Guo X, Lu H, Qi Z, Pan C, An X, Jiang S*, Liu S*. 3-Hydroxyphthalic Anhydride-modified Chicken Ovalbumin Exhibits Potent and Broad Anti-HIV-1 Activity: a Potential Microbicide for Preventing Sexual Transmission of HIV-1. Antimicrobial Agents and Chemotherapy, 2010, 54(5): 1700-1711
37.Wang HT, QiZ, Guo A, Mao QC, Lu H, AnXL, XiaCL, LiXJ, Debnath AK, Wu SG, Liu SW*, Jiang SB*. ADS-J1 inhibits HIV-1 entry by interacting with the gp41 pocket region and blocking the fusion-active gp41 core formation. Antimicrobial Agents and Chemotherapy, 2009; 53(12):4987-4998
38.Du LY, He YX, Zho YS, Liu SW, Zheng BJ, Jiang SB. The spike protein of SARS-CoV — a target for vaccine and therapeutic development. Nature Review of Microbiology, 2009; 7(3): 226-236
39.Liu SW*, Jing W, Cheng B, Lu H, Sun J, Yan X, Niu J, Farmar J, Wu S, Jiang S. HIV gp41 c-terminal heptad repeat contains multi-functional domains: relation to mechanisms of action of anti-HIV peptides.Journal of Biological Chemistry, 2007; 282(13): 9612-9620
40.Liu SW, Wu SG, Jiang SB. HIV entry inhibitors targeting gp41: from polypeptides to small-molecule compounds.Current Pharmaceutical Design,2007; 13(2): 143-162.
41.Jiang SB, Liu SW, Stone A. Chinaneeds safe and effective microbicides for preventing the sexual transmission of HIV.Lancet Infectious Diseases, 2006; 6(11): 681-682
42.Liu SW, Lu H, Niu J, Xu Y, Wu S, Jiang S. Different from the HIV fusion Inhibitor C34, the anti-HIV drug Fuzeon (T-20) inhibits HIV-1 entry by targeting multiple sites in gp41 and gp120. Journal of Biological Chemistry, 2005; 260(12): 11259-11273
43.Liu SW, Lu H, Neurath AR, Jiang S. Combination of candidate microbicides cellulose acetate 1,2-benzenedicarboxylate and UC781 results in synergistic and complementary effects against human immunodeficiency virus type 1 infection. Antimicrobial Agents and Chemotherapy, 2005; 49(5): 1830-1836
44.Liu SW, Lu H, Zhao Q, He Y, Niu J, Debnath AK, Wu S, Jiang S. Theaflavin derivatives in black tea and catechin derivatives in green tea inhibit HIV-1 entry by targeting gp41. Biochimica et Biophysica Acta - general subjects,2005; 1723(1-3):270-281
45.Liu SW, Xiao GF, Chen YB, He YX, Niu JK, Escalante CR, Xiong HB, Farmar J, Debnath AK, Tien P, Jiang SB. Interaction between the heptad repeat 1 and 2 regions in spike protein of SARS-associated coronavirus: Implication for virus fusogenic mechanism and identification of fusion inhibitors. Lancet, 2004; 363(9413): 938-947
46.Liu SW, Jiang SB. High throughput screening and characterization of HIV-1 entry inhibitors targeting gp41: theories and techniques.Current Pharmaceutical Design, 2004; 10(15): 1827-1843
47.Liu SW, Zhao Q, Jiang S. Determination of the HIV-1 gp41 fusogenic core conformation modeled by synthetic peptides: applicable for identification of HIV-1 fusion inhibitors. Peptides, 2003;24(9): 1303-1313
48.Liu SW, Boyer-Chatenet L, Lu H, Jiang S. Rapid and automated fluorescence-linked immunosorbent assay for high throughput screening of HIV-1 fusion inhibitors targeting gp41. Journal of Biomolecular Screening,2003; 8(6): 685-693
49.Liu SW, Jiang S, Wu Z, Lv L, Zhang J, Zhu Z, Wu S. Identification of an inhibitor of the HIV-1 gp41 six-helix bundle formation from extracts of Chinese medical herbs Prunella Vulgaris and Rhizoma Cibotte. Life Sciences, 2002; 71: 1779-1791
50.Liu SW, Lu H, Zhao Q, He Y, Niu J, Debnath AK, Wu S, Jiang S. Theaflavin derivatives in black tea and catechin derivatives in green tea inhibit HIV-1 entry by targeting gp41. Biochimica et Biophysica Acta - general subjects,2005; 1723(1-3):270-281
51.Liu SW, Xiao GF, Chen YB, He YX, Niu JK, Escalante CR, Xiong HB, Farmar J, Debnath AK, Tien P, Jiang SB. Interaction between the heptad repeat 1 and 2 regions in spike protein of SARS-associated coronavirus: Implication for virus fusogenic mechanism and identification of fusion inhibitors. Lancet, 2004; 363(9413): 938-947
52.Liu SW, Jiang SB. High throughput screening and characterization of HIV-1 entry inhibitors targeting gp41: theories and techniques.Current Pharmaceutical Design, 2004; 10(15): 1827-1843
53.Liu SW, Zhao Q, Jiang S. Determination of the HIV-1 gp41 fusogenic core conformation modeled by synthetic peptides: applicable for identification of HIV-1 fusion inhibitors. Peptides, 2003;24(9): 1303-1313
54.Liu SW, Boyer-Chatenet L, Lu H, Jiang S. Rapid and automated fluorescence-linked immunosorbent assay for high throughput screening of HIV-1 fusion inhibitors targeting gp41. Journal of Biomolecular Screening,2003; 8(6): 685-693
55.Liu SW, Jiang S, Wu Z, Lv L, Zhang J, Zhu Z, Wu S. Identification of an inhibitor of the HIV-1 gp41 six-helix bundle formation from extracts of Chinese medical herbs Prunella Vulgaris and Rhizoma Cibotte. Life Sciences, 2002; 71: 1779-1791

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